The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,965
Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., & Riccardi, C. (1991) · Journal of Immunological Methods · doi:10.1016/0022-1759(91)90198-o · Cited by 4,579
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116 · cited 1×
“FKBP12, the best-characterized member of the FKBP family of immunophilins, interacts with calcineurin only in the presence of FK506 (ref”
BackgroundBcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Hockenbery, D., Nuñez, G., Milliman, C., Schreiber, R. D., & Korsmeyer, S. J. (1990) · Nature · doi:10.1038/348334a0 · Cited by 3,720
Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81589-5 · Cited by 3,626
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Hockenbery, D. M., Oltvai, Z. N., Yin, X.-M., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,419
Mitochondrial control of cell death
Kroemer, G., & Reed, J. C. (2000) · Nature Medicine · doi:10.1038/74994 · Cited by 3,103
Zha, J., Harada, H., Yang, E., Jockel, J., & Korsmeyer, S. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81382-3 · Cited by 2,595
Shimizu, S., Narita, M., Tsujimoto, Y., & Tsujimoto, Y. (1999) · Nature · doi:10.1038/20959 · Cited by 2,178
Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
Yang, E., Zha, J., Jockel, J., Boise, L. H., Thompson, C. B., & Korsmeyer, S. J. (1995) · Cell · doi:10.1016/0092-8674(95)90411-5 · Cited by 2,100
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
Wolter, K. G., Hsu, Y.-T., Smith, C. L., Nechushtan, A., Xi, X.-G., & Youle, R. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.5.1281 · Cited by 1,806
Crabtree, G. R., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00699-2 · Cited by 1,323
The tetratricopeptide repeat: a structural motif mediating protein-protein interactions
Blatch, G. L., & Lässle, M. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199911)21:11<932::aid-bies5>3.0.co;2-n · Cited by 1,211
Ca 2+ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD
Wang, H.-G., Pathan, N., Ethell, I. M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Bobo, T., Franke, T. F., & Reed, J. C. (1999) · Science · doi:10.1126/science.284.5412.339 · Cited by 1,132
Puthalakath, H., Huang, D. C. S., O’Reilly, L. A., King, S. M., & Strasser, A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80456-6 · Cited by 1,054
Krajewski, S., Tanaka, S., Takayama, S., Schibler, M. J., Fenton, W. A., & Reed, J. C. (1993) · PubMed · Cited by 1,030
Inhibition of Bax Channel-Forming Activity by Bcl-2
Antonsson, B., Conti, F., Ciavatta, A., Montessuit, S., Lewis, S., Martinou, I., Bernasconi, L., Bernard, A., Mermod, J.-J., Mazzei, G., et al. (1997) · Science · doi:10.1126/science.277.5324.370 · Cited by 1,028
Green, D. R. (2000) · Cell · doi:10.1016/s0092-8674(00)00003-9 · Cited by 1,008
X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
Griffith, J. P., Kim, J. L., Kim, E. E., Sintchak, M. D., Thomson, J. A., Fitzgibbon, M. J., Fleming, M. A., Caron, P. R., Hsiao, K., & Navia, M. A. (1995) · Cell · doi:10.1016/0092-8674(95)90439-5 · Cited by 834
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
Brillantes, A.-M. B., Ondrias, K., Scott, A., Kobrinsky, E., Ondriašová, E., Moschella, M. C., Jayaraman, T., Landers, M., Ehrlich, B. E., & Marks, A. R. (1994) · Cell · doi:10.1016/0092-8674(94)90214-3 · Cited by 827
Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex
Kissinger, C. R., Parge, H. E., Knighton, D. R., Lewis, C. T., Pelletier, L. A., Tempczyk, A., Kalish, V. J., Tucker, K. D., Showalter, R. E., Moomaw, E. W., et al. (1995) · Nature · doi:10.1038/378641a0 · Cited by 762
Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?
Vander Heiden, M. G., & Thompson, C. B. (1999) · Nature Cell Biology · doi:10.1038/70237 · Cited by 659
Cameron, A. M., Steiner, J. P., Roskams, A. J., Ali, S. M., Ronnettt, G. V., & Snyder, S. H. (1995) · Cell · doi:10.1016/0092-8674(95)90124-8 · Cited by 476
Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition
Sussman, M. A., Lim, H. W., Gude, N., Taigen, T., Olson, E. N., Robbins, J., Colbert, M. C., Gualberto, A., Wieczorek, D. F., & Molkentin, J. D. (1998) · Science · doi:10.1126/science.281.5383.1690 · Cited by 461
Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia
Sharkey, J., & Butcher, S. P. (1994) · Nature · doi:10.1038/371336a0 · Cited by 455
Calcium, Calcineurin, and the Control of Transcription
Crabtree, G. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r000024200 · Cited by 440
González-García, M., Pérez-Ballestero, R., Ding, L., Duan, L., Boise, L. H., Thompson, C. B., & Núñez, G. (1994) · Development · doi:10.1242/dev.120.10.3033 · Cited by 433
Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice
Nakayama, K.-I., Nakayama, K., Negishi, I., Kuida, K., Shinkai, Y., Louie, M. C., Fields, L. E., Lucas, P. J., Stewart, V., Alt, F. W., et al. (1993) · Science · doi:10.1126/science.8372353 · Cited by 397
Self-citationNakayama, K., Nakayama, K., Negishi, I., Kuida, K., Sawa, H., & Loh, D. Y. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3700 · Cited by 395
Self-citationTargeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.
