Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, Toshiro, Vries, Robert G., Snippert, Hugo J., van de Wetering, Marc, Barker, Nick, Stange, Daniel E., van Es, Johan H., Abo, Arie, Kujala, Pekka, Peters, Peter J., Clevers, Hans·2009·Nature

DOI 10.1038/nature07935

Cited by (1,079)

Items 101–200 of 1,079

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis
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Induced pluripotent stem cells in disease modelling and drug discovery
R. Grant Rowe, George Q. Daley · 2019 · Nature Reviews Genetics
YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P. Fordham, Stine Lind Hansen, Hjalte List Larsen, Jordi Guiu, Mariana R. P. Alves, Carsten F. Rundsten et al. · 2017 · Cell stem cell
Cell fate specification and differentiation in the adult mammalian intestine
Joep Beumer, Hans C. Clevers · 2020 · Nature Reviews Molecular Cell Biology
A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo
Christopher G. Hubert, Maricruz Rivera, Lisa C. Spangler, Qiulian Wu, Stephen C. Mack, Briana C. Prager, Marta Couce, Roger E. McLendon, Andrew Edward Sloan, Jeremy N. Rich · 2016 · Cancer Research
Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids
Martinez-Guryn, Kristina, Hubert, Nathaniel, Frazier, Katya, Urlass, Saskia, Musch, Mark W., Ojeda, Patricia, Pierre, Joseph F., Miyoshi, Jun, Sontag, Timothy J., Cham, Candace M. et al. · 2018 · Cell Host & Microbe
Establishment of patient-derived cancer organoids for drug-screening applications
Else Driehuis, Kai Kretzschmar, Hans C. Clevers · 2020 · Nature Protocols
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
de Lau, Wim, Peng, Weng Chuan, Gros, Piet, Clevers, Hans · 2014 · Genes & Development
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells
Farin, Henner F., Van Es, Johan H., Clevers, Hans · 2012 · Gastroenterology
Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer
Alex Gregorieff, Yu Liu, Mohammad Reza Inanlou, Yuliya Khomchuk, Jeffrey L. Wrana · 2015 · Nature
Secreted and transmembrane wnt inhibitors and activators
Cruciat, C.-M., Niehrs, C. · 2013 · Cold Spring Harbor Perspectives in Biology
Stem cell fate in cancer growth, progression and therapy resistance
Nikki K. Lytle, Alison G. Barber, Tannishtha Reya · 2018 · Nature reviews. Cancer
A gp130–Src–YAP module links inflammation to epithelial regeneration
Taniguchi, Koji, Wu, Li-Wha, Grivennikov, Sergei I., de Jong, Petrus R., Lian, Ian, Yu, Fa-Xing, Wang, Kepeng, Ho, Samuel B., Boland, Brigid S., Chang, John T. et al. · 2015 · Nature
Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression
Seino, Takashi, Kawasaki, Shintaro, Shimokawa, Mariko, Tamagawa, Hiroki, Toshimitsu, Kohta, Fujii, Masayuki, Ohta, Yuki, Matano, Mami, Nanki, Kosaku, Kawasaki, Kenta et al. · 2018 · Cell Stem Cell
Organoids: A historical perspective of thinking in three dimensions
Simian, Marina, Bissell, Mina J. · 2017 · Journal of Cell Biology
Homeostasis of the gut barrier and potential biomarkers
Jerry Mark Wells, Robert J. Brummer, Muriel Derrien, Thomas Thornton MacDonald, Freddy J. Troost, Patrice D. Cani, Vassilia Théodorou, Jan P. Dekker, Agnès Méheust, Willem M. de Vos et al. · 2016 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice
Lingyan Ma, Yinhua Ni, Zhe Wang, Wenqing Tu, Liyang Ni, Fen Zhuge, Aqian Zheng, Luting Hu, Yufeng Zhao, Liujie Zheng et al. · 2020 · Gut Microbes
Plasticity of epithelial stem cells in tissue regeneration
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De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
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Intestinal Bacteria and the Regulation of Immune Cell Homeostasis
David A. Hill, David Artis · 2010 · Annual Review of Immunology
Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease
Alan M. Hanash, Jarrod A. Dudakov, Guoqiang Hua, Margaret Helen O'Connor, Lauren F. Young, Natalie V. Singer, Mallory L. West, Robert R. Jenq, Amanda M. Holland, Lucy W. Kappel et al. · 2012 · Immunity
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
Moshe Biton, Adam L. Haber, Noga Rogel, Grace Burgin, Semir Beyaz, Alexandra Schnell, Orr Ashenberg, Chien‐Wen Su, Christopher S. Smillie, Karthik Shekhar et al. · 2018 · Cell
Lgr5 stem cells are indispensable for radiation-induced intestinal regeneration
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Replacement of lost Lgr5-positive stem cells through plasticity of their enterocyte-lineage daughters
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Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny
Xiaolei Yin, Henner F. Farin, Johan H. van Es, Hans C. Clevers, Róbert Langer, Jeffrey M. Karp · 2013 · Nature Methods
