Cited by 2,079DNA Repair MechanismsTelomeres, Telomerase, and SenescenceBacterial Genetics and Biotechnology

The DOI matches its Crossref record; 141 of the 142 references it cites were found in a registry or an index.

Causes and consequences of replication stress

Open access

Zeman, Michelle K., Cimprich, Karlene A.·2014·Nature Cell Biology

Open this paper in CoChat — free account

Abstract

Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this response may be key to diagnosing and treating human diseases caused by defective responses to replication stress.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/ncb2897

Cites

141 of 141 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693
Genomic instability — an evolving hallmark of cancer
Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2858 · Cited by 2,397
An Oncogene-Induced DNA Damage Model for Cancer Development
Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851
DNA Damage Sensing by the ATM and ATR Kinases
Marechal, A., & Zou, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012716 · Cited by 1,514
DNA secondary structures: stability and function of G-quadruplex structures
Bochman, M. L., Paeschke, K., & Zakian, V. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3296 · Cited by 1,485
Ciliopathies
Hildebrandt, F., Benzing, T., & Katsanis, N. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1010172 · Cited by 1,331
Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11
Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., & Jasin, M. (2011) · Cell · doi:10.1016/j.cell.2011.03.041 · Cited by 1,292

Flagged first, then by citations

Show all 142 references

1 of the 142 references couldn’t be matched to a known paper.

