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5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Merlo, Adrian, Herman, James G., Mao, Li, Lee, Daniel J., Gabrielson, Edward, Burger, Peter C., Baylin, Stephen B., Sidransky, David·1995·Nature Medicine

DOI 10.1038/nm0795-686

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“P16, a tumor suppressor encoded by CDKN2A, has been found to gain de novo methylation in ~20% of different primary neoplasms.(21) Mutations in important and wellstudied tumor-suppressive genes, such as P53 and BRCA1, are frequently identified in multiple cancers.”
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Authors: Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B., & Sidransky, D.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 1995-07
Volume: 1
Issue: 7
Pages: 686-692
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/nm0795-686
OpenAlex: W1977706798
Cited by: 1,986
References: 6
FWCI: 37.42
Type: journal article
Language: en
Open access: closed

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5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

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