Molecular Mechanisms of Sleep and Wakefulness

Lipid rafts and signal transduction

Simons, K., & Toomre, D. K. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 6,252 · see citing works

Two-Process Model of Sleep Regulation

Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6166 · Cited by 3,895 · see citing works

Thalamocortical oscillations in the sleeping and aroused brain

Steriade, M., McCormick, D. A., & Sejnowski, T. J. (1993) · Science · doi:10.1126/science.8235588 · Cited by 3,564 · see citing works

Narcolepsy in orexin Knockout Mice

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095 · see citing works

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

Schröder, M., & Kaufman, R. J. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074134 · Cited by 3,035 · see citing works

Molecular Bases for Circadian Clocks

Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

Bertolotti, A., Zhang, Y., Hendershot, L. M., Harding, H. P., & Ron, D. (2000) · Nature Cell Biology · doi:10.1038/35014014 · Cited by 2,871 · see citing works

Sleep function and synaptic homeostasis

Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151 · see citing works

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · see citing works

ER stress and the unfolded protein response

Schröder, M., & Kaufman, R. J. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.06.056 · Cited by 1,750 · see citing works

The sleep switch: hypothalamic control of sleep and wakefulness

Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656 · see citing works

Sleep Homeostasis and Models of Sleep Regulation

Borb, A. A., & Achermann, P. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000894 · Cited by 1,503 · see citing works

Genetic variants and strains of the laboratory mouse

(1990) · Choice Reviews Online · doi:10.5860/choice.28-1324 · Cited by 1,492 · see citing works

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401 · see citing works

Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem

(2006) · PsycEXTRA Dataset · doi:10.1037/e719732007-001 · Cited by 1,333 · see citing works

Correlates of Sleep and Waking in Drosophila melanogaster

Shaw, P. J., Cirelli, C., Greenspan, R. J., & Tononi, G. (2000) · Science · doi:10.1126/science.287.5459.1834 · Cited by 1,300 · see citing works

Sleep and synaptic homeostasis: a hypothesis

Tononi, G., & Cirelli, C. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.004 · Cited by 1,217 · see citing works

Homer: a protein that selectively binds metabotropic glutamate receptors

Brakeman, P., Lanahan, A. A., O’Brien, R., Roche, K. W., Barnes, C. A., Huganir, R. L., & Worley, P. F. (1997) · Nature · doi:10.1038/386284a0 · Cited by 1,115 · see citing works

Activation of ventrolateral preoptic neurons during sleep

Sherin, J. E., Shiromani, P. J., McCarley, R. W., & Saper, C. B. (1996) · Science · doi:10.1126/science.271.5246.216 · Cited by 1,111 · see citing works

Rest in Drosophila is a sleep-like state

Hendricks, J. C., Finn, S. M., Panckeri, K. A., Chavkin, J., Williams, J. A., Sehgal, A., & Pack, A. I. (2000) · Neuron · doi:10.1016/s0896-6273(00)80877-6 · Cited by 1,050 · see citing works

Orchestrating the unfolded protein response in health and disease

Kaufman, R. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216886 · Cited by 1,015 · see citing works

Inducible gene targeting in mice using the Cre/lox system.

Sauer, B. (1998) · Methods · doi:10.1006/meth.1998.0593 · Cited by 858 · see citing works

Restoration of brain energy metabolism as the function of sleep

Benington, J. H., & Heller, H. C. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00057-o · Cited by 828 · see citing works

Spatiotemporal Gene Expression Targeting with the TARGET and Gene-Switch Systems in Drosophila

McGuire, S. E., Mao, Z., & Davis, R. L. (2004) · Science s STKE · doi:10.1126/stke.2202004pl6 · Cited by 762 · see citing works

Innervation of Histaminergic Tuberomammillary Neurons by GABAergic and Galaninergic Neurons in the Ventrolateral Preoptic Nucleus of the Rat