Sorted by citations

Items 401–500 of 1,001

Mild replication stress causes aneuploidy by deregulating microtubule dynamics in mitosis
Böhly, N., Kistner, M., & Bastians, H. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1658477 · Cited by 57
Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronized cell cycle progression in human cell culture
Trotter, E. W., & Hagan, I. (2020) · Open Biology · doi:10.1098/rsob.200200 · Cited by 47
Completing genome replication outside of S phase
Bhowmick, R., Hickson, I. D., & Liu, Y. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.08.023 · Cited by 53
Genome instability of ageing stem cells—Induction and defence mechanisms
Burkhalter, M. D., Rudolph, K. L., & Sperka, T. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.004 · Cited by 54
The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression
Chavez, D., Greer, B. H., & Eichman, B. F. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002905 · Cited by 53
High Basal Levels of γH2AX in Human Induced Pluripotent Stem Cells Are Linked to Replication-Associated DNA Damage and Repair
Vallabhaneni, H., Lynch, P. J., Chen, G., Park, K., Liu, Y., Goehe, R. W., Mallon, B. S., Boehm, M., & Hursh, D. A. (2018) · Stem Cells · doi:10.1002/stem.2861 · Cited by 55
Harnessing DNA Replication Stress for Novel Cancer Therapy
Zhu, H., Swami, U., Preet, R., & Zhang, J. (2020) · Genes · doi:10.3390/genes11090990 · Cited by 56
Multi-Omics Analysis Provides Novel Insight into Immuno-Physiological Pathways and Development of Thermal Resistance in Rainbow Trout Exposed to Acute Thermal Stress
Roh, H., Kim, A., Kim, N., Lee, Y., & Kim, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239198 · Cited by 54
Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions
Park, K., Ryoo, J., Jeong, H., Kim, M., Lee, S., Hwang, S.-Y., Ahn, J., Kim, D., Moon, H. C., Baek, D., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009523 · Cited by 54
miR-181a-regulated pathways in T-cell differentiation and aging
Kim, C., Ye, Z., Weyand, C. M., & Goronzy, J. J. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00240-1 · Cited by 55
Replication Stress Defines Distinct Molecular Subtypes Across Cancers
Takahashi, N., Kim, S. H., Schultz, C. W., Rajapakse, V. N., Zhang, Y., Redon, C. E., Fu, H., Pongor, L. S., Kumar, S., Pommier, Y. G., et al. (2021) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0168 · Cited by 64
Dormant Replication Origin Firing Links Replication Stress to Whole Chromosomal Instability in Human Cancer
Böhly, N., Schmidt, A.-K., Zhang, X., Slusarenko, B. O., Hennecke, M., Kschischo, M., & Bastians, H. (2021) · Cell Reports · doi:10.1016/j.celrep.2022.111836 · Cited by 51
Human CST abundance determines recovery from diverse forms of DNA damage and replication stress
Wang, F., Stewart, J. A., & Price, C. M. (2014) · Cell Cycle · doi:10.4161/15384101.2014.964100 · Cited by 52
Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells
Ly, T., Endo, A., & Lamond, A. I. (2015) · eLife · doi:10.7554/elife.04534 · Cited by 49
YAP controls retinal stem cell DNA replication timing and genomic stability
Cabochette, P., Vega‐López, G. A., Bitard, J., Parain, K., Chemouny, R., Masson, C., Borday, C., Hedderich, M., Henningfeld, K. A., Locker, M., et al. (2015) · eLife · doi:10.7554/elife.08488 · Cited by 52
TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres
Kibe, T., Zimmermann, M., & de Lange, T. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.004 · Cited by 52
Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders
Lu, L., Jin, W., & Wang, L. L. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.002 · Cited by 55
Endonuclease EEPD1 Is a Gatekeeper for Repair of Stressed Replication Forks
Kim, H.-S., Nickoloff, J. A., Wu, Y., Williamson, E. A., Sidhu, G. S., Reinert, B. L., Jaiswal, A. S., Srinivasan, G., Patel, B., Kong, K. Y., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.758235 · Cited by 51
Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis
Pauzaite, T., Thacker, U., Tollitt, J., & Copeland, N. A. (2016) · Biomolecules · doi:10.3390/biom7010001 · Cited by 52
ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells
Kim, D.-S., Liu, Y., Oberly, S., Freire, R., & Smolka, M. B. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky625 · Cited by 53
Impact of Replication Stress in Human Papillomavirus Pathogenesis
Moody, C. A. (2018) · Journal of Virology · doi:10.1128/jvi.01012-17 · Cited by 50
CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells
Rogers, R. F., Walton, M. I., Cherry, D. L., Collins, I., Clarke, P. A., Garrett, M. D., & Workman, P. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-1372 · Cited by 53
Genomic Instability in Multiple Myeloma
Alagpulinsa, D. A., Szalat, R. E., Poznansky, M. C., & Reis, R. J. S. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.05.006 · Cited by 53
Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma
Cissé, M. Y., Pyrdziak, S., Firmin, N., Gayte, L., Heuillet, M., Bellvert, F., Fuentes, M., Delpech, H., Riscal, R., Arena, G., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay2163 · Cited by 52
An mRNA expression-based signature for oncogene-induced replication-stress
Llobet, S. G., Bhattacharya, A., Everts, M., Kok, K., van der Vegt, B., Fehrmann, R. S. N., & van Vugt, M. A. T. M. (2022) · Oncogene · doi:10.1038/s41388-021-02162-0 · Cited by 50
Replication‐induced DNA secondary structures drive fork uncoupling and breakage
Williams, S. L., Casas-Delucchi, C. S., Raguseo, F., Guneri, D., Li, Y., Minamino, M., Fletcher, E. E., Yeeles, J. T. P., Keyser, U. F., Waller, Z. A. E., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2023114334 · Cited by 51
The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation
Houlihan, S. L., & Feng, Y. (2014) · eLife · doi:10.7554/elife.03297 · Cited by 49
RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress
Kanu, N., Zhang, T., Burrell, R. A., Chakraborty, A., Cronshaw, J. M., DaCosta, C., Gronroos, E. C., Pemberton, H. N., Anderton, E., Gonzalez, L., et al. (2015) · Oncogene · doi:10.1038/onc.2015.427 · Cited by 52
Profiling DNA damage response following mitotic perturbations
Pedersen, R. S., Karemore, G., Guðjόnsson, Þ., Rask, M., Neumann, B., Hèriché, J.-K., Pepperkok, R., Ellenberg, J., Gerlich, D. W., Lukas, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13887 · Cited by 49
A structure–function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance
Shemesh, K., Šebesta, M., Pačesa, M., Sau, S., Bronstein, A. M., Parnas, O., Liefshitz, B., Venclovas, Č., Krejčí, L., & Kupiec, M. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1348 · Cited by 51
Challenges to DNA replication in hypoxic conditions
Ng, N., Purshouse, K. R., Foskolou, I. P., Olcina, M. M., & Hammond, E. M. (2017) · FEBS Journal · doi:10.1111/febs.14377 · Cited by 55
An updated perspective on the polymerase division of labor during eukaryotic DNA replication
Guilliam, T. A., & Yeeles, J. T. P. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1811630 · Cited by 51
p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol
Carlsson, M. J., Vollmer, A. S., Demuth, P., Heylmann, D., Reich, D., Quarz, C., Rasenberger, B., Nikolova, T., Hofmann, T. G., Christmann, M., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05446-9 · Cited by 50
The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial
Giudice, E., Huang, T., Nair, J. R., Zurcher, G., McCoy, A., Nousome, D., Radke, M. R., Swisher, E. M., Lipkowitz, S., Ibanez, K. R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47215-6 · Cited by 51
Replication stalling and DNA microsatellite instability
Gadgil, R. Y., Barthelemy, J., Lewis, T., & Leffak, M. (2016) · Biophysical Chemistry · doi:10.1016/j.bpc.2016.11.007 · Cited by 52
CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition
Gadhikar, M. A., Zhang, J., Shen, L., Rao, X., Wang, J., Zhao, M., Kalu, N. N., Johnson, F. M., Byers, L. A., Heymach, J. V., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-2802 · Cited by 52
Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion
Elliott, I. A., Dann, A. M., Xu, S., Kim, S. S., Abt, E. R., Kim, W., Poddar, S., Moore, A. M., Zhou, L., Williams, J. L., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812410116 · Cited by 54
SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
Rageul, J., Park, J. J., Zeng, P. P., Lee, E., Yang, J., Hwang, S., Lo, N., Weinheimer, A. S., Schärer, O. D., Yeo, J.-E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19162-5 · Cited by 48
Signaling Pathways Regulated by UBR Box-Containing E3 Ligases
Kim, J. G., Shin, H., Seo, T., Nawale, L., Han, G., Kim, B. Y., Kim, S. J., & Cha‐Molstad, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158323 · Cited by 48
Beyond the Double-Strand Breaks: The Role of DNA Repair Proteins in Cancer Stem-Cell Regulation
Nathansen, J., Meyer, F., Müller, L., Schmitz, M., Borgmann, K., & Dubrovska, A. (2021) · Cancers · doi:10.3390/cancers13194818 · Cited by 51
The Mre11/Rad50/Nbs1 complex: Recent insights into catalytic activities and ATP-driven conformational changes
Paull, T. T., & Deshpande, R. A. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.07.007 · Cited by 54
Getting it done at the ends: Pif1 family DNA helicases and telomeres
Geronimo, C. L. A., & Zakian, V. A. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.021 · Cited by 47
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
Franz, A., Pirson, P. A., Pilger, D., Halder, S., Achuthankutty, D., Kashkar, H., Ramadan, K., & Hoppe, T. (2016) · Nature Communications · doi:10.1038/ncomms10612 · Cited by 50
