The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Open accessAbstract
Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as a tool to understand mechanisms behind ageing and age-associated diseases. In addition to and independently of increasing lifespan, CR has been reported to delay or prevent the occurrence of many chronic diseases in a variety of animals. Beneficial effects of CR on outcomes such as immune function, motor coordination and resistance to sarcopenia in rhesus monkeys have recently been reported. We report here that a CR regimen implemented in young and older age rhesus monkeys at the National Institute on Aging (NIA) has not improved survival outcomes. Our findings contrast with an ongoing study at the Wisconsin National Primate Research Center (WNPRC), which reported improved survival associated with 30% CR initiated in adult rhesus monkeys (7–14 years) and a preliminary report with a small number of CR monkeys. Over the years, both NIA and WNPRC have extensively documented beneficial health effects of CR in these two apparently parallel studies. The implications of the WNPRC findings were important as they extended CR findings beyond the laboratory rodent and to a long-lived primate. Our study suggests a separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“dietary restriction has been the most effective strategy to demonstrate an increase in lifespan across a whole range of investigated species, including nonhuman primates”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Mattison et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“dietary restriction (DR) increases lifespan or healthspan in all investigated eukaryote species, including unicellular and multicellular organisms of several distinct phyla, including non-human primates”
From The Hallmarks of Aging (2013) · cites this paper as Mattison et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“and is established to increase healthy lifespan in multiple species8,9.”
From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [9]
Experimental — accuracy not yet measuredIn the citing paper
“Two studies have addressed the effects of CR on non-human primates, but with different outcomes. One study observed prolonged life (Colman et al., 2009) while the other did not (Mattison et al., 2012).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Mattison et al., 2012
In the citing paper
“In contrast, the healthier ad libitum diet in the NIA study (Mattison et al., 2012) allowed for longer lifespan in control animals without conferring additional benefit from CR.”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Mattison et al., 2012
In the citing paper
“However, both studies point to the fact that CR increases healthspan in monkeys by reducing the risk for diabetes, cardiovascular disease, and cancer.”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Mattison et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Survival analysis using sas®: a practical guide
Allison, P. D. (1995) · International Linear Collider · Cited by 3,570
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277
Self-citationBjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501
Aging in Rhesus Monkeys: Relevance to Human Health Interventions
Roth, G. S., Mattison, J. A., Ottinger, M. A., Chachich, M. E., Lane, M. A., & Ingram, D. K. (2004) · Science · doi:10.1126/science.1102541 · Cited by 354
Self-citation“Control” laboratory rodents are metabolically morbid: Why it matters
Martin, B., Ji, S., Maudsley, S., & Mattson, M. P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912955107 · Cited by 354
Caloric Restriction in Humans: Impact on Physiological, Psychological, and Behavioral Outcomes
Redman, L. M., & Ravussin, É. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3253 · Cited by 348
Calorie restriction and prevention of age‐associated chronic disease
Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293
Can oxidative damage be treated nutritionally?
BERGER, M. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2004.10.003 · Cited by 276
Bodkin, N. L., Alexander, T. M., Ortmeyer, H. K., Johnson, E., & Hansen, B. C. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.3.b212 · Cited by 250
Research works printed but not linked: 1
- Roth, G. S. et al. Age-related changes in androgen levels of rhesus monkeys subjected to diet restriction. Endocr. J. 1, 227–234 (1993)
Cited by
Sorted by citations
Items 801–900 of 1,000
Nishizono, S., Wang, Z., Watanabe, Y., Ohata, Y., & Chiba, T. (2017) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.6.201 · Cited by 3
Bourg, É. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00002-4 · Cited by 3
Kobayashi, M., & Higami, Y. (2020) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.19-00193-2 · Cited by 3
Ernährung bei Krebs: Geeignet zur Vorbeugung und Therapie?