Sherin, J. E., Elmquist, J. K., Torrealba, F., & Saper, C. B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04705.1998 · Cited by 746 · see citing works

Zebrafish: a model system for the study of human disease

Dooley, K. A. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00074-5 · Cited by 745 · see citing works

Altered circadian activity rhythms and sleep in mice devoid of prion protein

Tobler, I., Gaus, S. E., Deboer, T., Achermann, P., Fischer, M. S., Rülicke, T., Moser, M., Oesch, B., McBride, P. A., & Manson, J. C. (1996) · Nature · doi:10.1038/380639a0 · Cited by 662 · see citing works

Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins

Xiao, B., Tu, J. C., Petralia, R. S., Yuan, J. P., Doan, A., Breder, C. D., Ruggiero, A. M., Lanahan, A. A., Wenthold, R. J., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80588-7 · Cited by 649 · see citing works

Extensive and divergent effects of sleep and wakefulness on brain gene expression

Cirelli, C., Gutierrez, C. M., & Tononi, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00814-6 · Cited by 627 · see citing works

The knockout mouse project

The Comprehensive Knockout Mouse Project Consortium (2004) · Nature Genetics · doi:10.1038/ng0904-921 · Cited by 608 · see citing works

Lipid Rafts in the Maintenance of Synapses, Dendritic Spines, and Surface AMPA Receptor Stability

Hering, H., Lin, C.-C., & Sheng, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03262.2003 · Cited by 602 · see citing works

Signaling the Unfolded Protein Response from the Endoplasmic Reticulum

Zhang, K., & Kaufman, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400008200 · Cited by 580 · see citing works

The Homeostatic Regulation of Sleep Need Is under Genetic Control

Franken, P., Chollet, D., & Tafti, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02610.2001 · Cited by 551 · see citing works

Lethargus is a Caenorhabditis elegans sleep-like state

Raizen, D. M., Zimmerman, J. E., Maycock, M. H., Ta, U. D., You, Y.-J., Sundaram, M. V., & Pack, A. I. (2008) · Nature · doi:10.1038/nature06535 · Cited by 536 · see citing works

Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish

Prober, D. A., Rihel, J., Onah, A. A., Sung, R.-J., & Schier, A. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4332-06.2006 · Cited by 508 · see citing works

Reduced sleep in Drosophila Shaker mutants

Cirelli, C., Bushey, D., Hill, S., Huber, R., Kreber, R. A., Ganetzky, B., & Tononi, G. (2005) · Nature · doi:10.1038/nature03486 · Cited by 474 · see citing works

Endoplasmic Reticulum Stress and the Development of Diabetes

Harding, H. P., & Ron, D. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s455 · Cited by 465 · see citing works

Analysing complex genetic traits with chromosome substitution strains

Nadeau, J. H., Singer, J. B., Matin, A., et al. (2000) · Nature Genetics · doi:10.1038/73427 · Cited by 462 · see citing works

Identification of Wake-Active Dopaminergic Neurons in the Ventral Periaqueductal Gray Matter

Lu, J., Jhou, T. C., & Saper, C. B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2244-05.2006 · Cited by 458 · see citing works

The nature and identification of quantitative trait loci: a community's view

Members of the Complex Trait Consortium (2003) · Nature Reviews Genetics · doi:10.1038/nrg1206 · Cited by 437 · see citing works

Melatonin promotes sleep-like state in zebrafish

Zhdanova, I. V., Wang, S. Y., Leclair, O. U., & Danilova, N. P. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02444-1 · Cited by 418 · see citing works

Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

Ango, F., Prézeau, L., Müller, T. H., Tu, J. C., Xiao, B., Worley, P. F., Pin, J., Bockaert, J., & Fagni, L. (2001) · Nature · doi:10.1038/35082096 · Cited by 410 · see citing works

Homeostatic, circadian, and emotional regulation of sleep

Saper, C. B., Cano, G., & Scammell, T. E. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20770 · Cited by 405 · see citing works

Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

Yokogawa, T., Marin, W., Faraco, J. H., Pézeron, G., Appelbaum, L., Zhang, J., Rosa, F., Mourrain, P., & Mignot, E. J.-M. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050277 · Cited by 402 · see citing works

Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

Hümmler, E., Cole, T. J., Blendy, J. A., Ganß, R., Aguzzi, A., Schmid, W., Beermann, F., & Schütz, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5647 · Cited by 389 · see citing works

Macromolecule biosynthesis: a key function of sleep

Mackiewicz, M., Shockley, K. R., Romer, M. A., Galante, R. J., Zimmerman, J. E., Naidoo, N. N., Baldwin, D. A., Jensen, S. T., Churchill, G. A., & Pack, A. I. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00275.2006 · Cited by 378 · see citing works

The Circadian<i>Clock</i>Mutation Alters Sleep Homeostasis in the Mouse

Naylor, E., Bergmann, B. M., Krauski, K., Zee, P. C., Takahashi, J. S., Vitaterna, M. H., & Turek, F. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08138.2000 · Cited by 367 · see citing works

Homer1a is a core brain molecular correlate of sleep loss

Maret, S., Dorsaz, S., Gurcel, L., Pradervand, S., Petit, B., Pfister, C., Hagenbüchle, O., O’Hara, B. F., Franken, P., & Tafti, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710131104 · Cited by 366 · see citing works

Gene expression in the brain across the sleep–waking cycle11Published on the World Wide Web on 30 October 2000.

Cirelli, C., & Tononi, G. (2000) · Brain Research · doi:10.1016/s0006-8993(00)03008-0 · Cited by 365 · see citing works

Recombinant Inbred Strains

Festing, M. F. W. (1979) · doi:10.1007/978-1-349-03816-9_10 · Cited by 354 · see citing works

Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice

Singer, J. B., Hill, A. E., Burrage, L. C., Olszens, K. R., Song, J., Justice, M. J., O’Brien, W. E., Conti, D. V., Witte, J. S., Lander, E. S., et al. (2004) · Science · doi:10.1126/science.1093139 · Cited by 347 · see citing works

Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.

Dorner, A. J., Wasley, L. C., & Kaufman, R. J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05201.x · Cited by 342 · see citing works

The Homer family proteins.

Shiraishi‐Yamaguchi, Y., & Furuichi, T. (2007) · Genome biology · doi:10.1186/gb-2007-8-2-206 · Cited by 324 · see citing works

Gene Expression Nervous System Atlas (GENSAT)

Heintz, N. (2004) · Nature Neuroscience · doi:10.1038/nn0504-483 · Cited by 323 · see citing works

Sleep EEG in the rat as a function of prior waking

Tobler, I., & Borbély, A. A. (1986) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(86)90044-1 · Cited by 319 · see citing works

Sleep and Sleep Regulation in Normal and Prion Protein-Deficient Mice

Tobler, I., Deboer, T., & Fischer, M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01869.1997 · Cited by 296 · see citing works

Novel Members of the Vesl/Homer Family of PDZ Proteins That Bind Metabotropic Glutamate Receptors

Kato, A., Ozawa, F., Saitoh, Y., Fukazawa, Y., Sugiyama, H., & Inokuchi, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23969 · Cited by 280 · see citing works

Rat genetics: attachign physiology and pharmacology to the genome

Jacob, H. J., & Kwitek, A. E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg702 · Cited by 274 · see citing works

Genetics and molecular biology of rhythms in Drosophila and other insects

Hall, J. C. (2003) · Advances in genetics · doi:10.1016/s0065-2660(03)48000-0 · Cited by 267 · see citing works

Endogenous sleep-promoting substances and sleep regulation

Borbely, A. A., & Tobler, I. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.2.605 · Cited by 259 · see citing works