Precision medicine for cancer with next-generation functional diagnostics
Friedman, Adam A., Letai, Anthony, Fisher, David E., Flaherty, Keith T. · 2015 · Nature Reviews Cancer
A rectal cancer organoid platform to study individual responses to chemoradiation
Ganesh, Karuna, Wu, Chao, O’Rourke, Kevin P., Szeglin, Bryan C., Zheng, Youyun, Sauvé, Charles-Etienne Gabriel, Adileh, Mohammad, Wasserman, Isaac, Marco, Michael R., Kim, Amanda S. et al. · 2019 · Nature Medicine
Self-organization and symmetry breaking in intestinal organoid development
Serra, Denise, Mayr, Urs, Boni, Andrea, Lukonin, Ilya, Rempfler, Markus, Challet Meylan, Ludivine, Stadler, Michael B., Strnad, Petr, Papasaikas, Panagiotis, Vischi, Dario et al. · 2019 · Nature
A brief history of organoids
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Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition
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Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
Lukas E. Dow, Kevin P. O’Rourke, Janelle M. Simon, Darjus Felix Tschaharganeh, Johan H. van Es, Hans C. Clevers, Scott W. Lowe · 2015 · Cell
Villification: How the Gut Gets Its Villi
Amy E. Shyer, T. Tallinen, Nandan L. Nerurkar, Zhiyan Wei, Eun Seok Gil, David Lee Kaplan, Clifford James Tabin, L. Mahadevan · 2013 · Science
Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
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Modeling mouse and human development using organoid cultures
Meritxell Huch, Bon‐Kyoung Koo · 2015 · Development
Restriction of intestinal stem cell expansion and the regenerative response by YAP
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RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
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High-resolution 3D imaging of fixed and cleared organoids
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Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells
Katrin Hoffmeyer, Angelo Raggioli, Stefan Rudloff, Roman Anton, Andreas Hierholzer, Ignacio del Valle, Kerstin Hein, Riana Vogt, Rolf Kemler · 2012 · Science
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
Farin, Henner F., Jordens, Ingrid, Mosa, Mohammed H., Basak, Onur, Korving, Jeroen, Tauriello, Daniele V. F., de Punder, Karin, Angers, Stephane, Peters, Peter J., Maurice, Madelon M. et al. · 2016 · Nature
Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays
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Interplay between metabolic identities in the intestinal crypt supports stem cell function
Rodríguez-Colman, Maria J., Schewe, Matthias, Meerlo, Maaike, Stigter, Edwin, Gerrits, Johan, Pras-Raves, Mia, Sacchetti, Andrea, Hornsveld, Marten, Oost, Koen C., Snippert, Hugo J. et al. · 2017 · Nature
Human organoids in basic research and clinical applications
Xiao-Yan Tang, Shanshan Wu, Da Wang, Chu Chu, Yuan Hong, Mengdan Tao, Hao Hu, Min Xu, Xing Long Guo, Yan Liu · 2022 · Signal Transduction and Targeted Therapy
The rise of three-dimensional human brain cultures
Sergiu P. Pașca · 2018 · Nature
Human Organoids: Tools for Understanding Biology and Treating Diseases
Frans Schutgens, Hans C. Clevers · 2019 · Annual Review of Pathology Mechanisms of Disease
Tissue geometry drives deterministic organoid patterning
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Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis
Narges Tajik, Michael Frech, Oscar Schulz, Fabian Schälter, Sébastien Lucas, Vugar Azizov, Kerstin Dürholz, Franziska Steffen, Yasunori Omata, Andreas Rings et al. · 2020 · Nature Communications
Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture
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Induced Pluripotent Stem Cells Meet Genome Editing
Hockemeyer, Dirk, Jaenisch, Rudolf · 2016 · Cell Stem Cell
Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders
Daniel M. Chopyk, Arash Grakoui · 2020 · Gastroenterology
Mechanisms of early placental development in mouse and humans
Myriam Hemberger, Courtney W. Hanna, Wendy Dean · 2019 · Nature Reviews Genetics
Organoid and Spheroid Tumor Models: Techniques and Applications
Sreenivasulu Gunti, Austin T.K. Hoke, Kenny Vu, Nyall R. London · 2021 · Cancers
Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids
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Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues
Simons, Benjamin D., Clevers, Hans · 2011 · Cell
Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions
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Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery
Fleur Weeber, Salo Ooft, Krijn Kristian Dijkstra, Emile E. Voest · 2017 · Cell chemical biology
