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Alterations of the human gut microbiome in liver cirrhosis
Abstract
Liver cirrhosis occurs as a consequence of many chronic liver diseases that are prevalent worldwide. Here we characterize the gut microbiome in liver cirrhosis by comparing 98 patients and 83 healthy control individuals. We build a reference gene set for the cohort containing 2.69 million genes, 36.1% of which are novel. Quantitative metagenomics reveals 75,245 genes that differ in abundance between the patients and healthy individuals (false discovery rate < 0.0001) and can be grouped into 66 clusters representing cognate bacterial species; 28 are enriched in patients and 38 in control individuals. Most (54%) of the patient-enriched, taxonomically assigned species are of buccal origin, suggesting an invasion of the gut from the mouth in liver cirrhosis. Biomarkers specific to liver cirrhosis at gene and function levels are revealed by a comparison with those for type 2 diabetes and inflammatory bowel disease. On the basis of only 15 biomarkers, a highly accurate patient discrimination index is created and validated on an independent cohort. Thus microbiota-targeted biomarkers may be a powerful tool for diagnosis of different diseases.
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“Studies in the past few years have demonstrated profound alterations of the intestinal microbiota in patients with cirrhosis, showing increased Enterobacteriacea as well as strains that are typically found in the oral microbiota, such as Veillonellaceae and Streptococcaceae, consistent with an invasion of microorganisms from the mouth to the gut in liver cirrhosis32,33.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [32]
In the citing paper
“Metagenomic studies have revealed substantial alterations in the composition of the gut microbiota in a range of CLD as well as in patients with cirrhosis12,32.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [32]
In the citing paper
“Key changes in the composition of the intestinal microbiota in cirrhosis include enrichment of Veillonella or Streptococcus as well as decreased bacteria from the order Clostridiales32.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [32]
In the citing paper
“Of note, the majority of the patient-enriched species were of buccal origin, suggesting an invasion of the gut from the mouth in liver cirrhosis32.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [32]
In the citing paper
“The gut microbiomes of patients with advanced liver disease and cirrhosis are characterized by an increase in potentially pathogenic bacteria, along with reduced numbers of bacteria with beneficial properties32,84,85.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [32]
In the citing paper
“Changes in the composition of the oral microbiome and the colonisation of the lower intestinal tract by oral-specific bacteria has been related to cirrhosis49.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [49]
In the citing paper
“Increased presence of Prevotella has been found in cirrhotics49”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [49]
Citations
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Self-citationPrincipal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Self-citationLinking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
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Gluud, L. L., Vilstrup, H., & Morgan, M. Y. (2016) · Hepatology · doi:10.1002/hep.28598 · Cited by 122
Periodontal therapy favorably modulates the oral-gut-hepatic axis in cirrhosis
Bajaj, J. S., Matin, P., White, M. B., Fagan, A., Deeb, J. G., Acharya, C., Dalmet, S. S., Sikaroodi, M., Gillevet, P. M., & Sahingur, S. E. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00230.2018 · Cited by 122
Giuffrè, M., Campigotto, M., Campisciano, G., Comar, M., & Crocè, L. S. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00161.2019 · Cited by 122