Effect of impulse blockage on cytochrome oxidase activity in monkey visual system

Wong‐Riley, M. T. T., & Carroll, E. W. (1984) · Nature · doi:10.1038/307262a0 · Cited by 243 · see citing works

Role of Molecular Oscillations in Generating Behavioral Rhythms in Drosophila

Yang, Z., & Sehgal, A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00218-5 · Cited by 240 · see citing works

Novel method for high-throughput phenotyping of sleep in mice

Pack, A. I., Galante, R. J., Maislin, G., Cater, J. R., Metaxas, D., Lu, S., Zhang, L., Smith, R. V., Kay, T., Lian, J., et al. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00139.2006 · Cited by 234 · see citing works

A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis

Hendricks, J. C., Williams, J. A., Panckeri, K. A., Kirk, D., Tello-Ruiz, M. K., Yin, J. C. P., & Sehgal, A. (2001) · Nature Neuroscience · doi:10.1038/nn743 · Cited by 231 · see citing works

Exploratory Behavior, Cortical BDNF Expression, and Sleep Homeostasis

Huber, R., Tononi, G., & Cirelli, C. (2007) · Sleep · doi:10.1093/sleep/30.2.129 · Cited by 224 · see citing works

The Rat as an Experimental Animal

Gill, T. J., Smith, G. J., Wissler, R. W., & Kunz, H. W. (1989) · Science · doi:10.1126/science.2665079 · Cited by 224 · see citing works

Sleep deprivation induces the unfolded protein response in mouse cerebral cortex

Naidoo, N. N., Giang, W., Galante, R. J., & Pack, A. I. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02952.x · Cited by 215 · see citing works

Identification and Characterization of a Novel Endoplasmic Reticulum (ER) DnaJ Homologue, Which Stimulates ATPase Activity of BiP in Vitro and Is Induced by ER Stress

Shen, Y., Meunier, L., & Hendershot, L. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112214200 · Cited by 215 · see citing works

Molecular Components of the Circadian System in Drosophila

Williams, J. A., & Sehgal, A. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.729 · Cited by 211 · see citing works

Brain-Derived Neurotrophic Factor Modulates Cerebellar Plasticity and Synaptic Ultrastructure

Carter, A. R., Chen, C., Schwartz, P. M., & Segal, R. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01316.2002 · Cited by 207 · see citing works

Altered sleep regulation in leptin-deficient mice

Laposky, A. D., Shelton, J., Bass, J., Dugovic, C., Perrino, N., & Turek, F. W. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00304.2005 · Cited by 203 · see citing works

Hypothalamic control of sleep

Szymusiak, R. S., Gvilia, I., & McGinty, D. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.013 · Cited by 200 · see citing works

Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking α1 G -subunit of T-type calcium channels

Lee, J., Kim, D., & Shin, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408089101 · Cited by 197 · see citing works

Functional genomics and rat models

Jacob, H. J. (1999) · Genome Research · doi:10.1101/gr.9.11.1013 · Cited by 190 · see citing works

The effect of 3-h and 6-h sleep deprivation on sleep and EEG spectra of the rat

Tobler, I., & Borbély, A. A. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90161-7 · Cited by 183 · see citing works

Hypothalamic regulation of sleep and arousal

McGinty, D. (2003) · Frontiers in bioscience · doi:10.2741/1159 · Cited by 178 · see citing works

Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer’s disease: A role for cholinergic transmission

Wisor, J. P., Edgar, D. M., Yesavage, J. A., Ryan, H. S., McCormick, C. M., Lapustea, N., & Murphy, G. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.018 · Cited by 169 · see citing works

Association of Excitatory Amino Acid Transporters, Especially EAAT2, with Cholesterol-rich Lipid Raft Microdomains

Butchbach, M. E. R., Tian, G., Guo, H., & Lin, C. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403938200 · Cited by 166 · see citing works

