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Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
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Cited by
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
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Ischemic Cell Death in Brain Neurons
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Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
Yu, S.-W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2002) · Science · doi:10.1126/science.1072221 · Cited by 1,826
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David, K. K. (2009) · Frontiers in Bioscience · doi:10.2741/3297 · Cited by 450
“Furthermore, PARP-1 KO mice are profoundly resistant to stroke and NMDA excitotoxicity (24-26).”
BackgroundNAD + Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death
Alano, C. C., Garnier, P., Ying, W., Higashi, Y., Kauppinen, T. M., & Swanson, R. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5552-09.2010 · Cited by 439
Animal models of focal and global cerebral ischemia
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Self-citationNuclear DNA damage signalling to mitochondria in ageing
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Self-citationTherapeutic applications of PARP inhibitors: Anticancer therapy and beyond
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Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke
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Neuronal death/survival signaling pathways in cerebral ischemia
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Self-citationARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD+ Depletion
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Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke
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Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases
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Inhibition of poly(ADP-ribose) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species
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Metadata
- Authors
- Eliasson, M. J. L., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A., Wang, Z.-Q., Dawson, T. M., Snyder, S. H., & Dawson, V. L.
- Venue
- Nature Medicine
- Published
- 1997-10
- Volume
- 3
- Issue
- 10
- Pages
- 1089-1095
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2085459880
- Cited by
- 1,018
- References
- 0
- FWCI
- 41.82
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.