Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain

Okhovat, Mariam; Berrio, Alejandro; Wallace, Gerard; Ophir, Alexander G.; Phelps, Steven M.

doi:10.1126/science.aac5791

Cited by 162Neuroendocrine regulation and behaviorAnimal Behavior and ReproductionEvolutionary Psychology and Human Behavior

Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain

Okhovat, Mariam, Berrio, Alejandro, Wallace, Gerard, Ophir, Alexander G., Phelps, Steven M.·2015·Science

DOI 10.1126/science.aac5791

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Abstract

Individual variation in social behavior seems ubiquitous, but we know little about how it relates to brain diversity. Among monogamous prairie voles, levels of vasopressin receptor (encoded by the gene avpr1a) in brain regions related to spatial memory predict male space use and sexual fidelity in the field. We find that trade-offs between the benefits of male fidelity and infidelity are reflected in patterns of territorial intrusion, offspring paternity, avpr1a expression, and the evolutionary fitness of alternative avpr1a alleles. DNA variation at the avpr1a locus includes polymorphisms that reliably predict the epigenetic status and neural expression of avpr1a, and patterns of DNA diversity demonstrate that avpr1a regulatory variation has been favored by selection. In prairie voles, trade-offs in the fitness consequences of social behaviors seem to promote neuronal and molecular diversity.

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Voles display remarkable individual variation in V1aR density in the retrosplenial cortex, a region involved in spatial memory, and this receptor density is related to Avpr1a polymorphisms, space use in relation to nesting, and sexual fidelity in males.
“Voles display remarkable individual variation in V1aR density in the retrosplenial cortex (155), a region involved in spatial memory, and this receptor density is related to Avpr1a polymorphisms, space use in relation to nesting, and sexual fidelity in males (156).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [156]
Variation in brain receptor distribution is determined by sequence variation in the receptor genes.
“This variation in brain receptor distribution is determined by sequence variation in the receptor genes [12,13].”
From Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry (2021) · cites this paper as [13]

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Variation in neural V1aR predicts sexual fidelity and space use among male prairie voles in semi-natural settings
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Molecular regulation of vasopressin receptor among (mostly) monogamous prairie voles
Okhovat, M. (2016) · Texas ScholarWorks (Texas Digital Library) · doi:10.15781/t2222rs6f

Authors: Okhovat, M., Berrio, A., Wallace, G., Ophir, A. G., & Phelps, S. M.
Affiliations: The University of Texas at Austin (US)
Department of Integrative Biology, University of Texas at Austin, 1 University Station, Campus Code C0930, Austin, TX 78712, USA.
Cornell University (US)
Corresponding author: Phelps, Steven M.
ORCID: Okhovat, Mariam
Wallace, Gerard
Ophir, Alexander G.
Phelps, Steven M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-12-11
Volume: 350
Issue: 6266
Pages: 1371-1374
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aac5791
OpenAlex: W2198514005
Cited by: 155
References: 45
Citations by year: 2026: 2 · 2025: 7 · 2024: 11 · 2023: 6 · 2022: 30 · 2021: 13 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 27 · 2016: 10 · 2015: 1
FWCI: 29.45
Type: journal article
Language: en
Open access: closed
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: NSF (IOS-0316451, IOS-1355188)
NIH (R21 HD059092)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
Keywords: Microtus ochrogaster, monogamy, sexual fidelity, vasopressin receptor, AVPR1A, brain gene expression, territorial intrusion, epigenetic regulation, DNA polymorphism, natural selection, spatial memory
MeSH terms: Alleles, Animals, Brain, Arvicolinae, DNA, Biological Evolution, Female, Male, Polymorphism, Genetic, Sexual Behavior, Sexual Behavior, Animal, Social Behavior, Territoriality, Receptors, Vasopressin, Epigenesis, Genetic, Spatial Memory, Grassland

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Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain

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