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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

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Genomic Instability in Mice Lacking Histone H2AX

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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Requirement of the MRN complex for ATM activation by DNA damage

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

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H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

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Mechanism and Regulation of Class Switch Recombination

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The MRE11 complex: starting from the ends

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MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

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The ATM-mediated DNA-damage response: taking shape

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Positional stability of single double-strand breaks in mammalian cells

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Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

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The MRN complex in double‐strand break repair and telomere maintenance

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A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

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Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

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Role of genomic instability and p53 in AID-induced c-myc–Igh translocations

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Assembly and function of DNA double-strand break repair foci in mammalian cells

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Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

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DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity

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The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

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DNA Strand Break Repair and Human Genetic Disease

McKinnon, P. J., & Caldecott, K. W. (2007) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115648 · Cited by 321

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

Lavin, M. F. (2007) · Oncogene · doi:10.1038/sj.onc.1210880 · Cited by 311

Mammalian SWI/SNF complexes facilitate DNA double‐strand break repair by promoting γ‐H2AX induction

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DNA Damage Response Genes and the Development of Cancer Metastasis

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Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder

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AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations

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Age to survive: DNA damage and aging

Schumacher, B., Garinis, G. A., & Hoeijmakers, J. H. J. (2008) · Trends in Genetics · doi:10.1016/j.tig.2007.11.004 · Cited by 266

Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin

Spycher, C., Miller, E. S., Townsend, K., Pavic, L., Morrice, N. A., Janščák, P., Stewart, G. S., & Stucki, M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709008 · Cited by 259

Nijmegen breakage syndrome (NBS)

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ATM and the Molecular Pathogenesis of Ataxia Telangiectasia

McKinnon, P. J. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132509 · Cited by 245

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

Dupré, A., Boyer-Châtenet, L., & Gautier, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1090 · Cited by 248

CtIP Links DNA Double-Strand Break Sensing to Resection

You, Z., Shi, L. Z., Zhu, Q., Wu, P., Zhang, Y.-W., Basilio, A., Tonnu, N., Verma, I. M., Berns, M. W., & Hunter, T. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.002 · Cited by 231

Characterization of Gonadal Transcriptomes from Nile Tilapia (Oreochromis niloticus) Reveals Differentially Expressed Genes

Tao, W., Yuan, J., Zhou, L., Sun, L., Sun, Y.-L., Yang, S., Li, M., Zeng, S., Huang, B., & Wang, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063604 · Cited by 230

Tip60: Connecting chromatin to DNA damage signaling

Sun, Y., Jiang, X., & Price, B. D. (2010) · Cell Cycle · doi:10.4161/cc.9.5.10931 · Cited by 230

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin

Melander, F., Bekker‐Jensen, S., Falck, J., Bártek, J., Mailand, N., & Lukas, J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708210 · Cited by 231

ATM signalling and cancer

Cremona, C. A., & Behrens, A. (2013) · Oncogene · doi:10.1038/onc.2013.275 · Cited by 219

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

Pellegrini, M., Celeste, A., Difilippantonio, S., Guo, R., Wang, W., Feigenbaum, L., & Nussenzweig, A. (2006) · Nature · doi:10.1038/nature05112 · Cited by 209

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

So, S., Davis, A. J., & Chen, D. J. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200906064 · Cited by 222

C9orf72 expansion disrupts ATM-mediated chromosomal break repair

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The Response to and Repair of RAG-Mediated DNA Double-Strand Breaks

Helmink, B. A., & Sleckman, B. P. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101320 · Cited by 199

The ATM signaling network in development and disease

Stracker, T. H., Roig, I., Knobel, P. A., & Marjanović, M. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00037 · Cited by 192

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

Adams, K. E., Medhurst, A. L., Dart, D. A., & Lakin, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209426 · Cited by 164

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

Duursma, A. M., Driscoll, R., Elias, J. E., & Cimprich, K. A. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.03.006 · Cited by 153

