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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Open accessAbstract
Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as a tool to understand mechanisms behind ageing and age-associated diseases. In addition to and independently of increasing lifespan, CR has been reported to delay or prevent the occurrence of many chronic diseases in a variety of animals. Beneficial effects of CR on outcomes such as immune function, motor coordination and resistance to sarcopenia in rhesus monkeys have recently been reported. We report here that a CR regimen implemented in young and older age rhesus monkeys at the National Institute on Aging (NIA) has not improved survival outcomes. Our findings contrast with an ongoing study at the Wisconsin National Primate Research Center (WNPRC), which reported improved survival associated with 30% CR initiated in adult rhesus monkeys (7–14 years) and a preliminary report with a small number of CR monkeys. Over the years, both NIA and WNPRC have extensively documented beneficial health effects of CR in these two apparently parallel studies. The implications of the WNPRC findings were important as they extended CR findings beyond the laboratory rodent and to a long-lived primate. Our study suggests a separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate.
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“dietary restriction has been the most effective strategy to demonstrate an increase in lifespan across a whole range of investigated species, including nonhuman primates”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Mattison et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“dietary restriction (DR) increases lifespan or healthspan in all investigated eukaryote species, including unicellular and multicellular organisms of several distinct phyla, including non-human primates”
From The Hallmarks of Aging (2013) · cites this paper as Mattison et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“and is established to increase healthy lifespan in multiple species8,9.”
From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [9]
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“Two studies have addressed the effects of CR on non-human primates, but with different outcomes. One study observed prolonged life (Colman et al., 2009) while the other did not (Mattison et al., 2012).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Mattison et al., 2012
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“In contrast, the healthier ad libitum diet in the NIA study (Mattison et al., 2012) allowed for longer lifespan in control animals without conferring additional benefit from CR.”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Mattison et al., 2012
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“However, both studies point to the fact that CR increases healthspan in monkeys by reducing the risk for diabetes, cardiovascular disease, and cancer.”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Mattison et al., 2012
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Cites
Survival analysis using sas®: a practical guide
Allison, P. D. (1995) · International Linear Collider · Cited by 3,570
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277
Self-citationBjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501
Aging in Rhesus Monkeys: Relevance to Human Health Interventions
Roth, G. S., Mattison, J. A., Ottinger, M. A., Chachich, M. E., Lane, M. A., & Ingram, D. K. (2004) · Science · doi:10.1126/science.1102541 · Cited by 354
Self-citation“Control” laboratory rodents are metabolically morbid: Why it matters
Martin, B., Ji, S., Maudsley, S., & Mattson, M. P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912955107 · Cited by 354
Caloric Restriction in Humans: Impact on Physiological, Psychological, and Behavioral Outcomes
Redman, L. M., & Ravussin, É. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3253 · Cited by 348
Calorie restriction and prevention of age‐associated chronic disease
Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293
Can oxidative damage be treated nutritionally?
BERGER, M. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2004.10.003 · Cited by 276
Bodkin, N. L., Alexander, T. M., Ortmeyer, H. K., Johnson, E., & Hansen, B. C. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.3.b212 · Cited by 250