Intratumor Heterogeneity: Novel Approaches for Resolving Genomic Architecture and Clonal Evolution
Gupta, R. G., & Somer, R. A. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0070 · Cited by 49
Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension
Bourgeois, A., Bonnet, S., Breuils‐Bonnet, S., Habbout, K., Paradis, R., Tremblay, È., Lampron, M.-C., Orcholski, M. E., Potus, F., Bertero, T., et al. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312537 · Cited by 48
A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
Guerra, S. L., Maertens, O., Kuzmickas, R., Raedt, T. D., Adeyemi, R. O., Guild, C. J., Guillemette, S., Redig, A. J., Chambers, E. S., Xu, M., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.03.004 · Cited by 49
A novel WEE1 pathway for replication stress responses
Pan, T., Qin, Q., Nong, C., Gao, S., Wang, L., Cai, B., Zhang, M., Wu, C., Chen, H., Li, T., et al. (2021) · Nature Plants · doi:10.1038/s41477-021-00855-8 · Cited by 46
Simultaneous electrochemical detection of guanine and adenine using reduced graphene oxide decorated with AuPt nanoclusters
Mao, B., Qian, L., Maduraiveeran, G., Liu, Z., & Chen, A. (2021) · Microchimica Acta · doi:10.1007/s00604-021-04926-7 · Cited by 49
Okazaki fragment maturation: DNA flap dynamics for cell proliferation and survival
Sun, H., Ma, L., Tsai, Y.-F., Abeywardana, T., Shen, B., & Zheng, L. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.06.014 · Cited by 48
Natural products targeting the ATR-CHK1 signaling pathway in cancer therapy
Ahmed, S., Alam, W., Aschner, M., Alsharif, K. F., Albrakati, A., Saso, L., & Khan, H. Z. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113797 · Cited by 51
DDX17 helicase promotes resolution of R-loop-mediated transcription–replication conflicts in human cells
Boleslavska, B., Oravetzova, A., Shukla, K., Naščáková, Z., Ibini, O., Hašanová, Z., Andrš, M., Kanagaraj, R., Dobrovolná, J., & Janščák, P. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac1116 · Cited by 50
Preclinical testing of an ATR inhibitor demonstrates improved response to standard therapies for esophageal cancer
Leszczyńska, K. B., Dobrynin, G., Leslie, R. E., Ient, J., Boumelha, A. J., Senra, J. M., Hawkins, M., Maughan, T., Mukherjee, S., & Hammond, E. M. (2016) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2016.10.023 · Cited by 48
Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities
Zafar, M. K., & Eoff, R. L. (2017) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.7b00157 · Cited by 49
Structural Basis for the Recruitment of Ctf18-RFC to the Replisome
Grabarczyk, D. B., Silkenat, S., & Kisker, C. (2017) · Structure · doi:10.1016/j.str.2017.11.004 · Cited by 48
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
Halder, S., Torrecilla, I., Burkhalter, M. D., Popović, M., Fielden, J., Vaz, B., Oehler, J., Pilger, D., Lessel, D., Wiseman, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11095-y · Cited by 47
Common Fragile Sites Are Characterized by Faulty Condensin Loading after Replication Stress
Boteva, L., Nozawa, R., Naughton, C., Samejima, K., Earnshaw, W. C., & Gilbert, N. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108177 · Cited by 54
Single-molecule mapping of replisome progression
Claussin, C., Vazquez, J., & Whitehouse, I. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.02.010 · Cited by 48
PARP inhibitor resistance in ovarian cancer: Underlying mechanisms and therapeutic approaches targeting the ATR/CHK1 pathway
Biegała, Ł., Gajek, A., Marczak, A., & Rogalska, A. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188633 · Cited by 50
The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1
Dhoonmoon, A., Nicolae, C. M., & Moldovan, G. (2022) · Nature Communications · doi:10.1038/s41467-022-32756-5 · Cited by 50
Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells
Wu, W., Barwacz, S. A., Bhowmick, R., Lundgaard, K., Dinis, M. M. G., Clausen, M., Kanemaki, M. T., & Liu, Y. (2023) · Nature Communications · doi:10.1038/s41467-023-35992-5 · Cited by 46
The effect of caffeine on cisplatin-induced apoptosis of lung cancer cells
Wang, G., Bhoopalan, V., Wang, D., Wang, L., & Xu, X. (2015) · Experimental Hematology and Oncology · doi:10.1186/2162-3619-4-5 · Cited by 47
The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study
Gutiérrez, B., Bellón, J. Á., Rivera, M., Molina, E., King, M., Marston, L., Torres‐González, F., Moreno‐Küstner, B., Moreno-Peral, P., Motrico, E., et al. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140097 · Cited by 49
Prolonged pemetrexed pretreatment augments persistence of cisplatin-induced DNA damage and eliminates resistant lung cancer stem-like cells associated with EMT
Tièche, C. C., Peng, R., Dorn, P., Froment, L., Schmid, R. A., & Marti, T. M. (2016) · BMC Cancer · doi:10.1186/s12885-016-2117-4 · Cited by 47