Inhibition of Hsp90 Compromises the DNA Damage Response to Radiation

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Structure and Function of the Phosphothreonine-Specific FHA Domain

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BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

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Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1

Shiotani, B., Nguyen, H. D., Håkansson, P., Maréchal, A., Tse, A., Tahara, H., & Zou, L. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.018 · Cited by 142

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

Kim, Y., Gerlitz, G., Furusawa, T., Catez, F., Nussenzweig, A., Oh, K., Kraemer, K. H., Shiloh, Y., & Bustin, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1817 · Cited by 139

The role of the DNA damage response in neuronal development, organization and maintenance

Barzilai, A., Biton, S., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.005 · Cited by 139

The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle

Biton, S., Barzilai, A., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.006 · Cited by 136

The multiple roles of the Mre11 complex for meiotic recombination

Borde, V. (2007) · Chromosome Research · doi:10.1007/s10577-007-1147-9 · Cited by 141

Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications

Toh, M.-R., & Ngeow, J. Y. Y. (2021) · The Oncologist · doi:10.1002/onco.13829 · Cited by 130

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Stracker, T. H., Morales, M., Couto, S. S., Hussein, H., & Petrini, J. H. J. (2007) · Nature · doi:10.1038/nature05740 · Cited by 126

Early events in the mammalian response to DNA double-strand breaks

Riches, L. C., Lynch, A. M., & Gooderham, N. J. (2008) · Mutagenesis · doi:10.1093/mutage/gen039 · Cited by 124

Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G1 and Resection-Mediated Inhibition of NHEJ in G2

Dimitrova, N., & de Lange, T. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00476-09 · Cited by 122

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

Polato, F., Callén, E., Wong, N., Faryabi, R. B., Bunting, S. F., Chen, H. T., Kozak, M., Kruhlak, M. J., Reczek, C. R., Lee, W., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131939 · Cited by 123

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

Buis, J. M., Stoneham, T., Spehalski, E. I., & Ferguson, D. O. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2212 · Cited by 126

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

Daniel, J. A., Pellegrini, M., Lee, J., Paull, T. T., Feigenbaum, L., & Nussenzweig, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805154 · Cited by 113

Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint

Yang, C., Tang, X., Guo, X., Niikura, Y., Kitagawa, K., Cui, K., Wong, S. T. C., Fu, L., & Xu, B. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.016 · Cited by 115

Loss of ATM kinase activity leads to embryonic lethality in mice

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The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation

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Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBSPreprint

Shull, E. R. P., Lee, Y., Nakane, H., Stracker, T. H., Zhao, J., Russell, H. R., Petrini, J. H. J., & McKinnon, P. J. (2009) · Genes & Development · doi:10.1101/gad.1746609 · Cited by 106

Responding to DNA double strand breaks in the nervous system

Lee, Y., & McKinnon, P. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.026 · Cited by 105

Meiotic recombination

Hunter, N. (2007) · Topics in current genetics · doi:10.1007/978-3-540-71021-9_14 · Cited by 102

Rapid activation of ATM on DNA flanking double-strand breaks

You, Z., Bailis, J. M., Johnson, S. A., Dilworth, S. M., & Hunter, T. R. (2007) · Nature Cell Biology · doi:10.1038/ncb1651 · Cited by 107

Class Switch Recombination: A Comparison Between Mouse and Human

Pan‐Hammarström, Q., Zhao, Y., & Hammarström, L. L. G. (2007) · Advances in immunology · doi:10.1016/s0065-2776(06)93001-6 · Cited by 103

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

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Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

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Genome sequencing in the clinic: the past, present, and future of genomic medicine

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The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensorPreprint

Morales, M., Theunissen, J.-W. F., Kim, C. F. B., Kitagawa, R., Kastan, M. B., & Petrini, J. H. J. (2005) · Genes & Development · doi:10.1101/gad.1373705 · Cited by 87

DNA repair: the link between primary immunodeficiency and cancer

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DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis

Xu, Y. (2006) · Nature reviews. Immunology · doi:10.1038/nri1804 · Cited by 91

DNA strand breaks, neurodegeneration and aging in the brain

Katyal, S., & McKinnon, P. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.008 · Cited by 87

Active Role for Nibrin in the Kinetics of Atm Activation

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DNA double-strand break signaling and human disorders

Bohgaki, T., Bohgaki, M., & Hakem, R. (2010) · Genome Integrity · doi:10.1186/2041-9414-1-15 · Cited by 95

ATMIN defines an NBS1‐independent pathway of ATM signalling

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Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double‐strand breaks

Yang, Y.-G., Saidi, A., Frappart, P., Min, W., Barrucand, C., Dumon-Jones, V., Michelon, J., Herceg, Z., & Wang, Z. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601411 · Cited by 84

Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage

Ziegler-Birling, C., Helmrich, A., Tora, L., & Torres‐Padilla, M. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082707cz · Cited by 82

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

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Ataxia-Telangiectasia and Related Diseases

Frappart, P., & McKinnon, P. J. (2006) · NeuroMolecular Medicine · doi:10.1385/nmm:8:4:495 · Cited by 81

Critical Involvement of the ATM-Dependent DNA Damage Response in the Apoptotic Demise of HIV-1-Elicited Syncytia

Perfettini, J., Nardacci, R., Bourouba, M., Subra, F., Gros, L., Séror, C., Manic, G., Rosselli, F., Amendola, A., Masdehors, P., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002458 · Cited by 83

The clinical manifestation of a defective response to DNA double-strand breaks as exemplified by Nijmegen breakage syndrome

Demuth, I., & Digweed, M. (2007) · Oncogene · doi:10.1038/sj.onc.1210876 · Cited by 77

Mapping of Switch Recombination Junctions, a Tool for Studying DNA Repair Pathways during Immunoglobulin Class Switching

Stavnezer, J., Björkman, A., Du, L., Cagigi, A., & Pan‐Hammarström, Q. (2010) · Advances in immunology · doi:10.1016/b978-0-12-380995-7.00003-3 · Cited by 88

ATM‐dependent DNA damage surveillance in T‐cell development and leukemogenesis: the DSB connection

Matei, I. R., Guidos, C. J., & Danska, J. S. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00361.x · Cited by 77

Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences

Jiang, G., & Sancar, A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.39-49.2006 · Cited by 70

Mdmx promotes genomic instability independent of p53 and Mdm2

Carrillo, A. M., Bouska, A., Arrate, M. P., & Eischen, C. M. (2015) · Oncogene · doi:10.1038/onc.2014.27 · Cited by 69

Sp1 Facilitates DNA Double-Strand Break Repair through a Nontranscriptional Mechanism

Beishline, K., Kelly, C. M., Olofsson, B. A., Koduri, S., Emrich, J., Greenberg, R. A., & Azizkhan‐Clifford, J. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00049-12 · Cited by 70

Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein

Kruger, L., Demuth, I., Neitzel, H., Varon, R., Sperling, K., Chrzańowska, K., Seemanová, E., & Digweed, M. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl126 · Cited by 67

UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function

Zhang, T., Cronshaw, J. M., Kanu, N., Snijders, A. P., & Behrens, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400230111 · Cited by 61

A kaleidoscopic view of ovarian genes associated with premature ovarian insufficiency and senescence

Yang, Q., Mümüşoğlu, S., Qin, Y., Sun, Y., & Hsueh, A. J. W. (2021) · The FASEB Journal · doi:10.1096/fj.202100756r · Cited by 63

Induction of genetic instability by gain-of-function p53 cancer mutants

Xu, Y. (2008) · Oncogene · doi:10.1038/sj.onc.1211023 · Cited by 63

Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy

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Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response

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