Essentials of Sleep Recordings in Drosophila: Moving Beyond Sleep Time

Andretic, R., & Shaw, P. J. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)93040-1 · Cited by 160 · see citing works

Sleep and wakefulness modulate gene expression in Drosophila

Cirelli, C., LaVaute, T. M., & Tononi, G. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03291.x · Cited by 155 · see citing works

Effects of interleukin-1β on sleep are mediated by the type I receptor

Fang, J., Wang, Y., & Krueger, J. M. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r655 · Cited by 152 · see citing works

The Transcription Factor DBP Affects Circadian Sleep Consolidation and Rhythmic EEG Activity

Franken, P., Lopez‐Molina, L., Marcacci, L., Schibler, U., & Tafti, M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00617.2000 · Cited by 149 · see citing works

Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep

Terao, A., Steininger, T. L., Hyder, K., Apte-Deshpande, A. D., Ding, J., Rishipathak, D., Davis, R. W., Heller, H. C., & Kilduff, T. S. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00695-4 · Cited by 148 · see citing works

Homeostatic Regulation of Sleep: A Role for Preoptic Area Neurons

Gvilia, I., Xu, F., McGinty, D., & Szymusiak, R. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2012-06.2006 · Cited by 145 · see citing works

On the Functional Significance of c-fos Induction During the Sleep-waking Cycle

Cirelli, C., & Tononi, G. (2000) · SLEEP · doi:10.1093/sleep/23.4.9 · Cited by 139 · see citing works

Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip® study

Terao, A., Wisor, J. P., Peyron, C., Apte-Deshpande, A. D., Wurts, S. W., Edgar, D. M., & Kilduff, T. S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.059 · Cited by 137 · see citing works

The Rat Genome Database, update 2007--Easing the path from disease to data and back again

Twigger, S. N., Shimoyama, M. E., Bromberg, S. K., Kwitek, A. E., Jacob, H. J., & the RGD Team (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl988 · Cited by 132 · see citing works

NMDA Receptor Stimulation and Brain-Derived Neurotrophic Factor Upregulate Homer 1a mRNA via the Mitogen-Activated Protein Kinase Cascade in Cultured Cerebellar Granule Cells

Sato, M., Suzuki, K., & Nakanishi, S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03797.2001 · Cited by 129 · see citing works

Pattern Recognition of Sleep in Rodents Using Piezoelectric Signals Generated by Gross Body Movements

Flores, A. E., Flores, J. E., Deshpande, H., Picazo, J. A., Xie, X., Franken, P., Heller, H. C., Grahn, D. A., & O’Hara, B. F. (2007) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2006.886938 · Cited by 127 · see citing works

Genetic Evidence for a Role of CREB in Sustained Cortical Arousal

Graves, L. A., Hellman, K. M., Veasey, S. C., Blendy, J. A., Pack, A. I., & Abel, T. G. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00882.2002 · Cited by 124 · see citing works

Identifying novel genes for atherosclerosis through mouse-human comparative genetics.

Wang, X.-S., Ishimori, N., Korstanje, R., Rollins, J., & Paigen, B. (2005) · American Journal of Human Genetics · doi:10.1086/431656 · Cited by 123 · see citing works

The need for a simple animal model to understand sleep

Hendricks, J. C., Sehgal, A., & Pack, A. I. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00048-9 · Cited by 123 · see citing works

Polysynaptic regulation of glutamate receptors and mitochondrial enzyme activities in the basal ganglia of rats with unilateral dopamine depletion

Porter, R., Greene, J., Higgins, D. S., et al. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-07192.1994 · Cited by 122 · see citing works

Transposable elements as tools for genomics and genetics in Drosophila

Ryder, E. (2003) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/2.1.57 · Cited by 122 · see citing works

Bioinformatics toolbox for narrowing rodent quantitative trait loci

DiPetrillo, K., Wang, X., Stylianou, I. M., & Paigen, B. J. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.09.008 · Cited by 121 · see citing works

