The DOI matches its Crossref record; 36 of the 38 references it cites were found in a registry or an index; 1 of the 31 sources its claims cite were checked for support.
An anatomically comprehensive atlas of the adult human brain transcriptome
Open accessAbstract
Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate functional and genetic brain architecture. Here we describe the generation and analysis of a transcriptional atlas of the adult human brain, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals. Transcriptional regulation varies enormously by anatomical location, with different regions and their constituent cell types displaying robust molecular signatures that are highly conserved between individuals. Analysis of differential gene expression and gene co-expression relationships demonstrates that brain-wide variation strongly reflects the distributions of major cell classes such as neurons, oligodendrocytes, astrocytes and microglia. Local neighbourhood relationships between fine anatomical subdivisions are associated with discrete neuronal subtypes and genes involved with synaptic transmission. The neocortex displays a relatively homogeneous transcriptional pattern, but with distinct features associated selectively with primary sensorimotor cortices and with enriched frontal lobe expression. Notably, the spatial topography of the neocortex is strongly reflected in its molecular topography—the closer two cortical regions, the more similar their transcriptomes. This freely accessible online data resource forms a high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain function.
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Claims the paper makes
65 Own result · 20 Not checked yet · 11 Own interpretation · 4 Own method · 4 No basis given · 1 Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“a large percentage of these common differentially expressed transcripts (48%, or 5,500 probes) are poorly annotated, including probes not mapped to the human genome (HG19; http://genome.ucsc.edu/cgi-bin/hgGateway), mapped to contig sequences, or not mapped to known GENCODE genes21.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global transcriptional architecture of the adult brain
What the sources say
- Supportedcites [21] Harrow, J. et al. GENCODE: producing a reference annotation for ENCODE. Genome Biol. 7, (suppl. 1)1–9 (2006) source
The citation follows “known GENCODE genes” and identifies the gene annotation used in the citing paper, rather than attributing its 48% (5,500-probe) result to Harrow et al. In “GENCODE annotation of the ENCODE regions,” the source describes its compiled GENCODE reference loci and transcripts, supporting that identification. (LLM, conf=0.88)
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
- Supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“that are highly conserved between individuals”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Abstract
plainn = 2- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The two or three clinically unremarkable adult male brains studied are sufficiently representative of the adult human brain for the atlas's general conclusions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“a significantly greater percentage than that observed across all genes (21%, P < 10−6, Mann–Whitney U-test).”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“tyrosine hydroxylase (TH) is enriched in the substantia nigra pars compacta (SNC), ventral tegmental area (VTA), and hypothalamic supraoptic and preoptic nuclei, as well as in the locus ceruleus”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
plaincorrelationaln = 2- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“brain-wide variation strongly reflects the distributions of major cell classes such as neurons, oligodendrocytes, astrocytes and microglia”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Abstract
boostedcorrelationaln = 2- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“no statistically significant hemispheric differences could be identified at this fine structural level that were corroborated in both brains (paired one-sided t-tests, P < 0.01, Benjamini–Hochberg (BH)-corrected).”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The two or three clinically unremarkable adult male brains studied are sufficiently representative of the adult human brain for the atlas's general conclusions.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“different regions and their constituent cell types displaying robust molecular signatures”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Abstract
plaincorrelationaln = 2- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The two or three clinically unremarkable adult male brains studied are sufficiently representative of the adult human brain for the atlas's general conclusions.
