The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
Open accessAbstract
We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and 38,295 controls for follow-up. We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10−20) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10−13). We also showed an association between common variation at 3q28 (TP63, rs13314271, OR = 1.13, P = 7.22 × 10−10) and lung adenocarcinoma that had been previously reported only in Asians. These findings provide further evidence for inherited genetic susceptibility to lung cancer and its biological basis. Additionally, our analysis demonstrates that imputation can identify rare disease-causing variants with substantive effects on cancer risk from preexisting genome-wide association study data.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 21,293
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
The Structure of Haplotype Blocks in the Human Genome
Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., et al. (2002) · Science · doi:10.1126/science.1069424 · Cited by 5,863
Comprehensive genomic characterization of squamous cell lung cancers
The Cancer Genome Atlas Research Network (2012) · Nature · doi:10.1038/nature11404 · Cited by 3,994
Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928
Wellcome Trust Case Control Consortium, Zeggini, E., Scott, L. J., Saxena, R., Voight, B. F., Marchini, J. L., Hu, T., de Bakker, P. I., Abecasis, G. R., Almgren, P., et al. (2008) · Nature Genetics · doi:10.1038/ng.120 · Cited by 1,864
Self-citationMaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
Li, Y., Willer, C. J., Ding, J., Scheet, P., & Abecasis, G. R. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20533 · Cited by 1,843
Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Imielinski, M., Berger, A. H., Hammerman, P. S., Hernandez, B., Pugh, T. J., Hodis, E., Cho, J., Suh, J., Capelletti, M., Sivachenko, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.029 · Cited by 1,789
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
Howie, B., Fuchsberger, C., Stephens, M., Marchini, J., & Abecasis, G. R. (2012) · Nature Genetics · doi:10.1038/ng.2354 · Cited by 1,737
Genotype imputation for genome-wide association studies
Marchini, J., & Howie, B. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2796 · Cited by 1,627
Cancer Risks in BRCA2 Mutation Carriers
Breast Cancer Linkage Consortium, T. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.15.1310 · Cited by 1,527
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., Manolescu, A., Thorleifsson, G., Stefansson, H., Ingason, A., et al. (2008) · Nature · doi:10.1038/nature06846 · Cited by 1,523
Self-citationSNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
Johnson, A. D., Handsaker, R. E., Pulit, S. L., Nizzari, M. M., O'Donnell, C. J., & de Bakker, P. I. W. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn564 · Cited by 1,330
Amos, C. I., Wu, X., Broderick, P., Gorlov, I. P., Gu, J., Eisen, T., Dong, Q., Zhang, Q., Gu, X., Vijayakrishnan, J., et al. (2008) · Nature Genetics · doi:10.1038/ng.109 · Cited by 1,310
Self-citationHung, R. J., McKay, J. D., Gaborieau, V., Boffetta, P., Hashibe, M., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., et al. (2008) · Nature · doi:10.1038/nature06885 · Cited by 1,275
Self-citationLarge-scale genotyping identifies 41 new loci associated with breast cancer risk
The Breast and Ovarian Cancer Susceptibility Collaboration, Michailidou, K., Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), kConFab Investigators, Australian Ovarian Cancer Study Group, The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network, Hall, P., Gonzalez-Neira, A., Ghoussaini, M., Dennis, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2563 · Cited by 1,069
Self-citationSequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior
The ENGAGE Consortium, Thorgeirsson, T. E., Gudbjartsson, D. F., Surakka, I., Vink, J. M., Amin, N., Geller, F., Sulem, P., Rafnar, T., Esko, T., et al. (2010) · Nature Genetics · doi:10.1038/ng.573 · Cited by 689
