Causes and consequences of replication stress

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693

Genomic instability — an evolving hallmark of cancer

Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2858 · Cited by 2,397

An Oncogene-Induced DNA Damage Model for Cancer Development

Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851

DNA Damage Sensing by the ATM and ATR Kinases

Marechal, A., & Zou, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012716 · Cited by 1,514

DNA secondary structures: stability and function of G-quadruplex structures

Bochman, M. L., Paeschke, K., & Zakian, V. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3296 · Cited by 1,485

Ciliopathies

Hildebrandt, F., Benzing, T., & Katsanis, N. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1010172 · Cited by 1,331

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., & Jasin, M. (2011) · Cell · doi:10.1016/j.cell.2011.03.041 · Cited by 1,292

Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair

Lima, M. D. S., Bouzid, H., Soares, D. G., Selle, F., Morel, C., Galmarini, C. M., Henriques, J. A. P., Larsen, A. K., & Escargueil, A. E. (2016) · Oncotarget · doi:10.18632/oncotarget.8292 · Cited by 31

Class I Histone Deacetylase HDAC1 and WRN RECQ Helicase Contribute Additively to Protect Replication Forks upon Hydroxyurea-induced Arrest

Kehrli, K., Phelps, M., Lazarchuk, P., Chen, E. Y., Monnat, R., & Sidorova, J. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.708594 · Cited by 28

Additive effects of a small molecular PCNA inhibitor PCNA-I1S and DNA damaging agents on growth inhibition and DNA damage in prostate and lung cancer cells

Lu, S., & Dong, Z. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223894 · Cited by 27

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

Schleicher, E. M., Dhoonmoon, A., Clements, K. E., Jackson, L. M., Stump, C. L., Nicolae, C. M., & Moldovan, G. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009176 · Cited by 31

Ubiquitylation at Stressed Replication Forks: Mechanisms and Functions

Mirsanaye, A. S., Typas, D., & Mailand, N. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.01.008 · Cited by 28

Replication initiation: Implications in genome integrity

Lin, Y.-C., & Prasanth, S. G. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103131 · Cited by 27

Viral Modulation of the DNA Damage Response and Innate Immunity: Two Sides of the Same Coin

Lopez, A., Doyle, R. N., Sandoval, C., Nisson, K., Yang, V. B., & Fregoso, O. I. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167327 · Cited by 31

Preventing and Overcoming Resistance to PARP Inhibitors: A Focus on the Clinical Landscape

Prados‐Carvajal, R., Irving, E., Lukashchuk, N., & Forment, J. V. (2021) · Cancers · doi:10.3390/cancers14010044 · Cited by 31

Mechanism for inverted-repeat recombination induced by a replication fork barrier

Marie, L., & Symington, L. S. (2022) · Nature Communications · doi:10.1038/s41467-021-27443-w · Cited by 26

Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress

Kurashima, K., Sekimoto, T., Oda, T., Kawabata, T., Hanaoka, F., & Yamashita, T. (2018) · Journal of Cell Science · doi:10.1242/jcs.212183 · Cited by 28

ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex

Kim, W., Zhao, F., Wu, R., Qin, S., Nowsheen, S., Huang, J., Zhou, Q., Chen, Y., Deng, M., Guo, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13321-z · Cited by 28

Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens

Black, J. A., Crouch, K., Lemgruber, L., Lapsley, C. T., Dickens, N. J., Tosi, L. R. O., Mottram, J. C., & McCulloch, R. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.049 · Cited by 29

EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells

García‐Rodríguez, N., Domínguez-García, I., Domínguez-Pérez, M. D. C., & Huertas, P. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae317 · Cited by 30

Multiple functions of PARP1 in the repair of DNA double strand breaks

Ortega, R., Bitler, B. G., & Arnoult, N. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103873 · Cited by 27

TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas

Liu, Z. R., Yanagisawa, K., Griesing, S., Iwai, M., Kano, K., Hotta, N., Kajino, T., Suzuki, M., & Takahashi, T. (2017) · Oncogene · doi:10.1038/onc.2016.524 · Cited by 26

A game of substrates: replication fork remodeling and its roles in genome stability and chemo-resistance

Sidorova, J. M. (2017) · Cell Stress · doi:10.15698/cst2017.12.114 · Cited by 29

Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing

Besteiro, M. A. G., Calzetta, N. L., Loureiro, S. M., Habif, M., Betous, R., Pillaire, M., Maffia, A., Sabbioneda, S., Hoffmann, J., & Gottifredi, V. (2019) · The EMBO Journal · doi:10.15252/embj.2018101284 · Cited by 28

Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites

Basbous, J., Aze, A., Chaloin, L., Lebdy, R., Hodroj, D., Ribeyre, C., Larroque, M., Shepard, C., Kim, B., Pruvost, A., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1162 · Cited by 27

Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma

Tamayo-Orrego, L., Gallo, D., Racicot, F., Bemmo, A., Mohan, S., Ho, B., Salameh, S., Hoang, T., Jackson, A. P., Brown, G. W., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0094-7 · Cited by 25

Clinical and Molecular Characterization of Fanconi Anemia Patients in Turkey

Toksoy, G., Alkaya, D. U., Bagirova, G., Avcı, Ş., Aghayev, A., Güneş, N., Altunoğlu, U., Alanay, Y., Başaran, S., Berkay, E. G., et al. (2020) · Molecular Syndromology · doi:10.1159/000509838 · Cited by 27

Anti‑inflammatory mechanism of berberine on lipopolysaccharide‑induced IEC‑18 models based on comparative transcriptomics

Xu, X., Zhang, L., Zhao, Y., Xu, B., Qin, W., Yan, Y., Yin, B., Xi, C., & Ma, L. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11602 · Cited by 27

A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

Hornsveld, M., Feringa, F. M., Krenning, L., van den Berg, J., Smits, L. M. M., Nguyen, N. B., Colman, M. J. R., Dansen, T. B., Medema, R. H., & Burgering, B. M. T. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108675 · Cited by 26

MYBL2 and ATM suppress replication stress in pluripotent stem cells

Blakemore, D., Vilaplana‐Lopera, N., Almaghrabi, R. O. M., Gonzalez, E., Moya, M., Ward, C., Murphy, G. J., Gambus, A., Petermann, E., Stewart, G. S., et al. (2021) · EMBO Reports · doi:10.15252/embr.202051120 · Cited by 25

R-Loops and Its Chro-Mates: The Strange Case of Dr. Jekyll and Mr. Hyde

Uruci, S., Lo, C. S. Y., Wheeler, D. L., & Taneja, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168850 · Cited by 26

The Influence of Oncogenic RAS on Chemotherapy and Radiotherapy Resistance Through DNA Repair Pathways

Cáceres-Gutiérrez, R. E., Alfaro‐Mora, Y., Andonegui, M. A., Díaz‐Chávez, J., & Herrera, L. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.751367 · Cited by 28

The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition

Zonderland, G., Vanzo, R., Gadi, S. A., Martín‐Doncel, E., Coscia, F., Mund, A., Lerdrup, M., Benada, J., Boos, D., & Toledo, L. I. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.08.006 · Cited by 26

New ruthenium( ii ) complexes with quinone diimine and substituted bipyridine as inert ligands: synthesis, characterization, mechanism of action, DNA/HSA binding affinity and cytotoxic activity

Međedović, M., Simović, A. R., Ćoćić, D., Senft, L., Matic, S. D., Todorović, D., Popović, S., Baskić, D., & Petrović, B. (2022) · Dalton Transactions · doi:10.1039/d2dt02993f · Cited by 27

G-Quadruplex Structures Are Key Modulators of Somatic Structural Variants in Cancers

Zhang, R., Shu, H., Wang, Y., Tao, T., Tu, J., Wang, C., Mergny, J., & Sun, X. S. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-3089 · Cited by 31

Mono-ADP-ribosylation by PARP10 and PARP14 in genome stability

Dhoonmoon, A., & Nicolae, C. M. (2023) · NAR Cancer · doi:10.1093/narcan/zcad009 · Cited by 28

Parp Inhibitors and Radiotherapy: A New Combination for Prostate Cancer (Systematic Review)

BELENCHON, I. R., Ruiz, C. B. C., Sáez, C., Osmán-García, I., & López, R. A. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612978 · Cited by 30

Human Adipose-Derived Stem Cells Expanded Under Ambient Oxygen Concentration Accumulate Oxidative DNA Lesions and Experience Procarcinogenic DNA Replication Stress

Betous, R., Renoud, M.-L., Hoede, C., González, I., Jones, N. B., Longy, M., Sensebé, L., Cazaux, C., & Hoffmann, J. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0401 · Cited by 29