In the paper
“many synapse-associated Gene Ontology (GO) categories13 were enriched in this gene set, even relative to the PSD genes as a whole, including synapse (GO: 0045202), synaptic vesicle (GO: 0008021), synaptic transmission (GO: 0007268), neurophysiological process (GO: 0050877) and receptor activity (GO: 0004872).”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
What the sources say
- Not checked yetcites [13] Huang da, W. Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature Protocols 4, 44–57 (2009) source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We found strong corroboration of overall expression levels and fold changes between structures in all three brains (Supplementary Fig. 2).”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
boostedcorrelationaln = 3 ·- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The two or three clinically unremarkable adult male brains studied are sufficiently representative of the adult human brain for the atlas's general conclusions.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Regional enrichments were conserved between the two brains (note similar peaks in paired rows for Brain 1 and 2; Fig. 2a)”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
plaincorrelationaln = 2- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The two or three clinically unremarkable adult male brains studied are sufficiently representative of the adult human brain for the atlas's general conclusions.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
- It may state two separate claims as one. 22
- Probably not a substantial claim. 11
- The quote only partly states this claim. 1
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“with distinct features associated selectively with primary sensorimotor cortices and with enriched frontal lobe expression”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Abstract
plaincorrelationaln = 2- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: The two or three clinically unremarkable adult male brains studied are sufficiently representative of the adult human brain for the atlas's general conclusions.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“One-hundred and seventy distinct structures were assayed at least once in both brains, and 146 structures twice or more (Supplementary Table 2).”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“One highly regionalized neuron-related module (M6) was enriched in the striatum (the dopamine receptorDRD1 in Fig. 2a is a hub gene).”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global transcriptional architecture of the adult brain
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
In the paper
“The gene modules identified in Brain 1 were well conserved in Brain 2 as a whole (Fig. 3b), both at the level of regional gene expression patterns (third row) and as measured by a module preservation index (fourth row) using a summary Z-statistic as described previously20.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global transcriptional architecture of the adult brain
What the sources say
- Not checked yetcites [20] Langfelder, P., Luo, R., Oldham, M. C. & Horvath, S. Is my network module preserved and reproducible? PLoS Comput. Biol. 7, e1001057 (2011) source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: The two or three clinically unremarkable adult male brains studied are sufficiently representative of the adult human brain for the atlas's general conclusions.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The results in Fig. 4b bear strong similarity to the plot in Fig. 4a, again with the neocortex and cerebellum displaying the least internal heterogeneity.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global transcriptional architecture of the adult brain
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
None of the sources cited for this claim have been checked yet.
In the paper
“Applied to the entire 911 sample set from Brain 1, genes were grouped into well-defined co-expression modules with specific anatomical distributions (Fig. 3a, b), consistent with previous studies in brain tissues18, 19.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global transcriptional architecture of the adult brain
What the sources say
- Not checked yetcites [18] Oldham, M. C. et al. Functional organization of the transcriptome in human brain. Nature Neurosci. 11, 1271–1282 (2008) source
- Not checked yetcites [19] Miller, J. A., Horvath, S. & Geschwind, D. H. Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proc. Natl Acad. Sci. USA 107, 12698–12703 (2010) source
plaincorrelationalSingle case- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the relative position of each lobe’s samples reflects the cortical topography, with the frontal pole and occipital striate cortex at opposite ends, precentral gyrus near postcentral gyrus, and so on.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Neocortical transcription reflects spatial topography
plaincorrelationalSingle case- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Not only do samples from each lobe group together, but the relative positions of the lobes are anatomically correct.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Neocortical transcription reflects spatial topography
plaincorrelationalSingle case- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The globus pallidus and striatum have highly distinct profiles, as do several specific subcortical regions including the midbrain raphe, pontine nuclei and inferior olivary complex.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global transcriptional architecture of the adult brain
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Other modules showed subcortical enrichment and correspond to expression in different types of glia (M8–M12), including microglia, astrocytes and oligodendrocytes.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global transcriptional architecture of the adult brain
plaincorrelationaln = 911- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This effect is strongest when limited to genes that are differential between gyri as above, but can also be seen using the entire ~30,000 gene set, achieving a fit of 12.48% between native and MDS coordinates (P < 10−4, Supplementary Fig. 10).”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Neocortical transcription reflects spatial topography
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“MDS-based sample correlations vary nearly linearly with 3D physical distance (Fig. 6e, inset), with a goodness of fit between native and MDS coordinates of 28.36% (P < 10−4, Supplementary Fig. 9).”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Neocortical transcription reflects spatial topography
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the first three principal components had striking selectivity for specific cortical regions (samples ordered by lobe and roughly rostral to caudal within each lobe) and were generally reproducible across both brains.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Neocortical transcription reflects spatial topography
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These first three components accounted for a large amount of the variance (PC1: 58% in Brain 1, 42% in Brain 2; PC2: 10% in Brain 1, 11% in Brain 2; PC3: 5% in Brain 1, 8% in Brain 2; Supplementary Fig. 8).”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Neocortical transcription reflects spatial topography
