A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

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Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes

McManus, M. T., Haines, B. B., Dillon, C. P., Whitehurst, C. E., van Parijs, L., Chen, J., & Sharp, P. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5754 · Cited by 215

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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Progress and problems with the use of viral vectors for gene therapy

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MicroRNA: Biogenesis, Function and Role in Cancer

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Transvascular delivery of small interfering RNA to the central nervous system

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Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

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p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia

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Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response

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Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

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Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

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Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

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BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H.-C., Xu, G., Koliatsos, V. E., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2766-05.2005 · Cited by 521

Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo

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Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

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An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis.

Sweet-Cordero, A., Mukherjee, S., Subramanian, A., You, H., Roix, J. J., Ladd-Acosta, C., Mesirov, J., Golub, T. R., & Jacks, T. (2005) · Nature Genetics · doi:10.1038/ng1490 · Cited by 414

NUMB controls p53 tumour suppressor activity

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Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis

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The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines

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Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex.

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Extracellular interactions between GluR2 and N-cadherin in spine regulation

Saglietti, L., Dequidt, C., Kamieniarz, K., Rousset, M.-C., Valnegri, P., Thoumine, O., Beretta, F., Fagni, L., Choquet, D., Sala, C., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.012 · Cited by 341

TNF-α Inhibits Asbestos-Induced Cytotoxicity via a NF-ΚB-Dependent Pathway, a Possible Mechanism for Asbestos-Induced Oncogenesis

Yang, H., Bocchetta, M., Kroczynska, B., Elmishad, A. G., Chen, Y., Liu, Z., Bubici, C., Mossman, B. T., Pass, H. I., Testa, J. R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604008103 · Cited by 322

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference

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Quaternary Structure, Protein Dynamics, and Synaptic Function of SAP97 Controlled by L27 Domain Interactions

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HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

DeLaForest, A., Nagaoka, M., Si-Tayeb, K., Noto, F. K., Konopka, G., Battle, M. A., & Duncan, S. A. (2011) · Development · doi:10.1242/dev.062547 · Cited by 219

Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization

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Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons

Mardinly, A. R., Spiegel, I., Patrizi, A., Centofante, E., Bazinet, J. E., Tzeng, C. P., Mandel-Brehm, C., Harmin, D. A., Adesnik, H., Fagiolini, M., et al. (2016) · Nature · doi:10.1038/nature17187 · Cited by 176

Nectin-like proteins mediate axon–Schwann cell interactions along the internode and are essential for myelination

Maurel, P., Einheber, S., Galinska, J., Thaker, P., Lam, I., Rubin, M. B., Scherer, S. S., Murakami, Y., Gutmann, D. H., & Salzer, J. L. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705132 · Cited by 177

TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function

Humphrey, M. B., Daws, M. R., Spusta, S. C., Niemi, E. C., Torchia, J. A., Lanier, L. L., Seaman, W. E., & Nakamura, M. C. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051016 · Cited by 162

Stable RNA interference: Comparison of U6 and H1 promoters in endothelial cells and in mouse brain

Mäkinen, P. I., Koponen, J. K., Kärkkäinen, A., Malm, T. M., Pulkkinen, K. H., Koistinaho, J., Turunen, M. P., & Ylä‐Herttuala, S. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.860 · Cited by 134

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

Shaw, A. T., Meissner, A., Dowdle, J. A., Crowley, D., Magendantz, M., Ouyang, C., Parisi, T., Rajagopal, J., Blank, L. J., Bronson, R. T., et al. (2007) · Genes & Development · doi:10.1101/gad.1526207 · Cited by 131

New tools for functional mammalian cancer genetics

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Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs

Aagaard, L. A., Zhang, J., von Eije, K. J., Li, H., Sætrom, P., Amarzguioui, M., & Rossi, J. J. (2008) · Gene Therapy · doi:10.1038/gt.2008.147 · Cited by 115

Human artificial chromosomes for gene delivery and the development of animal models

Kazuki, Y., & Oshimura, M. (2011) · Molecular Therapy · doi:10.1038/mt.2011.136 · Cited by 108

Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels

Kim, J.-H., Hong, S.-K., Wu, P.-K., Richards, A. L., Jackson, W. T., & Park, J.-I. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.08.001 · Cited by 108

Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis

Matsuki, T., Pramatarova, A., & Howell, B. W. (2008) · Journal of Cell Science · doi:10.1242/jcs.027334 · Cited by 92

Loss of T cell receptor-induced Bmi-1 in the KLRG1 + senescent CD8 + T lymphocyte

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RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes

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Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness

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Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex

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Device-based local delivery of siRNA against mammalian target of rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation

Takahashi, H., Wang, Y., & Grainger, D. W. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.019 · Cited by 58

Pathways Leading to Phosphorylation of P450c17 and to the Posttranslational Regulation of Androgen Biosynthesis

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Overexpression of c-Met in bone marrow mesenchymal stem cells improves their effectiveness in homing and repair of acute liver failure

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DNA polymerase β-dependent long patch base excision repair in living cells

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Defining the role of corticotropin releasing factor binding protein in alcohol consumption

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Single-cell and spatial RNA sequencing identify perturbators of microglial functions with aging

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MiR-137–3p rescue motoneuron death by targeting calpain-2

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Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocellular carcinoma

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