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Research works printed but not linked: 1
- Roth, G. S. et al. Age-related changes in androgen levels of rhesus monkeys subjected to diet restriction. Endocr. J. 1, 227–234 (1993)
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Sorted by citations
Items 301–400 of 1,000
Wilson, K. A., Chamoli, M., Hilsabeck, T. A. U., Pandey, M., Bansal, S., Chawla, G., & Kapahi, P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.018 · Cited by 57
Liao, C., & Kennedy, B. K. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-397920-9.00003-2 · Cited by 59
Age-related changes of myocardial ATP supply and demand mechanisms
Yaniv, Y., Juhaszova, M., & Sollott, S. J. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.06.001 · Cited by 56
Schriner, S. E., Lee, K. C., Truong, S., Salvadora, K. T., Maler, S., Nam, A., Lee, T., & Jafari, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063886 · Cited by 55
The zebrafish as a gerontology model in nervous system aging, disease, and repair
houcke, J. V., Groef, L. D., Dekeyster, E., & Moons, L. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.10.004 · Cited by 59
The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling
Long, Y. C., Tan, T. M. C., Inoue, T., & Tang, B. L. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00665.2013 · Cited by 57
Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society
Nikolich‐Žugich, J., Goldman, D. P., Cohen, P. R., Cortese, D. A., Fontana, L., Kennedy, B. K., Mohler, M. J., Olshansky, S. J., Perls, T. T., Perry, D. P., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv164 · Cited by 58
Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology
Guo, J., Cheng, J., North, B. J., & Wei, W. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.07.001 · Cited by 55
Development and Characterization of a Chemically Defined Food for Drosophila
Lee, W., & Micchelli, C. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067308 · Cited by 54
Ye, L., Widlund, A. L., Sims, C. A., Lamming, D. W., Guan, Y., Davis, J. G., Sabatini, D. M., Harrison, D. E., Vang, O., & Baur, J. A. (2013) · Aging · doi:10.18632/aging.100576 · Cited by 56
The conserved role of protein restriction in aging and disease
Mirzaei, H., Raynes, R., & Longo, V. D. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000239 · Cited by 55
Owczarz, M., Budzińska, M., Domaszewska-Szostek, A., Borkowska, J., Połosak, J., Gewartowska, M., Ślusarczyk, P., & Puzianowska‐Kuźnicka, M. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217720884 · Cited by 55
Does eating less make you live longer and better? An update on calorie restriction
Picca, A., Pesce, V., & Lezza, A. M. S. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s126458 · Cited by 57
Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
Bok, E., Jo, M., Lee, S., Lee, B.-R., Kim, J., & Kim, H.-J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030464 · Cited by 53
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de Magalhães, J. P. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1580 · Cited by 54
Khraiwesh, H. M., Lopez-Dominguez, J. A., López‐Lluch, G., Navas, P., de Cabo, R., Ramsey, J. J., Villalba, J. M., & González-Reyes, J. A. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt006 · Cited by 54
Kaeberlein, M. R. (2015) · Veterinary Pathology · doi:10.1177/0300985815591082 · Cited by 56
Nutrition and sarcopenia: A review of the evidence of nutritional influences
Abiri, B., & Vafa, M. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1412940 · Cited by 56
Contreras, N. A., Fontana, L., Tosti, V., & Nikolich‐Žugich, J. (2018) · GeroScience · doi:10.1007/s11357-018-0022-2 · Cited by 53
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Costello, K. R., & Schones, D. E. (2018) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1416 · Cited by 52
Cardioprotective Signature of Short-Term Caloric Restriction
Noyan, H., El-Mounayri, O., Isserlin, R., Arab, S., Momen, A., Cheng, H. S., Wu, J., Afroze, T., Li, R., Fish, J. E., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130658 · Cited by 54
What is an anti-aging treatment?
Gems, D. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.07.003 · Cited by 52
Multiomic profiling of the liver across diets and age in a diverse mouse population