Self-citationSequence variants at the TERT-CLPTM1L locus associate with many cancer types
Rafnar, T., Sulem, P., Stacey, S. N., Geller, F., Gudmundsson, J., Sigurdsson, A., Jakobsdottir, M., Helgadottir, H., Thorlacius, S., Aben, K. K. H., et al. (2009) · Nature Genetics · doi:10.1038/ng.296 · Cited by 609
Self-citationTravis, W. D., Brambilla, E., Noguchi, M., Nicholson, A. G., Geisinger, K., Yatabe, Y., Powell, C. A., Beer, D., Riely, G., Garg, K., et al. (2011) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201107-042st · Cited by 586
Lung cancer susceptibility locus at 5p15.33
Study, E., McKay, J. D., Hung, R. J., Gaborieau, V., Boffetta, P., Chabrier, A., Byrnes, G., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., et al. (2008) · Nature Genetics · doi:10.1038/ng.254 · Cited by 561
Self-citationParental origin of sequence variants associated with complex diseases
DIAGRAM Consortium, Kong, A., Steinthorsdottir, V., Masson, G., Thorleifsson, G., Sulem, P., Besenbacher, S., Jonasdottir, A., Sigurdsson, A., Kristinsson, K. T., et al. (2009) · Nature · doi:10.1038/nature08625 · Cited by 553
Self-citationCommon 5p15.33 and 6p21.33 variants influence lung cancer risk
Wang, Y., Broderick, P., Webb, E., Wu, X., Vijayakrishnan, J., Matakidou, A., Qureshi, M., Dong, Q., Gu, X., Chen, W. V., et al. (2008) · Nature Genetics · doi:10.1038/ng.273 · Cited by 551
Self-citationClayton, D. G., Walker, N. M., Smyth, D. J., Pask, R., Cooper, J. D., Maier, L. M., Smink, L. J., Lam, A. C., Ovington, N. R., Stevens, H. E., et al. (2005) · Nature Genetics · doi:10.1038/ng1653 · Cited by 526
The Nord-Trøndelag Health Study 1995-97 (HUNT 2): Objectives, contents, methods and participation
Holmen, J., Midthjell, K., Krüger, Ø., Langhammer, A., Holmen, T. L., Bratberg, G. H., Vatten, L., & Lund‐Larsen, P. G. (2003) · Cited by 526
Self-citation(1994) · Annals of Epidemiology · doi:10.1016/1047-2797(94)90036-1 · Cited by 524
Landi, M. T., Chatterjee, N., Yu, K., Goldin, L. R., Goldstein, A. M., Rotunno, M., Mirabello, L., Jacobs, K., Wheeler, W., Yeager, M., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.05.003 · Cited by 496
Self-citationLandi, M. T., Chatterjee, N., Yu, K., Goldin, L. R., Goldstein, A. M., Rotunno, M., Mirabello, L., Jacobs, K., Wheeler, W., Yeager, M., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.09.012 · Cited by 495
Self-citationCalle, E. E., Rodriguez, C., Jacobs, E. J., Almon, M. L., Chao, A., McCullough, M. L., Feigelson, H. S., & Thun, M. J. (2002) · Cancer · doi:10.1002/cncr.10197 · Cited by 484
Genetic Structure of Europeans: A View from the North–East
Nelis, M., Esko, T., Mägi, R., Zimprich, F., Zimprich, A., Toncheva, D., Karachanak, S., Piskáčková, T., Balaščák, I., Peltonen, L., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005472 · Cited by 428
Self-citationCancer risks in BRCA2 families: estimates for sites other than breast and ovary
van Asperen, C. J., Brohet, R. M., Meijers-Heijboer, E. J., Hoogerbrugge, N., Verhoef, S., Vasen, H. F. A., Ausems, M. G. E. M., Menko, F. H., Gomez Garcia, E. B., Klijn, J. G. M., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.028829 · Cited by 420
Calle, E. E., Rodriguez, C., Jacobs, E. J., Almon, M. L., Chao, A., McCullough, M. L., Feigelson, H. S., & Thun, M. J. (2002) · Cancer · doi:10.1002/cncr.101970 · Cited by 418
ProbABEL package for genome-wide association analysis of imputed data
Aulchenko, Y. S., Struchalin, M. V., & van Duijn, C. M. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-134 · Cited by 396
Differential confounding of rare and common variants in spatially structured populations
Mathieson, I., & McVean, G. (2012) · Nature Genetics · doi:10.1038/ng.1074 · Cited by 385
Hu, Z., Wu, C., Shi, Y., Guo, H., Zhao, X., Yin, Z., Yang, L., Dai, J., Hu, L., Tan, W., et al. (2011) · Nature Genetics · doi:10.1038/ng.875 · Cited by 367
