Causes and consequences of replication stress

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693

Genomic instability — an evolving hallmark of cancer

Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2858 · Cited by 2,397

An Oncogene-Induced DNA Damage Model for Cancer Development

Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851

DNA Damage Sensing by the ATM and ATR Kinases

Marechal, A., & Zou, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012716 · Cited by 1,514

DNA secondary structures: stability and function of G-quadruplex structures

Bochman, M. L., Paeschke, K., & Zakian, V. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3296 · Cited by 1,485

Ciliopathies

Hildebrandt, F., Benzing, T., & Katsanis, N. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1010172 · Cited by 1,331

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., & Jasin, M. (2011) · Cell · doi:10.1016/j.cell.2011.03.041 · Cited by 1,292

DOCK7 protects against replication stress by promoting RPA stability on chromatin

Gao, M., Guo, G., Huang, J., Hou, X., Ham, H., Kim, W., Zhao, F., Tu, X., Zhou, Q., Zhang, C., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab134 · Cited by 19

Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution

Matsuno, Y., Hyodo, M., Suzuki, M., Tanaka, Y., Horikoshi, Y., Murakami, Y., Torigoe, H., Mano, H., Tashiro, S., & Yoshioka, K. (2021) · iScience · doi:10.1016/j.isci.2021.102313 · Cited by 21

Post-Translational Modification of MRE11: Its Implication in DDR and Diseases

Lu, R., Zhang, H., Jiang, Y.-N., Wang, Z., Sun, L., & Zhou, Z. (2021) · Genes · doi:10.3390/genes12081158 · Cited by 20

Crosstalk between CST and RPA regulates RAD51 activity during replication stress

Lei, K., Yang, H., Chang, H.-Y., Yeh, H., Nguyen, D.-D., Lee, T.-Y., Lyu, X., Chastain, M., Chai, W., Li, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26624-x · Cited by 20

Characterizing and exploiting the many roles of aberrant H2B monoubiquitination in cancer pathogenesis

Jeusset, L. M., & McManus, K. J. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.12.007 · Cited by 19

ERCC6L2 mitigates replication stress and promotes centromere stability

Carnie, C. J., Armstrong, L. V., Šebesta, M., Ariza, A., Wang, X., Graham, E. B., Zhu, K., & Ahel, D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112329 · Cited by 20

The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer

Yeo, X. H., Sundararajan, V., Wu, Z., Phua, Z. J. C., Ho, Y. Y., Peh, K. L. E., Chiu, Y.-C., Tan, T. Z., Kappei, D., Ho, Y. S., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05045-0 · Cited by 21

Defective replication stress response inhibits lymphomagenesis and impairs lymphocyte reconstitution

Puccetti, M. V., Fischer, M. A., Arrate, M. P., Boyd, K. L., Duszynski, R. J., Betous, R., Cortez, D., & Eischen, C. M. (2016) · Oncogene · doi:10.1038/onc.2016.408 · Cited by 19

Current and Emerging Molecular Tests for Human Papillomavirus–Related Neoplasia in the Genomic Era

Leal, S. M., & Gulley, M. L. (2017) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2017.01.006 · Cited by 19

Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion

Miosge, L. A., Sontani, Y., Chuah, A., Horikawa, K., Russell, T., Mei, Y., Wagle, M. V., Howard, D. R., Enders, A., Tscharke, D. C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705795114 · Cited by 18

Modernizing Human Cancer Risk Assessment of Therapeutics

Fielden, M. R., Ward, L. D., Minocherhomji, S., Nioi, P., Lebrec, H. N., & Jacobson‐Kram, D. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.11.005 · Cited by 19

Prospect for Application of PARP Inhibitor in Patients with HER2 Negative Breast Cancer

Shao, N., Shi, Y., Yu, L., Ye, R., Shan, Z., Zhang, Z., Zhang, Y., & Lin, Y. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.30721 · Cited by 18

Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

Achuthankutty, D., Thakur, R. S., Haahr, P., Hoffmann, S., Drainas, A. P., Bizard, A. H., Weischenfeldt, J., Hickson, I. D., & Mailand, N. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201905064 · Cited by 19

Dicer prevents genome instability in response to replication stress

Fragkos, M., Barra, V., Egger, T., Bordignon, B., Lemacon, D. S., Naim, V., & Coquelle, A. (2019) · Oncotarget · doi:10.18632/oncotarget.27034 · Cited by 18

Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse

Urrutia, G., Salmonson, A., Toro-Zapata, J., de Assuncao, T. M., Mathison, A., Dusetti, N., Iovanna, J., Urrutia, R. A., & Lomberk, G. A. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0490 · Cited by 19

Mechanisms of mutagenesis induced by DNA lesions: multiple factors affect mutations in translesion DNA synthesis

Zhang, H. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1768205 · Cited by 18

Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress

Herbert, K. J., Puliyadi, R., Prevo, R., Rodríguez‐Berriguete, G., Ryan, A. J., Ramadan, K., & Higgins, G. S. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00655-1 · Cited by 19

Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress

Ackerson, S. M., Gable, C. I., & Stewart, J. A. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1849979 · Cited by 18

A Link between Replicative Stress, Lamin Proteins, and Inflammation

Willaume, S., Rass, E., Fontanilla-Ramirez, P., Moussa, A., Wanschoor, P., & Bertrand, P. (2021) · Genes · doi:10.3390/genes12040552 · Cited by 28

MicroRNAs and the DNA damage response: How is cell fate determined?

Visser, H., & Thomas, A. D. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103245 · Cited by 20

Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication

Goto, G. H., Zencir, S., Hirano, Y., Ogi, H., Ivessa, A., & Sugimoto, K. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005283 · Cited by 18

RecG controls DNA amplification at double‐strand breaks and arrested replication forks

Azeroglu, B., & Leach, D. R. F. (2017) · FEBS Letters · doi:10.1002/1873-3468.12583 · Cited by 19

The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks

Canal, B., Bertolin, A. P., Lee, G. H. B., Drury, L. S., Minamino, M., & Diffley, J. F. X. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.06.001 · Cited by 21

Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis

Boice, A., Lopez, K. E., PANDITA, R. K., Parsons, M. J., Charendoff, C. I., Charaka, V., Carisey, A. F., Pandita, T. K., & Bouchier‐Hayes, L. (2021) · Oncogene · doi:10.1038/s41388-021-02085-w · Cited by 18

The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells

Schleicher, E. M., Dhoonmoon, A., Jackson, L. M., Khatib, J. B., Nicolae, C. M., & Moldovan, G. (2022) · Oncogenesis · doi:10.1038/s41389-022-00410-w · Cited by 20

REV1: A novel biomarker and potential therapeutic target for various cancers

Zhu, N., Zhao, Y., Mi, M., Lu, Y., Tan, Y., Fang, X., Weng, S., & Yuan, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.997970 · Cited by 18

DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo

Naumann, J. A., Argyris, P. P., Carpenter, M. A., Gupta, H. B., Chen, Y., Temiz, N. A., Zhou, Y., Durfee, C. C., Proehl, J., Koniar, B. L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119305 · Cited by 18

Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration

Pearson, A. D. J., Federico, S. M., Gatz, S. A., Ortiz, M. V., Lesa, G. M., Scobie, N., Gounaris, I., Weiner, S. L., Weigel, B. J., Unger, T., et al. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.112950 · Cited by 20

Schistosoma mansoni–Induced Oxidative Stress Triggers Hepatocellular Proliferation

von Bülow, V., Schneider, M., Dreizler, D., Russ, L., Baier, A., Buß, N., Lichtenberger, J., Härle, L., Müller, H., Tschuschner, A., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.08.014 · Cited by 18

Processing of stalled replication forks in Bacillus subtilis

Carrasco, B., Torres, R., Álamo, M. M., Ramos, C., Ayora, S., & Alonso, J. C. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad065 · Cited by 19

A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers

Alruwaili, M., Zonneville, J., Naranjo, M. N., Serio, H., Melendy, T., Straubinger, R. M., Gillard, B. M., Foster, B. A., Rajan, P., Attwood, K. M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101434 · Cited by 18

ATR limits Rad18-mediated PCNA monoubiquitination to preserve replication fork and telomerase-independent telomere stability

Chen, S., Pan, C., Huang, J., & Liu, T. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00066-9 · Cited by 19

Concise Review: Induced Pluripotency by Defined Factors: Prey of Oxidative Stress

Qi, S., Fang, Z. H., Wang, D., Menéndez, P. R., Yao, K., & Ji, J. (2015) · Stem Cells · doi:10.1002/stem.1946 · Cited by 17

Human RAD52 protein regulates homologous recombination and checkpoint function in BRCA2 deficient cells

Mahajan, S., Raina, K., Verma, S., & Rao, B. J. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.12.013 · Cited by 18

PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells

Nicolae, C. M., O’Connor, M. J., Schleicher, E. M., Song, C., Gowda, R., Robertson, G. P., Dovat, S., & Moldovan, G. (2019) · Oncogene · doi:10.1038/s41388-019-0810-x · Cited by 18

XLF and H2AX function in series to promote replication fork stability

Chen, B.-R., Quinet, A., Byrum, A. K., Jackson, J., Berti, M., Thangavel, S., Bredemeyer, A. L., Hindi, I., Mosammaparast, N., Tyler, J. K., et al. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201808134 · Cited by 23

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

Ahmed, S. M., Ramani, P. D., Wong, S. Q. R., Zhao, X., Iványi-Nagy, R., Tang, C. L., Chua, C., Li, Z., Hentze, H., Tan, I. B., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215696 · Cited by 18

Replication origin location might contribute to genetic variability in Trypanosoma cruzi

de Araujo, C. B., da Cunha, J. P. C., Inada, D. T., Damasceno, J. D., Lima, A. R. J., Hiraiwa, P. M., Marques, C. A., Gonçalves, E. C., Nishiyama, M. Y., McCulloch, R., et al. (2020) · BMC Genomics · doi:10.1186/s12864-020-06803-8 · Cited by 18

Nuclear IGF1R interact with PCNA to preserve DNA replication after DNA-damage in a variety of human cancers

Chen, Y., Zhang, Y., Chen, Y., Ragaller, F., Liu, M., Corvigno, S., Dahlstrand, H. M., Carlson, J. W., Chen, Z., Näsman, A., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236291 · Cited by 18

The Roles of SPOP in DNA Damage Response and DNA Replication

Maekawa, M., & Higashiyama, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197293 · Cited by 18

Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress

Westhorpe, R., Keszthelyi, A., Minchell, N. E., Jones, D., & Baxter, J. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa963 · Cited by 18

Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction

Rieunier, G., Wu, X., Harris, L. E., Mills, J. V., Nandakumar, A. M., Colling, L., Seraia, E., Hatch, S. B., Ebner, D. V., Folkes, L. K., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2860 · Cited by 18

Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels

Fütterer, A., Gutiérrez, A., Pons, T., de Celis, J., Gutiérrez, J., Plaza, V. D., & Martínez‐A, C. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03906-2 · Cited by 18

The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

Schuhwerk, H., Kleemann, J., Gupta, P., van Roey, R., Armstark, I., Kreileder, M., Feldker, N., Ramesh, V., Hajjaj, Y., Fuchs, K., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111819 · Cited by 19

Overexpression of PP1–NIPP1 limits the capacity of cells to repair DNA double-strand breaks

Winkler, C., Rouget, R., Wu, D., Beullens, M., Eynde, A. V., & Bollen, M. (2018) · Journal of Cell Science · doi:10.1242/jcs.214932 · Cited by 18

Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases

Ahmed, S. M. Q., Sasikumar, J., Laha, S., & Das, S. P. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10209-3 · Cited by 17

eIF4E Threshold Levels Differ in Governing Normal and Neoplastic Expansion of Mammary Stem and Luminal Progenitor Cells

Avdulov, S. V., Herrera, J., Smith, K. A., Peterson, M., Gómez-García, J. R., Beadnell, T. C., Schwertfeger, K. L., Benyumov, A. O., Manivel, J. C., Li, S., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-2571 · Cited by 17

Affected chromosome homeostasis and genomic instability of clonal yeast cultures

Adamczyk, J., Deręgowska, A., Panek, A. D., Golec, E., Lewińska, A., & Wnuk, M. (2015) · Current Genetics · doi:10.1007/s00294-015-0537-3 · Cited by 17

Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling

Pal, S., Nixon, B. R., Glennon, M. S., Shridhar, P., Satterfield, S. L., Su, Y. R., & Becker, J. R. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021768 · Cited by 20

Quantitative profiling of adaptation to cyclin E overproduction

Limas, J. C., Littlejohn, A. N., House, A. M., Kedziora, K. M., Mouery, B. L., Ma, B., Fleifel, D., Walens, A., Aleman, M. M., Dominguez, D., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202201378 · Cited by 18

Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies

Balboni, B., Rinaldi, F., Previtali, V., Ciamarone, A., Girotto, S., & Cavalli, A. (2023) · Cancers · doi:10.3390/cancers15061817 · Cited by 20

Tissue Specificity of DNA Damage and Repair

Hoch, N. C. (2023) · Physiology · doi:10.1152/physiol.00006.2023 · Cited by 18

DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks

Pinto, L., Pailas, A., Bondarchenko, M., Sharma, A. B., Neumann, K., Rizzo, A. J., Jeanty, C., Nicot, N., Racca, C., Graham, M. K., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad1141 · Cited by 18

FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress

Tischler, J. D., Tsuchida, H., Bosire, R., Oda, T. T., Park, A., & Adeyemi, R. O. (2024) · Nature Communications · doi:10.1038/s41467-024-45139-9 · Cited by 17

TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks

Kong, L., Cheng, C., Cheruiyot, A., Yuan, J., Yang, Y., Hwang, S., Foust, D. J., Tsao, N., Wilkerson, E., Mosammaparast, N., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48988-6 · Cited by 16

p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis

Elfar, G. A., Aning, O. A., Ngai, T. W., Yeo, P., Chan, J. W. K., Sim, S. H., Goh, L., Ju, Y., Phua, C. Z. J., Yeo, J. Z. Z., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae811 · Cited by 17

Genetic immune escape in cancer: timing and implications for treatment

Martínez-Jiménez, F., & Chowell, D. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.11.002 · Cited by 17

Novel poly-ADP-ribose polymerase inhibitor combination strategies in ovarian cancer

McCann, K. E. (2017) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000428 · Cited by 19

Chromatin as a Platform for Modulating the Replication Stress Response

Fournier, L.-A., Kumar, A., & Stirling, P. C. (2018) · Genes · doi:10.3390/genes9120622 · Cited by 17

Distinct cellular responses to replication stress leading to apoptosis or senescence

Lukášová, E., Řezáčová, M., Bačı́ková, A., Šebejová, L., Vávrová, J., & Kozubek, S. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12632 · Cited by 17

From Powerhouse to Perpetrator—Mitochondria in Health and Disease

Fakouri, N. B., Hansen, T. L., Desler, C., Anugula, S., & Rasmussen, L. J. (2019) · Biology · doi:10.3390/biology8020035 · Cited by 19

Targeting DNA Replication Stress and DNA Double-Strand Break Repair for Optimizing SCLC Treatment

Bian, X., & Lin, W. (2019) · Cancers · doi:10.3390/cancers11091289 · Cited by 17

The impact of transcription-mediated replication stress on genome instability and human disease

Gnan, S., Liu, Y., Spagnuolo, M., & Chen, C.-L. (2020) · Genome Instability & Disease · doi:10.1007/s42764-020-00021-y · Cited by 16

PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway

Shen, M. C., Young, A., & Autexier, C. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103055 · Cited by 21

Role of HOXC10 in Cancer

Fang, J., Wang, J., Yu, L., & Xu, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.684021 · Cited by 17

Genotoxic Damage During Brain Development Presages Prototypical Neurodegenerative Disease

Kisby, G. E., & Spencer, P. S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.752153 · Cited by 17

DNA Repair

Borgmann, K., Köcher, S., Kriegs, M., Mansour, W. Y., Parplys, A. C., Rieckmann, T., & Rothkamm, K. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-662-49651-0_1 · Cited by 18

Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks

Weinheimer, A. S., Paung, Y., Rageul, J., Khan, A., Lo, N., Ho, B., Tong, M., Alphonse, S., Seeliger, M. A., & Kim, H. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102268 · Cited by 17

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance

Llorca-Cardeñosa, M. J., Aronson, L. I., Krastev, D. B., Nieminuszczy, J., Alexander, J. J., Song, F., Dylewska, M., Broderick, R., Brough, R., Zimmermann, A., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-4339 · Cited by 18

The ATR–WEE1 kinase module promotes SUPPRESSOR OF GAMMA RESPONSE 1 translation to activate replication stress responses

Chen, H., Pan, T., Zheng, X., Huang, Y., Wu, C., Yang, T., Gao, S., Wang, L., & Yan, S. (2023) · The Plant Cell · doi:10.1093/plcell/koad126 · Cited by 20

Substitution of Cytosine with Guanylurea Decreases the Stability of i-Motif DNA

Wright, E. P., Lamparska-Kupsik, K., Smith, S. S., & Waller, Z. A. E. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00628 · Cited by 17

DNA Double Strand Break Repair - Related Synthetic Lethality

Toma, M. M., Skórski, T., & Śliwiński, T. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180201114306 · Cited by 17

The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response

Barone, G., Arora, A., Ganesh, A. N., Abdel-Fatah, T. M. A., Moseley, P. M., Ali, R., Chan, S. Y. T., Savva, C., Schiavone, K., Carmell, N., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25686 · Cited by 17

Drugging in the absence of p53

Aning, O. A., & Cheok, C. F. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz012 · Cited by 16

Prevention of unwanted recombination at damaged replication forks

Lehmann, C. P., Jiménez-Martín, A., Branzei, D., & Tercero, J. A. (2020) · Current Genetics · doi:10.1007/s00294-020-01095-7 · Cited by 19

Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy

Sirinian, C., Peroukidis, S., Kriegsmann, K., Chaniotis, D. I., Koutras, A. K., Kriegsmann, M., & Papanastasiou, A. D. (2022) · Genes · doi:10.3390/genes13060994 · Cited by 15

Chronic stress promotes tumor immune evasion via the suppression of MHC-I expression and the upregulation of PD-L1.

Chen, Y., Qian, Y., Huang, W., Zhang, Y., Wu, M., Cheng, Y., Yang, N., & Liu, Y. (2022) · PubMed Central · Cited by 16

"Bridging the DNA divide": Understanding the interplay between replication- gaps and homologous recombination proteins RAD51 and BRCA1/2

Ramírez-Otero, M. A., & Costanzo, V. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103738 · Cited by 17

Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure

Noto, A., Valenzisi, P., Feo, F. D., Fratini, F., Kulikowicz, T., Sommers, J. A., Perdichizzi, B., Semproni, M., Palermo, V., Crescenzi, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-55958-z · Cited by 17

MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR

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Genomic stability during cellular reprogramming: Mission impossible?

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Impediment of Replication Forks by Long Non-coding RNA Provokes Chromosomal Rearrangements by Error-Prone Restart

Watanabe, T., Marotta, M. L., Suzuki, R., Diede, S. J., Tapscott, S. J., Niida, A., Chen, X., Mouakkad, L., Kondratova, A. A., Giuliano, A. E., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.103 · Cited by 18

Posttranscriptional control of the replication stress response via TTP-mediated Claspin mRNA stabilization

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Histone dynamics during DNA replication stress

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Rtt105 promotes high-fidelity DNA replication and repair by regulating the single-stranded DNA-binding factor RPA

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Nuclear Lipid Droplet Birth during Replicative Stress

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DNA Damage-p53/P21 Response Contributes to Ependymal Cell Development

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EEPD1 promotes repair of oxidatively-stressed replication forks

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Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate

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Gene amplification during myogenic differentiation

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Single-Molecule Optical-Trapping Techniques to Study Molecular Mechanisms of a Replisome

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Metnase Mediates Loading of Exonuclease 1 onto Single Strand Overhang DNA for End Resection at Stalled Replication Forks

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Intraspecific and intraorganismal copy number dynamics of retrotransposons and tandem repeat in Aegilops speltoides Tausch (Poaceae, Triticeae)

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Recent insights into the causes and consequences of chromosome mis-segregation

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Complex Mechanisms of Antimony Genotoxicity in Budding Yeast Involves Replication and Topoisomerase I-Associated DNA Lesions, Telomere Dysfunction and Inhibition of DNA Repair

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Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast Cancer

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The Role of the AT-Rich Interaction Domain 1A Gene (ARID1A) in Human Carcinogenesis

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DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in LMNA-cardiomyopathy

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RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells

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G2 arrest primes hematopoietic stem cells for megakaryopoiesis

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Signaling at Stalled Replication Forks

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GENOME STABILITY MECHANISMS DURING REPLICATION STRESS AND DNA DAMAGE RESPONSE IN PROLIFERATING CELLS

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Stalled Replication Forks under Replication Stress: Cellular Responses, Repair Mechanisms and Therapeutic Implications

Wang, Y. (2026) · Theoretical and Natural Science · doi:10.54254/2753-8818/2026.36489

The Adaptive Mechanisms and Checkpoint Responses to a Stressed DNA Replication Fork

Saldanha, J., Rageul, J., Patel, J. A., & Kim, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310488 · Cited by 28

Signaling of DNA Replication Stress Through the ATR Checkpoint

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