Causes and consequences of replication stress

Zeman, Michelle K., Cimprich, Karlene A.·2014·Nature Cell Biology

DOI 10.1038/ncb2897

Cited by (1,001)

Items 201–300 of 1,001

CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models
Haineng Xu, Erin M. George, Yasuto Kinose, Hyoung Kim, Jennifer Shah, Jasmine D. Peake, Benjamin I. Ferman, Sergey Medvedev, Thomas Murtha, Carter J. Barger et al. · 2021 · Cell Reports Medicine
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells
Jenni Nikkilä, Rahul Kumar, James Campbell, Inger Brandsma, Helen N. Pemberton, Fredrik Wållberg, Kinga Nagy, Ildikó Scheer, Beáta G. Vértessy, Artur A. Serebrenik et al. · 2017 · British Journal of Cancer
Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors
Yannick P. Kok, Sergi Guerrero Llobet, Pepijn M. Schoonen, Marieke Everts, Arkajyoti Bhattacharya, Rudolf S.N. Fehrmann, Nathalie van den Tempel, Marcel A.T.M. van Vugt · 2020 · Oncogenesis
Achieving Precision Death with Cell-Cycle Inhibitors that Target DNA Replication and Repair
Aimee K. Bence, Samuel McNeely, Richard Paul Beckmann · 2017 · Clinical Cancer Research
Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection
Shan Li, Zeno Lavagnino, Delphine Sangotokun Lemacon, Lingzhen Kong, Alessandro Ustione, Xue Wen Ng, Yuanya Zhang, Yingchun Wang, Bin Zheng, Helen M. Piwnica-Worms et al. · 2019 · Molecular Cell
NADPH oxidases: new actors in thyroid cancer?
Rabii Ameziane El Hassani, Martin Jean Schlumberger, Corinne Dupuy · 2016 · Nature Reviews Endocrinology
Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability
Carlo Rinaldi, Paolo Pizzul, Maria Pia Longhese, Diego Bonetti · 2021 · Frontiers in Cell and Developmental Biology
Efficacy of ATR inhibitors as single agents in Ewing sarcoma
Maria Nieto-Soler, Isabel Morgado-Palacin, Vanesa Lafarga, Emilio Lecona, Matilde Murga, Elsa Callén, Daniel Azorín, Javier Alonso, Andres Joaquin Lopez-Contreras, André Nussenzweig et al. · 2016 · Oncotarget
Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
Aleix Bayona‐Feliú, Anna Casas-Lamesa, Óscar Reina, Jordi Bernués, Fernando Azorı́n · 2017 · Nature Communications
Mechanisms of DNA Replication and Repair: Insights from the Study of G-Quadruplexes
Tracy M. Bryan · 2019 · Molecules
APOBEC3A damages the cellular genome during DNA replication
Abby M. Green, Sébastien Landry, Konstantin Budagyan, Daphne C. Avgousti, Sophia Z. Shalhout, Ashok S. Bhagwat, Matthew D. Weitzman · 2016 · Cell Cycle
The Causes and Consequences of Topological Stress during DNA Replication
Andrea Keszthelyi, Nicola E. Minchell, Jonathan Baxter · 2016 · Genes
Cytidine Deaminase Axis Modulated by miR-484 Differentially Regulates Cell Proliferation and Chemoresistance in Breast Cancer
Fu-Gui Ye, Chuan-Gui Song, Zhi-Gang Cao, Xia Chen, Dan-Na Chen, Li Chen, Shan Li, Feng Qiao, Hong Ling, Ling Yao et al. · 2015 · Cancer Research
A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy
C. Liu, Sriganesh Srihari, Kim‐Anh Lê Cao, Georgia Chenevix‐Trench, Peter T. Simpson, Mark A. Ragan, Kum Kum Khanna · 2014 · Nucleic Acids Research
Phase 1 study of the ATR inhibitor berzosertib in combination with cisplatin in patients with advanced solid tumours
Geoffrey Ira Shapiro, Robert Wesolowski, Craig Devoe, Simon Lord, John Robert Pollard, Bart S. Hendriks, Martin Falk, Iván Díaz-Padilla, Ruth Plummer, Timothy Anthony Yap · 2021 · British Journal of Cancer
WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress
Giuseppe Leuzzi, Veronica Marabitti, Pietro Pichierri, Annapaola Franchitto · 2016 · The EMBO Journal
Human CST facilitates genome-wide RAD51 recruitment to GC-rich repetitive sequences in response to replication stress
M. Chastain, Qing Zhou, Olga Shiva, Maria Fadri-Moskwik, Leanne S. Whitmore, Pingping Jia, Xueyu Dai, Chen-Hui Huang, Ping Ye, Wei-Hang Chai · 2016 · Cell Reports
Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage
Técher, Hervé, Koundrioukoff, Stéphane, Carignon, Sandra, Wilhelm, Therese, Millot, Gaël A., Lopez, Bernard S., Brison, Olivier, Debatisse, Michelle · 2016 · Cell Reports
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens
Samah W. Awwad, Almudena Serrano-Benítez, John Christopher Thomas, Vipul Gupta, Stephen P. Jackson · 2023 · Nature Reviews Molecular Cell Biology
Repair pathway choice for double-strand breaks
Yixi Xu, Dongyi Xu · 2020 · Essays in Biochemistry
Resistance to DNA repair inhibitors in cancer
Joseph S. Baxter, Diana A. Zatreanu, Stephen J. Pettitt, Christopher J. Lord · 2022 · Molecular Oncology
Effects of Replication and Transcription on DNA Structure-Related Genetic Instability
Guliang Wang, Karen M. Vásquez · 2017 · Genes
The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers
Elisa Monzón‐Casanova, Michael Screen, Manuel D. Díaz‐Muñoz, Richard Coulson, Sarah E. Bell, Greta Lamers, Michele Solimena, Christopher W. J. Smith, Martin Turner · 2018 · Nature Immunology
Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends
Song My Hoang, Roderick J. O’Sullivan · 2020 · Trends in cancer
Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress
Néstor García‐Rodríguez, Ronald P.C. Wong, Helle D. Ulrich · 2016 · Frontiers in Genetics
Reconstitution of translesion synthesis reveals a mechanism of eukaryotic DNA replication restart
Thomas A. Guilliam, Joseph T.P. Yeeles · 2020 · Nature Structural & Molecular Biology
PTEN regulates DNA replication progression and stalled fork recovery
Jin‐Xue He, Xi Kang, Yuxin Yin, K. Chao, Wen Hong Shen · 2015 · Nature Communications
Cell cycle dysregulation in cancer
Antonino Glaviano, Samarendra Kumar Singh, E. Hui Clarissa Lee, Elena Okina, Hiu Yan Lam, Daniela Carbone, E. Premkumar Reddy, Mark J. O’Connor, Andrew Koff, Garima Singh et al. · 2024 · Pharmacological Reviews
High-Resolution Profiling of Drosophila Replication Start Sites Reveals a DNA Shape and Chromatin Signature of Metazoan Origins
Federico Comoglio, Tommy Beat Schlumpf, Virginia Schmid, Remo Rohs, Christian Beisel, Renato Paro · 2015 · Cell Reports
BRCA2 functions: from DNA repair to replication fork stabilization
Amélie Fradet‐Turcotte, Justine Sitz, Damien Grapton, Alexandre Orthwein · 2016 · Endocrine Related Cancer
Excessive reactive oxygen species induce transcription-dependent replication stress
Martin Andrš, Henriette Stoy, Barbora Boleslavska, Nagaraja Chappidi, Radhakrishnan Kanagaraj, Zuzana Naščáková, Shruti Menon, Satyajeet Rao, Anna Oravetzova, Jana Dobrovolná et al. · 2023 · Nature Communications
Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation
Arun Kanakkanthara, Karthik B. Jeganathan, Jazeel F. Limzerwala, Darren J. Baker, Masakazu Hamada, Hyun-Ja Nam, Willemijn Hendrike van Deursen, Naomi Hamada, Ryan M. Naylor, Nicole A. Becker et al. · 2016 · Science
Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer
Andrew Webster, Mathijs Arnoud Sanders, Krupa Patel, Ralf Dietrich, Raymond J. Noonan, Francis P. Lach, Ryan R. White, Audrey M. Goldfarb, Kevin Hadi, Matthew M. Edwards et al. · 2022 · Nature
