The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
Abstract
Nitrite represents a bioactive reservoir of nitric oxide (NO) that may modulate vasodilation, respiration and cytoprotection after ischemia-reperfusion injury. Although nitrite formation is thought to occur via reaction of NO with oxygen, this third-order reaction cannot compete kinetically with the reaction of NO with hemoglobin to form nitrate. Indeed, the formation of nitrite from NO in the blood is limited when plasma is substituted with physiological buffers, which suggests that plasma contains metal-based enzymatic pathways for nitrite synthesis. We therefore hypothesized that the multicopper oxidase, ceruloplasmin, could oxidize NO to NO+, with subsequent hydration to nitrite. Accordingly, plasma NO oxidase activity was decreased after ceruloplasmin immunodepletion, in ceruloplasmin knockout mice and in people with congenital aceruloplasminemia. Compared to controls, plasma nitrite concentrations were substantially reduced in ceruloplasmin knockout mice, which were more susceptible to liver infarction after ischemia and reperfusion. The extent of hepatocellular infarction normalized after nitrite repletion. These data suggest new functions for the multicopper oxidases in endocrine NO homeostasis and nitrite synthesis, and they support the hypothesis that physiological concentrations of nitrite contribute to hypoxic signaling and cytoprotection.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It has been shown that low levels (pM/nM) are physiological and related to the activation of high affinity primary binding targets such as soluble guanylyl cyclase (sGC) and cytochrome c oxidase”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [863]
In the citing paper
“The nitrite level in cardiac tissue is a couple of times higher than that in plasma due to an unknown form of active transport from blood to tissues or due to the oxidation of endogenously generated-NO to nitrite by ceruloplasmin [96], and serves as a significant extravascular pool for NO during tissue hypoxia [97].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [96]
In the citing paper
“This concept is confirmed in mice deficient for ceruloplasmin that showed lower basal concentrations of plasma nitrite and less plasma nitrite elevation upon NO administration [78].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [78]
In the citing paper
“It was also shown that the addition of NO to blood generates significant concentrations of plasma nitrite that involved copper oxidation, which was found to be ceruloplasmin dependent NO oxidation [78, 79].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [78]
Citations
Cites
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Self-citationC ERULOPLASMIN M ETABOLISM AND F UNCTION
Hellman, N. E., & Gitlin, J. D. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.012502.114457 · Cited by 954
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788
The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum.
Osaki, S., Johnson, D. A., & Frieden, E. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96527-0 · Cited by 679
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · cited 1×
“In tissues, near-physiological concentrations of nitrite (”
Self-citationThe emerging biology of the nitrite anion
Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio1105-308 · Cited by 609
Self-citationWebb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · cited 1×
“In tissues, near-physiological concentrations of nitrite (”
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Gödecke, A., Schrader, J., Schulz, R., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00406-4 · Cited by 586
Aceruloplasminemia: molecular characterization of this disorder of iron metabolism.
