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Evaluation of candidate vaccine approaches for MERS-CoV

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Wang, Lingshu, Shi, Wei, Joyce, M. Gordon, Modjarrad, Kayvon, Zhang, Yi, Leung, Kwanyee, Lees, Christopher R., Zhou, Tongqing, Yassine, Hadi M., Kanekiyo, Masaru, Yang, Zhi-yong, Chen, Xuejun, Becker, Michelle M., Freeman, Megan, Vogel, Leatrice, Johnson, Joshua C., Olinger, Gene, Todd, John P., Bagci, Ulas, Solomon, Jeffrey, Mollura, Daniel J., Hensley, Lisa, Jahrling, Peter, Denison, Mark R., Rao, Srinivas S., Subbarao, Kanta, Kwong, Peter D., Mascola, John R., Kong, Wing-Pui, Graham, Barney S.·2015·Nature Communications

DOI 10.1038/ncomms8712

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Abstract

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) as a cause of severe respiratory disease highlights the need for effective approaches to CoV vaccine development. Efforts focused solely on the receptor-binding domain (RBD) of the viral Spike (S) glycoprotein may not optimize neutralizing antibody (NAb) responses. Here we show that immunogens based on full-length S DNA and S1 subunit protein elicit robust serum-neutralizing activity against several MERS-CoV strains in mice and non-human primates. Serological analysis and isolation of murine monoclonal antibodies revealed that immunization elicits NAbs to RBD and, non-RBD portions of S1 and S2 subunit. Multiple neutralization mechanisms were demonstrated by solving the atomic structure of a NAb-RBD complex, through sequencing of neutralization escape viruses and by constructing MERS-CoV S variants for serological assays. Immunization of rhesus macaques confers protection against MERS-CoV-induced radiographic pneumonia, as assessed using computerized tomography, supporting this strategy as a promising approach for MERS-CoV vaccine development.

