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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
Open accessAbstract
Exercise has beneficial effects on human health, including protection against metabolic disorders such as diabetes. However, the cellular mechanisms underlying these effects are incompletely understood. The lysosomal degradation pathway, autophagy, is an intracellular recycling system that functions during basal conditions in organelle and protein quality control. During stress, increased levels of autophagy permit cells to adapt to changing nutritional and energy demands through protein catabolism. Moreover, in animal models, autophagy protects against diseases such as cancer, neurodegenerative disorders, infections, inflammatory diseases, ageing and insulin resistance. Here we show that acute exercise induces autophagy in skeletal and cardiac muscle of fed mice. To investigate the role of exercise-mediated autophagy in vivo, we generated mutant mice that show normal levels of basal autophagy but are deficient in stimulus (exercise- or starvation)-induced autophagy. These mice (termed BCL2 AAA mice) contain knock-in mutations in BCL2 phosphorylation sites (Thr69Ala, Ser70Ala and Ser84Ala) that prevent stimulus-induced disruption of the BCL2-beclin-1 complex and autophagy activation. BCL2 AAA mice show decreased endurance and altered glucose metabolism during acute exercise, as well as impaired chronic exercise-mediated protection against high-fat-diet-induced glucose intolerance. Thus, exercise induces autophagy, BCL2 is a crucial regulator of exercise- (and starvation)-induced autophagy in vivo, and autophagy induction may contribute to the beneficial metabolic effects of exercise.
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“Exercise triggers autophagy by activating ULK1 and dissociating BCL2 from BECN1, thereby disinhibiting the initiation complex [484,485].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [485]
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Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Self-citationAutophagy and Viruses: Adversaries or Allies?
Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444
Self-citationAntimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,551
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
Self-citationA Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Self-citationPromotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311
Self-citationMizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,105
Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660
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Items 201–300 of 1,000
The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer
Yan, Y., Chen, X., Wang, X., Zhao, Z., Hu, W., Zeng, S., Wei, J., Yang, X., Qian, L., Zhou, S., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1172-5 · Cited by 113
Aspirin Recapitulates Features of Caloric Restriction
Pietrocola, F., Castoldi, F., Markaki, M., Lachkar, S., Chen, G., Enot, D. P., Durand, S., Bossut, N., Tong, M., Malik, S. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.024 · Cited by 114
Is There a Role of Autophagy in Depression and Antidepressant Action?
Gassen, N. C., & Rein, T. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00337 · Cited by 111
Packer, M. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01041-4 · Cited by 113
Self-citationToward the Treatment and Prevention of Alzheimer's Disease: Rational Strategies and Recent Progress
Gandy, S., & DeKosky, S. T. (2013) · Annual Review of Medicine · doi:10.1146/annurev-med-092611-084441 · Cited by 110
The fine tuning of metabolism, autophagy and differentiation during in vitro myogenesis
Fortini, P., Ferretti, C., Iorio, E., Cagnin, M., Garribba, L., Pietraforte, D., Falchi, M., Pascucci, B., Baccarini, S., Morani, F., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.50 · Cited by 116
Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner
Erlich, A. T., Brownlee, D., Beyfuss, K. A., & Hood, D. A. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00162.2017 · Cited by 112
Autophagy Exacerbates Muscle Wasting in Cancer Cachexia and Impairs Mitochondrial Function
Penna, F., Ballarò, R., Martínez-Cristóbal, P., Sala, D., Sebastián, D., Busquets, S., Muscaritoli, M., Argilés, J. M. A., Costelli, P., & Antonio Zorzano, A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.05.032 · Cited by 113
Targeting Bcl-2 for cancer therapy
