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Cited by 655

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Mesenchymal stem cell–based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α

Open access
Liu, Yi, Wang, Lei, Kikuiri, Takashi, Akiyama, Kentaro, Chen, Chider, Xu, Xingtian, Yang, Ruili, Chen, WanJun, Wang, Songlin, Shi, Songtao·2011·Nature Medicine
DOI 10.1038/nm.2542
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Abstract

Stem cell–based regenerative medicine is a promising approach in tissue reconstruction. Here we show that proinflammatory T cells inhibit the ability of exogenously added bone marrow mesenchymal stem cells (BMMSCs) to mediate bone repair. This inhibition is due to interferon γ (IFN-γ)–induced downregulation of the runt-related transcription factor 2 (Runx-2) pathway and enhancement of tumor necrosis factor α (TNF-α) signaling in the stem cells. We also found that, through inhibition of nuclear factor κB (NF-κB), TNF-α converts the signaling of the IFN-γ–activated, nonapoptotic form of TNF receptor superfamily member 6 (Fas) in BMMSCs to a caspase 3– and caspase 8–associated proapoptotic cascade, resulting in the apoptosis of these cells. Conversely, reduction of IFN-γ and TNF-α concentrations by systemic infusion of Foxp3+ regulatory T cells, or by local administration of aspirin, markedly improved BMMSC-based bone regeneration and calvarial defect repair in C57BL/6 mice. These data collectively show a previously unrecognized role of recipient T cells in BMMSC-based tissue engineering.

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Metadata

Authors
Liu, Y., Wang, L., Kikuiri, T., Akiyama, K., Chen, C., Xu, X., Yang, R., Chen, W., Wang, S., & Shi, S.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2011-11-20
Volume
17
Issue
12
Pages
1594-1601
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.2542
OpenAlex
W2053984526
Cited by
655
References
37
FWCI
16.90
Type
journal article
Language
en
Open access
green

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