A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination
Dubois, J.-C., Yates, M., Gaudreau-Lapierre, A., Clément, G., Cappadocia, L., Gaudreau, L. R., Zou, L., & Maréchal, A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx571 · Cited by 50
Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates
Daigh, L. H., Liu, C., Chung, M., Cimprich, K. A., & Meyer, T. (2018) · Cell Systems · doi:10.1016/j.cels.2018.05.011 · Cited by 49
Self-citation
Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions
Wu, X., Kabalane, H., Kahli, M., Petryk, N., Laperrousaz, B., Jaszczyszyn, Y., Drillon, G., Nicolini, F., Pérot, G., Robert, A., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky797 · Cited by 45
On the Interplay of the DNA Replication Program and the Intra-S Phase Checkpoint Pathway
Ciardo, D., Goldar, A., & Marheineke, K. (2019) · Genes · doi:10.3390/genes10020094 · Cited by 47
The mTOR pathway: Implications for DNA replication
Lamm, N., Rogers, S., & Cesare, A. J. (2019) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2019.04.002 · Cited by 51
Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy
Nickoloff, J. A., Taylor, L., Sharma, N., & Kato, T. A. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2020.89 · Cited by 47
Histone deficiency and accelerated replication stress in T cell aging
Kim, C., Jin, J., Ye, Z., Jadhav, R. R., Gustafson, C. E., Hu, B., Cao, W., Tian, L., Weyand, C. M., & Goronzy, J. J. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143632 · Cited by 44
NCOA4 links iron bioavailability to DNA metabolism
Federico, G., Carrillo, F., Dapporto, F., Chiariello, M., Santoro, M. M., Bellelli, R., & Carlomagno, F. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111207 · Cited by 49
Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses
Shaikh, N., Mazzagatti, A., Angelis, S. D., Johnson, S. C., Bakker, B., Spierings, D. C. J., Wardenaar, R., Maniati, E., Wang, J., Boemo, M. A., et al. (2022) · Genome biology · doi:10.1186/s13059-022-02781-0 · Cited by 47
Resveratrol stimulates the metabolic reprogramming of human CD4 + T cells to enhance effector function
Craveiro, M., Cretenet, G., Mongellaz, C., Matias, M. I., Caron, O., de Lima, M. C. P., Zimmermann, V. S., Solary, É., Dardalhon, V., Dulić, V., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aal3024 · Cited by 48
Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome
Srivastava, M., Chen, Z., Zhang, H., Tang, M., Wang, C., Jung, S. Y., & Chen, J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.099 · Cited by 47
ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response
Saxena, S., Dixit, S., Somyajit, K., & Nagaraju, G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.008 · Cited by 51
Targeting the DNA Damage Response for the Treatment of High Risk Neuroblastoma
Southgate, H. E. D., Chen, L., Curtin, N. J., & Tweddle, D. A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00371 · Cited by 48
Genome (in)stability at tandem repeats
Balzano, E., Pelliccia, F., & Giunta, S. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.10.003 · Cited by 50
The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
Xu, X., Ni, K., He, Y., Ren, J., Sun, C., Liu, Y., Aladjem, M. I., Burkett, S. S., Finney, R., Ding, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23809-2 · Cited by 42
EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart
Hambarde, S., Tsai, C.-L., PANDITA, R. K., Bacolla, A., Maitra, A., Charaka, V., Hunt, C. R., Kumar, R., Limbo, O., Meur, R. A. L., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.05.027 · Cited by 46
ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms
Leung, W., Simoneau, A., Saxena, S., Jackson, J., Patel, P. S., Limbu, M., Vindigni, A., & Zou, L. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112792 · Cited by 45
RecQ helicases and PARP1 team up in maintaining genome integrity
Veith, S., & Mangerich, A. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.12.006 · Cited by 44
Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1
Piekna‐Przybylska, D., Gaurav Sharma, A., Maggirwar, S. B., & Bambara, R. A. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1312225 · Cited by 47
Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase
Fordham, S. E., Blair, H. J., Elstob, C. J., Plummer, R., Drew, Y., Curtin, N. J., Heidenreich, O. T., Pal, D., Jamieson, D., Park, C., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2017015214 · Cited by 45
Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination–Proficient Pancreatic Cancer
Parsels, L. A., Engelke, C. G., Parsels, J. D., Flanagan, S. A., Zhang, Q., Tanska, D. M., Wahl, D. R., Canman, C. E., Lawrence, T. S., & Morgan, M. A. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0365 · Cited by 46
A basal-level activity of ATR links replication fork surveillance and stress response
