Cited by 2,177Gut microbiota and healthLiver Disease and TransplantationOral microbiology and periodontitis research

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Alterations of the human gut microbiome in liver cirrhosis

Abstract

Liver cirrhosis occurs as a consequence of many chronic liver diseases that are prevalent worldwide. Here we characterize the gut microbiome in liver cirrhosis by comparing 98 patients and 83 healthy control individuals. We build a reference gene set for the cohort containing 2.69 million genes, 36.1% of which are novel. Quantitative metagenomics reveals 75,245 genes that differ in abundance between the patients and healthy individuals (false discovery rate < 0.0001) and can be grouped into 66 clusters representing cognate bacterial species; 28 are enriched in patients and 38 in control individuals. Most (54%) of the patient-enriched, taxonomically assigned species are of buccal origin, suggesting an invasion of the gut from the mouth in liver cirrhosis. Biomarkers specific to liver cirrhosis at gene and function levels are revealed by a comparison with those for type 2 diabetes and inflammatory bowel disease. On the basis of only 15 biomarkers, a highly accurate patient discrimination index is created and validated on an independent cohort. Thus microbiota-targeted biomarkers may be a powerful tool for diagnosis of different diseases.

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Crossref · 10.1038/nature13568

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Metadata

Authors
Qin, N., Yang, F., Li, A., Prifti, E., Chen, Y., Shao, L., Guo, J., Le Chatelier, E., Yao, J., Wu, L., Zhou, J., Ni, S., Liu, L., Pons, N., Batto, J. M., Kennedy, S. P., Leonard, P., Yuan, C., Ding, W., Chen, Y., Hu, X., Zheng, B., Qian, G., Xu, W., Ehrlich, S. D., Zheng, S., & Li, L.
Affiliations
  • First Affiliated Hospital Zhejiang University (CN)
  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
  • Guy's Hospital (GB)
Corresponding author
  • Ehrlich, S. Dusko
  • Zheng, Shusen
  • Li, Lanjuan
Venue
Nature
Published
2014-07-23
Volume
513
Issue
7516
Pages
59-64
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W1964027278
Cited by
2,177
References
56
Citations by year
2026: 136 · 2025: 174 · 2024: 215 · 2023: 214 · 2022: 226 · 2021: 283 · 2020: 235 · 2019: 201 · 2018: 161 · 2017: 136 · 2016: 98 · 2015: 83 · 2014: 10
FWCI
44.66
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
Agence Nationale de la Recherche (ANR-11-DPBS-0001)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
liver cirrhosis, gut microbiota, microbiome biomarkers, oral bacteria, Veillonella, Streptococcus, diagnostic biomarkers, novel genes, type 2 diabetes, inflammatory bowel disease
MeSH terms
Chronic Disease, Diabetes Mellitus, Type 2, Feces, Genetic Markers, Health, Humans, Liver Cirrhosis, Mouth, Phylogeny, Reproducibility of Results, Inflammatory Bowel Diseases, Case-Control Studies, Gastrointestinal Tract, Metagenomics, Microbiota

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