The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Diversity, stability and resilience of the human gut microbiota
Open accessAbstract
Trillions of microbes inhabit the human intestine, forming a complex ecological community that influences normal physiology and susceptibility to disease through its collective metabolic activities and host interactions. Understanding the factors that underlie changes in the composition and function of the gut microbiota will aid in the design of therapies that target it. This goal is formidable. The gut microbiota is immensely diverse, varies between individuals and can fluctuate over time - especially during disease and early development. Viewing the microbiota from an ecological perspective could provide insight into how to promote health by targeting this microbial community in clinical treatments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, the composition of the remaining gut microbiota is remarkably diverse and dynamic, with both acute and chronic dietary exposures significantly affecting the overall microbial community (8,11).”
From The contributory role of gut microbiota in cardiovascular disease (2014) · cites this paper as [8]
In the citing paper
“We now know that the human gut harbors more than 100 trillion microbial cells, far outnumbering the human host cells of the body (8).”
From The contributory role of gut microbiota in cardiovascular disease (2014) · cites this paper as [8]
In the citing paper
“In spite of a consistency in the global composition, the intestinal microbiota seems to be highly variable among individuals at species-level phylotypes; usually Faecalibacterium prausnitzii (F.prausnitzii), Roseburia intestinalis, Bacteroides uniformis, and species of bifidobacteria and lactobacilli are present in most people [6] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [6]
In the citing paper
“Inter-individual variation in the gut microbiota composition and gene content is known to be vast (Lozupone et al., 2012).”
From Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women (2018) · cites this paper as Lozupone et al., 2012
In the citing paper
“In both a human-associated microbiota43-45 and macroecological46,47 context, higher phylogenetic diversity is associated with greater ecosystem resilience and productivity.”
From Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions (2013) · cites this paper as [45]
In the citing paper
“Host biology and environmental cues are both substantial contributors toward shaping gut-associated bacterial communities.3,56,57”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Self-citationStructure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Self-citationA human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Self-citationDiversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Self-citationResilience, Adaptability and Transformability in Social–ecological Systems
Walker, B., Holling, C. S., Carpenter, S. R., & Kinzig, A. P. (2004) · Ecology and Society · doi:10.5751/es-00650-090205 · Cited by 7,821
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Self-citationEnterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
Self-citation
Cited by
Sorted by citations
Items 501–600 of 1,040
Microcins in Enterobacteriaceae: Peptide Antimicrobials in the Eco-Active Intestinal Chemosphere
Baquero, F., Lanza, V. F., Baquero, M.-R., del Campo, R., & Bravo-Vázquez, D. A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02261 · Cited by 174
Islam, M. R., Rauf, A., Akash, S., Trisha, S. I., Nasim, A. H., Akter, M., Dhar, P. S., Ogaly, H. A., Hemeg, H. A., Wilairatana, P., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116034 · Cited by 174
Kuhn, K. A., Schulz, H. M., Regner, E. H., Severs, E., Hendrickson, J. D., Mehta, G., Whitney, A. K., Ir, D., Ohri, N., Robertson, C. E., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.55 · Cited by 173
Cross-Domain and Viral Interactions in the Microbiome
Rowan-Nash, A. D., Korry, B. J., Mylonakis, E. E., & Belenky, P. A. (2019) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00044-18 · Cited by 173
β-Defensins: Farming the Microbiome for Homeostasis and Health
Meade, K. G., & O’Farrelly, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03072 · Cited by 173
Parkinson’s Disease and the Gastrointestinal Microbiome