Arends, J. (2020) · Laryngo-Rhino-Otologie · doi:10.1055/a-1071-2691 · Cited by 3
The overlooked variable in animal studies: why diet makes a difference
Madhusoodanan, J. (2022) · Nature · doi:10.1038/d41586-022-01393-9 · Cited by 3
Unraveling Pathways of Health and Lifespan with Integrated Multiomics Approaches
Aon, M. A., Bernier, M., & de Cabo, R. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1831-8_9 · Cited by 3
Increased physical activity is not related to markers of cardiometabolic health in two lemur species
Rimbach, R., & Pontzer, H. (2023) · American Journal of Primatology · doi:10.1002/ajp.23564 · Cited by 3
Mechanisms underlying retardation of aging by dietary energy restriction
Shimokawa, I. (2023) · Pathology International · doi:10.1111/pin.13387 · Cited by 3
The Role of Nutrition in Healthy Hearing: Human Evidence
Spankovich, C. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-13473-4_6 · Cited by 3
Theories and Mechanisms of Aging
Behl, C., & Ziegler, C. (2013) · SpringerBriefs in molecular medicine · doi:10.1007/978-3-642-45179-9_3 · Cited by 3
Is it Time to State That Diet Restriction Does Not Increase Life span in Primates?
Bourg, É. L. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx159 · Cited by 3
Translational Research in the Fastest-Growing Population
High, K. P., & Kritchevsky, S. B. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800687-0.00031-1 · Cited by 3
Role of cereal bioactive compounds in the prevention of age-related diseases
Tomé, I., Peñas, E., Hernández‐Ledesma, B., & Martínez‐Villaluenga, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823482-2.00028-5 · Cited by 3
Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences
Cantó, C. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115003225 · Cited by 3
Fitness, nutrition and the molecular basis of chronic disease
McAtee, C. P. (2013) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2013.801234 · Cited by 3
General Thermodynamic Efficiency Loss and Scaling Behavior of Eukaryotic Organisms
Montemayor-Aldrete, J. A., Márquez-Caballé, R. F., del Castillo‐Mussot, M., & Cruz, F. (2020) · Biophysical Reviews and Letters · doi:10.1142/s1793048020500046 · Cited by 3
Aging and the Kidney: Clinical and Pathophysiologic Issues
Schlanger, L. E., Bailey, J. L., & Sands, J. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815876-0.00017-6 · Cited by 3
Occurrence of an accessory pancreatic duct in the sheep
Abdalla, O., & Sack, W. O. (1983) · American Journal of Veterinary Research · doi:10.2460/ajvr.1983.44.07.1182 · Cited by 3
Caloric Restriction Remodels Energy Metabolic Pathways of Gut Microbiota and Promotes Host AutophagyPreprint
Yang, Y., Chen, S., Liu, Y., Hou, Y., Xie, X., Zhang, X., Zhao, A., Zheng, X., Liu, J., Chen, T., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.16.251215 · Cited by 3
The Hunger Games as the Key to Happily Ever After?
Deere, J. A., Xu, C., Adelmant, C., Aboobaker, A. A., & Salguero‐Gómez, R. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad100 · Cited by 2
The nutrigenomic-epigenetic axis in cancer: from dietary bioactives to precision oncology
Boroomand, F., Karimi, M. A., Karimzadeh‐Soureshjani, E., Kiani-Shamsabadi, D., Farhang, F., Mardani, H., & Jafari, A. (2026) · Nutrition & Metabolism · doi:10.1186/s12986-026-01147-8 · Cited by 2
Rose, A., Muthukumarasamy, K. M., Dasari, H., Gaudreau, P., & Hiram, R. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103266 · Cited by 2
Haj‐Mirzaian, A., Afshari, K., & Abdolghaffari, A. H. (2020) · Springer eBooks · doi:10.1007/978-3-030-50287-4_24 · Cited by 3
Therapeutic Fasting: Are Patients Aged 65 and Over Ready?