Lan, Q., Hsiung, C. A., Matsuo, K., Hong, Y.-C., Seow, A., Wang, Z., Hosgood, H. D., Chen, K., Wang, J.-C., Chatterjee, N., et al. (2012) · Nature Genetics · doi:10.1038/ng.2456 · Cited by 335
Self-citationLung eQTLs to Help Reveal the Molecular Underpinnings of Asthma
Hao, K., Bossé, Y., Nickle, D. C., Paré, P. D., Postma, D. S., Laviolette, M., Sandford, A., Hackett, T. L., Daley, D., Hogg, J. C., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003029 · Cited by 309
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits
Styrkarsdottir, U., Thorleifsson, G., Sulem, P., Gudbjartsson, D. F., Sigurdsson, A., Jonasdottir, A., Jonasdottir, A., Oddsson, A., Helgason, A., Magnusson, O. T., et al. (2013) · Nature · doi:10.1038/nature12124 · Cited by 271
Self-citationOmenn, G. S., Goodman, G. E., Thornquist, M. D., Grizzle, J. E., Rosenstock, L., Barnhart, S., Balmes, J. R., Cherniack, M. G., Cullen, M. R., & Glass, A. G. (1994) · PubMed · Cited by 256
Self-citationEPIC-Germany – A Source for Studies into Diet and Risk of Chronic Diseases
Boeing, H., Wahrendorf, J., & Becker, N. (1999) · Annals of Nutrition and Metabolism · doi:10.1159/000012786 · Cited by 255
Broderick, P., Wang, Y., Vijayakrishnan, J., Matakidou, A., Spitz, M. R., Eisen, T., Amos, C. I., & Houlston, R. S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0680 · Cited by 234
Self-citationTimofeeva, M. N., Hung, R. J., Rafnar, T., Christiani, D. C., Field, J. K., Bickeböller, H., Risch, A., McKay, J. D., Wang, Y., Dai, J., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds334 · Cited by 232
Self-citationWu, W. K. K., Wong, H. P. S., Luo, S. W., Chan, K., Huang, F. Y., Hui, M. K. C., Lam, E. K. Y., Shin, V. Y., Ye, Y. N., Yang, Y. H., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0205 · Cited by 183
Self-citationBahassi, E. M., Ovesen, J. L., Riesenberg, A. L., Bernstein, W. Z., Hasty, P. E., & Stambrook, P. J. (2008) · Oncogene · doi:10.1038/onc.2008.17 · Cited by 180
Miki, D., Kubo, M., Takahashi, A., Yoon, K.-A., Kim, J., Lee, G. K., Zo, J. I., Lee, J. S., Hosono, N., Morizono, T., et al. (2010) · Nature Genetics · doi:10.1038/ng.667 · Cited by 179
A polymorphic stop codon in BRCA2
Mazoyer, S., Dunning, A. M., Serova, O., Dearden, J., Puget, N., Healey, C. S., Gayther, S. A., Mangion, J., Stratton, M. R., Lynch, H. T., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-253 · Cited by 174
Truncated BRCA2 is cytoplasmic: Implications for cancer-linked mutations
Spain, B. H., Larson, C. J., Shihabuddin, L. S., Gage, F. H., & Verma, I. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13920 · Cited by 161
Methods for etiologic and early marker investigations in the PLCO trial
Hayes, R. B., Sigurdson, A. J., Moore, L. E., Peters, U., Huang, W., Pinsky, P. F., Reding, D. J., Gelmann, E. P., Rothman, N., Pfeiffer, R. M., et al. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.06.013 · Cited by 143
Landi, M. T., Consonni, D., Rotunno, M., Bergen, A. W., Goldstein, A. M., Lubin, J. H., Goldin, L. R., Alavanja, M. C. R., Morgan, G. D., Subar, A. F., et al. (2008) · BMC Public Health · doi:10.1186/1471-2458-8-203 · Cited by 129
Self-citationFunctional Evaluation and Cancer Risk Assessment of BRCA2 Unclassified Variants
Wu, K., Hinson, S. R., Ohashi, A., Farrugia, D. J., Wendt, P., Tavtigian, S. V., Deffenbaugh, A. M., Goldgar, D. E., & Couch, F. J. (2005) · Cancer Research · doi:10.1158/0008-5472.417.65.2 · Cited by 125
McAllister, K. A., Bennett, L. M., Houle, C. D., Ward, T., Malphurs, J., Collins, N. K., Cachafeiro, C., Haseman, J., Goulding, E. H., Bunch, D. O., et al. (2002) · PubMed · Cited by 113
Gene Expression Profiles of Non-Small Cell Lung Cancer: Survival Prediction and New Biomarkers
Välk, K., Vooder, T., Kolde, R., Reintam, M.-A., Petzold, C., Vilo, J., & Metspalu, A. (2010) · Oncology · doi:10.1159/000322116 · Cited by 110
Self-citationFlores, E. R. (2007) · Cell Cycle · doi:10.4161/cc.6.3.3793 · Cited by 103
Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.