Physiological and Pathological Roles of RAD52 at DNA Replication Forks

Malacaria, E., Honda, M., Franchitto, A., Spies, M., & Pichierri, P. (2020) · Cancers · doi:10.3390/cancers12020402 · Cited by 25

Location, Location, Location: The Role of Nuclear Positioning in the Repair of Collapsed Forks and Protection of Genome Stability

Whalen, J. M., & Freudenreich, C. H. (2020) · Genes · doi:10.3390/genes11060635 · Cited by 25

Potential Relationship between Inadequate Response to DNA Damage and Development of Myelodysplastic Syndrome

Zhou, T., Chen, P., Gu, J. H., Bishop, A. J. R., Scott, L., Hasty, P., & Rebel, V. I. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16010966 · Cited by 26

Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective

Coller, H. A. (2019) · Comprehensive physiology · doi:10.1002/cphy.c190014 · Cited by 33

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress

Vasudevarao, M. D., Pena, D. P., Ihle, M., Bongiovanni, C., Maity, P., Geissler, D., Mohammadi, H. F., Rall-Scharpf, M., Niemann, J., Mommersteeg, M. T. M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56993-6 · Cited by 26

Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells

Desplancq, D., Freund, G., Conic, S., Sibler, A., Didier, P., Stoessel, A., Oulad‐Abdelghani, M., Vigneron, M., Wagner, J. E., Mély, Y., et al. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.03.003 · Cited by 27

Replication Stress and Consequential Instability of the Genome and Epigenome

Tsegay, P. S., Lai, Y., & Liu, Y. (2019) · Molecules · doi:10.3390/molecules24213870 · Cited by 31

SUMOylation mediates CtIP’s functions in DNA end resection and replication fork protection

Locke, A. J., Hossain, L., McCrostie, G., Ronato, D. A., Fitieh, A. M., Rafique, T. A., Mashayekhi, F., Motamedi, M., Masson, J., & Ismail, I. H. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1232 · Cited by 27

Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures

Chitwood, D. G., Wang, Q., Elliott, K. S., Bullock, A., Jordana, D., Li, Z., Wu, C. H., Harcum, S. W., & Saski, C. A. (2021) · BMC Biotechnology · doi:10.1186/s12896-020-00667-2 · Cited by 27

The eukaryotic replisome tolerates leading‐strand base damage by replicase switching

Guilliam, T. A., & Yeeles, J. T. P. (2021) · The EMBO Journal · doi:10.15252/embj.2020107037 · Cited by 25

USP13 regulates the replication stress response by deubiquitinating TopBP1

Kim, W., Zhao, F., Gao, H., Qin, S., Hou, J., Deng, M., Kloeber, J. A., Huang, J., Zhou, Q., Guo, G., et al. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103063 · Cited by 26

Inhibition of the DSB repair protein RAD51 potentiates the cytotoxic efficacy of doxorubicin via promoting apoptosis-related death pathways

Schürmann, L., Schumacher, L., Roquette, K., Brozović, A., & Fritz, G. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.08.006 · Cited by 26

The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair

Adeyemi, R. O., Willis, N. A., Elia, A. E. H., Clairmont, C. S., Li, S., Wu, X., D’Andrea, A. D., Scully, R., & Elledge, S. J. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.09.008 · Cited by 23

Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo

Jann, J.-C., Mossner, M., Riabov, V., Altrock, E., Schmitt, N., Flach, J., Xu, Q., Nowak, V., Obländer, J., Palme, I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26424-3 · Cited by 26

ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress

Wu, X., Xu, S., Wang, P., Wang, Z., Chen, H., Xu, X., & Peng, B. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2203783119 · Cited by 27

The nematode Oscheius tipulae as a genetic model for programmed DNA elimination

Dockendorff, T. C., Estrem, B., Reed, J., Simmons, J. R., Zadegan, S. B., Zagoskin, M. V., Terta, V., Villalobos, E., Seaberry, E. M., & Wang, J. (2022) · Current Biology · doi:10.1016/j.cub.2022.10.043 · Cited by 26

Excessive transcription-replication conflicts are a vulnerability of BRCA1 -mutant cancers

Patel, P. S., Algouneh, A., Krishnan, R., Reynolds, J. J., Nixon, K. C. J., Hao, J., Lee, J., Feng, Y., Fozil, C., Stanić, M., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad172 · Cited by 28

RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks

Moore, C. E., Yalcindag, S. E., Czeladko, H., Ravindranathan, R., Hanthi, Y. W., Levy, J. C., Sannino, V., Schindler, D., Ciccia, A., Costanzo, V., et al. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202106022 · Cited by 26

Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation

Minet, N., Boschat, A., Lane, R., Laughton, D., Beer, P. A., Asnagli, H., Soudais, C., Bourne, T., Fischer, A., Martin, E., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202302066 · Cited by 26

Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization

Buyukcelebi, K., Chen, X., Abdula, F., Elkafas, H., Duval, A. J., Öztürk, H., Seker-Polat, F., Jin, Q., Yin, P., Yue, F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39684-y · Cited by 26

Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain-containing Protein 3 (ZRANB3)

Badu-Nkansah, A., Mason, A. C., Eichman, B. F., & Cortez, D. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.709733 · Cited by 28

The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells

Chen, C., Tsao, N., Huang, L.-Y., Yen, Y., Liu, X., Lehman, C. E., Wang, Y.-H., Tseng, M., Chen, Y., Ho, Y.-C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.094 · Cited by 25

Replication fork regression and its regulation

Meng, X., & Zhao, X. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow110 · Cited by 31

Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1

Garzón, J., Rodríguez, R., Kong, Z., Chabes, A., Rodríguez‐Acebes, S., Méndez, J., Moreno, S., & García-Higuera, I. (2017) · Oncogene · doi:10.1038/onc.2017.186 · Cited by 26

Dna2 initiates resection at clean DNA double-strand breaks

Paudyal, S. C., Li, S., Yan, H., Hunter, T. R., & You, Z. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx830 · Cited by 30

Satb2 regulates proliferation and nuclear integrity of pre-osteoblasts

Dowrey, T. W., Schwager, E. E., Duong, J., Merkuri, F., Zárate, Y. A., & Fish, J. L. (2019) · Bone · doi:10.1016/j.bone.2019.07.017 · Cited by 26

The plant WEE1 kinase is involved in checkpoint control activation in nematode‐induced galls

Cabral, D., Banora, M. Y., Antonino, J. D., Rodiuc, N., Vieira, P. C., Coelho, R. R., Chevalier, C., Eekhout, T., Engler, G., Veylder, L. D., et al. (2019) · New Phytologist · doi:10.1111/nph.16185 · Cited by 29

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR

Dhoonmoon, A., Schleicher, E. M., Clements, K. E., Nicolae, C. M., & Moldovan, G. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa508 · Cited by 26

Behavior of replication origins in Eukaryota – spatio-temporal dynamics of licensing and firing

Musiałek, M. W., & Rybaczek, D. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1056421 · Cited by 25

SLFN11 is a general target for enhancing the sensitivity of cancer to chemotherapy (DNA-damaging agents)

Luan, J., Gao, X., Hu, F., Zhang, Y., & Gou, X. (2019) · Journal of drug targeting · doi:10.1080/1061186x.2019.1616746 · Cited by 24

Mapping genetic interactions in cancer: a road to rational combination therapies

Tutuncuoglu, B., & Krogan, N. J. (2019) · Genome Medicine · doi:10.1186/s13073-019-0680-4 · Cited by 25

Comparison of the different mechanisms of cytotoxicity induced by checkpoint kinase I inhibitors when used as single agents or in combination with DNA damage

Warren, N. J. H., & Eastman, A. R. (2019) · Oncogene · doi:10.1038/s41388-019-1079-9 · Cited by 27

Digenic inheritance of human primary microcephaly delineates centrosomal and non‐centrosomal pathways

Duerinckx, S., Jacquemin, V., Drunat, S., Vial, Y., Passemard, S., Perazzolo, C., Massart, A., Soblet, J., Racapé, J., Desmyter, L., et al. (2019) · Human Mutation · doi:10.1002/humu.23948 · Cited by 25

The mitotic checkpoint is a targetable vulnerability of carboplatin-resistant triple negative breast cancers

Moens, S., Zhao, P., Baietti, M. F., Marinelli, O., Haver, D. V., Impens, F., Floris, G., Marangoni, E., Neven, P., Annibali, D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-82780-6 · Cited by 25

PLK1 regulates the PrimPol damage tolerance pathway during the cell cycle

Bailey, L. J., Teague, R., Kolesár, P., Bainbridge, L. J., Lindsay, H. D., & Doherty, A. J. (2021) · Science Advances · doi:10.1126/sciadv.abh1004 · Cited by 24

Stimulation of adaptive gene amplification by origin firing under replication fork constraint