Gramont, B., Killian, M., Bernard, E., Martinez, L., Bruel, S., Galusca, B., Barth, N., & Célarier, T. (2022) · Nutrients · doi:10.3390/nu14102001 · Cited by 3
Comparative Physiology, Growth, and Development
Buck, W. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-417144-2.00008-1 · Cited by 2
Autophagy and Proteostasis in Cardiac Aging
Dai, D., & Rabinovitch, P. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805253-2.00015-8 · Cited by 2
Caloric Restriction, Longevity and Coenzyme Q
Burón, M. I., Parrado‐Fernández, C., González-Reyes, J. A., Fernández-del-Río, L., Gutiérrez-Casado, E., Calvo‐Rubio, M., Rodríguez-López, S., & Villalba, J. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-45642-9_15 · Cited by 2
Nonhuman Primate Models of Immunosenescence
Rivera, A., Rais, M., Barr, T., Arnold, N. D., Sureshchandra, S., & Messaoudi, I. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_80 · Cited by 2
Genetic and dietary influences on life span
Gu, Y., Lee, J. H., & Mayeux, R. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813955-4.00050-7 · Cited by 2
Smil, V. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190060664.003.0001 · Cited by 3
Diet restriction-induced mitochondrial signaling and healthy aging
Pinkerton, M., & Barrientos, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00027-8 · Cited by 2
Emerging Nutrition Approaches to Support the Mind and Muscle for Healthy Aging
Mey, G. M., & Mey, J. T. (2022) · Recent Progress in Nutrition · doi:10.21926/rpn.2204022 · Cited by 2
Granat, F., Trumel, C., Braun, J., & Bourgès-Abella, N. (2023) · Journal of medical primatology · doi:10.1111/jmp.12666 · Cited by 1
Sánchez‐Mendoza, L. M., González-Reyes, J. A., Rodríguez-López, S., García‐Caballero, C., Moreno, J. A., de Cabo, R., Burón, M. I., & Villalba, J. M. (2025) · GeroScience · doi:10.1007/s11357-025-01761-z · Cited by 2
Sarcopenia and Its Intervention
Sakuma, K., & Yamaguchi, A. (2015) · Healthy ageing and longevity · doi:10.1007/978-3-319-14830-4_7 · Cited by 2
Nutrition and the biology of human ageing: Molecular mechanisms underlying ageing
Gasser, S. M., & le Coutre, J. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0373-4 · Cited by 2
Memory consolidation — Mechanisms and opportunities for enhancement
Shaikh, N., & Coulthard, E. J. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0140-3 · Cited by 2
Duc, H. T. (2014) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2014.03.006 · Cited by 2
Introductory Chapter: Recent Studies on Cellular Aging and Rejuvenation
Shiomi, N. (2016) · InTech eBooks · doi:10.5772/63897 · Cited by 2
Cantó, C., & Houtkooper, R. H. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_10 · Cited by 2
Kumar, S., & Peterson, T. R. (2019) · Nutrition and Healthy Aging · doi:10.3233/nha-190064 · Cited by 2
Mechanisms and Late-Life Intervention of Aging
Goto, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_17 · Cited by 2
Gawęcka, A., Ryterská, K., Wysokiński, P., Ficek, K., Wilk, K., Banaszczak, M., Jakubczyk, K., Piotrowski, J., Czerwińska-Rogowska, M., Hołowko, J., et al. (2016) · Pomeranian Journal of Life Sciences · doi:10.21164/pomjlifesci.27 · Cited by 2
Calculation of basal metabolic rate in patients with morbid obesity treated in spa conditions
Adamczyk, P., Siwacki, S., Ponikowska, I., & Juszczak, K. (2022) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12996 · Cited by 2
Cellular lifespan and senescence: a complex balance between multiple cellular pathways
Dolivo, D., Hernandez, S. J., & Dominko, T. (2015) · Inside the Cell · doi:10.1002/icl3.1036 · Cited by 3
