The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Rare-earth-doped biological composites as in vivo shortwave infrared reporters
Open accessAbstract
The extension of in vivo optical imaging for disease screening and image-guided surgical interventions requires brightly emitting, tissue-specific materials that optically transmit through living tissue and can be imaged with portable systems that display data in real-time. Recent work suggests that a new window across the short-wavelength infrared region can improve in vivo imaging sensitivity over near infrared light. Here we report on the first evidence of multispectral, real-time short-wavelength infrared imaging offering anatomical resolution using brightly emitting rare-earth nanomaterials and demonstrate their applicability toward disease-targeted imaging. Inorganic-protein nanocomposites of rare-earth nanomaterials with human serum albumin facilitated systemic biodistribution of the rare-earth nanomaterials resulting in the increased accumulation and retention in tumour tissue that was visualized by the localized enhancement of infrared signal intensity. Our findings lay the groundwork for a new generation of versatile, biomedical nanomaterials that can advance disease monitoring based on a pioneering infrared imaging technique. The short-wavelength infrared spectral region is of interest for bio-imaging applications as biological tissue is transparent to such light. Here Naczynski et al. fabricate rare-earth-based nanomaterials and demonstrate multispectral, real-time short-wavelength infrared in-vivoimaging.
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Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Therapeutic Nanoparticles for Drug Delivery in Cancer
Cho, K., Wang, X., Nie, S., Chen, Z. (., & Shin, D. M. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1441 · Cited by 2,920
Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848
In vivo near-infrared fluorescence imaging
Frangioni, J. V. (2003) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2003.08.007 · Cited by 2,653
Imaging in the era of molecular oncology
Weissleder, R., & Pittet, M. J. (2008) · Nature · doi:10.1038/nature06917 · Cited by 2,364
A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors
Hardman, R. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8284 · Cited by 2,303
Nanomedicine: current status and future prospects
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2747rev · Cited by 2,029
Shedding light onto live molecular targets
Weissleder, R., & Ntziachristos, V. (2003) · Nature Medicine · doi:10.1038/nm0103-123 · Cited by 1,909
Upconversion nanophosphors for small-animal imaging
Zhou, J., Liu, Z., & Li, F. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15187h · Cited by 1,581
Mediating Tumor Targeting Efficiency of Nanoparticles Through Design
Perrault, S. D., Walkey, C., Jennings, T., Fischer, H. C., & Chan, W. C. W. (2009) · Nano Letters · doi:10.1021/nl900031y · Cited by 1,513
Cited by
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037
He, S., Song, J., Qu, J., & Cheng, Z. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00234g · Cited by 1,021
Carr, J. A., Franke, D., Caram, J. R., Perkinson, C. F., Saif, M., Askoxylakis, V., Datta, M., Fukumura, D., Jain, R. K., Bawendi, M. G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718917115 · Cited by 721
Next-generation in vivo optical imaging with short-wave infrared quantum dots
Bruns, O. T., Bischof, T. S., Harris, D. K., Franke, D., Shi, Y., Riedemann, L., Bartelt, A., Jaworski, F. B., Carr, J. A., Rowlands, C. J., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0056 · Cited by 686
Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658
Metadata
- Authors
- Naczynski, D. J., Tan, M. C., Zevon, M., Wall, B., Kohl, J., Kulesa, A., Chen, S., Roth, C. M., Riman, R. E., & Moghe, P. V.
- Venue
- Nature Communications
- Published
- 2013-07-22
- Volume
- 4
- Issue
- 1
- Pages
- 2199-2199
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1995651581
- Cited by
- 759
- References
- 37
- FWCI
- 15.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Naczynski, D. J., Tan, M. C., Zevon, M., Wall, B., Kohl, J., Kulesa, A., Chen, S., Roth, C. M., Riman, R. E., & Moghe, P. V. (2013). Rare-earth-doped biological composites as in vivo shortwave infrared reporters. Nature Communications. https://doi.org/10.1038/ncomms3199
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