plainSingle case- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Differential expression across hippocampal subfields could be validated by ISH.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Local patterning reflects hippocampal cytoarchitecture
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“38 transcripts demonstrated high correlation with the striatal module (M6), and 87 transcripts with the oligodendrocyte-associated module (M12; Fig. 3c)”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global transcriptional architecture of the adult brain
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
In the paper
“conservation and divergence in brain function between humans and other species provide essential information for the understanding of drug action, which is often poorly conserved across species6.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Introduction
What the sources say
- Not checked yetcites [6] Markou, A., Chiamulera, C., Geyer, M. A., Tricklebank, M. & Steckler, T. Removing obstacles in neuroscience drug discovery: the future path for animal models. Neuropsychopharmacology 34, 74–89 (2009) source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“consistent with the percentage of genes expressed in mouse brain by ISH (80%; ref. 1) and fetal human brain by microarrays (76%; ref. 11).”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
What the sources say
- Not checked yetcites [1] Lein, E. S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168–176 (2007) source
- Not checked yetcites [11] Johnson, M. B. et al. Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron 62 494–509 S0896–6273(09)00286–4 (2009) source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“this finding is consistent with a recent study of developing human neocortex that failed to identify hemispheric differences despite extensive efforts using microarrays and quantitative PCR11.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
What the sources say
- Not checked yetcites [11] Johnson, M. B. et al. Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron 62 494–509 S0896–6273(09)00286–4 (2009) source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“In rodents, brain- and transcriptome-wide, cellular-resolution maps of transcript distributions are widely useful resources to complement genomic sequence data1, 2, 3.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Introduction
What the sources say
- Not checked yetcites [1] Lein, E. S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168–176 (2007) source
- Not checked yetcites [2] Diez-Roux, G. et al. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 9, e1000582 (2011) source
- Not checked yetcites [3] Baldock, R. A. et al. EMAP and EMAGE: a framework for understanding spatially organized data. Neuroinformatics 1, 309–325 (2003) source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“we examined the 740 genes identified in the human excitatory postsynaptic density (PSD12)”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
What the sources say
- Not checked yetcites [12] Bayes, A. et al. Characterization of the proteome, diseases and evolution of the human postsynaptic density. Nature Neurosci. 14, 19–21 (2011) source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“gyral patterns do not correlate perfectly with either cytoarchitectural or functional cortical parcellation.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Discussion
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“testing for RNA quality (RNA integrity number >6)”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Methods > Post-mortem tissue acquisition and screening
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“which are frequently enriched in long-range projection neurons14.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
What the sources say
- Not checked yetcites [14] Hof, P. R., Nimchinsky, E. A. & Morrison, J. H. Neurochemical phenotype of corticocortical connections in the macaque monkey: quantitative analysis of a subset of neurofilament protein-immunoreactive projection neurons in frontal, parietal, temporal, and cingulate cortices. J. Comp. Neurol. 362, 109–133 (1995) source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The synapse-associated genes clustered into groups enriched in specific regions, indicative of a diverse set of excitatory synapse subtypes.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global mapping of transcript distributions
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“These two individuals were males of similar age and ethnicity and therefore do not capture population or sex diversity”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Discussion
plaindirectn = 2- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“the relative homogeneity of the two largest neuronal structures, with ~69 billion (cerebellar cortex) and ~16 billion (cortex) neurons out of the 86 billion neurons in the human brain33, is striking and suggests an evolutionary expansion of a canonical cortical blueprint34.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Discussion
What the sources say
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This suggests that many genes may be quite pleiotropic with respect to brain function, and that local gene regulation in specific cytoarchitectural nuclei is the most important level of resolution.”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Global transcriptional architecture of the adult brain
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
None of the sources cited for this claim have been checked yet.
In the paper
“this high degree of similarity is suggestive of a strong underlying common blueprint for the human brain transcriptome and is consistent with other recent studies of human neocortical gene expression4, 5”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Discussion
What the sources say
hedgedcorrelationaln = 2- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“specimens with no known neuropsychiatric or neuropathological history were collected”
§ An anatomically comprehensive atlas of the adult human brain transcriptome > Methods > Post-mortem tissue acquisition and screening
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
The paper relies on this without support.
The two or three clinically unremarkable adult male brains studied are sufficiently representative of the adult human brain for the atlas's general conclusions.
“Two complete normal male brains were analysed from donors aged 24 and 39 years”
“in a small number of high-quality, clinically unremarkable brains”
The paper relies on this without support.
Microarray transcript levels measured in post-mortem brain tissue reflect the in vivo transcriptional state of the corresponding brain regions.
“RNA was isolated from each sample and used to generate labelled cRNA probes for hybridization to custom 64K Agilent microarrays.”
“The output of the data generation pipeline described above is a detailed quantitative map of transcript distribution across the entire brain.”
The paper relies on this without support.
The primary feature distinguishing the human brain from other species is the enormous expansion of the neocortex relative to total brain volume.