Sirtuin functions in the brain: From physiological to pathological aspects
Shao, J., Zhang, T., Liu, T., Quan, Y., Fan, L., Liu, J., Yang, X. Y., Xie, Q. R., & Xia, W. (2014) · Journal of Shanghai Jiaotong University (Science) · doi:10.1007/s12204-014-1562-y · Cited by 2
Linger thermo theory part II: A weight unbiased methodology for setting life insurance premiums
Feria, E. H. (2013) · IEEE International Conference on Cybernetics (CYBCONF) · doi:10.1109/cybconf.2013.6617441 · Cited by 2
Ward, R. J. (2013) · Royal Society of Chemistry eBooks · doi:10.1039/9781849735896-00031 · Cited by 2
Regulation of Macroautophagy by Nutrients and Metabolites
Lorin, S., Pattingre, S., Meijer, A. J., & Codogno, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802167-5.00014-1 · Cited by 2
Aging and the Kidney: Clinical and Pathophysiological Issues
Schlanger, L. E., Bailey, J. L., & Sands, J. M. (2015) · Academic Press eBooks · Cited by 2
Aging Heart: Recent Research and Concepts
Nikhra, V. (2017) · Gerontology & Geriatrics Studies · doi:10.31031/ggs.2017.01.000501 · Cited by 3
Salinari, G., & Ruiu, G. (2018) · Genus · doi:10.1186/s41118-018-0028-8 · Cited by 2
Mechanisms of Hematopoietic Stem Cell Ageing and Targets for Hematopoietic Tumour Prevention
Liao, M., & Wang, J. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1117-8_8 · Cited by 2
Dietary patterns and the neoplastic‐prone tissue landscape of old age
Marongiu, F., & Laconi, E. (2020) · Aging and Cancer · doi:10.1002/aac2.12021 · Cited by 2
Hoyer-Allo, K. J. R., Späth, M. R., Hanßen, R., Johnsen, M., Brodesser, S., Kaufmann, K., Kiefer, K., Koehler, F. C., Göbel, H., Kubacki, T., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115485 · Cited by 2
How does the body know how old it is?
Mitteldorf, J. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112182 · Cited by 2
To eat or not to eat – Anti‐ageing effects of energy restriction
Neves, D., Martins, M. J., Passos, E., & Tomada, I. (2015) · Wiley eBooks · doi:10.1002/9781118823408.ch2 · Cited by 2
Human ageing, a biological view
Almeida, H., & Matos, L. (2015) · Wiley eBooks · doi:10.1002/9781118823408.ch1 · Cited by 2
Wang-Michelitsch, J., & Michelitsch, T. M. (2015) · arXiv (Cornell University) · doi:10.48550/arxiv.1505.07016 · Cited by 3
The caloric restriction fallacy, rodent diet aids and the tumor suppression theory of agingPreprint
Wolf, A. M. (2021) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/a2689 · Cited by 2
Sarcopenia: Molecular mechanism and current nutritional approach
Sakuma, K., Yamaguchi, A., & Shimizu, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821848-8.00103-7 · Cited by 2
Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in lifePreprint
Hadj‐Moussa, H., Ulusan, M., Horkai, D., Mirza, M. K. A., & Houseley, J. M. (2026) · eLife · doi:10.7554/elife.111611 · Cited by 2
Height and Risk of Adult Cancers: a Review
dos‐Santos‐Silva, I., & Denholm, R. (2016) · Current Epidemiology Reports · doi:10.1007/s40471-016-0084-6 · Cited by 1
Anti-aging Interventions: Caloric Restriction and Beyond
Ong, K. S., Lim, Z. S. T., & Setiawan, B. (2018) · Cermin Dunia Kedokteran · doi:10.55175/cdk.v50i9.726 · Cited by 1
Rejuvenation of mitochondrial function by time-controlled fasting
Sack, M. N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00017-5 · Cited by 1
Nicotinamide Adenine Dinucleotide and Aging
Jiang, Z., Luo, L., Qin, Y., Huang, Y., & Yan, S. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_28 · Cited by 1
Intermittent fasting: Is it beneficial for health?