Zhang, L., Lu, Z., & Zhao, X. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188569 · Cited by 114
Physical exercise increases autophagic signaling through ULK1 in human skeletal muscle
Møller, A. B., Vendelbo, M. H., Christensen, B., Clasen, B. F., Bak, A. M., Jørgensen, J. O. L., Møller, N., & Jessen, N. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01116.2014 · Cited by 109
Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management
Zhang, Y., Whaley‐Connell, A. T., Sowers, J. R., & Ren, J. T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.06.004 · Cited by 109
Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade
Maiese, K., Chong, Z. Z., Wang, S., & Shang, Y. C. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131113830 · Cited by 109
Autophagic response to exercise training in skeletal muscle with age
Kim, Y. A., Kim, Y. S., Oh, S. L., Kim, H.-J., & Song, W. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0246-7 · Cited by 108
Parkin is required for exercise-induced mitophagy in muscle: Impact of aging
Chen, C. C. W., Erlich, A. T., Crilly, M. J., & Hood, D. A. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00391.2017 · Cited by 108
Understanding the Role of Exercise in Cancer Cachexia Therapy
Hardee, J. P., Counts, B. R., & Carson, J. A. (2017) · American Journal of Lifestyle Medicine · doi:10.1177/1559827617725283 · Cited by 111
Puterman, E., & Epel, E. (2012) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2012.00465.x · Cited by 106
Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis
Li, L. O., Grevengoed, T. J., Paul, D. S., Ilkayeva, O., Koves, T. R., Pascual, F. L., Newgard, C. B., Muoio, D. M., & Coleman, R. (2014) · Diabetes · doi:10.2337/db13-1070 · Cited by 107
Mitophagy in Cardiovascular Diseases
Morciano, G., Patergnani, S., Bonora, M., Pedriali, G., Tarocco, A., Bouhamida, E., Marchi, S., Ancora, G., Anania, G., Wieckowski, M. R., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030892 · Cited by 110
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy
Wei, J., Zhao, Y., Liang, H., Du, W., & Wang, L. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.08.026 · Cited by 108
Shi, L., Zhang, T., Zhou, Y. G., Zeng, X., Ran, L., Zhang, Q., Zhu, J., & Mi, M. (2015) · Endocrine · doi:10.1007/s12020-015-0599-5 · Cited by 106
Autophagy in Diabetes: β-Cell Dysfunction, Insulin Resistance, and Complications
Barlow, A. D., & Thomas, D. (2015) · DNA and Cell Biology · doi:10.1089/dna.2014.2755 · Cited by 107
Fetterman, J. L., Holbrook, M., Flint, N., Feng, B., Bretón‐Romero, R., Linder, E. A., Berk, B. D., Duess, M., Farb, M. G., Gokce, N., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.01.043 · Cited by 105
Rowe, G. C., Safdar, A., & Arany, Z. P. (2014) · Circulation · doi:10.1161/circulationaha.113.001590 · Cited by 107
Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects
Mejías-Peña, Y., Estébanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., Almar, M., de Paz, J. A., González-Gallego, J., & Cuevas, M. J. (2017) · Aging · doi:10.18632/aging.101167 · Cited by 102
“In fact, the disruption of the Bcl2-beclin-1 complex is crucial to induce autophagy in mammalian cells [20,21].”
BackgroundResultInfluentialPhytochemicals as Prebiotics and Biological Stress Inducers
Martel, J., Ojcius, D. M., Ko, Y., & Young, J. D. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.02.008 · Cited by 103
Autophagy as a Potential Target for Sarcopenia: AUTOPHAGY REGULATION IN SARCOPENIA
Fan, J., Kou, X., Jia, S., Yang, X., Yang, Y., & Chen, N. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25260 · Cited by 101
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis
Nassif, M., Valenzuela, V., Rojas-Rivera, D., Vidal, R., Matus, S., Castillo, K., Fuentealba, Y., Kroemer, G., Levine, B., & Hetz, C. (2014) · Autophagy · doi:10.4161/auto.28784 · Cited by 100
Self-citationFritzen, A. M., Madsen, A. B., Kleinert, M., Treebak, J. T., Lundsgaard, A., Jensen, T. E., Richter, E. A., Wojtaszewski, J. F. P., Kiens, B., & Frøsig, C. (2015) · The Journal of Physiology · doi:10.1113/jp271405 · Cited by 103
Ubaida‐Mohien, C., González‐Freire, M., Lyashkov, A. E., Moaddel, R., Chia, C. W., Simonsick, E. M., Sen, R., & Ferrucci, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00312 · Cited by 102
Acquired Muscle Weakness in the Surgical Intensive Care Unit
Farhan, H. N., Moreno‐Duarte, I., Latronico, N., ZAFONTE, R. D., & Eikermann, M. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000874 · Cited by 104