Effect of forced locomotion on the rest-activity cycle of the cockroach

Tobler, I. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90180-8 · Cited by 120 · see citing works

Consomic rat model systems for physiological genomics

Cowley, A. W., Liang, M., Roman, R. J., Greene, A. S., & Jacob, H. J. (2004) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01334.x · Cited by 116 · see citing works

Sleep in Kcna2 knockout mice

Douglas, C. L., Vyazovskiy, V. V., Southard, T. L., Chiu, S. Y., Messing, A., Tononi, G., & Cirelli, C. (2007) · BMC Biology · doi:10.1186/1741-7007-5-42 · Cited by 115 · see citing works

Regulation of Hypocretin (Orexin) Expression in Embryonic Zebrafish

Faraco, J. H., Appelbaum, L., Marin, W., Gaus, S. E., Mourrain, P., & Mignot, E. J.-M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605811200 · Cited by 115 · see citing works

Behavioral analysis of CREB αΔ mutation on a B6/129 F1 hybrid background

Graves, L. A., Dalvi, A., Lucki, I., Blendy, J. A., & Abel, T. G. (2002) · Hippocampus · doi:10.1002/hipo.10003 · Cited by 109 · see citing works

Metabolic activity of the basal ganglia in parkinsonian syndromes in human and non-human primates: A cytochrome oxidase histochemistry study

Vila, M., Lévy, R., Herrero, M. T., Faucheux, B. A., Obeso, J. A., Agid, Y., & Hirsch, É. C. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00549-8 · Cited by 106 · see citing works

Altered Synapse Formation in the Adult Somatosensory Cortex of Brain-Derived Neurotrophic Factor Heterozygote Mice

Genoud, C., Knott, G. W., Sakata, K., Lu, B., & Welker, E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4040-03.2004 · Cited by 106 · see citing works

Multiple mechanisms limit the duration of wakefulness in Drosophila brain

Zimmerman, J. E., Rizzo, W., Shockley, K. R., Raizen, D. M., Naidoo, N. N., Mackiewicz, M., Churchill, G. A., & Pack, A. I. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00030.2006 · Cited by 104 · see citing works

Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts

Eroğlu, Ç., Brügger, B., Wieland, F., & Sinning, I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1737042100 · Cited by 100 · see citing works

Differences in gene expression between sleep and waking as revealed by mRNA differential display

Cirelli, C., & Tononi, G. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00057-6 · Cited by 100 · see citing works

Sleep, sleep disorders and hypocretin (orexin)

Mignot, E. J.-M. (2004) · Sleep Medicine · doi:10.1016/s1389-9457(04)90001-9 · Cited by 99 · see citing works

A Role for the Molecular Chaperone Protein BiP/GRP78 in Drosophila Sleep Homeostasis

Naidoo, N. N., Casiano, V., Cater, J. R., Zimmerman, J. E., & Pack, A. I. (2007) · SLEEP · doi:10.1093/sleep/30.5.557 · Cited by 98 · see citing works

An action plan for mouse genomics

Battey, J. F., Jordan, E., Cox, D. R., & Dove, W. F. (1999) · Nature Genetics · doi:10.1038/5012 · Cited by 98 · see citing works

Differences in brain gene expression between sleep and waking as revealed by mRNA differential display and cDNA microarray technology

Cirelli, C., & Tononi (1999) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1999.00008.x · Cited by 91 · see citing works

24‐h variation of vigilance in the cockroach Blaberus giganteus

Tobler, I., & Neuner‐Jehle, M. (1992) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1992.tb00044.x · Cited by 88 · see citing works

Zebrafish as a Genomics Research Model

Chen, E. Y., & Ekker, S. C. (2004) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201043376652 · Cited by 85 · see citing works