Yang, H., Guo, R., Li, S., Liang, F., Cheng, T., Zhao, X., Long, Y., Liu, F., Jiang, M., Zhang, Y., et al. (2020) · npj Biofilms and Microbiomes · doi:10.1038/s41522-020-00142-y · Cited by 122
Chu, W., Han, Q., Xu, J., Wang, J., Sun, Y., Li, W., Chen, Z.-J., & Du, Y. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.01.027 · Cited by 121
Unique Features of Ethnic Mongolian Gut Microbiome revealed by metagenomic analysis
Liu, W., Zhang, J., Wu, C., Cai, S., Huang, W., Chen, J., Xi, X., Liang, Z., Hou, Q., Zhou, B., et al. (2016) · Scientific Reports · doi:10.1038/srep34826 · Cited by 121
Self-citationAnnavajhala, M. K., Gomez‐Simmonds, A., Maćešić, N., Sullivan, S. B., Kress, A., Khan, S. D., Giddins, M. J., Stump, S., Kim, G., Narain, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12633-4 · Cited by 121
Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update
Fukui, H. (2020) · Gut and Liver · doi:10.5009/gnl20032 · Cited by 121
Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors
Zsichla, L., & Müller, V. (2023) · Viruses · doi:10.3390/v15010175 · Cited by 121
The Role of the Gut Microbiome on Chronic Kidney Disease
Sampaio‐Maia, B., Simões‐Silva, L., Pestana, M., Araújo, R., & Soares‐Silva, I. (2016) · Advances in applied microbiology · doi:10.1016/bs.aambs.2016.06.002 · Cited by 120
Serum Bile Acids Are Associated with Pathological Progression of Hepatitis B-Induced Cirrhosis
Wang, X., Xie, G., Zhao, A., Zheng, X., Huang, F., Wang, Y., Yao, C., Jia, W. P., & Liu, P. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00217 · Cited by 118
Meng, X., Li, S., Li, Y., Gan, R., & Li, H. (2018) · Nutrients · doi:10.3390/nu10101457 · Cited by 118
LaPierre, N., Ju, C. J. ‐., Zhou, G., & Wang, W. W. (2019) · Methods · doi:10.1016/j.ymeth.2019.03.003 · Cited by 118
Gut Microbiota in Intestinal and Liver Disease
Jones, R. M., & Neish, A. S. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-030320-095722 · Cited by 117
Sex-dependent impact of Roundup on the rat gut microbiome
Lozano, V. L., Defarge, N., Rocque, L.-M., Mesnage, R., Hennequin, D., Cassier, R., de Vendômois, J. S., Panoff, J.-M., Séralini, G., & Amiel, C. (2017) · Toxicology Reports · doi:10.1016/j.toxrep.2017.12.005 · Cited by 116
Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice
Li, B., Yang, G., Cheng, L., Zeng, B., Yu, J., Peng, X., Zhao, J., Li, W., Ren, B., Li, M., et al. (2019) · International Journal of Oral Science · doi:10.1038/s41368-018-0043-9 · Cited by 116
Kjærgaard, K., Mikkelsen, A. C. D., Wernberg, C. W., Grønkjær, L. L., Eriksen, P. L., Damholdt, M. F., Mookerjee, R. P., Vilstrup, H., Lauridsen, M. M., & Thomsen, K. L. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040673 · Cited by 116
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Qin, L., Liu, N., Bao, C.-L.-M., Yang, D.-Z., Ma, G.-X., Yi, W.-H., Xiao, G.-Z., & Cao, H.-L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00952-0 · Cited by 114
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Lira‐Junior, R., & Figueredo, C. M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i35.7963 · Cited by 114
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Yang, X., Lu, D., Zhuo, J., Lin, Z., Yang, M., & Xu, X. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.46405 · Cited by 113
Xia, X., Chen, J., Xia, J., Wang, B., Liu, H., Yang, L., Wang, Y., & Ling, Z. (2018) · Journal of International Medical Research · doi:10.1177/0300060518776064 · Cited by 112
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Park, J. W., Kim, S. E., Lee, N. Y., Kim, J. H., Jung, J.-H., Jang, M.-K., Park, S.-H., Lee, M.-S., Kim, D.-J., Kim, H.-S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010426 · Cited by 110
Sharma, A., Roy, A., Premkumar, M., Verma, N., Duseja, A. K., Taneja, S., Grover, S., Chopra, M., & Dhiman, R. K. (2022) · Hepatology International · doi:10.1007/s12072-022-10312-z · Cited by 110
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Mariadassou, M., Pichon, S., & Ebert, D. (2015) · Ecology Letters · doi:10.1111/ele.12478 · Cited by 108