Joksimović, Z., & Bastać, D. (2025) · Timocki medicinski glasnik · doi:10.5937/tmg2501024j · Cited by 1
Xia, S., Wang, M., Mo, X., Wang, J., Zheng, S., & Shen, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-02528-4 · Cited by 1
Thapa, D. K., Najam, W., Parker, E. S., Wang, X. R., Smith, D. L., Beyaztaş, U., Nelson, J. F., Austad, S. N., Churchill, G. A., & Allison, D. B. (2025) · GeroScience · doi:10.1007/s11357-025-01925-x · Cited by 1
Self-citationRingel, M. S. (2025) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1002/brv.70109 · Cited by 1
Gene therapy for aging: Current evidence and future directions
Zhang, Y. C., Gan, L., Wang, S., & Zhang, J. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103144 · Cited by 1
Pfabe, J. U., Cambraia, A., Dadi, P. K., Cutler, M., dos Santos, C., Acree, C., Habashy, A., Perkins, G. A., Ellisman, M. H., Jacobson, D. A., et al. (2026) · Cell Calcium · doi:10.1016/j.ceca.2026.103161 · Cited by 1
Facteurs modulant le vieillissement et la longévité : des relations linéaires ou plus complexes ?
Bourg, É. L. (2015) · La Presse Médicale · doi:10.1016/j.lpm.2015.05.011 · Cited by 1
Role of Oxidative Stress in Vascular Endothelial Cells Through Aging – a Double-Edged Sword
Thorin, É., & Thorin‐Trescases, N. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_66 · Cited by 1
The Impact of Cancer Treatments on Aging
Lee, C. D., & Longo, V. D. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_4 · Cited by 1
Reversal of Obesity: The Quest for the Optimum Dietary Regimen
Nicoll, R. (2017) · International Journal Of Nutrition · doi:10.14302/issn.2379-7835.ijn-17-1548 · Cited by 1
A Framework for Uncovering the Roles of Calories and Macronutrients in Health and Aging
Solon‐Biet, S. M., Wahl, D., Raubenheimer, D., Couteur, D. G. L., Simpson, S. J., & Cogger, V. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00008-7 · Cited by 1
Stark, J. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108695428.002 · Cited by 1
Oral Mucosal Keratinocyte Stem Cells
Kang, M., Mehrazarin, S., & Park, N. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397157-9.00026-6 · Cited by 1
Fasting and Caloric Restriction for Healthy Aging and Longevity
Sharma, S., & Kaur, G. (2021) · Healthy ageing and longevity · doi:10.1007/978-3-030-83017-5_24 · Cited by 1
Nutrition in Brain Aging: Its Relevance to Age-Associated Neurodegeneration
Maruyama, W., Nagai, M. S., & Naoi, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_20 · Cited by 1
Caloric Restriction and Biomarkers of Aging
Racette, S. B., & Das, S. K. (2024) · Springer eBooks · doi:10.1007/978-3-031-49622-6_1 · Cited by 1
Diet-Modifiable Redox Alterations in Ageing and Cancer
Hine, C., Patel, A. K., & Ponti, A. K. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_7 · Cited by 1
Energy Balance, IGF-1, and Cancer: Causal Lessons from Genetically Engineered Mice
Hursting, S. D., Rossi, E. L., Bowers, L. W., & Lashinger, L. M. (2015) · Energy balance and cancer · doi:10.1007/978-3-319-16733-6_6 · Cited by 1
Aging in the Single-Celled Eukaryote, S. cerevisiae
He, C. Z., & Kennedy, B. K. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_2 · Cited by 1
Modeling Aging and Age-Associated Pathology in Zebrafish
houcke, J. V., Bollaerts, I., Groef, L. D., & Moons, L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00025-7 · Cited by 1
Vaiserman, A. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12295-4 · Cited by 1
Dietary and Nutritional Regulation
Murphy, T., & Thuret, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801977-1.00006-4 · Cited by 1