Initial Characterization of a Rat Model of Diabetic Nephropathy

Nóbrega, M. A., Fleming, S., Roman, R. J., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.3.735 · Cited by 81 · see citing works

Cytokine- and microbially induced sleep responses of interleukin-10 deficient mice

Toth, L. A., & Opp, M. R. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.6.r1806 · Cited by 75 · see citing works

Requirement of TrkB for synapse elimination in developing cerebellar Purkinje cells

Bosman, L. W. J., Hartmann, J., Barski, J. J., Lepier, A., Noll‐Hussong, M., Reichardt, L. F., & Konnerth, A. (2007) · Journal of Neurocytology · doi:10.1007/s11068-006-9002-z · Cited by 72 · see citing works

Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system

Zhang, J., Obál, F., Fang, J., Collins, B., & Krueger, J. M. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13232-8 · Cited by 72 · see citing works

A Novel Gain-of-Function Mutant of the Cyclic GMP-Dependent Protein Kinase egl-4 Affects Multiple Physiological Processes in Caenorhabditis elegans

Raizen, D. M., Cullison, K., Pack, A. I., & Sundaram, M. V. (2006) · Genetics · doi:10.1534/genetics.106.057380 · Cited by 62 · see citing works

Genome-wide search for new genes controlling plasma lipid concentrations in mice and humans

Wang, X., & Paigen, B. J. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000162317.09054.9d · Cited by 59 · see citing works

Analysis of the QTL for sleep homeostasis in mice:Homer1ais a likely candidate

Mackiewicz, M., Paigen, B. J., Naidoo, N. N., & Pack, A. I. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00189.2007 · Cited by 59 · see citing works

Effect of rest deprivation on motor activity of fish

Tobler, I., & Borb�ly, A. A. (1985) · Journal of Comparative Physiology A · doi:10.1007/bf01350078 · Cited by 51 · see citing works

Homer1a and 1bc levels in the rat somatosensory cortex vary with the time of day and sleep loss

Nelson, S. E., Duricka, D., Campbell, K., Churchill, L., & Krueger, J. M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.089 · Cited by 51 · see citing works

NMDA Receptors are not Alone: Dynamic Regulation of NMDA Receptor Structure and Function by Neuregulins and Transient Cholesterol-Rich Membrane Domains Leads to Disease-Specific Nuances of Glutamate- Signalling

Schrattenholz, A. S., & Šoškić, V. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606776894519 · Cited by 51 · see citing works

Differences in Activity of Cytochrome C Oxidase in Brain Between Sleep and Wakefulness

Nikonova, E. V., Vijayasarathy, C., Zhang, L., Cater, J. R., Galante, R. J., Ward, S. E., Avadhani, N. G., & Pack, A. I. (2005) · SLEEP · doi:10.1093/sleep/28.1.21 · Cited by 49 · see citing works

Physiogenomic resources for rat models of heart, lung and blood disorders

Malek, R. L., Wang, H.-Y., Kwitek, A. E., Greene, A. S., BHAGABATI, N. K., Borchardt, G. J., Cahill, L., Currier, T., Frank, B. C., Fu, X., et al. (2006) · Nature Genetics · doi:10.1038/ng1693 · Cited by 49 · see citing works

Genomics and Clinical Medicine: Rationale for Creating and Effectively Evaluating Animal Models

Swanson, K. S., Mazur, M. J., Vashisht, K., Rund, L. A., Beever, J. E., Counter, C. M., & Schook, L. B. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422900902 · Cited by 48 · see citing works

Conditional expression of UAS‐transgenes in the adult eye with a new gene‐switch vector system

Roman, G., & Davis, R. L. (2002) · genesis · doi:10.1002/gene.10133 · Cited by 45 · see citing works

Proteomic characterization of lipid rafts markers from the rat intestinal brush border

Nguyen, H. T. T., Amine, A. B., Lafitte, D., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.141 · Cited by 43 · see citing works

