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Rare-earth-doped biological composites as in vivo shortwave infrared reporters
Open accessAbstract
The extension of in vivo optical imaging for disease screening and image-guided surgical interventions requires brightly emitting, tissue-specific materials that optically transmit through living tissue and can be imaged with portable systems that display data in real-time. Recent work suggests that a new window across the short-wavelength infrared region can improve in vivo imaging sensitivity over near infrared light. Here we report on the first evidence of multispectral, real-time short-wavelength infrared imaging offering anatomical resolution using brightly emitting rare-earth nanomaterials and demonstrate their applicability toward disease-targeted imaging. Inorganic-protein nanocomposites of rare-earth nanomaterials with human serum albumin facilitated systemic biodistribution of the rare-earth nanomaterials resulting in the increased accumulation and retention in tumour tissue that was visualized by the localized enhancement of infrared signal intensity. Our findings lay the groundwork for a new generation of versatile, biomedical nanomaterials that can advance disease monitoring based on a pioneering infrared imaging technique. The short-wavelength infrared spectral region is of interest for bio-imaging applications as biological tissue is transparent to such light. Here Naczynski et al. fabricate rare-earth-based nanomaterials and demonstrate multispectral, real-time short-wavelength infrared in-vivoimaging.
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Metadata
- Authors
- Naczynski, D. J., Tan, M. C., Zevon, M., Wall, B., Kohl, J., Kulesa, A., Chen, S., Roth, C. M., Riman, R. E., & Moghe, P. V.
- Venue
- Nature Communications
- Published
- 2013-07-22
- Volume
- 4
- Issue
- 1
- Pages
- 2199-2199
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1995651581
- Cited by
- 759
- References
- 37
- FWCI
- 15.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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