Harris, Z. L., Takahashi, Y., Miyajima, H., Serizawa, M., MacGillivray, R. T., & Gitlin, J. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2539 · Cited by 558 · cited 1×
“Ceruloplasmin has ferroxidase activity that is responsible for the oxidation of ferrous iron to its ferric form, which is necessary for efficient iron efflux from the cel”
BackgroundSelf-citationEnzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520
Flagged first, then by citations
Cited by
Sorted by citations
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739
Self-citationDiagnosis and treatment of Wilson disease: An update
Roberts, E. A., & Schilsky, M. L. (2008) · Hepatology · doi:10.1002/hep.22261 · Cited by 1,304
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
Paulsen, C. E., & Carroll, K. S. (2013) · Chemical Reviews · doi:10.1021/cr300163e · Cited by 1,313
Food sources of nitrates and nitrites: The physiologic context for potential health benefits
Hord, N. G., Tang, Y., & Bryan, N. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27131 · Cited by 1,069
Methods to detect nitric oxide and its metabolites in biological samples
Bryan, N. S., & Grisham, M. B. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.04.026 · Cited by 1,005
Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599
Self-citationShiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555
Self-citationSources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Self-citationNitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435
Self-citationLi, Z., Wang, Y., Wang, J., Tang, Z., Pounds, J. G., & Lin, Y. (2010) · Analytical Chemistry · doi:10.1021/ac101405a · Cited by 426
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401
Cortese-Krott, M. M., Koning, A. M., Kuhnle, G., Nagy, P., Bianco, C. L., Pasch, A., Wink, D. A., Fukuto, J. M., Jackson, A. A., van Goor, H., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7083 · Cited by 371
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
Jansson, E. Å., Huang, L., Malkey, R., Govoni, M., Nihlén, C., Olsson, A., Stensdotter, M., Petersson, J., Holm, L., Weitzberg, E., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.92 · Cited by 356
Dejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712133 · Cited by 334
Self-citationCeruloplasmin and other copper binding components of blood plasma and their functions: an update
Linder, M. C. (2016) · Metallomics · doi:10.1039/c6mt00103c · Cited by 327
The functional nitrite reductase activity of the heme-globins
Gladwin, M. T., & Kim-Shapiro, D. B. (2008) · Blood · doi:10.1182/blood-2008-01-115261 · Cited by 293
Self-citationConnecting the Chemical and Biological Properties of Nitric Oxide
Toledo, J. C., & Augusto, O. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300042g · Cited by 294
Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling
Smith, B. C., & Marletta, M. A. (2012) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2012.10.016 · Cited by 279
The chemical biology of S-nitrosothiols
Broniowska, K. A., & Hogg, N. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4590 · Cited by 259
Self-citationKapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248
Measurement of circulating nitrite and S-nitrosothiols by reductive chemiluminescence
MacArthur, P. H., Shiva, S., & Gladwin, M. T. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.12.012 · Cited by 235
Self-citationSerum copper to zinc ratio: Relationship with aging and health status
Malavolta, M., Piacenza, F., Basso, A., Giacconi, R., Costarelli, L., & Mocchegiani, E. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.01.004 · Cited by 230
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin
Basu, S., Grubina, R., Huang, J., Conradie, J., Huang, Z., Jeffers, A., Jiang, A., He, X., Azarov, I., Seibert, R., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.46 · Cited by 224
Self-citationLang, J. D., Teng, X., Chumley, P., Crawford, J. H., Isbell, T. S., Chacko, B. K., Liu, Y., Jhala, N., Crowe, D. R., Smith, A. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31892 · Cited by 224
Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function
Shiva, S. (2013) · Redox Biology · doi:10.1016/j.redox.2012.11.005 · Cited by 207
Self-citationFélétou, M. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00031ed1v01y201105isp019 · Cited by 224
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
DEZFULIAN, C., RAAT, N., SHIVA, S., & GLADWIN, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.001 · Cited by 198
Self-citationEndothelial nitric oxide synthase in red blood cells: Key to a new erythrocrine function?
Cortese-Krott, M. M., & Kelm, M. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.027 · Cited by 186
Dezfulian, C., Shiva, S., Alekseyenko, A., Pendyal, A., Beiser, D. G., Munasinghe, J. P., Anderson, S. A., Chesley, C. F., Vanden Hoek, T. L., & Gladwin, M. T. (2009) · Circulation · doi:10.1161/circulationaha.109.853267 · Cited by 174
Self-citationTherapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases
Omar, S. A., Webb, A. J., Lundberg, J. O., & Weitzberg, E. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12441 · Cited by 175
Stokes, K. Y., Dugas, T. R., Tang, Y., Garg, H., Guidry, E., & Bryan, N. S. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01291.2008 · Cited by 171
Nitric oxide: Orchestrator of endothelium-dependent responses
Félétou, M., Köhler, R., & Vanhoutte, P. M. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.585658 · Cited by 169
Regulating oxygen activity of perovskites to promote NOx oxidation and reduction kinetics
Hwang, J., Rao, R. R., Giordano, L., Akkiraju, K., Wang, X. R., Crumlin, E. J., Bluhm, H., & Shao‐Horn, Y. (2021) · Nature Catalysis · doi:10.1038/s41929-021-00656-4 · Cited by 161
Self-citationSiddiqi, N., Neil, C., Bruce, M., MacLennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N. H., Lim, P. O., Hildick‐Smith, D., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu096 · Cited by 155
Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells
Ramos, D., Mar, D., Ishida, M., Vargas, R. E., Gaite, M., Montgomery, A. P., & Linder, M. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149516 · Cited by 156
Nitrite and nitrate chemical biology and signalling
DeMartino, A. W., Kim‐Shapiro, D. B., Patel, R. P., & Gladwin, M. T. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14484 · Cited by 162
Self-citationHemoglobin Redox Reactions and Red Blood Cell Aging
Rifkind, J. M., & Nagababu, E. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4867 · Cited by 156
Ceruloplasmin Is an Endogenous Inhibitor of Myeloperoxidase
Chapman, A., Mocatta, T. J., Shiva, S., Seidel, A., Chen, B., Khalilova, I. S., Paumann-Page, M., Jameson, G. N. L., Winterbourn, C. C., & Kettle, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.418970 · Cited by 153
Self-citationThe molecular and cellular basis of copper dysregulation and its relationship with human pathologies
Maung, M. T., Carlson, A., Olea‐Flores, M., Elkhadragy, L., Schachtschneider, K. M., Navarro‐Tito, N., & Padilla‐Benavides, T. (2021) · The FASEB Journal · doi:10.1096/fj.202100273rr · Cited by 158
Generation of HNO and HSNO from Nitrite by Heme‐Iron‐Catalyzed Metabolism with H2S
Miljkovic, J. L., Kenkel, I., Ivanović‐Burmazović, I., & Filipovic, M. R. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201305669 · Cited by 148
Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits
Machha, A., & Schechter, A. N. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0192-5 · Cited by 146
Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care
Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145
Dietary Nitrate, Nitric Oxide, and Cardiovascular Health
Bondonno, C. P., Croft, K. D., & Hodgson, J. M. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.811212 · Cited by 141
Nitric oxide in the pulmonary vasculature
Coggins, M. P., & Bloch, K. D. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.142943 · Cited by 138
Reactions of NO and nitrite with heme models and proteins
Ford, P. C. (2010) · Inorganic Chemistry · doi:10.1021/ic902073z · Cited by 138
Baker, J. E., Su, J., Fu, X., Hsu, A., Gross, G. J., Tweddell, J. S., & Hogg, N. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.07.057 · Cited by 137
Bailey, S. J., Winyard, P. G., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., & Jones, A. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00503.2010 · Cited by 132
The Key Role of Nitric Oxide in Hypoxia: Hypoxic Vasodilation and Energy Supply–Demand Matching
Umbrello, M., Dyson, A., Feelisch, M., & Singer, M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4979 · Cited by 138
Influence of copper on early development: Prenatal and postnatal considerations
Uriu‐Adams, J. Y., Scherr, R. E., Lanoue, L., & Keen, C. L. (2010) · BioFactors · doi:10.1002/biof.85 · Cited by 128
Schilsky, M. L., Roberts, E. A., Bronstein, J. M., Dhawan, A. K., Hamilton, J. P., Rivard, A. M., Washington, M. K., Weiss, K. H., & Zimbrean, P. C. (2022) · Hepatology · doi:10.1002/hep.32801 · Cited by 136
Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health
Kapil, V., Weitzberg, E., Lundberg, J. O., & Ahluwalia, A. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.03.162 · Cited by 130
Nitric oxide synthase-derived plasma nitrite predicts exercise capacity
Rassaf, T., Lauer, T., Heiss, C., Balzer, J., Mangold, S., Leyendecker, T., Rottler, J., Drexhage, C., Meyer, C., & Kelm, M. (2007) · British Journal of Sports Medicine · doi:10.1136/bjsm.2007.035758 · Cited by 122
Miyajima, H. (2014) · Neuropathology · doi:10.1111/neup.12149 · Cited by 120
Self-citationAlamdari, D. H., Moghaddam, A. B., Amini, S., Keramati, M. R., Zarmehri, A. M., Alamdari, A. H., Damsaz, M., Banpour, H., Yarahmadi, A., & Koliakos, G. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173494 · Cited by 120
Liu, X., Huang, Y., Pokreisz, P., Vermeersch, P., Marsboom, G., Swinnen, M., Verbeken, E. K., Santos, J., Pellens, M., Gillijns, H., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.04.069 · Cited by 119
On the chemical biology of the nitrite/sulfide interaction
Cortese-Krott, M. M., Fernandez, B. O., Kelm, M., Butler, A. R., & Feelisch, M. (2015) · Nitric Oxide · doi:10.1016/j.niox.2014.12.009 · Cited by 115
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113
“This concept is confirmed in mice deficient for ceruloplasmin that showed lower basal concentrations of plasma nitrite and less plasma nitrite elevation upon NO administration [78].”
BackgroundHematian, S., Garcia‐Bosch, I., & Karlin, K. D. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00265 · Cited by 118
Novel Biomarkers of Heart Failure
Savic-Radojevic, A. R., Pljesa-Ercegovac, M. S., Matic, M., Simic, D., Radovanović, S., & Simic, T. P. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.09.002 · Cited by 113
Pignatelli, P., Fabietti, G., Ricci, A., Piattelli, A., & Curia, M. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207538 · Cited by 113
Sickle Cell Disease: Role of Oxidative Stress and Antioxidant Therapy
Vona, R., Sposi, N. M., Mattia, L., Gambardella, L., Straface, E., & Pietraforte, D. (2021) · Antioxidants · doi:10.3390/antiox10020296 · Cited by 122
Aceruloplasminemia: A Severe Neurodegenerative Disorder Deserving an Early Diagnosis
Marchi, G., Busti, F., Zidanes, A. L., Castagna, A., & Girelli, D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00325 · Cited by 106
Schopfer, M. P., Wang, J., & Karlin, K. D. (2010) · Inorganic Chemistry · doi:10.1021/ic100033y · Cited by 104
Alef, M. J., Vallabhaneni, R., Carchman, E., Morris, S. M., Shiva, S., Wang, Y., Kelley, E. E., Tarpey, M. M., Gladwin, M. T., Tzeng, E., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44079 · Cited by 101
Self-citationCeruloplasmin: Macromolecular Assemblies with Iron-Containing Acute Phase Proteins
Самыгина, В. Р., Av, S., Bourenkov, G. P., Petoukhov, M. V., Pulina, M. O., Zakharova, E. T., Vasilyev, V. B., Bartunik, H. D., & Svergun, D. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067145 · Cited by 101
Does Ceruloplasmin Defend Against Neurodegenerative Diseases?
Wang, B., & Wang, X. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180508113025 · Cited by 104
Self-citationCysteine-mediated redox signalling in the mitochondria
Bak, D. W., & Weerapana, E. (2014) · Molecular BioSystems · doi:10.1039/c4mb00571f · Cited by 102
Copper(II) Activation of Nitrite: Nitrosation of Nucleophiles and Generation of NO by Thiols
Kundu, S., Kim, W. Y., Bertke, J. A., & Warren, T. H. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b11332 · Cited by 101
Zuckerbraun, B. S., George, M. P., & Gladwin, M. T. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq370 · Cited by 99
Self-citationRaat, N. J. H., Noguchi, A. C., Liu, V. B., Raghavachari, N., Liu, D., Xu, X., Shiva, S., Munson, P. J., & Gladwin, M. T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.015 · Cited by 97
Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy
Zhang, Y., Janssens, S. P., Wingler, K., Schmidt, H. H. H. W., & Moens, A. L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01315.2010 · Cited by 99
The nitrate‐nitrite‐nitric oxide pathway: Its role in human exercise physiology
Bailey, S. J., Vanhatalo, A., Winyard, P. G., & JONES, A. M. (2011) · European Journal of Sport Science · doi:10.1080/17461391.2011.635705 · Cited by 101
Fujisawa, K., Tateda, A., Miyashita, Y., Okamoto, K., Paulat, F., Praneeth, V. K. K., Merkle, A. C., & Lehnert, N. (2008) · Journal of the American Chemical Society · doi:10.1021/ja075071d · Cited by 94
NO-Rich Diet for Lifestyle-Related Diseases
Kobayashi, J., Ohtake, K., & Uchida, H. (2015) · Nutrients · doi:10.3390/nu7064911 · Cited by 94
An Emerging Role of Defective Copper Metabolism in Heart Disease
Liu, Y., & Miao, J. (2022) · Nutrients · doi:10.3390/nu14030700 · Cited by 94
Ceruloplasmin/Transferrin System Is Related to Clinical Status in Acute Stroke
Altamura, C., Squitti, R., Pasqualetti, P., Gaudino, C., Palazzo, P., Tibuzzi, F., Lupoi, D., Cortesi, M., Rossini, P. M., & Vernieri, F. (2009) · Stroke · doi:10.1161/strokeaha.108.536714 · Cited by 94
Kim, H.-J., Son, H., Bailey, S. M., & Lee, J. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90632.2008 · Cited by 92
Nitrite mediates cytoprotection after ischemia/reperfusion by modulating mitochondrial function
Shiva, S., & Gladwin, M. T. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0009-3 · Cited by 91
Self-citationLauer, T., Heiss, C., Balzer, J., Kehmeier, E., Mangold, S., Leyendecker, T., Rottler, J., Meyer, C., Merx, M. W., Kelm, M., et al. (2008) · Basic Research in Cardiology · doi:10.1007/s00395-008-0714-3 · Cited by 88
Mitochondria as metabolizers and targets of nitrite
Shiva, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.09.002 · Cited by 87
Self-citationNitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases
Maia, L. B., & Moura, J. J. G. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-014-1234-2 · Cited by 88
Wang, J., Krizowski, S., Fischer-Schrader, K., Niks, D., Tejero, J., Sparacino-Watkins, C., Wang, L., Ragireddy, V., Frizzell, S., Kelley, E. E., et al. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5397 · Cited by 84
Self-citationIsbell, T. S., Gladwin, M. T., & Patel, R. P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00759.2007 · Cited by 82
Self-citationHeinecke, J. L., & Ford, P. C. (2009) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2009.07.021 · Cited by 82
Effects of nitrite on modulating ROS generation following ischemia and reperfusion
Raat, N. J. H., Shiva, S., & Gladwin, M. T. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.02.002 · Cited by 79
Self-citationCastiglione, N., Rinaldo, S., Giardina, G., Stelitano, V., & Cutruzzolà, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4196 · Cited by 81
The biology of mammalian multi-copper ferroxidases
Helman, S. L., Zhou, J., Fuqua, B. K., Lu, Y., Collins, J. F., Chen, H., Vulpe, C. D., Anderson, G. J., & Frazer, D. M. (2022) · BioMetals · doi:10.1007/s10534-022-00370-z · Cited by 83
Dissecting copper biology and cancer treatment: ‘Activating Cuproptosis or suppressing Cuproplasia’
Yang, Y., Li, M., Chen, G., Liu, S., Guo, H., Dong, X., Wang, K., Geng, H., Jiang, J., & Li, X. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215395 · Cited by 76
The Molecular Mechanisms of Defective Copper Metabolism in Diabetic Cardiomyopathy
Cui, X., Wang, Y., Liu, H., Shi, M., Wang, J., & Wang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5418376 · Cited by 77
Nitrite‐dependent nitric oxide synthesis by molybdenum enzymes
Bender, D. A., & Schwarz, G. (2018) · FEBS Letters · doi:10.1002/1873-3468.13089 · Cited by 76
Ceruloplasmin in neurodegenerative diseases
Texel, S. J., Xu, X., & Harris, Z. L. (2008) · Biochemical Society Transactions · doi:10.1042/bst0361277 · Cited by 75
Self-citationBueno, M., Wang, J., Mora, A. L., & Gladwin, M. T. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4833 · Cited by 68
Self-citationAi, K., Huang, J., Xiao, Z., Yang, Y.-R., Bai, Y., & Peng, J. (2021) · Materials Today Chemistry · doi:10.1016/j.mtchem.2020.100402 · Cited by 70
Shining a light on tissue NO stores: Near infrared release of NO from nitrite and nitrosylated hemes
Shiva, S., & Gladwin, M. T. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.10.005 · Cited by 68
Self-citationZhang, X., Zhang, Y., Zhang, R., Jiang, X., Midgley, A. C., Liu, Q., Kang, H., Wu, J., Khalique, A., Qian, M., et al. (2022) · Advanced Materials · doi:10.1002/adma.202110352 · Cited by 67
Clinical and Genetic Association of Serum Ceruloplasmin With Cardiovascular Risk
Tang, W. H. W., Wu, Y., Hartiala, J., Fan, Y., Stewart, A. F. R., Roberts, R., McPherson, R., Fox, P. L., Allayee, H., & Hazen, S. L. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.237040 · Cited by 65
di Patti, M. C. B., Cutone, A., Polticelli, F., Rosa, L., Lepanto, M. S., Valenti, P., & Musci, G. (2018) · BioMetals · doi:10.1007/s10534-018-0087-5 · Cited by 66
Heme/Copper Assembly Mediated Nitrite and Nitric Oxide Interconversion
Hematian, S., Siegler, M. A., & Karlin, K. D. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3083818 · Cited by 64
Shao, X., Liu, W., Lu, K., Xu, W.-N., Zhang, W., Wang, Y., & Zhu, J. (2012) · Aquaculture · doi:10.1016/j.aquaculture.2012.01.018 · Cited by 64
Rassaf, T., Ferdinandy, P., & Schulz, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12291 · Cited by 62
Metadata
- Authors
- Shiva, S., Wang, X., Ringwood, L. A., Xu, X., Yuditskaya, S., Annavajjhala, V., Miyajima, H., Hogg, N., Harris, Z. L., & Gladwin, M. T.
- Affiliations
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Hamamatsu University (JP)
- Medical College of Wisconsin (US)
- Corresponding author
- Gladwin, Mark T
- ORCID
- Venue
- Nature Chemical Biology
- Published
- 2006-08-13
- Volume
- 2
- Issue
- 9
- Pages
- 486-493
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W1973480138
- Cited by
- 359
- References
- 52
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 17 · 2022: 22 · 2021: 22 · 2020: 17 · 2019: 13 · 2018: 13 · 2017: 15 · 2016: 19 · 2015: 22 · 2014: 24 · 2013: 28 · 2012: 24
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Keywords
- ceruloplasmin, nitric oxide homeostasis, multicopper oxidase, aceruloplasminemia, ischemia-reperfusion injury, liver infarction, hypoxia signaling, cytoprotection, nitrate
- MeSH terms
- Animals, Catalysis, Ceruloplasmin, Endocrine System, Erythrocytes, Female, Homeostasis, Humans, Liver, Male, Mice, Transgenic, Nitric Oxide, Nitrites, Oxidation-Reduction, Plasma, Vasodilation, Reperfusion Injury, Nitric Oxide Synthase, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