Whale, A. J., King, M. R., Hull, R. M., Krueger, F., & Houseley, J. M. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1257 · Cited by 25

RAD51 paralogs: Expanding roles in replication stress responses and repair

Bhattacharya, D., Sahoo, S., Nagraj, T., Dixit, S., Dwivedi, H. K., & Nagaraju, G. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102313 · Cited by 26

Replication stress by Py–Im polyamides induces a non-canonical ATR-dependent checkpoint response

Martinez, T. F., Phillips, J. W., Karanja, K. K., Polaczek, P., Wang, C.-M., Li, B. C., Campbell, J. L., & Dervan, P. B. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku866 · Cited by 27

A crucial role for ATR in the regulation of deoxycytidine kinase activity

Beyaert, M., Starczewska, E., Neste, E. V. D., & Bontemps, F. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.11.022 · Cited by 26

UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response

Signore, M., Buccarelli, M., Pilozzi, E., Luca, G. D., Cappellari, M., Fanciulli, M., Goeman, F., Melucci, E., Biffoni, M., & Ricci‐Vitiani, L. (2016) · Oncotarget · doi:10.18632/oncotarget.9859 · Cited by 25

Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral Replication

Kucharski, T. J., Ng, T. F., Sharon, D. M., Navid-Azarbaijani, P., Tavassoli, M., & Teodoro, J. G. (2016) · Journal of Virology · doi:10.1128/jvi.00936-16 · Cited by 25

SCF β‐Tr CP ubiquitinates CHK 1 in an AMPK ‐dependent manner in response to glucose deprivation

Ma, Y., Cui, D., Xiong, X., Inuzuka, H., Wei, W., Sun, Y., North, B. J., & Zhao, Y. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12403 · Cited by 25

Replication stress: Driver and therapeutic target in genomically instable cancers

Schoonen, P. M., Llobet, S. G., & van Vugt, M. A. T. M. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.10.006 · Cited by 26

Roles of OB-Fold Proteins in Replication Stress

Nguyen, D.-D., Kim, E. Y., Sang, P. B., & Chai, W.-H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.574466 · Cited by 25

Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

Fukuda, K., Takeuchi, S., Arai, S., Nanjo, S., Sato, S., Kotani, H., Kita, K., Nishiyama, A., Sakaguchi, H., Ohtsubo, K., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101578 · Cited by 24

The Role of γH2AX in Replication Stress-induced Carcinogenesis: Possible Links and Recent Developments

Fragkos, M., Choleza, M., & Papadopoulou, P. (2023) · Cancer Diagnosis & Prognosis · doi:10.21873/cdp.10266 · Cited by 30

Profound synthetic lethality between SMARCAL1 and FANCM

Feng, S., Liu, K., Shang, J., Hoeg, L., Pastore, G., Yang, W. E., Roy, S., Sastre-Moreno, G., Young, J. T. F., Wu, W., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.10.016 · Cited by 24

The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells

Bertolin, A. P., Canal, B., Yekezare, M., Early, A. E., Zeng, J., Instrell, R., Howell, M., & Diffley, J. F. X. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.06.002 · Cited by 27

Role of DNA polymerase κ in the maintenance of genomic stability

Pillaire, M., Betous, R., & Hoffmann, J. (2014) · Molecular & Cellular Oncology · doi:10.4161/mco.29902 · Cited by 30

Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

Barnes, R. P., & Eckert, K. A. (2017) · Genes · doi:10.3390/genes8010019 · Cited by 26

Role of specialized DNA polymerases in the limitation of replicative stress and DNA damage transmission

Bournique, E., Dall’Osto, M., Hoffmann, J., & Bergoglio, V. (2017) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2017.08.002 · Cited by 26

Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal Cancer

Tomasini, P. P., Guecheva, T. N., Leguisamo, N. M., Péricart, S., Brunac, A., Hoffmann, J., & Saffi, J. (2021) · Cancers · doi:10.3390/cancers13133130 · Cited by 25

A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability

Wang, L., Li, J., Zhou, H., Zhang, W., Gao, J. X., & Zheng, P. (2021) · Nature Communications · doi:10.1038/s41467-021-25827-6 · Cited by 27

The tumor suppression theory of aging

Wolf, A. M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111583 · Cited by 27

Pharmacologic inhibition of ataxia telangiectasia and Rad3‐related (ATR) in the treatment of head and neck squamous cell carcinoma

Karukonda, P., Odhiambo, D. A., & Mowery, Y. M. (2021) · Molecular Carcinogenesis · doi:10.1002/mc.23384 · Cited by 22

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Davidson, S. M., Heyman, J. E., O’Brien, J. P., Liu, A. C., Schmidt, D. R., Israelsen, W. J., Dayton, T. L., Sehgal, R., Bronson, R. T., Freinkman, E., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-2352 · Cited by 24

Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and Radiotherapy

Nickoloff, J. A. (2022) · Molecules · doi:10.3390/molecules27154736 · Cited by 30

Proper RPA acetylation promotes accurate DNA replication and repair

Gan, X., Zhang, Y., Jiang, D., Shi, J., Zhao, H., Xie, C., Wang, Y., Xu, J., Zhang, X., Cai, G., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad291 · Cited by 24

MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops

Işık, E., Shukla, K., Pospíšilová, M., König, C., Andrš, M., Rao, S., Rosano, V., Dobrovolná, J., Krejčí, L., & Janščák, P. (2024) · Science Advances · doi:10.1126/sciadv.adk2685 · Cited by 24

Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related

Beggs, K. M., Maiuri, A. R., Fullerton, A. M., Poulsen, K. L., Breier, A. B., Ganey, P. E., & Roth, R. A. (2015) · Toxicology · doi:10.1016/j.tox.2015.03.002 · Cited by 24

Mutations in Replicative Stress Response Pathways Are Associated with S Phase-specific Defects in Nucleotide Excision Repair

Bélanger, F., Angers, J.-P., Fortier, É., Hammond-Martel, I., Costantino, S., Drobetsky, E., & Wurtele, H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.685883 · Cited by 24

Gamma‐irradiated quiescent cells repair directly induced double‐strand breaks but accumulate persistent double‐strand breaks during subsequent DNA replication

Minakawa, Y., Atsumi, Y., Shinohara, A., Murakami, Y., & Yoshioka, K. (2016) · Genes to Cells · doi:10.1111/gtc.12381 · Cited by 25

NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protection

Abeyta, A., Castellà, M., Jacquemont, C. F., & Taniguchi, T. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1259038 · Cited by 26

The Role of the Transcriptional Response to DNA Replication Stress

Herlihy, A. E., & de Bruin, R. A. M. (2017) · Genes · doi:10.3390/genes8030092 · Cited by 26

Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis

Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Desler, C., Hasan‐Olive, M. M., Martín-Pardillos, A., Tsaalbi‐Shtylik, A., Thomsen, K., Lauritzen, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12662-3 · Cited by 24

Replication stress in hematopoietic stem cells in mouse and man

Flach, J., & Milyavsky, M. (2017) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2017.10.001 · Cited by 23

Everything in Moderation: Lessons Learned by Exploiting Moderate Replication Stress in Cancer

Nazareth, D., Jones, M. V., & Gabrielli, B. G. (2019) · Cancers · doi:10.3390/cancers11091320 · Cited by 24

Transcription activity contributes to the firing of non-constitutive origins in African trypanosomes helping to maintain robustness in S-phase duration

da Silva, M. S., Cayres-Silva, G. R., Vitarelli, M. D. O., Marin, P. A., Hiraiwa, P. M., de Araujo, C. B., Scholl, B. B., Ávila, A. R., McCulloch, R., Reis, M. S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-54366-w · Cited by 24

Cancer Therapy and Replication Stress

Kotsantis, P., Jones, R. M., Higgs, M. R., & Petermann, E. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.12.003 · Cited by 24

Signaling at Stalled Replication Forks

Mordes, D. A., & Cortez, D. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_2

GENOME STABILITY MECHANISMS DURING REPLICATION STRESS AND DNA DAMAGE RESPONSE IN PROLIFERATING CELLS

Seol, J.-M., Kwon, E.-B., Moon, T.-H., Nam, S.-Y., & Jin, K.-H. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.22693628

Stalled Replication Forks under Replication Stress: Cellular Responses, Repair Mechanisms and Therapeutic Implications

Wang, Y. (2026) · Theoretical and Natural Science · doi:10.54254/2753-8818/2026.36489

The Adaptive Mechanisms and Checkpoint Responses to a Stressed DNA Replication Fork

Saldanha, J., Rageul, J., Patel, J. A., & Kim, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310488 · Cited by 28

Signaling of DNA Replication Stress Through the ATR Checkpoint

Shiotani, B., & Zou, L. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_16 · Cited by 1