Chopan, M., & Littenberg, B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169876 · Cited by 108
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Liu, Z., Li, N., Fang, H., Chen, X., Guo, Y., Gong, S., Niu, M., Zhou, H., Jiang, Y., Chang, P., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900398rr · Cited by 107
Kaji, K., Takaya, H., Saikawa, S., Furukawa, M., Sato, S., Kawaratani, H., Kitade, M., Moriya, K., Namisaki, T., Akahane, T., et al. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i47.8355 · Cited by 107
Liu, R., Kang, J. D., Sartor, R. B., Sikaroodi, M., Fagan, A., Gavis, E. A., Zhou, H., Hylemon, P. B., Herzog, J., Li, X., et al. (2019) · Hepatology · doi:10.1002/hep.30827 · Cited by 107
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Gao, J., Zhao, X., Hu, S., Huang, Z., Hu, M., Jin, S., Lu, B., Sun, K., Wang, Z., Fu, J., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.08.002 · Cited by 107
Shen, H., Ye, F., Xie, L., Yang, J., Li, Z., Xu, P., Meng, F., Li, L., Chen, Y., Bo, X., et al. (2015) · Scientific Reports · doi:10.1038/srep17450 · Cited by 107
Self-citationHomogeneous Biosensing Based on Magnetic Particle Labels
Schrittwieser, S., Pelaz, B., Parak, W. J., Lentijo-Mozo, S., Soulantica, K., Dieckhoff, J., Ludwig, F., Günther, A., Tschöpe, A., & Schotter, J. (2016) · Sensors · doi:10.3390/s16060828 · Cited by 106
Zheng, H., Chen, M., Li, Y., Wang, Y., Lin, W., Liao, Z., Wang, M., Ma, F., Liao, Q., & Xie, Z. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01703 · Cited by 106
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Ye, Z., Wu, C., Zhang, N., Du, L., Cao, Q., Huang, X., Tang, J., Wang, Q., Li, F., Zhou, C., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1700754 · Cited by 106
Self-citationWang, Y., Wang, S., Wu, C., Chen, X., Duan, Z., Xu, Q., Jiang, W., Xu, L., Wang, T., Su, L., et al. (2019) · mSystems · doi:10.1128/msystems.00450-19 · Cited by 105
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Roşca, A. E., Ieșanu, M. I., Zahiu, C. D. M., Voiculescu, S. E., Paslaru, A. C., & Zăgrean, A. (2020) · Molecules · doi:10.3390/molecules25235681 · Cited by 105
Liu, Y., Méric, G., Havulinna, A. S., Teo, S. M., Åberg, F. O., Ruuskanen, M. O., Sanders, J. G., Zhu, Q., Tripathi, A., Verspoor, K. M., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.03.002 · Cited by 105
Yamazaki, K. (2023) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2023.08.003 · Cited by 105
Lei, Y., Tang, L., Chen, Q., Wu, L., He, W., Tu, D., Wang, S., Chen, Y., Liu, S., Xie, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34671-1 · Cited by 104
Self-citationThe Pharmabiotic Approach to Treat Hyperammonemia
Liu, J., Lkhagva, E., Chung, H., Kim, H., & Hong, S. (2018) · Nutrients · doi:10.3390/nu10020140 · Cited by 104
Baltazar-Díaz, T. A., González-Hernández, L. A., Aldana-Ledesma, J. M., Rodríguez, M. P., Vega‐Magaña, N., Zepeda‐Morales, A. S. M., López-Roa, R. I., del Toro‐Arreola, S., Martínez‐López, E., Salazar-Montes, A. M., et al. (2022) · Microorganisms · doi:10.3390/microorganisms10061231 · Cited by 104
Nuzum, N. D., Loughman, A., Szymlek-Gay, E. A., Hendy, A., Teo, W.-P., & Macpherson, H. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.003 · Cited by 103
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Delorme, C., Abraham, A., Renault, P., & Guédon, É. (2014) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2014.10.001 · Cited by 103
Ling, Z., Liu, X., Cheng, Y., Jiang, X., Jiang, H., Wang, Y., & Li, L. (2015) · Scientific Reports · doi:10.1038/srep17098 · Cited by 103
Self-citationShi, D., Lv, L., Fang, D., Wu, W., Hu, C., Xu, L., Chen, Y., Guo, J., Hu, X., Li, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07091-1 · Cited by 103
Self-citationRühlemann, M. C., Liwinski, T., Heinsen, F., Bang, C., Zenouzi, R., Kummen, M., Thingholm, L. B., Tempel, M., Lieb, W., Karlsen, T. H., et al. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15375 · Cited by 102