Lubomski, M., Tan, A. H., Lim, S.-Y., Holmes, A. J., Davis, R. L., & Sue, C. M. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09320-1 · Cited by 172
Microbiomes: unifying animal and plant systems through the lens of community ecology theory
Christian, N., Whitaker, B. K., & Clay, K. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00869 · Cited by 172
Miller, G. E., Engen, P. A., Gillevet, P. M., Shaikh, M. W., Sikaroodi, M., Forsyth, C. B., Mutlu, E., & Keshavarzian, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148952 · Cited by 172
Defining the gut microbiota in individuals with periodontal diseases: an exploratory study
Lourenço, T. G. B., Spencer, S. J., Alm, E. J., & Colombo, A. P. V. (2018) · Journal of Oral Microbiology · doi:10.1080/20002297.2018.1487741 · Cited by 172
Clark, A. P., & Mach, N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00627 · Cited by 171
The effects of grape and red wine polyphenols on gut microbiota – A systematic review
Nash, V., Ranadheera, C. S., Georgousopoulou, E. N., Mellor, D. D., Panagiotakos, D. B., McKune, A. J., Kellett, J., & Naumovski, N. (2018) · Food Research International · doi:10.1016/j.foodres.2018.07.019 · Cited by 171
Fernandes, R., Viana, S., Nunes, S., & Reis, F. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.032 · Cited by 171
Clinical translation of advanced colonic drug delivery technologies
Awad, A., Madla, C. M., McCoubrey, L. E., Ferraro, F., Gavins, F. K. H., Buanz, A. B. M., Gaisford, S., Orlu, M., Siepmann, F., Siepmann, J., et al. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114076 · Cited by 171
A multi-omic future for microbiome studies
Jansson, J. K., & Baker, E. S. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.49 · Cited by 170
Self-citationDeterminants of IBD Heritability: Genes, Bugs, and More
Turpin, W., Goethel, A., Bedrani, L., & Croitoru, M. K. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy085 · Cited by 170
Elucidating Bacterial Gene Functions in the Plant Microbiome
Levy, A., Conway, J. M., Dangl, J. L., & Woyke, T. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.09.005 · Cited by 170
Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease
Sultan, S., El‐Mowafy, M., Elgaml, A., Ahmed, T. A., Hassan, H., & Mottawea, W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715506 · Cited by 170
Fungi inhabiting the healthy human gastrointestinal tract: a diverse and dynamic community
Hallen‐Adams, H. E., Kachman, S. D., Kim, J., Legge, R. M., & Martínez, I. (2015) · Fungal ecology · doi:10.1016/j.funeco.2015.01.006 · Cited by 169
Role of the intestinal microbiome in liver disease
Henao‐Mejia, J., Elinav, E., Thaiss, C. A., Licona-Limón, P., & Flavell, R. A. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.07.001 · Cited by 169
Targeting the Microbiota to Address Diet-Induced Obesity: A Time Dependent Challenge
Clarke, S. F., Murphy, E. F., O’Sullivan, Ó., Ross, R. P., O’Toole, P. W., Shanahan, F., & Cotter, P. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065790 · Cited by 169
Hird, S. M., Carstens, B. C., Cardiff, S. W., Dittmann, D. L., & Brumfield, R. T. (2014) · PeerJ · doi:10.7717/peerj.321 · Cited by 169
A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders
Ng, Q. X., Loke, W., Venkatanarayanan, N., Lim, D. Y., Soh, A. Y. S., & Yeo, W. S. (2019) · Medicina · doi:10.3390/medicina55050129 · Cited by 169
The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis
Freedman, S. N., Shahi, S. K., & Mangalam, A. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0588-x · Cited by 168
Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia
Chen, H., Zheng, X., & Zheng, Y. (2014) · Cell · doi:10.1016/j.cell.2014.10.028 · Cited by 168
Zarkasi, K. Z., Abell, G. C. J., Taylor, R. S., Neuman, C., Hatje, E., Tamplin, M. L., Katouli, M., & Bowman, J. P. (2014) · Journal of Applied Microbiology · doi:10.1111/jam.12514 · Cited by 168
The Intestinal Fate of Citrus Flavanones and Their Effects on Gastrointestinal Health
Stevens, Y., Rymenant, E. V., Grootaert, C., Camp, J. V., Possemiers, S., Masclee, A., & Jonkers, D. M. A. E. (2019) · Nutrients · doi:10.3390/nu11071464 · Cited by 168
Estimating diversity in networked ecological communities
Willis, A. D., & Martin, B. D. (2020) · Biostatistics · doi:10.1093/biostatistics/kxaa015 · Cited by 168
