Cited by 166TGF-β signaling in diseasesGenetic Associations and EpidemiologyDevelopmental Biology and Gene Regulation

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Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice

Bonyadi, Mortaza, Rusholme, Sarah A.B., Cousins, Frances M., Su, Helen C., Biron, Christine A., Farrall, Martin, Akhurst, Rosemary J.·1997·Nature Genetics

DOI 10.1038/ng0297-207

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Abstract

The transforming growth factor beta 1 (TGF beta 1) signalling pathway is important in embryogenesis and has been implicated in hereditary haemorrhagic telangiectasia (HHT), atherosclerosis, tumorigenesis and immunomodulation. Therefore, identification of factors which modulate TGF beta 1 bioactivity in vivo is important. On a mixed genetic background, approximately 50% Tgfb1-/- conceptuses die midgestation from defective yolk sac vasculogenesis. The other half are developmentally normal but die three weeks postpartum. Intriguingly, the vascular defects of Tgfb1-/- mice share histological similarities to lesions seen in HHT patients. It has been suggested that dichotomy in Tgfb1-/- lethal phenotypes is due to maternal TGF beta 1 rescue of some, but not all, Tgfb1-/- embryos12. Here we show that the Tgfb1-/- phenotype depends on the genetic background of the conceptus. In NIH/Ola, C57BL/6J/Ola and F1 conceptuses, Tgfb1-/- lethality can be categorized into three developmental classes. A major codominant modifier gene of embryo lethality was mapped to proximal mouse chromosome 5, using a genome scan for non-mendelian distribution of alleles in Tgfb1-/- neonatal animals which survive prenatal lethality. This gene accounts for around three quarters of the genetic effect between mouse strains and can, in part, explain the distribution of the three lethal phenotypes. This approach, using neonatal DNA samples, is generally applicable to identification of loci that influence the effect of early embryonic lethal mutations, thus furthering knowledge of genetic interactions that occur during early mammalian development in vivo.

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Authors: Bonyadi, M., Rusholme, S. A. B., Cousins, F. M., Su, H. C., Biron, C. A., Farrall, M., & Akhurst, R. J.
Affiliations: University of Glasgow (GB)
University of Oxford (GB)
Brown University (US)
Centre for Human Genetics (GB)
Corresponding author: Akhurst, Rosemary J.
ORCID: Bonyadi, Mortaza
Su, Helen C.
Farrall, Martin
Akhurst, Rosemary J.
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 1997-02
Volume: 15
Issue: 2
Pages: 207-211
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng0297-207
OpenAlex: W2064113953
Cited by: 166
References: 34
Citations by year: 2025: 3 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 7
FWCI: 5.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: TGF-β1, embryonic lethality, genetic modifiers, hereditary hemorrhagic telangiectasia, chromosome 5, genetic background, genome scan, mouse strains
MeSH terms: Animals, Chromosome Mapping, Crosses, Genetic, Fetal Death, Embryonic and Fetal Development, Genes, Lethal, Hematopoiesis, Mice, Inbred C57BL, Phenotype, Yolk Sac, Transforming Growth Factor beta, Mice, Knockout, Microsatellite Repeats, Mice

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Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice

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