Nguyen, M., Millar, D. G., Yong, V. W., Korsmeyer, S. J., & Shore, G. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74386-5 · Cited by 393
Shibasaki, F., Kondo, E., Akagi, T., & McKeon, F. (1997) · Nature · doi:10.1038/386728a0 · Cited by 364
Immunosuppressive drugs: the first 50 years and a glance forward
Allison, A. C. (2000) · Immunopharmacology · doi:10.1016/s0162-3109(00)00186-7 · Cited by 350
Specific Interaction of Type I Receptors of the TGF-β Family with the Immunophilin FKBP-12
Wang, T., Donahoe, P. K., & Zervos, A. S. (1994) · Science · doi:10.1126/science.7518616 · Cited by 331
Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.
Lyons, W. E., George, E. B., Dawson, T. M., Steiner, J. P., & Snyder, S. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3191 · Cited by 285
Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.
Shibasaki, F., & McKeon, F. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.3.735 · Cited by 252
Galigniana, M. D., Radanyi, C., Renoir, J.-M., Housley, P. R., & Pratt, W. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010809200 · Cited by 236 · cited 1×
“FKBP52 links the glucocorticoid receptor to dynein, a motor protein that mediates the retrograde transport of vesicles along microtubules towards the nucleu”
BackgroundCalcineurin and mitochondrial function in glutamate‐induced neuronal cell death
Ankarcrona, M., Dypbukt, J. M., Orrenius, S., & Nicotera, P. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00959-3 · Cited by 230
Mitochondria-the suicide organelles
Ferri, K. F., & Kroemer, G. (2001) · BioEssays · doi:10.1002/1521-1878(200102)23:2<111::aid-bies1016>3.0.co;2-y · Cited by 198
Tanaka, S., Saito, K., & Reed, J. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82073-7 · Cited by 190
Schiene-Fischer, C., & Yu, C. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02326-2 · Cited by 182
Immunophilins: Beyond Immunosuppression
Hamilton, G. S., & Steiner, J. P. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm980307x · Cited by 178
Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells.
Alnemri, E. S., Robertson, N. M., Fernandes, T. F., Croce, C. M., & Litwack, G. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7295 · Cited by 167
Horie, C., Suzuki, H., Sakaguchi, M., & Mihara, K. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-12-0570 · Cited by 154
Common Pathway for the Ubiquitination of IκBα, IκBβ, and IκBε Mediated by the F-Box Protein FWD1
Shirane, M., Hatakeyama, S., Hattori, K., Nakayama, K., & Nakayama, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28169 · Cited by 87
Self-citationLam, E., Martin, M. M., & Wiederrecht, G. (1995) · Gene · doi:10.1016/0378-1119(95)00216-s · Cited by 78
Serine/threonine phosphatases in the nervous system
Stemmer, P. M., & Klee, C. B. (1991) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(91)90010-5 · Cited by 67
Regulation of tumor necrosis factor cytotoxicity by calcineurin
Kantrow, S. P., Gierman, J. L., Jaligam, V. R., Zhang, P., Piantadosi, C. A., Summer, W. R., & Lancaster, J. R. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02083-4 · Cited by 27
Cited by
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis
Wang, X., Venable, J., LaPointe, P., Hutt, D. M., Koulov, A. V., Coppinger, J., Gurkan, C., Kellner, W., Matteson, J., Plutner, H., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.043 · Cited by 601
Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis
Kim, H., Tu, H.-C., Ren, D., Takeuchi, O., Jeffers, J. R., Zambetti, G. P., Hsieh, J. J.-D., & Cheng, E. H.-Y. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.030 · Cited by 600
FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy
Bhujabal, Z., Birgisdottir, Å. B., Sjøttem, E., Brenne, H. B., Øvervatn, A., Habisov, S., Kirkin, V., Lamark, T., & Johansen, T. (2017) · EMBO reports · doi:10.15252/embr.201643147 · Cited by 417
Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38
Bai, X., Ma, D., Liu, A., Shen, X., Wang, Q. J., Liu, Y., & Jiang, Y. (2007) · Science · doi:10.1126/science.1147379 · Cited by 382
Metadata
- Authors
- Shirane, M., & Nakayama, K. I.
- Venue
- Nature Cell Biology
- Published
- 2002-12-23
- Volume
- 5
- Issue
- 1
- Pages
- 28-37
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2063839793
- Cited by
- 318
- References
- 48
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.