The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Open accessAbstract
Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as a tool to understand mechanisms behind ageing and age-associated diseases. In addition to and independently of increasing lifespan, CR has been reported to delay or prevent the occurrence of many chronic diseases in a variety of animals. Beneficial effects of CR on outcomes such as immune function, motor coordination and resistance to sarcopenia in rhesus monkeys have recently been reported. We report here that a CR regimen implemented in young and older age rhesus monkeys at the National Institute on Aging (NIA) has not improved survival outcomes. Our findings contrast with an ongoing study at the Wisconsin National Primate Research Center (WNPRC), which reported improved survival associated with 30% CR initiated in adult rhesus monkeys (7–14 years) and a preliminary report with a small number of CR monkeys. Over the years, both NIA and WNPRC have extensively documented beneficial health effects of CR in these two apparently parallel studies. The implications of the WNPRC findings were important as they extended CR findings beyond the laboratory rodent and to a long-lived primate. Our study suggests a separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“dietary restriction has been the most effective strategy to demonstrate an increase in lifespan across a whole range of investigated species, including nonhuman primates”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Mattison et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“dietary restriction (DR) increases lifespan or healthspan in all investigated eukaryote species, including unicellular and multicellular organisms of several distinct phyla, including non-human primates”
From The Hallmarks of Aging (2013) · cites this paper as Mattison et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“and is established to increase healthy lifespan in multiple species8,9.”
From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [9]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Two studies have addressed the effects of CR on non-human primates, but with different outcomes. One study observed prolonged life (Colman et al., 2009) while the other did not (Mattison et al., 2012).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Mattison et al., 2012
In the citing paper
“In contrast, the healthier ad libitum diet in the NIA study (Mattison et al., 2012) allowed for longer lifespan in control animals without conferring additional benefit from CR.”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Mattison et al., 2012
In the citing paper
“However, both studies point to the fact that CR increases healthspan in monkeys by reducing the risk for diabetes, cardiovascular disease, and cancer.”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Mattison et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Survival analysis using sas®: a practical guide
Allison, P. D. (1995) · International Linear Collider · Cited by 3,570
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277
Self-citationBjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501
Aging in Rhesus Monkeys: Relevance to Human Health Interventions
Roth, G. S., Mattison, J. A., Ottinger, M. A., Chachich, M. E., Lane, M. A., & Ingram, D. K. (2004) · Science · doi:10.1126/science.1102541 · Cited by 354
Self-citation“Control” laboratory rodents are metabolically morbid: Why it matters
Martin, B., Ji, S., Maudsley, S., & Mattson, M. P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912955107 · Cited by 354
Caloric Restriction in Humans: Impact on Physiological, Psychological, and Behavioral Outcomes
Redman, L. M., & Ravussin, É. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3253 · Cited by 348
Calorie restriction and prevention of age‐associated chronic disease
Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293
Can oxidative damage be treated nutritionally?
BERGER, M. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2004.10.003 · Cited by 276
Bodkin, N. L., Alexander, T. M., Ortmeyer, H. K., Johnson, E., & Hansen, B. C. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.3.b212 · Cited by 250
Research works printed but not linked: 1
- Roth, G. S. et al. Age-related changes in androgen levels of rhesus monkeys subjected to diet restriction. Endocr. J. 1, 227–234 (1993)
Cited by
Sorted by citations
Items 101–200 of 1,000
Vitale, G., Pellegrino, G., Vollery, M., & Hofland, L. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00027 · Cited by 166
Regulation of reproduction and longevity by nutrient-sensing pathways
Templeman, N. M., & Murphy, C. T. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201707168 · Cited by 175
Ramis, M. R., Esteban, S., Miralles, A., Tan, D., & Reiter, R. J. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.008 · Cited by 165
Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms
Hwangbo, D., Lee, H., Abozaid, L. S., & Min, K. (2020) · Nutrients · doi:10.3390/nu12041194 · Cited by 173
Calorie restriction mimetics: Can you have your cake and eat it, too?