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[20] Processing of X-ray diffraction data collected in oscillation mode
Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475
Features and development of Coot
Emsley, P., Lohkamp, B., Scott, W. G., & Cowtan, K. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444910007493 · Cited by 29,915
PHENIX : a comprehensive Python-based system for macromolecular structure solution
Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L.-W., Kapral, G. J., Grosse-Kunstleve, R. W., et al. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444909052925 · Cited by 23,716
Phaser crystallographic software
McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Storoni, L. C., & Read, R. J. (2007) · Journal of Applied Crystallography · doi:10.1107/s0021889807021206 · Cited by 20,612
A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12
REED, L. J., & MUENCH, H. (1938) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a118408 · Cited by 19,926
MolProbity : all-atom structure validation for macromolecular crystallography
Chen, V. B., Arendall, W. B., Headd, J. J., Keedy, D. A., Immormino, R. M., Kapral, G. J., Murray, L. W., Richardson, J. S., & Richardson, D. C. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444909042073 · Cited by 14,115
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L.-W., Kapral, G. J., Grosse-Kunstleve, R. W., et al. (2012) · International Tables for Crystallography · doi:10.1107/97809553602060000865 · Cited by 7,334
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.
Naldini, L., Blömer, U., Gage, F. H., Trono, D., & Verma, I. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11382 · Cited by 1,499
Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study
Assiri, A., Al-Tawfiq, J. A., Al-Rabeeah, A. A., Al-Rabiah, F. A., Al-Hajjar, S., Al-Barrak, A., Flemban, H., Al-Nassir, W. N., Balkhy, H. H., Al-Hakeem, R. F., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70204-4 · Cited by 1,435
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
McLellan, J. S., Chen, M., Joyce, M. G., Sastry, M., Stewart-Jones, G. B. E., Yang, Y., Zhang, B., Chen, L., Srivatsan, S., Zheng, A., et al. (2013) · Science · doi:10.1126/science.1243283 · Cited by 1,126
Self-citation
Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells
Stevens, T. L., Bossie, A., Sanders, V. M., Fernandez-Botran, R., Coffman, R. L., Mosmann, T. R., & Vitetta, E. S. (1988) · Nature · doi:10.1038/334255a0 · Cited by 933
Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody
McLellan, J. S., Chen, M., Leung, S., Graepel, K. W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., et al. (2013) · Science · doi:10.1126/science.1234914 · Cited by 883
Self-citation
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Lu, G., Hu, Y., Wang, Q., Qi, J., Gao, F., Li, Y., Zhang, Y., Zhang, W., Yuan, Y., Bao, J., et al. (2013) · Nature · doi:10.1038/nature12328 · Cited by 739
Self-citation
Refinement of severely incomplete structures with maximum likelihood in BUSTER–TNT
Blanc, E., Roversi, P., Vonrhein, C., Flensburg, C., Lea, S. M., & Bricogne, G. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904016427 · Cited by 717
A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice
Yang, Z.-Y., Kong, W.-P., Huang, Y., Roberts, A., Murphy, B. R., Subbarao, K., & Nabel, G. J. (2004) · Nature · doi:10.1038/nature02463 · Cited by 665
Self-citation
A decade after SARS: strategies for controlling emerging coronaviruses
Graham, R. L., Donaldson, E. F., & Baric, R. S. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3143 · Cited by 655
Rapid generation of a mouse model for Middle East respiratory syndrome
Zhao, J., Li, K., Wohlford-Lenane, C., Agnihothram, S. S., Fett, C., Zhao, J., Gale, M. J., Baric, R. S., Enjuanes, L., Gallagher, T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323279111 · Cited by 452
Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity
Buchholz, U. J., Bukreyev, A., Yang, L., Lamirande, E. W., Murphy, B. R., Subbarao, K., & Collins, P. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403492101 · Cited by 385
Self-citation
Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk
Breban, R., Riou, J., & Fontanet, A. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61492-0 · Cited by 385
Human Infection with MERS Coronavirus after Exposure to Infected Camels, Saudi Arabia, 2013
Memish, Z. A., Cotten, M., Meyer, B., Watson, S. J., Alsahafi, A. J., Al Rabeeah, A. A., Corman, V. M., Sieberg, A., Makhdoom, H. Q., Assiri, A., et al. (2014) · Emerging Infectious Diseases · doi:10.3201/eid2006.140402 · Cited by 365
Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility
Cauchemez, S., Fraser, C., Van Kerkhove, M. D., Donnelly, C. A., Riley, S., Rambaut, A., Enouf, V., van der Werf, S., & Ferguson, N. M. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70304-9 · Cited by 347
Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice
Coleman, C. M., Liu, Y. V., Mu, H., Taylor, J. K., Massare, M., Flyer, D. C., Glenn, G. M., Smith, G. E., & Frieman, M. B. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.04.016 · Cited by 293
Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies
Zhu, Z., Chakraborti, S., He, Y., Roberts, A., Sheahan, T., Xiao, X., Hensley, L. E., Prabakaran, P., Rockx, B., Sidorov, I. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701000104 · Cited by 287
Self-citation
Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus
Scobey, T., Yount, B. L., Sims, A. C., Donaldson, E. F., Agnihothram, S. S., Menachery, V. D., Graham, R. L., Swanstrom, J., Bove, P. F., Kim, J. D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311542110 · Cited by 283
A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial
Martin, J. E., Louder, M. K., Holman, L. A., Gordon, I. J., Enama, M. E., Larkin, B. D., Andrews, C. A., Vogel, L., Koup, R. A., Roederer, M., et al. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.09.026 · Cited by 267
Self-citation
DNA vaccination: antigen presentation and the induction of immunity
Shedlock, D. J., & Weiner, D. B. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.6.793 · Cited by 259
Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses
Yang, Z.-Y., Werner, H. C., Kong, W.-P., Leung, K., Traggiai, E., Lanzavecchia, A., & Nabel, G. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409065102 · Cited by 253
Self-citation
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Mou, H., Raj, V. S., van Kuppeveld, F. J. M., Rottier, P. J. M., Haagmans, B. L., & Bosch, B. J. (2013) · Journal of Virology · doi:10.1128/jvi.01277-13 · Cited by 241
Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody
Prabakaran, P., Gan, J., Feng, Y., Zhu, Z., Choudhry, V., Xiao, X., Ji, X., & Dimitrov, D. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600697200 · Cited by 238
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Ying, T., Du, L., Ju, T. W., Prabakaran, P., Lau, C. C. Y., Lu, L., Liu, Q., Wang, L., Feng, Y., Wang, Y., et al. (2014) · Journal of Virology · doi:10.1128/jvi.00912-14 · Cited by 233
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Tang, X.-C., Agnihothram, S. S., Jiao, Y., Stanhope, J., Graham, R. L., Peterson, E. C., Avnir, Y., Tallarico, A. S. C., Sheehan, J., Zhu, Q., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402074111 · Cited by 232
Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein
Jiang, L., Wang, N., Zuo, T., Shi, X., Poon, K.-M. V., Wu, Y., Gao, F., Li, D., Wang, R., Guo, J., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008140 · Cited by 218
DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials
Ledgerwood, J. E., Wei, C.-J., Hu, Z., Gordon, I. J., Enama, M. E., Hendel, C. S., McTamney, P. M., Pearce, M. B., Yassine, H. M., Boyington, J. C., et al. (2011) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70240-7 · Cited by 188
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Cavanagh, D. (1983) · Journal of General Virology · doi:10.1099/0022-1317-64-12-2577 · Cited by 184
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Mansoor, A., Bagci, U., Xu, Z., Foster, B., Olivier, K. N., Elinoff, J. M., Suffredini, A. F., Udupa, J. K., & Mollura, D. J. (2014) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2014.2337057 · Cited by 162
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Du, L., Kou, Z., Ma, C., Tao, X., Wang, L., Zhao, G., Chen, Y.-Q., Yu, F., Tseng, C.-T. K., Zhou, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081587 · Cited by 162
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Briese, T., Mishra, N., Jain, K., Zalmout, I. S., Jabado, O. J., Karesh, W. B., Daszak, P., Mohammed, O. B., Alagaili, A. N., & Lipkin, W. I. (2014) · mBio · doi:10.1128/mbio.01146-14 · Cited by 161
A Human T-Cell Leukemia Virus Type 1 Regulatory Element Enhances the Immunogenicity of Human Immunodeficiency Virus Type 1 DNA Vaccines in Mice and Nonhuman Primates
Barouch, D. H., Yang, Z.-Y., Kong, W.-P., Korioth-Schmitz, B., Sumida, S. M., Truitt, D. M., Kishko, M. G., Arthur, J. C., Miura, A., Mascola, J. R., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.8828-8834.2005 · Cited by 160
Self-citation
Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine
Catanzaro, A. T., Roederer, M., Koup, R. A., Bailer, R. T., Enama, M. E., Nason, M., Martin, J. E., Rucker, S., Andrews, C. A., Gomez, P. L., et al. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.02.050 · Cited by 151
Self-citation
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Du, L., Zhao, G., Yang, Y., Qiu, H., Wang, L., Kou, Z., Tao, X., Yu, H., Sun, S., Tseng, C.-T. K., et al. (2014) · Journal of Virology · doi:10.1128/jvi.00433-14 · Cited by 142
Self-citation
Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines
Ma, C., Li, Y., Wang, L., Zhao, G., Tao, X., Tseng, C.-T. K., Zhou, Y., Du, L., & Jiang, S. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.02.004 · Cited by 139
Self-citation
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de Wit, E., Prescott, J. B., Baseler, L. J., Bushmaker, T., Thomas, T., Lackemeyer, M. G., Martellaro, C., Milne-Price, S., Haddock, E., Haagmans, B. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069127 · Cited by 139
DNA-Mediated Immunization in Mice Induces a Potent MHC Class I-Restricted Cytotoxic T Lymphocyte Response to the Hepatitis B Envelope Protein
Davis, H. L., Schirmbeck, R., Reimann, J., & Whalen, R. G. (1995) · Human Gene Therapy · doi:10.1089/hum.1995.6.11-1447 · Cited by 139
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Ledgerwood, J. E., Zephir, K., Hu, Z., Wei, C.-J., Chang, L., Enama, M. E., Hendel, C. S., Sitar, S., Bailer, R. T., Koup, R. A., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit180 · Cited by 123
Self-citation
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Ohnuma, K., Haagmans, B. L., Hatano, R., Raj, V. S., Mou, H., Iwata, S., Dang, N. H., Bosch, B., & Morimoto, C. (2013) · Journal of Virology · doi:10.1128/jvi.02448-13 · Cited by 95
Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness
Sui, J., Deming, M. E., Rockx, B., Liddington, R., Zhu, Q. K., Baric, R. S., & Marasco, W. A. (2014) · Journal of Virology · doi:10.1128/jvi.02232-14 · Cited by 68
DNA Priming Prior to Inactivated Influenza A(H5N1) Vaccination Expands the Antibody Epitope Repertoire and Increases Affinity Maturation in a Boost-Interval–Dependent Manner in Adults
Khurana, S., Wu, J., Dimitrova, M., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit178 · Cited by 57
Structural Insights into Immune Recognition of the Severe Acute Respiratory Syndrome Coronavirus S Protein Receptor Binding Domain
Pak, J. E., Sharon, C., Satkunarajah, M., Aupérin, T. C., Cameron, C., Kelvin, D. J., Seetharaman, J., Cochrane, A., Plummer, F. A., Berry, J. D., et al. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.03.042 · Cited by 55
Modulation of the Immune Response to the Severe Acute Respiratory Syndrome Spike Glycoprotein by Gene-Based and Inactivated Virus Immunization
Kong, W., Xu, L., Stadler, K., Ulmer, J. B., Abrignani, S., Rappuoli, R., & Nabel, G. J. (2005) · Journal of Virology · doi:10.1128/jvi.79.22.13915-13923.2005 · Cited by 40
Self-citation
Modulation of immune responses in mice to recombinant antigens from PE and PPE families of proteins of Mycobacterium tuberculosis by the Ribi adjuvant
Chaitra, M. G., Nayak, R., & Shaila, M. S. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.07.026 · Cited by 35