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Yeoh, Y. K., Sun, Y., Ip, L., Wang, L., Chan, F. K. L., Miao, Y., & Ng, S. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-12721-4 · Cited by 102
Heidrich, B., Vital, M., Plumeier, I., Döscher, N., Kahl, S., Kirschner, J., Ziegert, S., Solbach, P., Lenzen, H., Potthoff, A., et al. (2017) · Liver International · doi:10.1111/liv.13485 · Cited by 101
Iebba, V., Guerrieri, F., Gregorio, V. D., Levrero, M., Gagliardi, A., Santangelo, F., Sobolev, A. P., Circi, S., Giannelli, V., Mannina, L., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26509-y · Cited by 101
Zhou, W., Zhang, D., Li, Z., Jiang, H., Li, J., Ren, R., Gao, X., Li, J., Wang, X., Wang, W., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02882-7 · Cited by 101
Liu, Q., Li, B., Li, Y., Wei, Y., Huang, B., Liang, J., You, Z., Li, Y., Qian, Q., Wang, R., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323565 · Cited by 101
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Zhang, X., Lau, H. C.-H., & Yu, J. Q. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2024.100018 · Cited by 100
Zhou, Y., Hu, L., Tang, W., Li, D., Ma, L., Liu, H., Zhang, S., Zhang, X., Dong, L., Chen, S., et al. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-01028-4 · Cited by 99
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Xie, Y., Ding, F., Di, W., Lv, Y., Xia, F., Sheng, Y., Yu, J., & Ding, G. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.10932 · Cited by 98
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Zhang, C., Yu, L., Ma, C., Jiang, S., Zhang, Y., Wang, S., Tian, F., Xue, Y., Zhao, J., Zhang, H., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.10.011 · Cited by 98
Self-citationLiao, C., Rolling, T., Djuković, A., Fei, T., Mishra, V., Liu, H., Lindberg, C., Dai, L., Zhai, B., Peled, J. U., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01680-3 · Cited by 98
Ren, W., Yin, J., Xiao, H., Chen, S., Liu, G., Tan, B., Li, N., Peng, Y., Li, T., Zeng, B., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00685 · Cited by 98
Kina-Tanada, M., Sakanashi, M., Tanimoto, A., Kaname, T., Matsuzaki, T., Noguchi, K., Uchida, T., Nakasone, J., Kozuka, C., Ishida, M., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4259-6 · Cited by 97
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Oñate, F. P., Chamignon, C., Burz, S. D., Lapaque, N., Monnoye, M., Philippe, C., Bredel, M., Chêne, L., Farin, W., Paillarse, J.-M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512232 · Cited by 97
Zhuge, A., Li, S., Han, S., Yuan, Y., Shen, J., Wu, W., Wang, K., Xia, J., Wang, Q., Gu, Y., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.010 · Cited by 97
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Fleury, V., Zekeridou, A., Lazarević, V., Gaïa, N., Giannopoulou, C., Genton, L., Cancela, J., Girard, M., Goldstein, R., Bally, J. F., et al. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-202459 · Cited by 95
Fang, D., Shi, D., Lv, L., Gu, S., Wu, W., Chen, Y., Guo, J., Li, A., Hu, X., Guo, F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09395-8 · Cited by 95
Self-citationGluud, L. L., Vilstrup, H., & Morgan, M. Y. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003044.pub3 · Cited by 95
Tan, Z., Yang, T., Wang, Y., Xing, K., Zhang, F., Zhao, X., Ao, H., Chen, S., Liu, J., & Wang, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01546 · Cited by 94
Metagenomic cross-talk: the regulatory interplay between immunogenomics and the microbiome
Levy, M., Thaiss, C. A., & Elinav, E. (2015) · Genome Medicine · doi:10.1186/s13073-015-0249-9 · Cited by 94
Horvath, A., Rainer, F., Bashir, M., Leber, B., Schmerboeck, B., Klymiuk, I., Groselj-Strele, A., Durdevic, M., Freedberg, D. E., Abrams, J. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48352-5 · Cited by 93
Han, D., Gao, P., Li, R., Tan, P., Xie, J., Zhang, R., & Li, J. (2020) · Journal of Advanced Research · doi:10.1016/j.jare.2020.07.010 · Cited by 93