Ingram, D. K., & Roth, G. S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.11.005 · Cited by 164
Self-citationWhat are the roles of calorie restriction and diet quality in promoting healthy longevity?
Rizza, W., Veronese, N., & Fontana, L. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.11.002 · Cited by 168
Intermittent fasting in the prevention and treatment of cancer
Clifton, K., Ma, C. X., Fontana, L., & Peterson, L. L. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21694 · Cited by 166
Molecular mechanisms underlying genotype‐dependent responses to dietary restriction
Schleit, J., Johnson, S. C., Bennett, C. F., Simko, M., Trongtham, N., Castanza, A., Hsieh, E. J., Moller, R. M., Wasko, B. M., Delaney, J. R., et al. (2013) · Aging Cell · doi:10.1111/acel.12130 · Cited by 159
Epigenetic linkage of aging, cancer and nutrition
Daniel, M. G., & Tollefsbol, T. O. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107110 · Cited by 161
Fasting and Caloric Restriction in Cancer Prevention and Treatment
Brandhorst, S., & Longo, V. D. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42118-6_12 · Cited by 166
Optimal body weight for health and longevity: bridging basic, clinical, and population research
Fontana, L., & Hu, F. B. (2014) · Aging Cell · doi:10.1111/acel.12207 · Cited by 157
Healthy Aging and Dietary Patterns
Dominguez, L. J., Veronese, N., Baiamonte, E., Guarrera, M., Parisi, A., Ruffolo, C., Tagliaferri, F., & Barbagallo, M. (2022) · Nutrients · doi:10.3390/nu14040889 · Cited by 164
Non-human primates as a model for aging
Colman, R. J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.008 · Cited by 159
Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates
Pifferi, F., Terrien, J., Marchal, J., Dal‐Pan, A., Djelti, F., Hardy, I., Chahory, S., Cordonnier, N., Desquilbet, L., Hurion, M., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0024-8 · Cited by 167
Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases
Rinninella, E., Cintoni, M., Raoul, P. C., Ianiro, G., Laterza, L., Lopetuso, L. R., Ponziani, F. R., Gasbarrini, A., & Mele, M. C. (2020) · Microorganisms · doi:10.3390/microorganisms8081140 · Cited by 153
Tian, X. Y., Ganeshan, K., Hong, C., Nguyen, K. D., Qiu, Y., Kim, J., Tangirala, R. K., Tontonoz, P., & Chawla, A. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.003 · Cited by 155
Aging and Caloric Restriction Research: A Biological Perspective with Translational Potential
Balasubramanian, P., Howell, P. R., & Anderson, R. M. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.06.015 · Cited by 148
Intermittent fasting attenuates inflammasome activity in ischemic stroke
Fann, D. Y., Santro, T., Manzanero, S., Widiapradja, A., Cheng, Y., Lee, S.-Y., Chunduri, P., Jo, D., Stranahan, A. M., Mattson, M. P., et al. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.017 · Cited by 148
Ajona, D., Ortiz‐Espinosa, S., Lozano, T., Expósito, F., Calvo, A., Valencia, K., Redrado, M., Remírez, A., Lecanda, F., Alignani, D., et al. (2020) · Nature Cancer · doi:10.1038/s43018-019-0007-9 · Cited by 154
Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease
Brandhorst, S., & Longo, V. D. (2019) · Circulation Research · doi:10.1161/circresaha.118.313352 · Cited by 148
Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice
Aon, M. A., Bernier, M., Mitchell, S. J., Germanio, C. D., Mattison, J. A., Ehrlich, M. R., Colman, R. J., Anderson, R. M., & de Cabo, R. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.018 · Cited by 147
Self-citationAnti-aging pharmacology: Promises and pitfalls
Vaiserman, A. M., Lushchak, O. V., & Koliada, A. K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.004 · Cited by 148
Sánchez-Román, I., & Barja, G. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.021 · Cited by 146