Feyler, A., Voho, A., Bouchardy, C., et al. (2002) · PubMed · Cited by 101
The Effect of CHEK2 Variant I157T on Cancer Susceptibility: Evidence from a Meta-Analysis
Han, F., Guo, C., & Liu, L. (2013) · DNA and Cell Biology · doi:10.1089/dna.2013.1970 · Cited by 98
Petitjean, A., Ruptier, C., Tribollet, V., Hautefeuille, A. H., Chardon, F., Cavard, C., Puisieux, A., Hainaut, P. L., & de Fromentel, C. C. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm258 · Cited by 93
The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose
Dally, H., Edler, L., ger, B. J., Schmezer, P., Spiegelhalder, B., Dienemann, H., Drings, P., Schulz, V., Kayser, K., Bartsch, H., et al. (2003) · Pharmacogenetics · doi:10.1097/00008571-200310000-00004 · Cited by 90
Self-citationp51A (TAp63γ), a p53 homolog, accumulates in response to DNA damage for cell regulation
Katoh, I., Aisaki, K., Kurata, S., Ikawa, S., & Ikawa, Y. (2000) · Oncogene · doi:10.1038/sj.onc.1203644 · Cited by 90
Occupational Exposure to Vinyl Chloride, Acrylonitrile and Styrene and Lung Cancer Risk (Europe)
Scélo, G., Constantinescu, V., Csiki, I. E., Zaridze, D. G., Szeszenia‐Dąbrowska, N., Rudnai, P., Lissowska, J., Fabiánová, E., Cassidy, A., Slámová, A., et al. (2004) · Cancer Causes & Control · doi:10.1023/b:caco.0000036444.11655.be · Cited by 86
Self-citationGermline BRCA2 mutations and the risk of esophageal squamous cell carcinoma
Akbari, M. R., Malekzadeh, R., Nasrollahzadeh, D., Amanian, D., Islami, F., Li, S., Zandvakili, I., Shakeri, R., Sotoudeh, M., Aghcheli, K., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210739 · Cited by 83
Martin, S., Matsubayashi, H., Rogers, C. D., Philips, J., Couch, F. J., Brune, K. A., Yeo, C. J., Kern, S. E., Hruban, R. H., & Goggins, M. (2005) · Oncogene · doi:10.1038/sj.onc.1208411 · Cited by 81
Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case–control study
Brennan, P., McKay, J., Moore, L. E., Zaridze, D. G., Mukeria, A., Szeszenia‐Dabrowska, N., Lissowska, J., Rudnai, P., Fabiánová, E., Mateș, D., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm127 · Cited by 80
Self-citationNational study of colorectal cancer genetics
Penegar, S., Wood, W., Lubbe, S. J., Chandler, I. R., Broderick, P., Papaemmanuil, E., Sellick, G. S., Gray, R. G., Peto, J., & Houlston, R. S. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603997 · Cited by 71
Self-citationGenetic Polymorphisms in 15q25 and 19q13 Loci, Cotinine Levels, and Risk of Lung Cancer in EPIC
Timofeeva, M. N., McKay, J., Smith, G. D., Johansson, M., Byrnes, G. B., Chabrier, A., Relton, C. L., Ueland, P. M., Vollset, S. E., Midttun, Ø., et al. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0496 · Cited by 71
Self-citationCigarette smoking increases copy number alterations in nonsmall-cell lung cancer
Huang, Y., Lin, X., Liu, Y., Chirieac, L. R., McGovern, R., Wain, J. R., Heist, R. S., Skaug, V., Zienolddiny, S., Haugen, A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102769108 · Cited by 60
Self-citationConstitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers
Cybulski, C., Masojc, B., Oszutowska–Mazurek, D., Jaworowska, E., Grodzki, T., Waloszczyk, P., Serwatowski, P., Pankowski, J., Huzarski, T., Byrski, T., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn044 · Cited by 58
Self-citationShi, J., Chatterjee, N., Rotunno, M., Wang, Y., Pesatori, A. C., Consonni, D., Li, P., Wheeler, W., Broderick, P., Henrion, M., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0246 · Cited by 57
Self-citationNuclear Localization Signals of the BRCA2 Protein
Yano, K., Morotomi, K., Saito, H., Kato, M., Matsuo, F., & Miki, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2392 · Cited by 56
Eisen, T. G., Matakidou, A., & Houlston, R. S. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-244 · Cited by 42
Self-citationDally, H., Bartsch, H., & Risch, A. (2003) · PubMed · Cited by 12
Self-citation
Cited by
Planchard, D., Popat, S., Kerr, K., Novello, S., Smit, E. F., Faivre-Finn, C., Mok, T. S., Reck, M., Van Schil, P. E., Hellmann, M. D., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy275 · Cited by 2,274
ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Demontis, D., Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium, 23andMe Research Team, Walters, R. K., Martin, J., Mattheisen, M., Als, T. D., Agerbo, E., Baldursson, G., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0269-7 · Cited by 2,203
Bade, B. C., & Dela Cruz, C. S. (2020) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2019.10.001 · Cited by 1,911
SpiroMeta Consortium, McKay, J. D., Hung, R. J., Han, Y., Zong, X., Carreras-Torres, R., Christiani, D. C., Caporaso, N. E., Johansson, M., Xiao, X., et al. (2017) · Nature Genetics · doi:10.1038/ng.3892 · Cited by 720
Self-citationThe Telomeres Mendelian Randomization Collaboration, Haycock, P. C., Burgess, S., Nounu, A., Zheng, J., Okoli, G. N., Bowden, J., Wade, K. H., Timpson, N. J., Evans, D. M., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.5945 · Cited by 513
Self-citation
Metadata
- Authors
- Wang, Y., McKay, J. D., Rafnar, T., Wang, Z., Timofeeva, M. N., Broderick, P., Zong, X., Laplana, M., Wei, Y., Han, Y., Lloyd, A., Delahaye-Sourdeix, M., Chubb, D., Gaborieau, V., Wheeler, W., Chatterjee, N., Thorleifsson, G., Sulem, P., Liu, G., Kaaks, R., Henrion, M., Kinnersley, B., Vallée, M., Le Calvez-Kelm, F., Stevens, V. L., Gapstur, S. M., Chen, W. V., Zaridze, D., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Krokan, H. E., Gabrielsen, M. E., Skorpen, F., Vatten, L., Njølstad, I., Chen, C., Goodman, G., Benhamou, S., Vooder, T., Välk, K., Nelis, M., Metspalu, A., Lener, M., Lubiński, J., Johansson, M., Vineis, P., Agudo, A., Clavel-Chapelon, F., Bueno-de-Mesquita, H. B., Trichopoulos, D., Khaw, K.-T., Johansson, M., Weiderpass, E., Tjønneland, A., Riboli, E., Lathrop, M., Scelo, G., Albanes, D., Caporaso, N. E., Ye, Y., Gu, J., Wu, X., Spitz, M. R., Dienemann, H., Rosenberger, A., Su, L., Matakidou, A., Eisen, T., Stefansson, K., Risch, A., Chanock, S. J., Christiani, D. C., Hung, R. J., Brennan, P., Landi, M. T., Houlston, R. S., & Amos, C. I.
- Venue
- Nature Genetics
- Published
- 2014-06-01
- Volume
- 46
- Issue
- 7
- Pages
- 736-741
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2072881647
- Cited by
- 454
- References
- 71
- FWCI
- 21.60
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