“The primary feature that distinguishes the human brain from that of other species is the enormous expansion of the neocortex relative to total brain volume.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We found that the thalamic–neocortex separation is conserved in mice and recapitulated both this divide and thalamic marker genes in independent single-cell, bulk and microarray data in both mice and humans8,39,40,43”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [8]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Surprisingly, it turned out that transcription profiles in the adult neocortex are relatively homogeneous throughout the cortex, although a certain level of heterogeneity still does exist (Hawrylycz et al., 2012; Kang et al., 2011; Pletikos et al., 2014)”
From Genetic Changes Shaping the Human Brain (2015) · cites this paper as Hawrylycz et al., 2012
The cited source says what the claim attributes to it.
In the citing paper
“Although some brain regions relevant to AD have been studied individually at scale or jointly in samples from a few individuals8–16, a comprehensive molecular characterization of region-specific differences in AD is currently lacking”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [8]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The AHBA data were corrected for batch effects and normalized to the 75% quantile, as previously described (Hawrylycz et al., 2012). BSS data also were quantile normalized.”
From Aerobic glycolysis in the human brain is associated with development and neotenous gene expression (2014) · cites this paper as Hawrylycz et al., 2012
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“RAB10 is expressed in all cell types in human and mouse brains [53, 54]”
From Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience (2017) · cites this paper as [53]
Experimental — accuracy not yet measured
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“and is widely expressed in all regions of both the human and mouse brains [53, 54]”
From Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience (2017) · cites this paper as [53]
Experimental — accuracy not yet measuredIn the citing paper
“Recent important advances include the evaluation of spatial and temporal transcriptomes by the Allen Brain Institute and BrainSpan8,11–13”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [12]
In the citing paper
“For example, when evaluating co-expression across brain regions, hubs in modules that are associated with specific regions, such as the cerebellum, are usually markers for predominant cell types, such as granule cells11,12,26,32.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [12]
In the citing paper
“Network approaches are particularly useful for relating whole-tissue-level changes to data from these high-resolution experiments11–13,26 (FIG. 2a).”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [12]
In the citing paper
“A major advantage of network analysis over DGE analysis is that it can identify multiple levels of molecular organization within the hierarchy of brain region, cell type, organelle and molecular pathways using only transcriptional data, and can thus enable integration with other information, such as known pathway annotations, protein interactions and other molecular profiling data11,12,26,27”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [12]
In the citing paper
“Moreover, this study found that genes in these modules have dynamic developmental trajectories, demonstrating a role for ASD risk genes in neural development.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [12]
In the citing paper
“Given that the human brain transcriptome has a reproducible structure12,26”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [12]
In the citing paper
“The first study to do this identified co-expression modules that had cell type-specific and region-specific expression patterns using nearly 1,000 adult brain regions12,109, and identified neuronal gene-enriched modules containing ASD candidate genes and ASD GWAS signals.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [12]
In the citing paper
“Approximately 95% of RefSeq genes are expressed in developing neocortex, compared with 84% identified using these arrays in adult23.”
From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [23]
In the citing paper
“The atlas of the mid-gestational human brain described here, part of the BrainSpan Atlas of the Developing Human Brain, builds on digital molecular brain atlasing efforts in mouse20,22,24 and adult human23 by providing transcriptome resources on prenatal specimens typically inaccessible for research.”
From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [23]
In the citing paper
“Each have reinforced findings of significant differences in the transcriptome between neuronal cell-types, brain regions, developmental stages, and species.”
From Decoding neuroproteomics: integrating the genome, translatome and functional anatomy (2014) · cites this paper as [12]
In the citing paper
“In situ hybridization and microarray data, for example the Allen Brain Atlases (Hawrylycz et al., 2012; Lein et al., 2007), have also established that mRNA transcripts encoding these five NPPs and that many other NPPs and NP-GPCR genes are expressed differentially in many brain regions.”
From Single-cell transcriptomic evidence for dense intracortical neuropeptide networks (2019) · cites this paper as Hawrylycz et al., 2012
In the citing paper
“Despite its relative homogeneity compared to other brain regions, human neocortex shows variations in transcriptional patterns that are consistent across individuals and are correlated with topographical position across the cortical sheet3.”
From Canonical genetic signatures of the adult human brain (2015) · cites this paper as [3]
In the citing paper
“Although the anatomical sampling in this study was not cell type-specific, some of these networks appear to represent co-expression in broad cell classes such as telencephalic neurons, oligodendrocytes, astrocytes and vasculature, as observed previously3, 5.”