Dietary restriction.; mitochondrial function and aging: From yeast to humans
Ruetenik, A., & Barrientos, A. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.005 · Cited by 139
System-wide Benefits of Intermeal Fasting by Autophagy
Martínez-López, N., Tarabra, E., Toledo, M., Macia, M. G., Sahu, S., Coletto, L., Batista‐González, A., Barzilai, N., Pessin, J. E., Schwartz, G. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.020 · Cited by 140
Macronutrients and caloric intake in health and longevity
Solon‐Biet, S. M., Mitchell, S. J., de Cabo, R., Raubenheimer, D., Couteur, D. G. L., & Simpson, S. J. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0173 · Cited by 140
Being cool: how body temperature influences ageing and longevity
Keil, G., Cummings, E., & de Magalhães, J. P. (2015) · Biogerontology · doi:10.1007/s10522-015-9571-2 · Cited by 144
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease
Cianflone, E., Torella, M., Biamonte, F., Angelis, A. D., Urbanek, K., Costanzo, F. S., Rota, M., Ellison, G. M., & Torella, D. (2020) · Cells · doi:10.3390/cells9061558 · Cited by 137
Tang, D., Tao, S., Chen, Z., Koliesnik, I. O., Calmes, P. G., Hoerr, V., Han, B., Gebert, N., Zörnig, M., Löffler, B., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151100 · Cited by 133
Choi, I. Y., Lee, C., & Longo, V. D. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.042 · Cited by 133
Caloric restriction and cancer: molecular mechanisms and clinical implications
Meynet, O., & Ricci, J. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.001 · Cited by 143
Prehn, K., von Schwartzenberg, R. J., Mai, K., Zeitz, U., Witte, A. V., Hampel, D. J., Szela, A.-M., Fabian, S., Grittner, U., Spranger, J., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw008 · Cited by 139
Healthy Aging—Nutrition Matters: Start Early and Screen Often
Roberts, S. B., Silver, R. E., Das, S. K., Fielding, R. A., Gilhooly, C. H., Jacques, P. F., Kelly, J. M., Mason, J. B., McKeown, N. M., Reardon, M. A., et al. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab032 · Cited by 138
Calorie restriction and cancer prevention: a mechanistic perspective
Hursting, S. D., Dunlap, S. M., Ford, N. A., Hursting, M. J., & Lashinger, L. M. (2013) · Cancer & Metabolism · doi:10.1186/2049-3002-1-10 · Cited by 137
Natural compounds with anti-ageing activity
Argyropoulou, A., Aligiannis, N., Trougakos, I. P., & Skaltsounis, A. (2013) · Natural Product Reports · doi:10.1039/c3np70031c · Cited by 132
Kaeberlein, M. (2013) · F1000Prime Reports · doi:10.12703/p5-5 · Cited by 112
Mouse models of ageing and their relevance to disease
Kõks, S., Dogan, S., Tuna, B. G., González-Navarro, H., Potter, P., & Vandenbroucke, R. E. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.10.001 · Cited by 125
Mercken, E. M., Majounie, E., Ding, J., Guo, R., Kim, J., Bernier, M., Mattison, J. A., Cookson, M., Gorospe, M., de Cabo, R., et al. (2013) · Aging · doi:10.18632/aging.100598 · Cited by 125
Self-citationGräff, J., Kahn, M., Samiei, A., Gao, J., Ota, K. T., Rei, D., & Tsai, L.-H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5657-12.2013 · Cited by 124
Will calorie restriction work in humans?
Cava, E., & Fontana, L. (2013) · Aging · doi:10.18632/aging.100581 · Cited by 124
Baumeier, C., Kaiser, D., Heeren, J., Scheja, L., John, C., Weise, C., Eravci, M., Lagerpusch, M., Schulze, G., Joost, H., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.01.013 · Cited by 122
Calorie restriction in rodents: Caveats to consider
Ingram, D. K., & de Cabo, R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.008 · Cited by 123
Self-citationRegulation of longevity by FGF21: interaction between energy metabolism and stress responses
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.004 · Cited by 121
Metformin: Do we finally have an anti-aging drug?
Anisimov, V. N. (2013) · Cell Cycle · doi:10.4161/cc.26928 · Cited by 125
Caloric restriction and its mimetics
Lee, S.-H., & Min, K.-J. (2013) · BMB Reports · doi:10.5483/bmbrep.2013.46.4.033 · Cited by 119
The road ahead for health and lifespan interventions
Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101037 · Cited by 118
Molecular signatures of longevity: Insights from cross-species comparative studies
Ma, S., & Gladyshev, V. N. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.007 · Cited by 120
Most, J., Gilmore, L. A., Smith, S. R., Han, H., Ravussin, E., & Redman, L. M. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00261.2017 · Cited by 117
Fujitsuka, N., Asakawa, A., Morinaga, A., Amitani, M. S., Amitani, H., Katsuura, G., Sawada, Y., Sudo, Y., Uezono, Y., Mochiki, E., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.220 · Cited by 114
Nutrition and Healthy Ageing: Calorie Restriction or Polyphenol-Rich “MediterrAsian” Diet?
Pallauf, K., Giller, K., Huebbe, P., & Rimbach, G. H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/707421 · Cited by 116
Nutritional strategies to optimise cognitive function in the aging brain
Wahl, D., Cogger, V. C., Solon‐Biet, S. M., Waern, R. V. R., Gokarn, R., Pulpitel, T., de Cabo, R., Mattson, M. P., Raubenheimer, D., Simpson, S. J., et al. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.006 · Cited by 118
Linking the Metabolic State and Mitochondrial DNA in Chronic Disease, Health, and Aging
Picard, M. A., & Turnbull, D. M. (2013) · Diabetes · doi:10.2337/db12-1203 · Cited by 119
A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction
Li, J., Zhang, C.-X., Liu, Y., Chen, K., & Chen, G. (2017) · Oncotarget · doi:10.18632/oncotarget.20084 · Cited by 117
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
Xie, K., Neff, F., Markert, A., Rozman, J., Aguilar‐Pimentel, J. A., Amarie, O. V., Becker, L., Brommage, R., Garrett, L., Henzel, K. S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00178-3 · Cited by 117
Aspirin Recapitulates Features of Caloric Restriction
Pietrocola, F., Castoldi, F., Markaki, M., Lachkar, S., Chen, G., Enot, D. P., Durand, S., Bossut, N., Tong, M., Malik, S. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.024 · Cited by 114
Vera, E., Bernardes de Jesus, B., Foronda, M., Flores, J. M., & Blasco, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053760 · Cited by 111
Metabolic effects of resveratrol: Addressing the controversies
Bitterman, J. L., & Chung, J. H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1808-8 · Cited by 109
Cunha-Santos, J., Duarte-Neves, J., Carmona, V., Guarente, L., Pereira de Almeida, L., & Cavadas, C. (2016) · Nature Communications · doi:10.1038/ncomms11445 · Cited by 109
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
Cassidy, L. D., Young, A. R. J., Young, C. N. J., Soilleux, E. J., Fielder, E., Weigand, B. M., Lagnado, A., Brais, R., Ktistakis, N. T., Wiggins, K. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14187-x · Cited by 108
Translational models for vascular cognitive impairment: a review including larger species
Hainsworth, A. H., Allan, S. M., Boltze, J., Cunningham, C. J., Farris, C. W., Head, E., Ihara, M., Isaacs, J. D., Kalaria, R. N., Oberstein, S. A. J. L., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0793-9 · Cited by 111
Pignolo, R. J. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.10.005 · Cited by 113
Significance of Resveratrol in Clinical Management of Chronic Diseases
Wahab, A., Gao, K., Jia, C., Zhang, F., Tian, G., Murtaza, G., & Chen, J. (2017) · Molecules · doi:10.3390/molecules22081329 · Cited by 113
Antiaging agents: safe interventions to slow aging and healthy life span extension
Liu, J. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00339-y · Cited by 112
Autophagy in ageing and ageing-associated diseases
He, L., Lu, J., & Yue, Z. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.188 · Cited by 107
Caloric restriction and cellular senescence
Fontana, L., Nehme, J., & Demaria, M. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.10.005 · Cited by 104
Neuroprotective effects of dietary restriction: Evidence and mechanisms
Pani, G. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.03.004 · Cited by 103
The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
Gensous, N., Franceschi, C., Santoro, A., Milazzo, M., Garagnani, P., & Bacalini, M. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20082022 · Cited by 103
Longevity: Lesson from Model Organisms
Taormina, G., Ferrante, F., Vieni, S., Grassi, N., Russo, A. G., & Mirisola, M. G. (2019) · Genes · doi:10.3390/genes10070518 · Cited by 112
Nutrient Sensing, Signaling and Ageing: The Role of IGF-1 and mTOR in Ageing and Age-Related Disease
Johnson, S. C. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_3 · Cited by 104
Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity
Statzer, C., Park, J. Y. C., & Ewald, C. Y. (2023) · Aging and Disease · doi:10.14336/ad.2022.1116 · Cited by 106
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Bartman, S., Coppotelli, G., & Ross, J. M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46030130 · Cited by 110
Mitochondria’s Role in Skin Ageing
Stout, R., & Birch‐Machin, M. A. (2019) · Biology · doi:10.3390/biology8020029 · Cited by 103
Mild suppression of hyperinsulinemia to treat obesity and insulin resistance
Page, M. M., & Johnson, J. D. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.03.018 · Cited by 99
Aging: A mitochondrial DNA perspective, critical analysis and an update
Shokolenko, I. N. (2014) · World Journal of Experimental Medicine · doi:10.5493/wjem.v4.i4.46 · Cited by 101
Resveratrol in mammals: effects on aging biomarkers, age‐related diseases, and life span
Marchal, J., Pifferi, F., & Aujard, F. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12214 · Cited by 101
Health in children: A conceptual framework for use in healthy ageing research
Felix, J. F., Voortman, T., van den Hooven, E. H., Sajjad, A., Leermakers, E. T. M., Tharner, A., Jong, J. C. K., Duijts, L., Verhulst, F. C., de Jongste, J. C., et al. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.09.011 · Cited by 99
Ortega-Molina, A., Lopez-Guadamillas, E., Mattison, J. A., Mitchell, S. J., Muñoz‐Martín, M., Iglesias, G., Gutierrez, V. M., Vaughan, K. L., Szarowicz, M. D., González‐García, I., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.017 · Cited by 99
Self-citationReduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice
Schafer, M. J., Alldred, M. J., Lee, S. H., Calhoun, M. E., Petkova, E., Mathews, P. M., & Ginsberg, S. D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.10.043 · Cited by 97
Brüssow, H. (2013) · Microbial Biotechnology · doi:10.1111/1751-7915.12063 · Cited by 110
Current nutritional and pharmacological anti-aging interventions
Ros, M., & Carrascosa, J. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165612 · Cited by 86
Present and future of anti-ageing epigenetic diets
Bacalini, M. G., Friso, S., Olivieri, F., Pirazzini, C., Giuliani, C., Capri, M., Santoro, A., Franceschi, C., & Garagnani, P. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.006 · Cited by 100
Liang, Y., Liu, C., Lu, M., Dong, Q., Wang, Z., Wang, Z., Xiong, W., Zhang, N., Zhou, J., Liu, Q., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24146-z · Cited by 94
The pathobiology of polycystic kidney disease from a metabolic viewpoint
Menezes, L. F., & Germino, G. G. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0183-y · Cited by 96
Willcox, B. J., & Willcox, D. C. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000019 · Cited by 92
Nuclear receptor signal transduction in C. elegans
Antebi, A. (2015) · WormBook · doi:10.1895/wormbook.1.64.2 · Cited by 93
Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity
Brandhorst, S., & Longo, V. D. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz079 · Cited by 92
Elyahu, Y., & Monsonego, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101231 · Cited by 93
Mihaylova, M. M., Chaix, A., Delibegović, M., Ramsey, J. J., Bass, J. T., Melkani, G. C., Singh, R., Chen, Z., Ja, W. W., Shirasu-Hiza, M., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.008 · Cited by 97
Self-citationZhang, W. B., Sinha, D. B., Pittman, W. E., Hvatum, E., Stroustrup, N., & Pincus, Z. (2016) · Cell Systems · doi:10.1016/j.cels.2016.09.003 · Cited by 94
Regulation of metabolic health by essential dietary amino acids
Green, C. L., & Lamming, D. W. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.004 · Cited by 91
Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity
Wu, Z., Song, L., Liu, S., & Huang, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079319 · Cited by 89
Vainshtein, A., Grumati, P., Sandri, M., & Bonaldo, P. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1096-z · Cited by 88
Towards a unified mechanistic theory of aging
Barja, G. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.05.016 · Cited by 90
Bartley, J. M., Zhou, X., Kuchel, G. A., Weinstock, G. M., & Haynes, L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01164 · Cited by 87
Nutrition and longevity—From mechanisms to uncertainties
Ekmekcioglu, C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1676698 · Cited by 87
Antibody persistence and T-cell balance: Two key factors confronting HIV vaccine development
Lewis, G. K., DeVico, A. L., & Gallo, R. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413550111 · Cited by 88
Pharmacological Strategies to Retard Cardiovascular Aging
Alfaras, I., Germanio, C. D., Bernier, M., Csiszár, A., Ungvari, Z. I., Lakatta, E. G., & de Cabo, R. (2016) · Circulation Research · doi:10.1161/circresaha.116.307475 · Cited by 87
Interventions for age-related diseases: Shifting the paradigm
Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 92
Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness
Fry, J., Sayah, L. A., Weisbrod, R. M., Roy, I. V., Weng, X., Cohen, R. A., Bachschmid, M. M., & Seta, F. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07622 · Cited by 87
Heestand, B., Shen, Y., Liu, W., Magner, D. B., Storm, N., Meharg, C., Habermann, B. H., & Antebi, A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003651 · Cited by 89
Metadata
- Authors
- Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., Barnard, D., Ward, W. F., Qi, W., Ingram, D. K., & de Cabo, R.
- Affiliations
- National Institutes of Health (US)
- University of Alabama at Birmingham (US)
- The University of Texas at San Antonio Health Science Center (US)
- Pennington Biomedical Research Center (US)
- Corresponding author
- Mattison, Julie A.
- Ingram, Donald K.
- Venue
- Nature
- Published
- 2012-08-29
- Volume
- 489
- Issue
- 7415
- Pages
- 318-321
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3832985
- OpenAlex
- W2053493267
- Cited by
- 1,145
- References
- 31
- Citations by year
- 2026: 25 · 2025: 41 · 2024: 35 · 2023: 46 · 2022: 60 · 2021: 103 · 2020: 79 · 2019: 66 · 2018: 88 · 2017: 105 · 2016: 86 · 2015: 124 · 2014: 119 · 2013: 140 · 2012: 26
- FWCI
- 42.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (ZIAAG000371)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056336)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- caloric restriction, rhesus monkeys, lifespan extension, survival, healthspan, aging, age-related diseases, metabolic profile, non-human primates, diet composition
- MeSH terms
- Aging, Animals, Blood Glucose, Cardiovascular Diseases, Cholesterol, Female, Health, Humans, Longevity, Macaca mulatta, Male, Monkey Diseases, Neoplasms, Triglycerides, United States, Incidence, Survival Rate, Age of Onset, Models, Animal, Caloric Restriction, Uncertainty, Kaplan-Meier Estimate, National Institute on Aging (U.S.)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
