mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Herranz, Nicolás, Gallage, Suchira, Mellone, Massimiliano, Wuestefeld, Torsten, Klotz, Sabrina, Hanley, Christopher J., Raguz, Selina, Acosta, Juan Carlos +17 more·2015·Nature Cell Biology
DOI 10.1038/ncb3225
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- Targeting Senescent Cells for a Healthier Aging: Challenges and OpportunitiesSong, Shuling, Tchkonia, Tamara, Jiang, Jing, Kirkland, James L., Sun, Yu · 2020 · Advanced Science
- Calcium signaling and cellular senescenceNadine Martin, David Bernard · 2017 · Cell Calcium
- The Fountain of Youth by Targeting Senescent Cells?de Keizer, Peter L.J. · 2017 · Trends in Molecular Medicine
- Targeting senescent cells: approaches, opportunities, challengesCayetano von Kobbe · 2019 · Aging
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- Chronic inflammation and sarcopenia: A regenerative cell therapy perspectiveJagadish Kumar Chhetri, Philipe de Souto Barreto, Bertrand Fougère, Yves Rolland, Bruno J. Vellas, Matteo Cesari · 2018 · Experimental Gerontology
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- Molecular Mechanisms Contributing to Mesenchymal Stromal Cell AgingSimona Neri, Rosa Maria Borzı̀ · 2020 · Biomolecules
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- Oncogene-induced senescence: From biology to therapyZhu, Haoran, Blake, Shaun, Kusuma, Frances K, Pearson, Richard B, Kang, Jian, Chan, Keefe T · 2020 · Mechanisms of Ageing and Development
- Cellular senescence: a promising strategy for cancer therapySeongju Lee, Jae‐Seon Lee · 2019 · BMB Reports
- The landscape of human tissue and cell type specific expression and co-regulation of senescence genesXu, Peng, Wang, Minghui, Song, Won-min, Wang, Qian, Yuan, Guo-Cheng, Sudmant, Peter H., Zare, Habil, Tu, Zhidong, Orr, Miranda E., Zhang, Bin · 2022 · Molecular Neurodegeneration
- Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosisMellone, Massimiliano, Hanley, Christopher J., Thirdborough, Steve, Mellows, Toby, Garcia, Edwin, Woo, Jeongmin, Tod, Joanne, Frampton, Steve, Jenei, Veronika, Moutasim, Karwan A. et al. · 2016 · Aging
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- Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging ResearchAssylzhan Yessenkyzy, Timur M. Saliev, Marina Zhanaliyeva, Abdul‐Razak Masoud, Bauyrzhan A. Umbayev, Shynggys Sergazy, Елена Алексеевна Кривых, Alexander Gulyayev, Talgat S. Nurgozhin · 2020 · Nutrients
- Expansion and Cell-Cycle Arrest: Common Denominators of Cellular SenescenceOgrodnik, Mikolaj, Salmonowicz, Hanna, Jurk, Diana, Passos, João F. · 2019 · Trends in Biochemical Sciences
- Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapiesMariantonietta D’Ambrosio, Jesús Gil · 2023 · Developmental Cell
- To clear, or not to clear (senescent cells)? That is the questionLujambio, Amaia · 2016 · BioEssays
- Cellular senescence, DNA damage, and neuroinflammation in the aging brainWenyan Zhang, Hong‐Shuo Sun, Xiaoying Wang, Aaron S. Dumont, Qiang Liu · 2024 · Trends in Neurosciences
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- Targeting senescence as an anticancer therapyLaura Bousset, Jesús Gil · 2022 · Molecular Oncology
- Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor GrowthXiangnan Guan, Kyle M. LaPak, Rebecca C. Hennessey, Christina Y. Yu, Reena Shakya, Jianying Zhang, Christin Elizabeth Burd · 2016 · Molecular Cancer Research
- Targeting senescent cells for a healthier longevity: the roadmap for an era of global agingSun, Yu, Li, Qingfeng, Kirkland, James L · 2022 · Life Medicine
- A Network Module for the Perseus Software for Computational Proteomics Facilitates Proteome Interaction Graph AnalysisJan Daniel Rudolph, Jürgen Cox · 2019 · Journal of Proteome Research
- Evidence and perspectives of cell senescence in neurodegenerative diseasesSi, Zizhen, Sun, Linlin, Wang, Xidi · 2021 · Biomedicine & Pharmacotherapy
- Caloric restriction and cellular senescenceFontana, Luigi, Nehme, Jamil, Demaria, Marco · 2018 · Mechanisms of Ageing and Development
- Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic StrategiesJie Xu, Lili Zhou, Youhua Liu · 2020 · Frontiers in Pharmacology
