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Netting neutrophils in autoimmune small-vessel vasculitis
Open accessAbstract
Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.
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Metadata
- Authors
- Kessenbrock, K., Krumbholz, M., Schönermarck, U., Back, W., Gross, W. L., Werb, Z., Gröne, H.-J., Brinkmann, V., & Jenne, D. E.
- Venue
- Nature Medicine
- Published
- 2009-05-17
- Volume
- 15
- Issue
- 6
- Pages
- 623-625
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2043756611
- Cited by
- 1,648
- References
- 16
- FWCI
- 24.18
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- www.springer.com/tdm (tdm)
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