Trosvik, P., & de Muinck, E. J. (2015) · Microbiome · doi:10.1186/s40168-015-0107-4 · Cited by 167
Understanding the Impact of Omega‐3 Rich Diet on the Gut Microbiota
Esquives, B. S. N., Sanchez‐Gonzalez, M. A., Salyakina, D., & Coffman, J. A. (2016) · Case Reports in Medicine · doi:10.1155/2016/3089303 · Cited by 167
Role of the microbiome, probiotics, and ‘dysbiosis therapy’ in critical illness
Wischmeyer, P. E., McDonald, D. T., & Knight, R. D. (2016) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000321 · Cited by 167
Self-citationHypothalamic Inflammation in Human Obesity Is Mediated by Environmental and Genetic Factors
Kreutzer, C., Peters, S., Schulte, D. M., Fangmann, D., Türk, K., Wolff, S., van Eimeren, T., Ahrens, M., Beckmann, J. H., Schafmayer, C., et al. (2017) · Diabetes · doi:10.2337/db17-0067 · Cited by 167
Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms
Ren, X., & Chen, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.602697 · Cited by 167
Gut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis
Li, X., Shan, Q., Wu, X., Miao, H., & Zhao, Y. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05532-5 · Cited by 167
The distinct ecological and social roles that wild spaces play in urban ecosystems
Threlfall, C. G., & Kendal, D. (2017) · Urban forestry & urban greening · doi:10.1016/j.ufug.2017.05.012 · Cited by 166
Facilitation promotes invasions in plant‐associated microbial communities
Li, M., Wei, Z., Wang, J., Jousset, A., Friman, V., Xu, Y., Shen, Q., & Pommier, T. (2018) · Ecology Letters · doi:10.1111/ele.13177 · Cited by 166
Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions
Pantazi, A. C., Bălașa, A. L., Mihai, C. M., Chisnoiu, T., Lupu, V. V., Kassim, M. A. K., Mihai, L., Frecuș, C. E., Chirila, S. I., Lupu, A., et al. (2023) · Nutrients · doi:10.3390/nu15163647 · Cited by 166
The gut microbiome and aquatic toxicology: An emerging concept for environmental health
Adamovský, O., Buerger, A. N., Wormington, A. M., Ector, N., Griffitt, R. J., Bisesi, J. H., & Martyniuk, C. J. (2018) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4249 · Cited by 165
Microbiota-Derived Metabolites in Tumor Progression and Metastasis
Rossi, T., Vergara, D., Fanini, F., Maffia, M., Bravaccini, S., & Pirini, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165786 · Cited by 165
The role of glycosylation in IBD
Τheodoratou, E., Campbell, H. J., Ventham, N. T., Kolarich, D., Pučić‐Baković, M., Zoldoš, V., Fernandes, D. L., Pemberton, I. K., Rudan, I., Kennedy, N. A., et al. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.78 · Cited by 164
Cocoa and Dark Chocolate Polyphenols: From Biology to Clinical Applications
Magrone, T., Russo, M. A., & Jirillo, E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00677 · Cited by 164
Nishida, K., Sawada, D., Kawai, T., Kuwano, Y., Fujiwara, S., & Rokutan, K. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13594 · Cited by 164
The effect of physical exercise on anticancer immunity
Fiuza‐Luces, C., Valenzuela, P. L., Gálvez, B. G., Ramírez, M. R., López‐Soto, A., Simpson, R. J., & Lucía, A. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00943-0 · Cited by 164
A single genus in the gut microbiome reflects host preference and specificity
Eren, A. M., Sogin, M. L., Morrison, H. G., Vineis, J. H., Fisher, J. C., Newton, R. J., & McLellan, S. L. (2014) · The ISME Journal · doi:10.1038/ismej.2014.97 · Cited by 163
Childhood malnutrition and the intestinal microbiome
Kane, A. V., Dinh, D. M., & Ward, H. (2014) · Pediatric Research · doi:10.1038/pr.2014.179 · Cited by 163
Perturbation and restoration of the fathead minnow gut microbiome after low-level triclosan exposure
Narrowe, A. B., Lantz, M. A., Smith, E. P., Bower, K. J., Roane, T. M., Vajda, A. M., & Miller, C. S. (2015) · Microbiome · doi:10.1186/s40168-015-0069-6 · Cited by 163
Challenges of metabolomics in human gut microbiota research
Smirnov, K. S., Maier, T. V., Walker, A., Heinzmann, S. S., Forcisi, S., Martínez, I., Walter, J., & Schmitt‐Kopplin, P. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.03.006 · Cited by 163
How the microbiota shapes rheumatic diseases
de Wiele, T. V., Praet, J. T. V., Marzorati, M., Drennan, M. B., & Elewaut, D. S. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.85 · Cited by 163
Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome
Ussar, S., Fujisaka, S., & Kahn, C. R. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.07.004 · Cited by 163
Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth
Zhong, C., Qu, C., Wang, B., Liang, S., & Zeng, B. (2017) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000814 · Cited by 163
Host contributes to longitudinal diversity of fecal microbiota in swine selected for lean growth
Lu, D., Tiezzi, F., Schillebeeckx, C., McNulty, N. P., Schwab, C. R., Shull, C. M., & Maltecca, C. (2018) · Microbiome · doi:10.1186/s40168-017-0384-1 · Cited by 163
Barrila, J., Crabbé, A., Yang, J., Franco, K., Nydam, S. D., Forsyth, R. J., Davis, R. R., Gangaraju, S., Ott, C. M., Coyne, C. B., et al. (2018) · Infection and Immunity · doi:10.1128/iai.00282-18 · Cited by 163
Community ecology as a framework for human microbiome research
Gilbert, J. A., & Lynch, S. V. (2019) · Nature Medicine · doi:10.1038/s41591-019-0464-9 · Cited by 163
Antibacterial Weapons: Targeted Destruction in the Microbiota
Chassaing, B., & Cascalès, E. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2018.01.006 · Cited by 162
Artacho, A., Isaac, S., Nayak, R. R., Flor‐Duro, A., Alexander, M., Koo, I., Manasson, J., Smith, P. B. W., Rosenthal, P., Homsi, Y., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41622 · Cited by 162
Gut microbiota and short‐chain fatty acid alterations in cachectic cancer patients
Ubachs, J., Ziemons, J., Soons, Z., Aarnoutse, R., van Dijk, D. P. J., Penders, J., van Helvoort, A., Smidt, M. L., Kruitwagen, R. F. P. M., Baade‐Corpelijn, L., et al. (2021) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12804 · Cited by 161
Parasitic Protozoa and Interactions with the Host Intestinal Microbiota
Burgess, S. L., Gilchrist, C. A., Lynn, T. C., & Petri, W. A. (2017) · Infection and Immunity · doi:10.1128/iai.00101-17 · Cited by 161
Ma, T., Villot, C., Renaud, D. L., Skidmore, A. L., Chevaux, E., Steele, M. A., & Guan, L. L. (2020) · The ISME Journal · doi:10.1038/s41396-020-0678-3 · Cited by 161
Implications of Gut Microbiota in Neurodegenerative Diseases
Zhang, H., Chen, Y., Wang, Z., Xie, G., Liu, M., Yuan, B., Chai, H., Wang, W., & Cheng, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.785644 · Cited by 161
Functional Dynamics of the Gut Microbiome in Elderly People during Probiotic Consumption
Eloe-Fadrosh, E. A., Brady, A., Crabtree, J., Drabek, E. F., Ma, B., Mahurkar, A., Ravel, J., Haverkamp, M., Fiorino, A.-M., Botelho, C., et al. (2015) · mBio · doi:10.1128/mbio.00231-15 · Cited by 160
Moens, F., Weckx, S., & Vuyst, L. D. (2016) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2016.05.015 · Cited by 160
Modulation of the gut microbiota by prebiotic fibres and bacteriocins
Umu, Ö. C. O., Rudi, K., & Diep, D. B. (2017) · Microbial Ecology in Health and Disease · doi:10.1080/16512235.2017.1348886 · Cited by 160
Effect of Functional Oligosaccharides and Ordinary Dietary Fiber on Intestinal Microbiota Diversity
Cheng, W., Lü, J., Li, B., Lin, W., Zhang, Z., Wei, X., Sun, C., Chi, M., Bi, W., Yang, B., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01750 · Cited by 160
Bo, T., Zhang, X., Wen, J., Deng, K., Qin, X.-W., & Wang, D. (2019) · The ISME Journal · doi:10.1038/s41396-019-0492-y · Cited by 159
Codella, R., Luzi, L., & Terruzzi, I. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.11.016 · Cited by 158
Hirsch, B. E., Saraiya, N., Poeth, K., Schwartz, R. M., Epstein, M. E., & Honig, G. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-015-0930-z · Cited by 158
Umu, Ö. C. O., Frank, J. A., Fangel, J. U., Oostindjer, M., da Silva, C. S., Bolhuis, J. E., Bosch, G., Willats, W. G. T., Pope, P. B., & Diep, D. B. (2015) · Microbiome · doi:10.1186/s40168-015-0078-5 · Cited by 158
Disturbance induced decoupling between host genetics and composition of the associated microbiome
Wegner, K. M., Volkenborn, N., Peter, H., & Eiler, A. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-252 · Cited by 158
Global research priorities for infections that affect the nervous system
John, C. C., Carabin, H., Montano, S. M., Bangirana, P., Zunt, J. R., & Peterson, P. K. (2015) · Nature · doi:10.1038/nature16033 · Cited by 158
Reshaping the gut microbiota: Impact of low calorie sweeteners and the link to insulin resistance?