Why we age — a new evolutionary view
Peregrim, I. (2017) · Biologia · doi:10.1515/biolog-2017-0064 · Cited by 1
Somatotropic Axis’ Role in Ageing and Longevity Could Depend on Life-History Strategies of Species
Bourg, É. L. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-63001-4_2 · Cited by 1
Circadian Clocks and mTOR Signaling
Gupta, R., & Kondratov, R. V. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-64543-8_9 · Cited by 1
Ernährungskonzepte für den alternden Menschen
Kochlik, B., Grune, T., & Weber, D. (2017) · Der Diabetologe · doi:10.1007/s11428-017-0249-z · Cited by 1
Smith, J. T., & Schneider, B. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00029-4 · Cited by 1
Introductory Chapter: Design of an Ideal Diet Using Common Foods
Shiomi, N. (2018) · InTech eBooks · doi:10.5772/intechopen.77100 · Cited by 1
Dominguez, L. J., & Barbagallo, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11370-4 · Cited by 2
Moving beyond the current limits of data analysis in longevity and healthy lifespan studies
Goh, W. W. B., Thalappilly, S., & Thibault, G. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.08.008 · Cited by 2
Deng, W., Guan, G., Xiao, C., Qu, G., Xue, J., Qin, C., Han, H., & Wang, Y. (2019) · Aging · doi:10.18632/aging.102219 · Cited by 1
Neuropeptide Y inhibits hepatocarcinogenesis in overnutrition in mice
Kinoshita, A., Hayashi, H., Kusano, N., Inoue, S., Komatsu, T., Mori, R., Park, S., Takatsuki, M., Eguchi, S., & Shimokawa, I. (2019) · Institutional Repositories DataBase (IRDB) · doi:10.11343/amn.63.11 · Cited by 1
“Diet and Exercise Will Help You Live Longer”: The Meme that Turns on Housekeeping Genes
Escobar, K. A., Visconti, L. M., Wallace, A., & VanDusseldorp, T. A. (2019) · Advances in Geriatric Medicine and Research · doi:10.20900/agmr20200002 · Cited by 2
Aging, Calorie Restriction and Calorie Restriction Mimetics
Čepelak, I., Dodig, S., & Dodig, D. Č. (2019) · Rad Hrvatske akademije znanosti i umjetnosti Medicinske znanosti · doi:10.21857/9e31lhnddm · Cited by 2
Metadata
- Authors
- Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., Barnard, D., Ward, W. F., Qi, W., Ingram, D. K., & de Cabo, R.
- Affiliations
- National Institutes of Health (US)
- University of Alabama at Birmingham (US)
- The University of Texas at San Antonio Health Science Center (US)
- Pennington Biomedical Research Center (US)
- Corresponding author
- Mattison, Julie A.
- Ingram, Donald K.
- Venue
- Nature
- Published
- 2012-08-29
- Volume
- 489
- Issue
- 7415
- Pages
- 318-321
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3832985
- OpenAlex
- W2053493267
- Cited by
- 1,145
- References
- 31
- Citations by year
- 2026: 25 · 2025: 41 · 2024: 35 · 2023: 46 · 2022: 60 · 2021: 103 · 2020: 79 · 2019: 66 · 2018: 88 · 2017: 105 · 2016: 86 · 2015: 124 · 2014: 119 · 2013: 140 · 2012: 26
- FWCI
- 42.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (ZIAAG000371)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056336)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- caloric restriction, rhesus monkeys, lifespan extension, survival, healthspan, aging, age-related diseases, metabolic profile, non-human primates, diet composition
- MeSH terms
- Aging, Animals, Blood Glucose, Cardiovascular Diseases, Cholesterol, Female, Health, Humans, Longevity, Macaca mulatta, Male, Monkey Diseases, Neoplasms, Triglycerides, United States, Incidence, Survival Rate, Age of Onset, Models, Animal, Caloric Restriction, Uncertainty, Kaplan-Meier Estimate, National Institute on Aging (U.S.)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