Jin, Y., Wu, Y., Zeng, Z., Jin, C., Wu, S., Wang, Y., & Fu, Z. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw150 · Cited by 93
Lau, L. H. S., & Wong, S. H. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-8684-7_9 · Cited by 93
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Alazawi, W., Bernabé, E., Tai, D., Janicki, T., Kemos, P., Samsuddin, S., Syn, W., Gillam, D. G., & Turner, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185902 · Cited by 93
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Wang, W., Xu, S., Ren, Z., Jiang, J., & Zheng, S. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0640-8 · Cited by 92
Self-citationBajaj, J. S., Betrapally, N. S., Hylemon, P. B., Thacker, L. R., Daita, K., Kang, D. J., White, M. B., Unser, A. B., Fagan, A., Gavis, E. A., et al. (2015) · Scientific Reports · doi:10.1038/srep18559 · Cited by 92
Disorganized Gut Microbiome Contributed to Liver Cirrhosis Progression: A Meta-Omics-Based Study
Shao, L., Ling, Z., Chen, D., Liu, Y., Yang, F., & Li, L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03166 · Cited by 92
Self-citationSHAMAN: a user-friendly website for metataxonomic analysis from raw reads to statistical analysis
Volant, S., Lechat, P., Woringer, P., Motreff, L., Campagne, P., Malabat, C., Kennedy, S., & Ghozlane, A. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-03666-4 · Cited by 92
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Zhai, S., Zhu, Y., Feng, P., Li, M., Wang, W., Yang, L., & Yang, Y. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101037 · Cited by 92
Forry, S. P., Servetas, S. L., Kralj, J. G., Soh, K., Hadjithomas, M., Cano, R. J., Carlin, M. R., de Amorim, M. G., Auch, B., Bakker, M. G., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-57981-4 · Cited by 92
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Tikhonov, M. (2016) · eLife · doi:10.7554/elife.15747 · Cited by 92
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Han, P., Sun, D., & Yang, J. (2016) · Biomedical Reports · doi:10.3892/br.2016.718 · Cited by 92
Microbiota and gastrointestinal cancer
Weng, M., Chiu, Y., Wei, P., Chiang, C.-W., Fang, H., & Wei, S. (2019) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2019.01.002 · Cited by 91
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Nobs, S. P., Tuganbaev, T., & Elinav, E. (2019) · EMBO Reports · doi:10.15252/embr.201847129 · Cited by 91
Hamid, H., Zhang, J. Y., Li, W. X., Liu, C., Li, M., Zhao, L. H., Ji, C., & Ma, Q. G. (2019) · Poultry Science · doi:10.3382/ps/pey596 · Cited by 90
Metadata
- Authors
- Qin, N., Yang, F., Li, A., Prifti, E., Chen, Y., Shao, L., Guo, J., Le Chatelier, E., Yao, J., Wu, L., Zhou, J., Ni, S., Liu, L., Pons, N., Batto, J. M., Kennedy, S. P., Leonard, P., Yuan, C., Ding, W., Chen, Y., Hu, X., Zheng, B., Qian, G., Xu, W., Ehrlich, S. D., Zheng, S., & Li, L.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Guy's Hospital (GB)
- Corresponding author
- Ehrlich, S. Dusko
- Zheng, Shusen
- Li, Lanjuan
- ORCID
- Venue
- Nature
- Published
- 2014-07-23
- Volume
- 513
- Issue
- 7516
- Pages
- 59-64
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1964027278
- Cited by
- 2,177
- References
- 56
- Citations by year
- 2026: 136 · 2025: 174 · 2024: 215 · 2023: 214 · 2022: 226 · 2021: 283 · 2020: 235 · 2019: 201 · 2018: 161 · 2017: 136 · 2016: 98 · 2015: 83 · 2014: 10
- FWCI
- 44.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-DPBS-0001)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- liver cirrhosis, gut microbiota, microbiome biomarkers, oral bacteria, Veillonella, Streptococcus, diagnostic biomarkers, novel genes, type 2 diabetes, inflammatory bowel disease
- MeSH terms
- Chronic Disease, Diabetes Mellitus, Type 2, Feces, Genetic Markers, Health, Humans, Liver Cirrhosis, Mouth, Phylogeny, Reproducibility of Results, Inflammatory Bowel Diseases, Case-Control Studies, Gastrointestinal Tract, Metagenomics, Microbiota
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