Sleep and wakefulness in c-fos and fos B gene knockout mice

Shiromani, P. J., Basheer, R., Thakkar, J., Wagner, D., Greco, M. A., & Charness, M. E. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00123-6 · Cited by 39 · see citing works

Paradoxical Sleep in Mice Lacking M3 and M2/M4 Muscarinic Receptors

Goutagny, R., Comte, J., Salvert, D., Gomeza, J., Yamada, M., Wess, J., Luppi, P., & Fort, P. (2005) · Neuropsychobiology · doi:10.1159/000087560 · Cited by 37 · see citing works

Haplotype-based genetics in mice and rats

Cuppen, E. P. J. G. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.03.010 · Cited by 35 · see citing works

Regulation of mitochondrial gene expression by energy demand in neural cells

Mehrabian, Z., Liu, L., Fiskum, G. M., Rapoport, S. I., & Chandrasekaran, K. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03066.x · Cited by 30 · see citing works

The worm's sense of smell

Melkman, T., & Sengupta, P. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.07.005 · Cited by 25 · see citing works

Functional genomics of sleep

Mackiewicz, M., & Pack, A. I. (2003) · Respiratory Physiology & Neurobiology · doi:10.1016/s1569-9048(03)00045-4 · Cited by 21 · see citing works

PHYSIOLOGICAL GENETICS: APPLICATION TO HYPERTENSION RESEARCH

Jacob, H. J. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.03078.x · Cited by 20 · see citing works

Consomic Rats for the Identification of Genes and Pathways Underlying Cardiovascular DiseasePreprint

Roman, R. J., Cowley, A. W., Greene, A. S., et al. (2002) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2002.67.309 · Cited by 18 · see citing works

Shaking up sleep research

Hendricks, J. C. (2005) · Nature Neuroscience · doi:10.1038/nn0605-703 · Cited by 8 · see citing works

Untitled work

Sánchez (2002) · doi:10.1379/1466-1268(2002)007

About Sleep's Role in Memory

Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works

Sleep, Health, and Society

Grandner, M. A. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.10.012 · Cited by 720 · see citing works

The energy allocation function of sleep: A unifying theory of sleep, torpor, and continuous wakefulness

Schmidt, M. H. (2014) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.001 · Cited by 291 · see citing works

Sleep Is Associated with the Metabolic Syndrome in a Multi-Ethnic Cohort of Midlife Women: The SWAN Sleep Study

Hall, M. H., Okun, M. L., Sowers, M., Matthews, K. A., Kravitz, H. M., Hardin, K., Buysse, D. J., Bromberger, J. T., Owens, J. F., Karpov, I., et al. (2012) · SLEEP · doi:10.5665/sleep.1874 · Cited by 123 · see citing works

Obesity, diabetes, and exercise associated with sleep-related complaints in the American population

Grandner, M. A., Patel, N. P., Perlis, M. L., Gehrman, P. R., Xie, D., Sha, D., Pigeon, W. R., Teff, K., Weaver, T., & Gooneratne, N. S. (2011) · Journal of Public Health · doi:10.1007/s10389-011-0398-2 · Cited by 58 · see citing works

Whole blood genome-wide gene expression profile in males after prolonged wakefulness and sleep recovery

Pellegrino, R., Sunaga, D. Y., Guindalini, C., Martins, R. C. S., Mazzotti, D. R., Wei, Z., Daye, Z. J., Andersen, M. L., & Tufik, S. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00058.2012 · Cited by 42 · see citing works

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

KOMPLIKASI REGIONAL ANESTESI PADA PEDIATRIK

Sari, D. (2023) · Jurnal Komplikasi Anestesi · doi:10.22146/jka.v5i1.7322

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia

Interleucinas na encefalopatia hipóxico-isquêmica

Ceccon, M. E. J. R. (2003) · Jornal de Pediatria · doi:10.1590/s0021-75572003000400002 · Cited by 14 · see citing works