Cited by 136Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsBarrier Structure and Function Studies

Converting juvenile into adult plasticity: a role for the brain's extracellular matrix

Open access
Gundelfinger, Eckart D., Frischknecht, Renato, Choquet, Daniel, Heine, Martin·2010·European Journal of Neuroscience

Abstract

In higher vertebrates, the extracellular matrix (ECM) wrapping cells of the adult brain differs significantly from that of the developing and juvenile brain. The mature ECM is established at the end of critical periods for wiring and it restricts the regenerative potential and constrains the plasticity of the adult brain. In particular, perineuronal nets, elaborate ECM structures that surround distinct neurons and wrap synapses, are hallmarks of the adult brain and seem to massively affect brain plasticity. Why have these, at first glance futile, limitations evolved? What is the return for these drawbacks? What are the mechanisms of restriction and how is adult plasticity implemented? Recent progress both at the systemic level and at the molecular physiological level has shed some new light on these questions. In this review we will survey the evidence for potential functions of the adult ECM in making established brain features, including imprinted memories, resistant to extinction, and we will discuss potential mechanisms by which the ECM limits juvenile and implements adult plasticity. In particular we will focus on some aspects of adult ECM function. First we will discuss its influence on diffusion of cations in the extracellular space and on volume transmission, second we will consider its potential role in regulating the lateral diffusion of cell surface receptors and finally we will discuss mechanisms to locally modulate ECM functions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1460-9568.2010.07253.x

Cites

141 of 141 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Gundelfinger, E. D., Frischknecht, R., Choquet, D., & Heine, M.
Affiliations
  • Leibniz Institute for Neurobiology (DE)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Gundelfinger, Eckart D.
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2010-06
Volume
31
Issue
12
Pages
2156-2165
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2097087118
Cited by
136
References
141
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 11 · 2022: 5 · 2021: 18 · 2020: 10 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 13 · 2013: 13 · 2012: 7
FWCI
0.81
Type
journal article
Language
en
Open access
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
extracellular matrix, perineuronal nets, adult brain plasticity, critical period, memory consolidation, memory extinction, cation diffusion, volume transmission, receptor lateral diffusion, synaptic plasticity
MeSH terms
Animals, Brain, Extracellular Matrix, Humans, Synaptic Transmission, Neuronal Plasticity, Synapses

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review