He, Y., Wang, W., Xu, X., Yang, B., Yu, X., Wu, Y., & Wang, J. (2021) · Bone · doi:10.1016/j.bone.2021.116182 · Cited by 99
Challenging Oneself Intermittently to Improve Health
Mattson, M. P. (2014) · Dose-Response · doi:10.2203/dose-response.14-028.mattson · Cited by 98
Autophagy and Protein Turnover Signaling in Slow-Twitch Muscle during Exercise
PAGANO, A. F., PY, G., BERNARDI, H., CANDAU, R. B., & SANCHEZ, A. M. J. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000237 · Cited by 96
Single swim sessions in C. elegans induce key features of mammalian exercise
Laranjeiro, R., Harinath, G., Burke, D., Braeckman, B. P., & Driscoll, M. (2017) · BMC Biology · doi:10.1186/s12915-017-0368-4 · Cited by 98
Stevanović, J., Beleza, J., Coxito, P. M., Ascensão, A. A. M. R., & Magalhães, J. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.015 · Cited by 99
The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing
Sun‐Wang, J. L., Ivanova, S., & Antonio Zorzano, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101203 · Cited by 98
Pedro, J. M. B., Wei, Y., Sica, V., Maiuri, M. C., Zou, Z., Kroemer, G., & Levine, B. (2015) · Autophagy · doi:10.1080/15548627.2015.1017191 · Cited by 99
Self-citationTargeting autophagy in osteoporosis: From pathophysiology to potential therapy
Li, X., Xu, J., Dai, B., Wang, X., Guo, Q., & Qin, L. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101098 · Cited by 97
Englund, D. A., Zhang, X., Aversa, Z., & LeBrasseur, N. K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111595 · Cited by 94
Exploring the emerging complexity in transcriptional regulation of energy homeostasis
Lempradl, A. M., Pospisilik, J. A., & Penninger, J. M. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3941 · Cited by 100
Bloemberg, D., & Quadrilatero, J. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00261.2018 · Cited by 100
Crosstalk between apoptosis and autophagy signaling pathways
(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2020.01.003 · Cited by 92
Functions of BCL-X L at the Interface between Cell Death and Metabolism
Michels, J., Kepp, O., Senovilla, L., Lissa, D., Castedo, M., Kroemer, G., & Galluzzi, L. (2013) · International Journal of Cell Biology · doi:10.1155/2013/705294 · Cited by 99
van der Sloot, K. W. J., Amini, M., Peters, V., Dijkstra, G. D. H., & Alizadeh, B. Z. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001217 · Cited by 92
Mitochondria and Aging—The Role of Exercise as a Countermeasure
Nilsson, M. I., & Tarnopolsky, M. A. (2019) · Biology · doi:10.3390/biology8020040 · Cited by 92
Targeting autophagy as a potential therapeutic approach for melanoma therapy
Liu, H., He, Z., & Simon, H. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.06.008 · Cited by 95
Jeon, H., & Im, G. (2016) · Connective Tissue Research · doi:10.1080/03008207.2016.1240790 · Cited by 93
Wang, L., Scott, I., Zhu, L., Wu, K., Han, K., Chen, Y., Guček, M., & Sack, M. N. (2017) · Nature Communications · doi:10.1038/s41467-017-00521-8 · Cited by 91
Relevance of Autophagy in Parenchymal and Non-Parenchymal Liver Cells for Health and Disease
Weiskirchen, R., & Tacke, F. (2019) · Cells · doi:10.3390/cells8010016 · Cited by 91
DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity
Soussi, H., Reggio, S., Alili, R., Prado, C., Mutel, S., Pini, M., Rouault, C., Clément, K., & Dugail, I. (2015) · Diabetes · doi:10.2337/db14-1933 · Cited by 93
Posttranslational Modification and Quality Control
Wang, X., Pattison, J. S., & Su, H. (2013) · Circulation Research · doi:10.1161/circresaha.112.268706 · Cited by 94
CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury
Bezzerides, V. J., Platt, C., Lerchenmüller, C., Paruchuri, K., Oh, N. L., Xiao, C., Cao, Y., Mann, N., Spiegelman, B. M., & Rosenzweig, A. (2016) · JCI Insight · doi:10.1172/jci.insight.85904 · Cited by 90
Chen, Y., Zhang, W., Guo, X., Ren, J., & Gao, A. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2004-4 · Cited by 89
Vainshtein, A., Grumati, P., Sandri, M., & Bonaldo, P. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1096-z · Cited by 88
Is exercise a senolytic medicine? A systematic review
Chen, X., Yi, Z., Wong, G. T., Hasan, K. M. M., Kwan, J. S., Ma, A. C., & Chang, R. C. (2021) · Aging Cell · doi:10.1111/acel.13294 · Cited by 88
Shi, L., Zhang, T., Liang, X., Hu, Q., Huang, J., Zhou, Y. G., Chen, M., Zhang, Q., Zhu, J., & Mi, M. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.03.009 · Cited by 89