Cancer stem cells from colorectal cancer-derived cell lines
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Menstruation: science and society
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Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases
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Organoids: Modeling Development and the Stem Cell Niche in a Dish
Kai Kretzschmar, Hans C. Clevers · 2016 · Developmental Cell
The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability
Ida Schoultz, Åsa V. Keita · 2020 · Cells
Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids
Sabina Lukovac, Clara Belzer, Linette Pellis, Bart J. F. Keijser, Willem M. de Vos, Roy C. Montijn, Guus Roeselers · 2014 · mBio
Cytosystems dynamics in self-organization of tissue architecture
Yoshiki Sasai · 2013 · Nature
Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer
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Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury
Hiroyuki Miyoshi, Rieko Ajima, Christine T. Luo, Terry P. Yamaguchi, Thaddeus S. Stappenbeck · 2012 · Science
Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
Jan Paul Medema, Louis Vermeulen · 2011 · Nature
Recapitulating macro-scale tissue self-organization through organoid bioprinting
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Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development
Yong Soo Lee, Tae-Young Kim, Yeji Kim, Su-Hyun Lee, Seungil Kim, Sung Wan Kang, Jin‐Young Yang, In‐Jeoung Baek, Young Hoon Sung, Yun‐Yong Park et al. · 2018 · Cell Host & Microbe
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Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability
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EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila
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FXR Regulates Intestinal Cancer Stem Cell Proliferation
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Human heart-forming organoids recapitulate early heart and foregut development
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Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal
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Colon Cancer Stem Cells: Promise of Targeted Therapy
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An Immunosurveillance Mechanism Controls Cancer Cell Ploidy
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Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
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Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging
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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
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Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells
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Cell death in the gut epithelium and implications for chronic inflammation
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A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions
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Genetically engineered cerebral organoids model brain tumor formation
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Engineered materials for organoid systems
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Towards organoid culture without Matrigel
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The hope and the hype of organoid research
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Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling
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Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration
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Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
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Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22
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The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity
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Next-Generation Regenerative Medicine: Organogenesis from Stem Cells in 3D Culture
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Stem Cells and the Niche: A Dynamic Duo
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Organoid Models of Tumor Immunology
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Xenograft and organoid model systems in cancer research
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Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury
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Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance
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