From Canonical genetic signatures of the adult human brain (2015) · cites this paper as [3]
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Metadata
- Authors
- Hawrylycz, M. J., Lein, E. S., Guillozet-Bongaarts, A. L., Shen, E. H., Ng, L., Miller, J. A., van de Lagemaat, L. N., Smith, K. A., Ebbert, A., Riley, Z. L., Abajian, C., Beckmann, C. F., Bernard, A., Bertagnolli, D., Boe, A. F., Cartagena, P. M., Chakravarty, M. M., Chapin, M., Chong, J., Dalley, R. A., Daly, B. D., Dang, C., Datta, S., Dee, N., Dolbeare, T. A., Faber, V., Feng, D., Fowler, D. R., Goldy, J., Gregor, B. W., Haradon, Z., Haynor, D. R., Hohmann, J. G., Horvath, S., Howard, R. E., Jeromin, A., Jochim, J. M., Kinnunen, M., Lau, C., Lazarz, E. T., Lee, C., Lemon, T. A., Li, L., Li, Y., Morris, J. A., Overly, C. C., Parker, P. D., Parry, S. E., Reding, M., Royall, J. J., Schulkin, J., Sequeira, P. A., Slaughterbeck, C. R., Smith, S. C., Sodt, A. J., Sunkin, S. M., Swanson, B. E., Vawter, M. P., Williams, D., Wohnoutka, P., Zielke, H. R., Geschwind, D. H., Hof, P. R., Smith, S. M., Koch, C., Grant, S. G. N., & Jones, A. R.
- Affiliations
- Allen Institute for Brain Science (US)
- Radboud University Nijmegen (NL)
- University of California, Irvine (US)
- University of Maryland Medical Center (US)
- University of Maryland, Baltimore (US)
- University of Washington (US)
- Banyan Biomarkers (United States) (US)
- Georgetown University (US)
- University of California, Los Angeles (US)
- Icahn School of Medicine at Mount Sinai (US)
- University of Oxford (GB)
- University of Edinburgh (GB)
- Corresponding author
- Hawrylycz, Michael J.
- ORCID
- Hawrylycz, Michael J.
- Lein, Ed S.
- Guillozet-Bongaarts, Angela L.
- Ng, Lydia
- Miller, Jeremy A.
- Smith, Kimberly A.
- Beckmann, Christian F.
- Bernard, Amy
- Bertagnolli, Darren
- Chakravarty, M. Mallar
- Chapin, Mike
- Chong, Jimmy
- Dalley, Rachel A.
- Dee, Nick
- Dolbeare, Tim A.
- Feng, David
- Fowler, David R.
- Goldy, Jeff
- Gregor, Benjamin W.
- Haynor, David R.
- Hohmann, John G.
- Horvath, Steve
- Lee, Changkyu
- Li, Ling
- Li, Yang
- Parker, Patrick D.
- Reding, Melissa
- Schulkin, Jay
- Sunkin, Susan M.
- Vawter, Marquis P.
- Wohnoutka, Paul
- Geschwind, Daniel H.
- Hof, Patrick R.
- Smith, Stephen M.
- Grant, Seth G. N.
- Jones, Allan R.
- Venue
- Nature
- Published
- 2012-09
- Volume
- 489
- Issue
- 7416
- Pages
- 391-399
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4243026
- OpenAlex
- W2055655674
- Semantic Scholar
- 44c6c5a71047351f81db358eabf87882c5232718
- Cited by
- 3,083
- References
- 38
- Citations by year
- 2026: 341 · 2025: 365 · 2024: 320 · 2023: 259 · 2022: 267 · 2021: 274 · 2020: 243 · 2019: 173 · 2018: 165 · 2017: 163 · 2016: 169 · 2015: 134 · 2014: 123 · 2013: 72 · 2012: 10
- FWCI
- 43.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- University of Twente Research Information (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- Wellcome Trust (066717, 077155)
- European Commission (241498, 242167, 241995)
- Health Resources and Services Administration
- National Institute of Standards and Technology
- U.S. Public Health Service (1C76HF15069-01-00, 1C76HF19619-01-00)
- National Institute of Mental Health (R01MH085801, R37MH060233)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- human brain transcriptome, transcriptional atlas, gene expression mapping, differential gene expression, gene co-expression, neuronal cell types, oligodendrocytes, astrocytes, microglia, primary sensorimotor cortex, frontal lobe, calbindin-D28k, hippocampus, postmortem brain, brain cell types
- MeSH terms
- Adult, Anatomy, Artistic, Animals, Atlases as Topic, Brain, Dopamine, Health, Hippocampus, Humans, Macaca mulatta, Male, RNA, Messenger, Species Specificity, In Situ Hybridization, Neocortex, Internet, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Databases, Genetic, Mice, Post-Synaptic Density, Transcriptome, Calbindins, S100 Calcium Binding Protein G
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