Fiuza‐Luces, C., Simpson, R. J., Ramírez, M. R., Lucía, A., & Berger, N. A. (2015) · Bone Marrow Transplantation · doi:10.1038/bmt.2015.195 · Cited by 91
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Wang, X., Ni, L., Yang, L., Duan, Q., Chen, C., Edin, M. L., Zeldin, D. C., & Wang, D. W. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.087122 · Cited by 90
Satoh, T., Wang, L., Espinosa‐Díez, C., Wang, B., Hahn, S. A., Noda, K., Rochon, E. R., Dent, M. R., Levine, A. R., Baust, J., et al. (2021) · Circulation · doi:10.1161/circulationaha.121.053889 · Cited by 87
Aging and brain rejuvenation as systemic events
Bouchard, J. J., & Villeda, S. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12969 · Cited by 90
Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies
Grumati, P., & Bonaldo, P. (2012) · Cells · doi:10.3390/cells1030325 · Cited by 96
Ouimet, M. I. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.03.007 · Cited by 86
Kuramoto, K., Liang, H., Hong, J., & He, C. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.01.011 · Cited by 87
Self-citationPhysical Inactivity and Low Fitness Deserve More Attention to Alter Cancer Risk and Prognosis
Sanchis‐Gomar, F., Lucía, A., Yvert, T. P., Ruiz‐Casado, A., Pareja-Galeano, H., Santos‐Lozano, A., Fiuza‐Luces, C., Garatachea, N., Lippi, G., Bouchard, C., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0320 · Cited by 91
Maki, T., Yamamoto, D., Nakanishi, S., Iida, K., Iguchi, G., Takahashi, Y., Kaji, H., Chihara, K., & Okimura, Y. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.07.005 · Cited by 85
BAG3-mediated proteostasis at a glance
Klimek, C., Kathage, B., Wördehoff, J., & Höhfeld, J. (2017) · Journal of Cell Science · doi:10.1242/jcs.203679 · Cited by 91
Sujkowski, A. L., Bazzell, B. G., Carpenter, K., Arking, R., & Wessells, R. J. (2015) · Aging · doi:10.18632/aging.100789 · Cited by 87
Mitochondrial quality control: The role of mitophagy in aging
Shi, R., Guberman, M., & Kirshenbaum, L. A. (2017) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2017.11.008 · Cited by 87
Young, C., Sinadinos, A., Lefebvre, A., Chan, P., Arkle, S., Vaudry, D., & Górecki, D. C. (2015) · Autophagy · doi:10.4161/15548627.2014.994402 · Cited by 88
Xu, J., Qin, X., Cai, X., Yang, L., Xing, Y., Li, J., Zhang, L., Tang, Y., Liu, J., Zhang, X., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.012 · Cited by 84
Role of islet β cell autophagy in the pathogenesis of diabetes
Lee, M. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.08.005 · Cited by 83
Zhong, L., Shu, W., Dai, W., Gao, B., & Xiong, S. (2017) · Journal of Virology · doi:10.1128/jvi.00001-17 · Cited by 83
Ferrari, F., Bock, P. M., Motta, M. T., & Helal, L. C. A. S. (2019) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20190224 · Cited by 90
TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise
Liu, Y., Nguyen, P., Wang, X., Zhao, Y., Meacham, C. E., Zou, Z., Bordieanu, B., Johanns, M., Vertommen, D., Wijshake, T., et al. (2020) · Nature · doi:10.1038/s41586-020-1992-7 · Cited by 85
Self-citationExercise and cancer: a position statement from the Spanish Society of Medical Oncology
Pollán, M., Casla-Barrio, S., Alfaro, J., Esteban, C., Seguí, M. Á., Lucía, A., & Martín, M. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02312-y · Cited by 93
Quercetin alleviates high glucose-induced Schwann cell damage by autophagy
Qu, L., Liang, X., Bei, G., & Liu, W. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.135328 · Cited by 84
The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia
Shen, K., Sidik, H., & Talbot, W. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.055 · Cited by 81
Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle
Fritzen, A. M., Frøsig, C., Jeppesen, J. F., Jensen, T. E., Lundsgaard, A., Serup, A. K., Schjerling, P., Proud, C. G., Richter, E. A., & Kiens, B. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.03.005 · Cited by 86
Resveratrol Modulates Apoptosis and Autophagy Induced by High Glucose and Palmitate in Cardiac Cells
Xu, K., Liu, X., Ke, Z., Yao, Q., Guo, S., & Liu, C. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000489442 · Cited by 81
Autophagy, signaling and obesity
Lavallard, V., Meijer, A. J., Codogno, P., & Gual, P. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.003 · Cited by 85
Autophagy in Toxicology: Cause or Consequence?