Nettleton, J. E., Reimer, R. A., & Shearer, J. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.029 · Cited by 158
Sex and strain dependent differences in mucosal immunology and microbiota composition in mice
Elderman, M. E., Hugenholtz, F., Belzer, C., Boekschoten, M. V., van Beek, A. A., de Haan, B., Savelkoul, H. F. J., de Vos, P., & Faas, M. M. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0186-6 · Cited by 158
New perspectives of Lactobacillus plantarum as a probiotic: The gut-heart-brain axis
Liu, Y.-W., Liong, M., & Tsai, Y.-C. (2018) · The Journal of Microbiology · doi:10.1007/s12275-018-8079-2 · Cited by 158
Hydroxycinnamic acids and human health: recent advances
Coman, V., & Vodnar, D. C. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10010 · Cited by 158
Gao, F.-Z., Zou, H., Wu, D.-L., Chen, S., He, L.-Y., Zhang, M., Bai, H., & Ying, G. (2020) · Environment International · doi:10.1016/j.envint.2020.105484 · Cited by 158
Pan, W.-H., Sommer, F., Falk-Paulsen, M., Ulas, T., Best, L., Fazio, A., Kachroo, P., Luzius, A., Jentzsch, M., Rehman, A., et al. (2018) · Genome Medicine · doi:10.1186/s13073-018-0534-5 · Cited by 157
Janek, D., Zipperer, A., Kulik, A., Krismer, B., & Peschel, A. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005812 · Cited by 157
Kanbay, M., Onal, E. M., Afşar, B., Dağel, T., Yerlikaya, A., Covic, A. C., & Vaziri, N. D. (2018) · International Urology and Nephrology · doi:10.1007/s11255-018-1873-2 · Cited by 157
Wu, J., Liu, J., Li, S., Ma, H., & Wang, Y. (2020) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796020001055 · Cited by 157
Rangel, I., Sundin, J., Fuentes, S., Repsilber, D., de Vos, W. M., & Brummer, R. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13399 · Cited by 156
The Gordian Knot of dysbiosis, obesity and NAFLD
Mehal, W. Z. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.146 · Cited by 156
Siegerstetter, S.-C., Schmitz‐Esser, S., Magowan, E. A., Wetzels, S. U., Zebeli, Q., Lawlor, P. G., O’Connell, N. E., & Metzler-Zebeli, B. U. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187766 · Cited by 156
Rethinking the Coral Microbiome: Simplicity Exists within a Diverse Microbial Biosphere
Hernández‐Agreda, A., Leggat, W. P., Bongaerts, P., Herrera, C., & Ainsworth, T. D. (2018) · mBio · doi:10.1128/mbio.00812-18 · Cited by 155
Dietary Components That May Influence the Disturbed Gut Microbiota in Chronic Kidney Disease
Mafra, D., Borges, N. A., Alvarenga, L., Esgalhado, M., Cardozo, L., Lindholm, B., & Stenvinkel, P. (2019) · Nutrients · doi:10.3390/nu11030496 · Cited by 155
Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota
Nagashima, K., Sawa, S., Nitta, T., Tsutsumi, M., Okamura, T., Penninger, J. M., Nakashima, T., & Takayanagi, H. (2017) · Nature Immunology · doi:10.1038/ni.3732 · Cited by 154
Hu, J., Raikhel, V., Gopalakrishnan, K., Fernandez-Hernandez, H., Lambertini, L., Manservisi, F., Falcioni, L., Bua, L., Belpoggi, F., Teitelbaum, S. L., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0173-2 · Cited by 154
Influence of Exercise on the Human Gut Microbiota of Healthy Adults: A Systematic Review
Ortiz-Alvarez, L., Xu, H., & Martínez‐Téllez, B. (2020) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000126 · Cited by 154
Kang, D., Adams, J. B., Vargason, T., Santiago, M., Hahn, J., & Krajmalnik‐Brown, R. (2020) · mSphere · doi:10.1128/msphere.00314-20 · Cited by 154
Wan, Y., Zuo, T., Xu, Z., Zhang, F., Zhan, H., Dorothy, C. H. A. N., Leung, T.-F., Yeoh, Y. K., Chan, F. K. L., Chan, R., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-324015 · Cited by 154
Randomized Controlled Trial of Strain-Specific Probiotic Formulation (Renadyl) in Dialysis Patients
Ranganathan, N., Pechenyak, B., Vyas, U., Ranganathan, P., Weinberg, A. D., Liang, P., Mallappallil, M. C., Norin, A. J., Friedman, E. A., & Saggi, S. J. (2014) · BioMed Research International · doi:10.1155/2014/568571 · Cited by 153