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de Wit, E., van Doremalen, N., Falzarano, D., & Munster, V. J. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.81 · Cited by 3,510
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
Wang, Q., Zhang, Y., Wu, L., Niu, S., Song, C., Zhang, Z., Lu, G., Qiao, C., Hu, Y., Yuen, K.-Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.045 · Cited by 2,892
“Notably, the S2 regions between SARS-CoV and SARS-CoV-2 exhibit higher sequence identity (~90%) and also contain neutralizing epitopes (Duan et al., 2005; Wang et al., 2015).”
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Corbett, K. S., Edwards, D. K., Leist, S. R., Abiona, O. M., Boyoglu-Barnum, S., Gillespie, R. A., Himansu, S., Schäfer, A., Ziwawo, C. T., DiPiazza, A. T., et al. (2020) · Nature · doi:10.1038/s41586-020-2622-0 · Cited by 1,615
Self-citation
Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children
Zimmermann, P., & Curtis, N. (2020) · Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002660 · Cited by 1,077
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
Pallesen, J., Wang, N., Corbett, K. S., Wrapp, D., Kirchdoerfer, R. N., Turner, H. L., Cottrell, C. A., Becker, M. M., Wang, L., Shi, W., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707304114 · Cited by 1,073
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Authors: Wang, L., Shi, W., Joyce, M. G., Modjarrad, K., Zhang, Y., Leung, K., Lees, C. R., Zhou, T., Yassine, H. M., Kanekiyo, M., Yang, Z.-Y., Chen, X., Becker, M. M., Freeman, M., Vogel, L., Johnson, J. C., Olinger, G., Todd, J. P., Bagci, U., Solomon, J., Mollura, D. J., Hensley, L., Jahrling, P., Denison, M. R., Rao, S. S., Subbarao, K., Kwong, P. D., Mascola, J. R., Kong, W.-P., & Graham, B. S.
Venue: Nature Communications
Publisher: Springer Science and Business Media LLC
Published: 2015-07-28
Volume: 6
Issue: 1
Pages: 7712-7712
ISSN: 2041-1723 (ISSN-L)
DOI: 10.1038/ncomms8712
OpenAlex: W2270879391
Cited by: 299
References: 50
FWCI: 17.83
Type: journal article
Language: en
Open access: gold

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Evaluation of candidate vaccine approaches for MERS-CoV

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