Orrenius, S., Kaminskyy, V. O., & Zhivotovsky, B. (2012) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140210 · Cited by 81
Møller, A. B., Kampmann, U., Hedegaard, J., Thorsen, K., Nordentoft, I., Vendelbo, M. H., Møller, N., & Jessen, N. (2017) · Scientific Reports · doi:10.1038/srep43775 · Cited by 82
Nichenko, A. S., Southern, W. M., Atuan, M., Luan, J., Peissig, K. B., Foltz, S. J., Beedle, A. M., Warren, G. L., & Call, J. A. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00066.2016 · Cited by 80
Thorburn, A. M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.810739 · Cited by 80
Chen, Y., Tao, J., Zhao, P., Tang, W., Xu, J., Zhang, K., & Zou, C. (2019) · Nature Communications · doi:10.1038/s41467-019-10475-8 · Cited by 80
Killackey, S. A., Bi, Y., Soares, F., Hammi, I., Winsor, N. J., Sater, A. A. A., Philpott, D. J., Arnoult, D., & Girardin, S. E. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.06.004 · Cited by 83
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Harnett, M. M., Pineda, M. A., de Laté, P. L., Eason, R. J., Besteiro, S., Harnett, W., & Langsley, G. (2017) · Biomedical Journal · doi:10.1016/j.bj.2016.12.004 · Cited by 89
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Metadata
- Authors
- He, C., Bassik, M. C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., Korsmeyer, S., Packer, M., May, H. I., Hill, J. A., Virgin, H. W., Gilpin, C., Xiao, G., Bassel-Duby, R., Scherer, P. E., & Levine, B.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Dana-Farber Cancer Institute (US)
- Howard Hughes Medical Institute (US)
- Washington University in St. Louis (US)
- Corresponding author
- Levine, Beth
- ORCID
- Venue
- Nature
- Published
- 2012-01-18
- Volume
- 481
- Issue
- 7382
- Pages
- 511-515
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3518436
- OpenAlex
- W2082476985
- Cited by
- 1,136
- References
- 36
- Citations by year
- 2026: 40 · 2025: 47 · 2024: 49 · 2023: 55 · 2022: 64 · 2021: 90 · 2020: 93 · 2019: 76 · 2018: 93 · 2017: 99 · 2016: 94 · 2015: 112 · 2014: 82 · 2013: 80 · 2012: 61
- FWCI
- 79.93
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-11-06)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Heart, Lung, and Blood Institute (R0I HL090842, R0I HL080244, R01HL090842)
- National Cancer Institute (R01CA112023, R01CA109618, P30CA142543)
- National Institute of Allergy and Infectious Diseases (R01AI084887, R0I AI084887)
- National Institute of Diabetes and Digestive and Kidney Diseases (RCI DK086629, R01DK055758, 1P01 DK0887761, RC1DK086629, P01DK088761)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- Bcl-2, Bcl-2 phosphorylation, skeletal muscle, myocardium, glucose metabolism, impaired glucose tolerance, high-fat diet, endurance, starvation-induced autophagy, exercise metabolism, diabetes protection
- MeSH terms
- Beclin-1, Animals, Autophagy, Cells, Cultured, Dietary Fats, Physical Exertion, Food Deprivation, Glucose, Glucose Tolerance Test, Homeostasis, Male, Mice, Transgenic, Mutation, Myocardium, Phosphorylation, Physical Conditioning, Animal, Physical Endurance, Protein Binding, Proto-Oncogene Proteins, Running, Glucose Intolerance, Muscle, Skeletal, Proto-Oncogene Proteins c-bcl-2, Leptin, Apoptosis Regulatory Proteins, Mice, Adiponectin, Gene Knock-In Techniques
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