Archaea associated with human surfaces: not to be underestimated
Bang, C., & Schmitz, R. A. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv010 · Cited by 153
Cowan, T., Palmnäs, M. S. A., Yang, J. J., Bomhof, M. R., Ardell, K., Reimer, R. A., Vogel, H. J., & Shearer, J. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.12.009 · Cited by 153
Putignani, L., CHIERICO, F. D., Vernocchi, P., Cicala, M., Cucchiara, S., & Dallapiccola, B. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000602 · Cited by 153
Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors
Pluznick, J. L. (2016) · Kidney International · doi:10.1016/j.kint.2016.06.033 · Cited by 153
Microbial legacies alter decomposition in response to simulated global change
Martiny, J. B. H., Martiny, A. C., Weihe, C., Lu, Y., Berlemont, R., Brodie, E., Goulden, M. L., Treseder, K. K., & Allison, S. (2016) · The ISME Journal · doi:10.1038/ismej.2016.122 · Cited by 153
The enteric nervous system promotes intestinal health by constraining microbiota composition
Rolig, A. S., Mittge, E. K., Ganz, J., Troll, J. V., Melancon, E., Wiles, T. J., Alligood, K., Stephens, W. Z., Eisen, J. S., & Guillemin, K. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2000689 · Cited by 152
Functional Impacts of the Intestinal Microbiome in the Pathogenesis of Inflammatory Bowel Disease
Li, J. S. Y., Butcher, J., Mack, D. R., & Stintzi, A. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000215 · Cited by 152
Genome-wide screen identifies host colonization determinants in a bacterial gut symbiont
Powell, J. E., Leonard, S. P., Kwong, W. K., Engel, P., & Moran, N. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610856113 · Cited by 152
The role of microbiome in rheumatoid arthritis treatment
Bodkhe, R., Balakrishnan, B., & Taneja, V. (2019) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x19844632 · Cited by 152
Henriques, S. F., Dhakan, D. B., Serra, L., Francisco, A. P., Carvalho-Santos, Z., Baltazar, C., Elias, A. P., Anjos, M., Zhang, T., Maddocks, O. D. K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18049-9 · Cited by 152
Gut microbiome alterations in patients with stage 4 hepatitis C
Mahmoud, A., Adel, A., EL-Gendy, A. O., Essam, T. M., & Aziz, R. K. (2016) · Gut Pathogens · doi:10.1186/s13099-016-0124-2 · Cited by 151
Human Gut Microbiota: Toward an Ecology of Disease
Selber‐Hnatiw, S., Rukundo, B., Ahmadi, M., Akoubi, H., Al-Bizri, H., Aliu, A. F., Ambeaghen, T. U., Avetisyan, L., Bahar, I., Baird, A., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01265 · Cited by 151
Metadata
- Authors
- Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R.
- Affiliations
- University of Colorado Boulder (US)
- Washington University in St. Louis (US)
- Lawrence Berkeley National Laboratory (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Knight, Rob
- Venue
- Nature
- Published
- 2012-09
- Volume
- 489
- Issue
- 7415
- Pages
- 220-230
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3577372
- OpenAlex
- W2116846792
- Cited by
- 5,533
- References
- 78
- Citations by year
- 2026: 367 · 2025: 457 · 2024: 504 · 2023: 425 · 2022: 511 · 2021: 515 · 2020: 571 · 2019: 425 · 2018: 459 · 2017: 368 · 2016: 329 · 2015: 217 · 2014: 220 · 2013: 155 · 2012: 7
- FWCI
- 17.47
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK030292, K01DK090285)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- gut microbiota, microbial diversity, microbial community stability, microbial resilience, host-microbe interactions, microbiota composition, microbiota dynamics, disease susceptibility, early development, microbiota-targeted therapy, ecological perspective
- MeSH terms
- Diet, Environment, Health, Humans, Intestinal Mucosa, Intestines, Biodiversity, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