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- Cellular senescence and its role in white adipose tissueUlf Smith, Qian Li, Mikael Rydén, Kirsty L. Spalding · 2021 · International Journal of Obesity
- The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulationMurali Palangat, Dimitrios G. Anastasakis, Dennis Liang Fei, Katherine E. Lindblad, Robert K. Bradley, Christopher Simon Hourigan, Markus Hafner, Daniel R. Larson · 2019 · Genes & Development
- Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneityGuillon, Jordan, Petit, Coralie, Toutain, Bertrand, Guette, Catherine, Lelièvre, Eric, Coqueret, Olivier · 2019 · Cell Cycle
- Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritisZichang Liu, Yu Zhuang, Lianfei Fang, Changyong Yuan, Xudong Wang, Kaili Lin · 2022 · Bioactive Materials
- Emerging role of aging in the progression of NAFLD to HCCYongyuan He, Yinghong Su, Chengcheng Duan, Siyuan Wang, Wei Guo He, Yingting Zhang, Xiaofei An, Ming He · 2022 · Ageing Research Reviews
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- Tumor microenvironment and cellular senescence: Understanding therapeutic resistance and harnessing strategiesHanxin Liu, Huifang Zhao, Yu Sun · 2021 · Seminars in Cancer Biology
- Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cellsYoukun Bi, Xinlong Qiao, Zhaokui Cai, Hailian Zhao, Rong Ye, Qun Liu, Linbo Gao, Yingqi Liu, Bo Liang, Yixuan Liu et al. · 2025 · Cell Metabolism
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- Cellular senescence in cancer: clinical detection and prognostic implicationsDomen, Andreas, Deben, Christophe, Verswyvel, Jasper, Flieswasser, Tal, Prenen, Hans, Peeters, Marc, Lardon, Filip, Wouters, An · 2022 · Journal of Experimental & Clinical Cancer Research
- Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cellsVanessa López-Polo, Máté Maus, Emmanouil Zacharioudakis, Miguel Lafarga, Camille Stephan‐Otto Attolini, Francisco Madeira Marques, Marta Kovatcheva, Evripidis Gavathiotis, Manuel Serrano · 2024 · Nature Communications
- Hsp90 inhibitors as senolytic drugs to extend healthy agingFuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D. · 2018 · Cell Cycle
- Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitorsMeharena, Hiruy S., Marco, Asaf, Dileep, Vishnu, Lockshin, Elana R., Akatsu, Grace Y., Mullahoo, James, Watson, L. Ashley, Ko, Tak, Guerin, Lindsey N., Abdurrob, Fatema et al. · 2022 · Cell Stem Cell
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- Dissecting primary and secondary senescence to enable new senotherapeutic strategiesTesfahun Dessale Admasu, Michael J. Rae, Alexandra Stolzing · 2021 · Ageing Research Reviews
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- Cancer secretome and inflammation: The bright and the dark sides of NF-κBDaria Capece, Daniela Verzella, Alessandra Tessitore, Edoardo Alesse, Carlo Capalbo, Francesca Zazzeroni · 2017 · Seminars in Cell and Developmental Biology
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- ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent mannerFat‐Moon Suk, Chi‐Ching Chang, Ren-Jye Lin, Shyr‐Yi Lin, Shih-Chen Liu, Chia-Feng Jau, Yu‐Chih Liang · 2018 · Scientific Reports
- Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repairYehezqel Elyahu, Alon Monsonego · 2020 · Ageing Research Reviews
- The redox-senescence axis and its therapeutic targetingNatalie Y.L. Ngoi, Angeline Qiu Xia Liew, Stephen Jun Fei Chong, Matthew Steven Davids, Marie‐Véronique Clement, Shazib Pervaiz · 2021 · Redox Biology
- mTOR Activity and Autophagy in Senescent Cells, a Complex PartnershipÁngel Cayo, Raúl Segovia, Whitney Venturini, Rodrigo Moore‐Carrasco, Claudio A. Valenzuela, Nelson E. Brown · 2021 · International Journal of Molecular Sciences
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- Cellular senescence: Implications for metabolic diseaseMarissa J. Schafer, Jordan D. Miller, Nathan K. LeBrasseur · 2016 · Molecular and Cellular Endocrinology
- The molecular basis of mTORC1-regulated translationCarson C. Thoreen · 2017 · Biochemical Society Transactions
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