Yin, Y., Lee, W. T. C., Gupta, D., Xue, H., Tonzi, P., Borowiec, J. A., Huang, T. T., Modesti, M., & Rothenberg, E. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.08.009 · Cited by 45
Roles of ATM and ATR in DNA double strand breaks and replication stress
Williams, R. M., & Zhang, X. (2020) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2020.11.005 · Cited by 46
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages
Chakraborty, S., Schirmeisen, K., & Lambert, S. (2023) · DNA repair · doi:10.1016/j.dnarep.2023.103548 · Cited by 44
Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7
Katoh, M., Nomura, S., Yamada, S., Ito, M., Hayashi, H., Katagiri, M., Heryed, T., Fujiwara, T., Takeda, N., Nishida, M., et al. (2024) · Circulation · doi:10.1161/circulationaha.123.064719 · Cited by 45
Double-strand break repair on sex chromosomes: challenges during male meiotic prophase
Lu, L., & Yu, X. (2015) · Cell Cycle · doi:10.1080/15384101.2014.998070 · Cited by 48
Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease
Lu, D., Rauhauser, A. A., Li, B., Ren, C., McEnery, K., Zhu, J., Chaki, M., Vadnagara, K., El-Hadi, S., Jetten, A. M., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.03.006 · Cited by 47
ATR-mediated regulation of nuclear and cellular plasticity
Kidiyoor, G. R., Kumar, A., & Foiani, M. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.020 · Cited by 45
Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication
Singh, S., Vaughan, C. A., Frum, R. A., Grossman, S. R., Deb, S., & Deb, S. P. (2017) · Journal of Clinical Investigation · doi:10.1172/jci87724 · Cited by 45
Formation of γH2AX and pATM Foci in Human Mesenchymal Stem Cells Exposed to Low Dose-Rate Gamma-Radiation
Ul’yanenko, S. E., Pustovalova, M. V., Koryakin, S. N., Beketov, E. E., Лычагин, А. А., Ulyanenko, L. N., Каприн, А. Д., Grekhova, A., Ozerova, A. M., Ozerov, I. V., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112645 · Cited by 44
Human CtIP: A ‘double agent’ in DNA repair and tumorigenesis
Mozaffari, N. L., Pagliarulo, F., & Sartori, A. A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.09.001 · Cited by 45
Hypoxia-induced SETX links replication stress with the unfolded protein response
Ramachandran, S., Ma, T. S., Griffin, J., Ng, N., Foskolou, I. P., Hwang, M., Victori, P., Cheng, W., Buffa, F. M., Leszczyńska, K. B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24066-z · Cited by 42
One‐Step Enzymatic Labeling Reveals a Critical Role of O‐GlcNAcylation in Cell‐Cycle Progression and DNA Damage Response
Tian, Y., Zhu, Q., Sun, Z., Geng, D., Lin, B., Su, X., He, J., Guo, M., Xu, H., Zhao, Y., et al. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202110053 · Cited by 42
Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway
Majera, D., Skrott, Z., Chroma, K., Merchut-Maya, J. M., Mistrik, M., & Bartek, J. (2020) · Cells · doi:10.3390/cells9020469 · Cited by 43
Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial
Abel, M. L., Takahashi, N., Peer, C. J., Redon, C. E., Nichols, S., Vilimas, R. J., Lee, M.-J., Lee, S., Shelat, M., Kattappuram, R., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0536 · Cited by 43
Fork coupling directs DNA replication elongation and termination
Liu, Y., Zhangding, Z., Liu, X., Gan, T., Chen, A., Wu, J., Liang, H., Chen, M., Guo, Y., Lu, R., et al. (2024) · Science · doi:10.1126/science.adj7606 · Cited by 44
Senataxin controls meiotic silencing through ATR activation and chromatin remodeling
Yeo, A. J., Bécherel, O. J., Luff, J., Graham, M. E., Richard, D. J., & Lavin, M. F. (2015) · Cell Discovery · doi:10.1038/celldisc.2015.25 · Cited by 37

Authors: Zeman, M. K., & Cimprich, K. A.
Affiliations: Stanford Medicine (US)
Corresponding author: Cimprich, Karlene A.
ORCID: Cimprich, Karlene A.
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2013-12-24
Volume: 16
Issue: 1
Pages: 2-9
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb2897
PMC: PMC4354890
OpenAlex: W2040860750
Cited by: 2,079
References: 142
Citations by year: 2026: 158 · 2025: 182 · 2024: 173 · 2023: 197 · 2022: 190 · 2021: 233 · 2020: 209 · 2019: 162 · 2018: 147 · 2017: 150 · 2016: 137 · 2015: 103 · 2014: 37
FWCI: 8.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM100489)
National Institute of Environmental Health Sciences (R01ES016486)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: replication stress, genomic instability, ATR kinase, replication stress response, replication fork restart, single-stranded DNA, DNA damage response, cell survival, DNA replication defects, human disease
MeSH terms: Disease, DNA Replication, Eukaryotic Cells, Humans, Models, Biological, Stress, Physiological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Causes and consequences of replication stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks