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Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex
Open accessAbstract
Brain cells are immersed in a complex structure forming the extracellular matrix. The composition of the matrix gradually matures during postnatal development, as the brain circuitry reaches its adult form. The fully developed extracellular environment stabilizes neuronal connectivity and decreases cortical plasticity as highlighted by the demonstration that treatments degrading the matrix are able to restore synaptic plasticity in the adult brain. The mechanisms through which the matrix inhibits cortical plasticity are not fully clarified. Here we show that a prominent component of the matrix, chondroitin sulfate proteoglycans (CSPGs), restrains morphological changes of dendritic spines in the visual cortex of adult mice. By means of in vivo and in vitro two-photon imaging and electrophysiology, we find that after enzymatic digestion of CSPGs, cortical spines become more motile and express a larger degree of structural and functional plasticity.
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“At postsynaptic sites, ChABC enhances dendritic spine number and motility, while presynaptic terminals tend to show enhanced sprouting and synapse numbers [40–42].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [41]
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Metadata
- Authors
- de Vivo, L., Landi, S., Panniello, M., Baroncelli, L., Chierzi, S., Mariotti, L., Spolidoro, M., Pizzorusso, T., Maffei, L., & Ratto, G. M.
- Affiliations
- Istituto Nanoscienze (IT)
- Scuola Normale Superiore (IT)
- Neuroscience Institute (IT)
- Corresponding author
- Ratto, G.M.
- Venue
- Nature Communications
- Published
- 2013-02-12
- Volume
- 4
- Issue
- 1
- Pages
- 1484-1484
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2071272614
- Cited by
- 148
- References
- 40
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 10 · 2022: 11 · 2021: 19 · 2020: 13 · 2019: 4 · 2018: 18 · 2017: 12 · 2016: 5 · 2015: 13 · 2014: 18 · 2013: 5
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, cc-by-nc-nd)
- RePEc: Research Papers in Economics (submittedVersion)
- Unicam Scientific Publications (University of Camerino) (submittedVersion)
- Funders
- European Commission (223326)
- Regione Toscana
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- extracellular matrix, chondroitin sulfate proteoglycans, dendritic spines, spine motility, synaptic plasticity, adult visual cortex, neuronal connectivity, matrix degradation, postnatal brain development, structural plasticity
- MeSH terms
- Aging, Animals, Electrodes, Evoked Potentials, Visual, Extracellular Matrix, Fluorescence, Male, Mice, Inbred C57BL, Movement, Neuronal Plasticity, Chondroitin Sulfate Proteoglycans, Visual Cortex, Long-Term Potentiation, Chondroitin ABC Lyase, Dendritic Spines, Green Fluorescent Proteins, Mice
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