Williams, E. G., Pfister, N., Roy, S., Statzer, C., Haverty, J., Ingels, J. F., Bohl, C. J., Hasan, M., Čuklina, J., Bühlmann, P., et al. (2021) · Cell Systems · doi:10.1016/j.cels.2021.09.005 · Cited by 52
Nutrition modulation of human aging: The calorie restriction paradigm
Das, S. K., Balasubramanian, P., & Weerasekara, Y. K. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.011 · Cited by 51
Lopez, T. E., Schriner, S. E., Okoro, M. C., Lu, D., Chiang, B. T., Huey, J., & Jafari, M. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2013.0190 · Cited by 52
Minois, N., Rockenfeller, P., Smith, T., & Carmona‐Gutiérrez, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102435 · Cited by 51
Progress on the role of DNA methylation in aging and longevity
Xiao, F., Kong, Q., Perry, B., & He, Y. (2016) · Briefings in Functional Genomics · doi:10.1093/bfgp/elw009 · Cited by 51
Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies
Vaughan, K. L., Kaiser, T. A., Peaden, R., Anson, R. M., de Cabo, R., & Mattison, J. A. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx088 · Cited by 54
Self-citationBai, M., Wang, Y., Han, R., Xu, L., Huang, M., Zhao, J., Lin, Y., Song, S., & Chen, Y. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108493 · Cited by 51
An integrative approach to dietary balance across the life course
Raubenheimer, D., Senior, A. M., Mirth, C. K., Cui, Z., Hou, R., Couteur, D. G. L., Solon‐Biet, S. M., Léopold, P., & Simpson, S. J. (2022) · iScience · doi:10.1016/j.isci.2022.104315 · Cited by 50
Tang, D., Tran, Y., Dawes, P., & Gopinath, B. (2023) · Antioxidants · doi:10.3390/antiox12040878 · Cited by 50
Experimental Models for Aging and their Potential for Novel Drug Discovery
Folch, J., Busquets, O., Ettcheto, M., Sánchez‐López, E., Pallàs, M., Beas‐Zárate, C., Marin, M., Casadesús, G., Olloquequi, J., Auladell, C., et al. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170707155345 · Cited by 53
The Role of Ghrelin and Ghrelin Signaling in Aging
Amitani, M. S., Amitani, H., Cheng, K., Kairupan, T. S., Sameshima, N., Shimoshikiryo, I., Mizuma, K., Rokot, N. T., Nerome, Y., Owaki, T., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071511 · Cited by 53
Oral health in geroscience: animal models and the aging oral cavity
An, J. Y., Darveau, R. P., & Kaeberlein, M. R. (2017) · GeroScience · doi:10.1007/s11357-017-0004-9 · Cited by 51
A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction
Chiba, T., Tamashiro, Y., Park, D., Kusudo, T., Fujie, R., Komatsu, T., Kim, S. E., Park, S., Hayashi, H., Mori, R., et al. (2014) · Scientific Reports · doi:10.1038/srep04517 · Cited by 52
Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta)
Didier, E. S., Sugimoto, C., Bowers, L. C., Khan, I. A., & Kuroda, M. J. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-25 · Cited by 49
Barger, J. L., Vann, J. M., Cray, N., Pugh, T. D., Mastaloudis, A., Hester, S. N., Wood, S. M., Newton, M. A., Weindruch, R. H., & Prolla, T. A. (2017) · Aging Cell · doi:10.1111/acel.12608 · Cited by 50
Dietary Factors in the Control of Gut Homeostasis, Intestinal Stem Cells, and Colorectal Cancer
Francescangeli, F., Angelis, M. L. D., & Zeuner, A. (2019) · Nutrients · doi:10.3390/nu11122936 · Cited by 51
Immune Memory in Aging: a Wide Perspective Covering Microbiota, Brain, Metabolism, and Epigenetics
Bulut, O. P., Kılıç, G., & Domínguez‐Andrés, J. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08905-x · Cited by 50
Verburgh, K. (2014) · Aging Cell · doi:10.1111/acel.12284 · Cited by 51
NutrimiRAging: Micromanaging Nutrient Sensing Pathways through Nutrition to Promote Healthy Aging
Micó, V., Berninches, L., Tapia, J., & Daimiel, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050915 · Cited by 50
The force is strong with this one: metabolism (Over)powers stem cell fate
Wei, P., Dove, K. K., Bensard, C., Schell, J. C., & Rutter, J. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.007 · Cited by 47
Does diet influence aging? Evidence from animal studies
Couteur, D. G. L., Raubenheimer, D., Solon‐Biet, S. M., de Cabo, R., & Simpson, S. J. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13530 · Cited by 46
Missios, P., Zhou, Y., Guachalla, L. M., von Figura, G., Wegner, A., Chakkarappan, S. R., Binz, T. M., Gompf, A., Hartleben, G., Burkhalter, M. D., et al. (2014) · Nature Communications · doi:10.1038/ncomms5924 · Cited by 49
Animal and human models to understand ageing
Lees, H., Walters, H., & Cox, L. S. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.06.008 · Cited by 50
Miyazawa, T., Nakagawa, K., Kim, S. H., Thomas, M. J., Paul, L., Zingg, J.-M., Dolnikowski, G. G., Roberts, S. B., Kimura, F., Miyazawa, T., et al. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0250-6 · Cited by 47
Gutiérrez-Casado, E., Khraiwesh, H. M., Lopez-Dominguez, J. A., Montero-Guisado, J., López‐Lluch, G., Navas, P., de Cabo, R., Ramsey, J. J., González-Reyes, J. A., & Villalba, J. M. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly161 · Cited by 49
Proinflammatory Arterial Stiffness Syndrome: A Signature of Large Arterial Aging
Wang, M., Monticone, R. E., & McGraw, K. R. (2018) · Journal of Vascular Research · doi:10.1159/000490244 · Cited by 52
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Brandhorst, S. (2021) · GeroScience · doi:10.1007/s11357-020-00317-7 · Cited by 50
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Mao, L., & Franke, J. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140713109 · Cited by 47
The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice
Lin, W., Chen, J., Wang, J.-C., Chen, L.-Y., Lin, C.-H., Hsieh, T.-R., Wang, M.-F., Fu, T., & Wang, P. (2013) · AGE · doi:10.1007/s11357-013-9606-z · Cited by 47
Lashinger, L. M., O’Flanagan, C. H., Dunlap, S. M., Rasmussen, A. J., Sweeney, S., Guo, J. Y., Lodi, A., Tiziani, S., White, E., & Hursting, S. D. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0158-4 · Cited by 48
McKay, A. S., Costa, E. K., Chen, J., Hu, C., Chen, X., Bedbrook, C. N., Khondker, R. C., Thielvoldt, M., Singh, P. P., Wyss‐Coray, T., et al. (2022) · eLife · doi:10.7554/elife.69008 · Cited by 48
Manipulation of health span and function by dietary caloric restriction mimetics
Roth, G. S., & Ingram, D. K. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12834 · Cited by 46
Self-citationMauro, C. R., Tao, M., Yu, P., Trevino-Villarreal, J. H., Longchamp, A., Kristal, B. S., Ozaki, C. K., & Mitchell, J. R. (2014) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2014.07.004 · Cited by 46
Riera, C. E., & Dillin, A. G. (2015) · Nature Medicine · doi:10.1038/nm.4005 · Cited by 48
Marti, N., Bouchoucha, N., Sauter, K., & Flück, C. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174224 · Cited by 46
Does senescence promote fitness in Caenorhabditis elegans by causing death?
Lohr, J. N., Galimov, E. R., & Gems, D. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.008 · Cited by 47
Sun, X., Wheeler, C. T., Yolitz, J., Laslo, M., Alberico, T., Sun, Y., Song, Q., & Zou, S. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.022 · Cited by 45
Mitchell, S. E., Tang, Z., Kerbois, C., Delville, C., Derous, D., Green, C. L., Wang, Y., Han, J., Chen, L., Douglas, A., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15294 · Cited by 45
Kazemi, A., Speakman, J. R., Soltani, S., & Djafarian, K. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.07.030 · Cited by 47
Restoring aged stem cell functionality: Current progress and future directions
Spehar, K., Pan, A., & Beerman, I. (2020) · Stem Cells · doi:10.1002/stem.3234 · Cited by 46
Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids
Lu, J., Temp, U., Müller-Hartmann, A., Eßer, J., Grönke, S., & Partridge, L. (2020) · Nature Aging · doi:10.1038/s43587-020-00001-7 · Cited by 46
Longevity and aging. Role of free radicals and xanthine oxidase. A review
Labat‐Robert, J., & Robert, L. (2014) · Pathologie Biologie · doi:10.1016/j.patbio.2014.02.009 · Cited by 46
Giacomello, E., & Toniolo, L. (2021) · Nutrients · doi:10.3390/nu13072346 · Cited by 45
DNA methylation age analysis of rapamycin in common marmosets
Horvath, S., Zoller, J. A., Haghani, A., Lu, A. T.-H., Raj, K., Jasinska, A. J., Mattison, J. A., & Salmon, A. B. (2021) · GeroScience · doi:10.1007/s11357-021-00438-7 · Cited by 45
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Han, C. J., & Someya, S. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.014 · Cited by 45
Should animal fats be back on the table? A critical review of the human health effects of animal fat
Barendse, W. (2014) · Animal Production Science · doi:10.1071/an13536 · Cited by 44
The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?
Austad, S. N. (2016) · Advances in Geroscience · doi:10.1007/978-3-319-23246-1_1 · Cited by 43
Energy restriction and potential energy restriction mimetics
Nikolai, S., Pallauf, K., Huebbe, P., & Rimbach, G. H. (2015) · Nutrition Research Reviews · doi:10.1017/s0954422415000062 · Cited by 43
Mitchell, S. E., Delville, C., Konstantopedos, P., Derous, D., Green, C. L., Wang, Y., Han, J. J., Promislow, D., Douglas, A., Chen, L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8158 · Cited by 44
Tani, Y., Kondo, N., Nagamine, Y., Shinozaki, T., Kondo, K., Kawachi, I. I., & Fujiwara, T. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw146 · Cited by 43
Promoting healthspan and lifespan with caloric restriction in primates
Pifferi, F., Terrien, J., Perret, M., Epelbaum, J., Blanc, S., Picq, J., Dhénain, M., & Aujard, F. (2019) · Communications Biology · doi:10.1038/s42003-019-0348-z · Cited by 45
Walker, E. M., Slisarenko, N., Gerrets, G. L., KISSINGER, P. J., Didier, E. S., Kuroda, M. J., Veazey, R. S., Jazwinski, S. M., & Rout, N. (2019) · GeroScience · doi:10.1007/s11357-019-00099-7 · Cited by 43
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Gouspillou, G., & Hepple, R. T. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.03.004 · Cited by 42
Arnold, C. R., Pritz, T., Brunner, S., Knabb, C., Salvenmoser, W., Holzwarth, B., Thedieck, K., & Grubeck-Loebenstein, B. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.018 · Cited by 42
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González-Rodríguez, P., Füllgrabe, J., & Joseph, B. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01159-4 · Cited by 44
Ensminger, D. C., Salvador‐Pascual, A., Arango, B. G., Allen, K. N., & Vázquez‐Medina, J. P. (2021) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2021.110929 · Cited by 45
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Salguero‐Gómez, R. (2017) · Evolutionary Ecology · doi:10.1007/s10682-017-9923-2 · Cited by 41
Mixed results for dieting monkeys
Austad, S. N. (2012) · Nature · doi:10.1038/nature11484 · Cited by 41
Giller, K., Huebbe, P., Doering, F., Pallauf, K., & Rimbach, G. H. (2013) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2013.0101 · Cited by 42
Plasticity of lifespan: a reaction norm perspective
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Ng, L. T., Ng, L. F., Tang, R. M. Y., Barardo, D., Halliwell, B. B., Moore, P. K., & Gruber, J. (2020) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-020-0044-8 · Cited by 42
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Metadata
- Authors
- Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., Barnard, D., Ward, W. F., Qi, W., Ingram, D. K., & de Cabo, R.
- Affiliations
- National Institutes of Health (US)
- University of Alabama at Birmingham (US)
- The University of Texas at San Antonio Health Science Center (US)
- Pennington Biomedical Research Center (US)
- Corresponding author
- Mattison, Julie A.
- Ingram, Donald K.
- Venue
- Nature
- Published
- 2012-08-29
- Volume
- 489
- Issue
- 7415
- Pages
- 318-321
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3832985
- OpenAlex
- W2053493267
- Cited by
- 1,145
- References
- 31
- Citations by year
- 2026: 25 · 2025: 41 · 2024: 35 · 2023: 46 · 2022: 60 · 2021: 103 · 2020: 79 · 2019: 66 · 2018: 88 · 2017: 105 · 2016: 86 · 2015: 124 · 2014: 119 · 2013: 140 · 2012: 26
- FWCI
- 42.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (ZIAAG000371)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056336)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- caloric restriction, rhesus monkeys, lifespan extension, survival, healthspan, aging, age-related diseases, metabolic profile, non-human primates, diet composition
- MeSH terms
- Aging, Animals, Blood Glucose, Cardiovascular Diseases, Cholesterol, Female, Health, Humans, Longevity, Macaca mulatta, Male, Monkey Diseases, Neoplasms, Triglycerides, United States, Incidence, Survival Rate, Age of Onset, Models, Animal, Caloric Restriction, Uncertainty, Kaplan-Meier Estimate, National Institute on Aging (U.S.)
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