Chromosome Instability in Fanconi Anemia: From Breaks to Phenotypic Consequences
Benilde García‐de Teresa, Alfredo Rodríguez, Sara Frı́as · 2020 · Genes
Phase I Study of Ceralasertib (AZD6738), a Novel DNA Damage Repair Agent, in Combination with Weekly Paclitaxel in Refractory Cancer
Seung Tae Kim, Simon A. Smith, Peter G. S. Mortimer, Arsène‐Bienvenu Loembé, Heejin Cho, Kyoung‐Mee Kim, Claire L. Smith, Sophie E. Willis, Itziar Irurzun‐Arana, Aliénor Berges et al. · 2021 · Clinical Cancer Research
Mammalian endoreplication emerges to reveal a potential developmental timer
Alberto Gandarillas, Rut Molinuevo, Natalia Sanz‐Gómez · 2018 · Cell Death and Differentiation
HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins
Hrecka, Kasia, Hao, Caili, Shun, Ming-Chieh, Kaur, Sarabpreet, Swanson, Selene K., Florens, Laurence, Washburn, Michael P., Skowronski, Jacek · 2016 · Proceedings of the National Academy of Sciences
Canada's residential school system: measuring the intergenerational impact of familial attendance on health and mental health outcomes
Hackett, Christina, Feeny, David, Tompa, Emile · 2016 · Journal of Epidemiology and Community Health
Advances in Targeted Therapies for Triple-Negative Breast Cancer
Kelly Elizabeth McCann, Sara Alsterlind Hurvitz, Nicholas Patrick McAndrew · 2019 · Drugs
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
Miranda K. Culley, Jingsi Zhao, Yi‐Yin Tai, Ying Tang, Dror Perk, Vinny Negi, Qiujun Yu, Chen-Shan Chen Woodcock, Adam L. Handen, Gil Speyer et al. · 2021 · Journal of Clinical Investigation
The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression?
Shouying Xu, Chao Tang · 2021 · Frontiers in Oncology
HERC2-USP20 axis regulates DNA damage checkpoint through Claspin
Jian Yuan, Kuntian Luo, Min Deng, Yunhui Li, Ping Yin, Bowen Gao, Yuan Fang, Puqiang Wu, Tongzheng Liu, Zhenkun Lou · 2014 · Nucleic Acids Research
Inherited DNA lesions determine G1 duration in the next cell cycle
Aleksandra Lezaja, Matthias Altmeyer · 2017 · Cell Cycle
Pathways for maintenance of telomeres and common fragile sites during DNA replication stress
Özgün Özer, Ian David Hickson · 2018 · Open Biology
MCMs in Cancer: Prognostic Potential and Mechanisms
Si Yu, Guanqun Wang, Yue Shi, Haifeng Xu, Yongchang Zheng, Yang Chen · 2020 · Analytical Cellular Pathology
Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
Romain Donné, Maëva Saroul-Aïnama, Pierre Cordier, Adel Hammoutène, Christelle Kaboré, Mira Stadler, Ivan Nemazanyy, Isabelle Galy–Fauroux, Mounia Herrag, Tobias Riedl et al. · 2022 · Developmental Cell
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres
Vincent Spegg, Ανδρέας Παναγόπουλος, Merula Stout, Aswini Krishnan, Giordano Reginato, Ralph Imhof, Bernd Roschitzki, Petr Ćejka, Matthias Altmeyer · 2023 · Nature Structural & Molecular Biology
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin
Shobhan Gaddameedhi, Christopher P. Selby, Michael G. Kemp, Rui Ye, Aziz Sancar · 2014 · Journal of Investigative Dermatology
The Emerging Role of Cohesin in the DNA Damage Response
Ireneusz Litwin, Ewa Pilarczyk, Robert Wysocki · 2018 · Genes
FANCM regulates repair pathway choice at stalled replication forks
Arvind Panday, Nicholas A. Willis, Rajula Elango, Francesca Menghi, Erin E. Duffey, Edison T. Liu, Ralph Scully · 2021 · Molecular Cell
USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.
Zlatanou, A, Sabbioneda, S, Miller, E S, Greenwalt, A, Aggathanggelou, A, Maurice, M M, Lehmann, A R, Stankovic, T, Reverdy, C, Colland, F et al. · 2016 · Oncogene
Toward understanding genomic instability, mitochondrial dysfunction and aging
Fakouri, Nima B., Hou, Yujun, Demarest, Tyler G., Christiansen, Louise S., Okur, Mustafa N., Mohanty, Joy G., Croteau, Deborah L., Bohr, Vilhelm A. · 2019 · The FEBS Journal
PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours
Magnus T. Dillon, Z. Boylan, Deborah Ann Smith, Jeane Guevara, K. Mohammed, Clare Peckitt, Mark P. Saunders, Udai Banerji, Glen Clack, Simon A. Smith et al. · 2018 · Clinical and Translational Radiation Oncology
Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
Amaia Ercilla, Jan Benada, Sampath Amitash Gadi, Gijs Zonderland, G. Baldi, Kumar Somyajit, Fena Ochs, Vincenzo Costanzo, Jiri Lukas, Luis Ignacio Toledo · 2020 · Cell Reports
A fork in the road: Where homologous recombination and stalled replication fork protection part ways
Stephanie Tye, George E. Ronson, Joanna R. Morris · 2020 · Seminars in Cell and Developmental Biology
EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair
Yuehan Wu, Suk‐Hee Lee, Elizabeth A. Williamson, Brian L. Reinert, Ju Hwan Cho, Fen Xia, Aruna Shanker Jaiswal, Gayathri Srinivasan, Bhavita Patel, Alexis Brantley et al. · 2015 · PLoS Genetics
3D genome organization contributes to genome instability at fragile sites
Dan Sarni, Takayo Sasaki, Michal Irony‐Tur Sinai, Karin Miron, Juan Carlos Rivera‐Mulia, Brian Magnuson, Mats E. Ljungman, David M. Gilbert, Batsheva Kerem · 2020 · Nature Communications
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy
Zu Ye, Yin Shi, Susan P. Lees-Miller, John A. Tainer · 2021 · Frontiers in Immunology
Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability
Hao-Lian Wang, Yan Chen, Yun-Qian Wang, Juan Tan, Juan Tan, Qianqian Liu, Chun-Min Li, Xuemei Tong, Qin‐Yan Gao, Jie Hong et al. · 2022 · Nature Communications
Genome homeostasis defects drive enlarged cells into senescence
Sandhya Manohar, Marianna E. Estrada, Federico Uliana, Karla Vuina, Patricia Moyano Alvarez, Robertus A.M. de Bruin, Gabriel E. Neurohr · 2023 · Molecular Cell
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
Saskia Hoffmann, Stine Bech Smedegaard, Kyosuke Nakamura, Gulnahar B. Mortuza, Markus Räschle, Alain Ibáñez de Opakua, Yasuyoshi Oka, Yunpeng Feng, Francisco J. Blanco, Matthias Mann et al. · 2015 · The Journal of Cell Biology
Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease
Raquel Buj, Katherine M. Aird · 2018 · Frontiers in Endocrinology
Targeting DNA repair and replication stress in the treatment of ovarian cancer
Junko Murai · 2017 · International Journal of Clinical Oncology
Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance
Violeta Serra, Anderson T. Wang, Marta Castroviejo‐Bermejo, Urszula M. Polanska, Marta Palafox, Andrea Herencia-Ropero, Gemma N. Jones, Zhongwu Lai, Joshua Armenia, Filippos Michopoulos et al. · 2022 · Clinical Cancer Research
Synthetic lethal strategies for the development of cancer therapeutics
Natalie Y.L. Ngoi, David Gallo, Carlos Torrado, Mirella Nardo, Daniel Durocher, Timothy Anthony Yap · 2024 · Nature Reviews Clinical Oncology
DNA Replication Origins and Fork Progression at Mammalian Telomeres
Mitsunori Higa, Masatoshi Fujita, Kazumasa Yoshida · 2017 · Genes
PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress
Emily M. Schleicher, Adri M. Galvan, Yuka Imamura Kawasawa, George‐Lucian Moldovan, Claudia M. Nicolae · 2018 · Nucleic Acids Research
Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
Javier Garzón, Sebastian Ursich, Massimo Lopes, Shin‐ichiro Hiraga, Anne D. Donaldson · 2019 · Cell Reports
cGAS/STING cross-talks with cell cycle and potentiates cancer immunotherapy
Zi‐Jie Long, Jundan Wang, Jue‐Qiong Xu, Xinxing Lei, Quentin Liu · 2022 · Molecular Therapy
DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities
Anne-Sophie Boyer, David Walter, Claus Storgaard Sørensen · 2016 · Seminars in Cancer Biology
Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome
Keith Wheaton, Denise Campuzano, Weili Ma, Michal Sheinis, Brandon Ho, Grant W. Brown, Samuel Benchimol · 2017 · Molecular and Cellular Biology
Zika Virus Infection Induces DNA Damage Response in Human Neural Progenitors That Enhances Viral Replication
Christy Hammack, Sarah C. Ogden, Joseph C. Madden, Angelica Medina, Chongchong Xu, Ernest O. N. Phillips, Yuna Son, Allaura S. Cone, Serena Giovinazzi, Ruth Didier et al. · 2019 · Journal of Virology
MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading
Axel Delamarre, Antoine Barthe, Christophe de La Roche Saint-André, Pierre Luciano, Romain Forey, Ismaël Padioleau, Magdalena Skrzypczak, Krzysztof Ginalski, Vincent Géli, Philippe Pasero et al. · 2019 · Molecular Cell
Homologous recombination deficiency real-time clinical assays, ready or not?
Katherine Cynthia Fuh, Mary Margaret Mullen, Barbara Blachut, Elizabeth H. Stover, Panagiotis A. Konstantinopoulos, Joyce F. Liu, Ursula A. Matulonis, Dineo Khabele, Nima Mosammaparast, Alessandro Vindigni · 2020 · Gynecologic Oncology
Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression
Charikleia Papadopoulou, Guillaume Guilbaud, Davide Schiavone, Julian E. Sale · 2015 · Cell Reports
A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase
Nandini Sakurikar, Ruth H. Thompson, Ryan E. Montano, Alan R. Eastman · 2015 · Oncotarget
Female-biased embryonic death from inflammation induced by genomic instability
Adrian J. McNairn, Chen-Hua Chuang, Jordana C. Bloom, Marsha D. Wallace, John C. Schimenti · 2019 · Nature
DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy
Bas Pilzecker, Olimpia Alessandra Buoninfante, Heinz Jacobs · 2019 · Nucleic Acids Research
The Hammer and the Dance of Cell Cycle Control
Ανδρέας Παναγόπουλος, Matthias Altmeyer · 2020 · Trends in Biochemical Sciences
Modulation of the DNA damage response during the life cycle of human papillomaviruses
Daniel C. Anacker, Cary A. Moody · 2016 · Virus Research
53BP1 Mediates ATR-Chk1 Signaling and Protects Replication Forks under Conditions of Replication Stress
Joonyoung Her, Chandni Ray, Jake Altshuler, Haiyan Zheng, Samuel F. Bunting · 2018 · Molecular and Cellular Biology
Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage
Maria Chiara Raso, Nikola Djoric, Franziska Walser, Sandra Hess, Fabian Marc Schmid, Sibylle Burger, Klaus‐Peter Knobeloch, Lorenza Penengo · 2020 · The Journal of Cell Biology
Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress
Lucy A. Young, Lenka Oplustil O’Connor, Christelle de Renty, Margaret H. Veldman-Jones, Thierry Dorval, Zena Wilson, David R. Jones, Deborah Lawson, Rajesh Odedra, Apolinar Maya‐Mendoza et al. · 2019 · Cancer Research
DNA replication stress: oncogenes in the spotlight
Luiza M. F. Primo, Leonardo K. Teixeira · 2019 · Genetics and Molecular Biology
Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders
Triantafyllos Chavakis, Ben Wielockx, George Hajishengallis · 2021 · Annual Review of Physiology
Key Proteins of Replication Stress Response and Cell Cycle Control as Cancer Therapy Targets
Alvina I. Khamidullina, Yaroslav E. Abramenko, Alexandra V. Bruter, Victor Vyacheslavovich Tatarskiy · 2024 · International Journal of Molecular Sciences
The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma
Mike I. Walton, Paul D. Eve, Angela Hayes, Alan T. Henley, Melanie R. Valenti, Alexis K. de Haven Brandon, Gary Box, Kathy J. Boxall, Matthew Tall, Karen E. Swales et al. · 2015 · Oncotarget
The fork and the kinase: A DNA replication tale from a CHK1 perspective
Marina Alejandra González Besteiro, Vanesa Gottifredi · 2014 · Mutation Research/Reviews in Mutation Research
Connecting the Dots: From DNA Damage and Repair to Aging
Mei‐Ren Pan, Kaiyi Li, Shiaw‐Yih Lin, Wen-Chun Hung · 2016 · International Journal of Molecular Sciences
BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía et al. · 2017 · EMBO Molecular Medicine
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery
Peter Tonzi, Yandong Yin, Chelsea Wei Ting Lee, Eli Rothenberg, Tony T. Huang · 2018 · eLife
Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma
Chia‐Hua Chen, Pin‐Yuan Chen, You-Yu Lin, Li-Ying Feng, Shin-Han Chen, Chia‐Yuan Chen, Yin-Cheng Huang, Chiung-Yin Huang, Shih-Ming Jung, Leslie Y. Chen et al. · 2019 · Journal of neurosurgery
RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
Paul M. Yenerall, Amit Kumar Das, Shan Wang, Rahul Krishna Kollipara, Long Shan Li, Pamela Andrea Villalobos, Josiah Flaming, Yu‐Fen Lin, Kenneth E. Huffman, Brenda C. Timmons et al. · 2019 · Cell chemical biology
Making it or breaking it: DNA methylation and genome integrity
Anusha Sriraman, Turja K. Debnath, Blerta Xhemalçe, Kyle M. Miller · 2020 · Essays in Biochemistry
The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal
Karol Kramarz, Kamila Schirmeisen, Virginie Boucherit, Anissia Ait Saada, Claire Lovo, Benoı̂t Palancade, Catherine H. Freudenreich, Sarah Lambert · 2020 · Nature Communications
Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers
Robert Lu, Hilda A. Pickett · 2022 · Open Biology
DNA replication stress: from molecular mechanisms to human disease
Sergio Muñoz, Juan Méndez · 2016 · Chromosoma
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Galanos, Panagiotis, Pappas, George, Polyzos, Alexander, Kotsinas, Athanassios, Svolaki, Ioanna, Giakoumakis, Nickolaos N., Glytsou, Christina, Pateras, Ioannis S., Swain, Umakanta, Souliotis, Vassilis L. et al. · 2018 · Genome Biology
DNA-Sensing and Nuclease Gene Expressions as Markers for Colorectal Cancer Progression
Chin‐An Yang, Hsi‐Yuan Huang, Ya‐Sian Chang, Chia‐Li Lin, I‐Lu Lai, Jan‐Gowth Chang · 2016 · Oncology
DNA Damage Response and Spindle Assembly Checkpoint Function throughout the Cell Cycle to Ensure Genomic Integrity
Katherine S. Lawrence, Thinh Chau, JoAnne Engebrecht · 2015 · PLoS Genetics