Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

Kong, Weijia, Wei, Jing, Abidi, Parveen, Lin, Meihong, Inaba, Satoru, Li, Cong, Wang, Yanling, Wang, Zizheng +8 more·2004·Nature Medicine

DOI 10.1038/nm1135

Cited by (1,002)

Items 201–300 of 1,002

Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients
Marazzi, Giuseppe, Cacciotti, Luca, Pelliccia, Francesco, Iaia, Luigi, Volterrani, Maurizio, Caminiti, Giuseppe, Sposato, Barbara, Massaro, Rosalba, Grieco, Fabrizia, Rosano, Giuseppe · 2011 · Advances in Therapy
Excretion of Berberine and Its Metabolites in Oral Administration in Rats
Jingyi Ma, Ru Feng, Xiang‐Shan Tan, Chao Ma, Jia‐Wen Shou, Jie Fu, Min Huang, Chi‐Yu He, Shuonan Chen, Zhenxiong Zhao et al. · 2013 · Journal of Pharmaceutical Sciences
Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells
Jian-Jun Lu, Lingyi Fu, Zhipeng Tang, Changlin Zhang, Lijun Qin, Jingshu Wang, Zhenlong Yu, Dingbo Shi, Xiangsheng Xiao, Fang‐Yun Xie et al. · 2015 · Oncotarget
Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition
Dong Hou, Guangwei Xu, Caibo Zhang, Boxuan Li, Junchao Qin, Xiaohe Hao, Qiao Liu, Xiyu Zhang, Jinsong Liu, Jian‐Jun Wei et al. · 2017 · Cell Death and Disease
Berberine Directly Affects the Gut Microbiota to Promote Intestinal Farnesoid X Receptor Activation
Yuan Tian, Jingwei Cai, Wei Gui, Robert G. Nichols, Imhoi Koo, Jingtao Zhang, Mallappa Anitha, Andrew D. Patterson · 2018 · Drug Metabolism and Disposition
Berberine inhibits PTP1B activity and mimics insulin action
Chunhua Chen, Yuebo Zhang, Cheng Huang · 2010 · Biochemical and Biophysical Research Communications
Curcumin supplementation regulates lipid metabolism in broiler chickens
Zhenglu Xie, Guozhi Shen, Yang Wang, Changbiao Wu · 2018 · Poultry Science
Nanotechnology-Based Strategies for Berberine Delivery System in Cancer Treatment: Pulling Strings to Keep Berberine in Power
Muhammad Javed Iqbal, Cristina Quispe, Zeeshan Javed, Haleema Sadia, Qamar Raza Qadri, Shahid Raza, Bahare Salehi, Natália Alves Martins, Zeinab Abdulwanis Mohamed, Jaafaru Sani Mohammed et al. · 2021 · Frontiers in Molecular Biosciences
Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase
Weihua Liu, Ziqing Hei, Hong Nie, Futian Tang, Heqing Huang, Xuejuan Li, Yan-hui DENG, Shaorui Chen, Fenfen Guo, Wenge Huang et al. · 2008 · Chinese Medical Journal
Optimization of ultrasonic-assisted extraction of bioactive alkaloid compounds from rhizoma coptidis (Coptis chinensis Franch.) using response surface methodology
Hui Teng, Yong Hee Choi · 2013 · Food Chemistry
Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophagesThis article is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.
Lindsei K. Sarna, Nan Wu, Sun‐Young Hwang, Yaw Loong Siow, O Karmin · 2010 · Canadian Journal of Physiology and Pharmacology
Protective Effects of Berberine on Doxorubicin-Induced Hepatotoxicity in Mice
Xiaoyan Zhao, Jie Zhang, Nannan Tong, Youran Chen, Yonghuang Luo · 2012 · Biological and Pharmaceutical Bulletin
Berberine as a Promising Safe Anti-Cancer Agent- Is there a Role for Mitochondria?
Cátia V. Diogo, Nuno G. Machado, Inês A. Barbosa, Teresa L. Serafim, Ana Burgeiro, Paulo Jorge Oliveira · 2011 · Current Drug Targets
Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147
Qian Hou, Xu Tang, Han-Qiang Liu, Junqi Tang, Ying Yang, Xiaohong Jing, Qian Xiao, Wen Wang, Xingchun Gou, Zongren Wang · 2011 · Cancer Science
Protective Effects of Berberine against Low-Density Lipoprotein (LDL) Oxidation and Oxidized LDL-Induced Cytotoxicity on Endothelial Cells
Yih‐Shou Hsieh, Wu‐Hsien Kuo, Ta-Wei Lin, Horng‐Rong Chang, Teseng-His Lin, Pei‐Ni Chen, Shu‐Chen Chu · 2007 · Journal of Agricultural and Food Chemistry
Berberine alleviates dextran sodium sulfate-induced colitis by improving intestinal barrier function and reducing inflammation and oxidative stress
Lichao Zhang, Yue Wang, Ling‐Chang Tong, Sheng Sun, Wei‐Ye Liu, Su Zhang, Rong-Mei Wang, Zhi-Bin Wang, Ling Li · 2017 · Experimental and Therapeutic Medicine
Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling
Xi Xie, Xiuting Chang, Lei Chen, Kaipeng Huang, Juan Huang, Shaogui Wang, Xiaoyan Shen, Peiqing Liu, Heqing Huang · 2013 · Molecular and Cellular Endocrinology
Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats
Yitong Liu, Haiping Hao, Hong‐Guang Xie, Hua Lv, Changxiao Liu, Guangji Wang · 2009 · Journal of Pharmaceutical Sciences
Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines
S.H. Park, Ji Hyun Sung, E. J. Kim, Namhyun Chung · 2014 · Brazilian Journal of Medical and Biological Research
Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement
Hang Zhou, Lili Feng, Fang Xu, Yi Sun, Yuxiang Ma, Xiong Zhang, Hailiang Liu, Ge Xu, Xuefeng Wu, Yan Shen et al. · 2017 · Biomedicine & Pharmacotherapy
Joint position statement on "Nutraceuticals for the treatment of hypercholesterolemia" of the Italian society of diabetology (SID) and of the Italian society for the study of arteriosclerosis (SISA)
Pirro, M., Vetrani, C., Bianchi, C., Mannarino, M.R., Bernini, F., Rivellese, A.A. · 2017 · Nutrition, Metabolism and Cardiovascular Diseases
Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention
Meng, Shu, Wang, Lian‐Sheng, Huang, Zhou‐Qing, Zhou, Qing, Sun, Ying‐Gang, Cao, Jia‐Tian, Li, Yi‐Gang, Wang, Chang‐Qian · 2012 · Clinical and Experimental Pharmacology and Physiology
Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress
Zhiguo Zhang, Bo Li, Xiang-jian Meng, Shuangshuang Yao, Lina Jin, Jian Yang, Jiqiu Wang, Huizhi Zhang, Zhijian Zhang, Dongsheng Cai et al. · 2016 · Scientific Reports
Berberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and Inflammation in Rats
Yong Zhang, Xiaoguang Li, Qing-Wei Zhang, Jia-Min Li, Jiaming Ju, N. Du, Xin Liu, Xiaohui Chen, Fei-Ran Cheng, Lei Yang et al. · 2014 · Journal of Pharmacology and Experimental Therapeutics
Berberine: A Promising Treatment for Neurodegenerative Diseases
Ziqian Cheng, Chenglan Kang, Songtian Che, Jingyun Su, Qihan Sun, Tongtong Ge, Yi Chen Guo, Jiayin Lv, Zhihui Sun, Wei Yang et al. · 2022 · Frontiers in Pharmacology
Insights into drug discovery from natural medicines using reverse pharmacokinetics
Haiping Hao, Xiao Zheng, Guangji Wang · 2014 · Trends in Pharmacological Sciences
A nutraceutical approach (Armolipid Plus) to reduce total and LDL cholesterol in individuals with mild to moderate dyslipidemia: Review of the clinical evidence
Barrios, Vivencio, Escobar, Carlos, Cicero, Arrigo Francesco Giuseppe, Burke, David, Fasching, Peter, Banach, Maciej, Bruckert, Eric · 2017 · Atherosclerosis Supplements
Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease
Xinxia Chang, Zhe Wang, Jinlan Zhang, Hongmei Yan, Hua Bian, Mingfeng Xia, Huandong Lin, Jian‐Dong Jiang, Xin Gao · 2016 · Journal of Translational Medicine
A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation
Donna N. Petersen, Julie Hawkins, Wanida Ruangsiriluk, Kimberly A. Stevens, Bruce A. Maguire, Thomas N. O’Connell, Benjamin N. Rocke, Markus Boehm, Roger B. Ruggeri, Tim Rolph et al. · 2016 · Cell chemical biology
Berberine Analogues as a Novel Class of the Low-Density-Lipoprotein Receptor Up-Regulators: Synthesis, Structure−Activity Relationships, and Cholesterol-Lowering Efficacy
Yinghong Li, Peng Yang, Weijia Kong, Yanxiang Wang, Chang-qin Hu, Zeng-Yan Zuo, Yueming Wang, Hong Gao, Limei Gao, Yanchun Feng et al. · 2008 · Journal of Medicinal Chemistry
Berberine-induced LDLR up-regulation involves JNK pathway
Seahyoung Lee, Hyun‐Joung Lim, Jin‐Hee Park, Kuy‐Sook Lee, Yangsoo Jang, Hyun‐Young Park · 2007 · Biochemical and Biophysical Research Communications
Protective effect of berberine against myocardial ischemia reperfusion injury: role of Notch1/Hes1-PTEN/Akt signaling
Liming Yu, Feijiang Li, Guolong Zhao, Yang Yang, Zhenxiao Jin, Mengen Zhai, Wenjun Yu, Lin Zhao, Wensheng Chen, Weixun Duan et al. · 2015 · APOPTOSIS
Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51
Qiao Liu, Haiyan Jiang, Zhaojian Liu, Yu Wang, Minnan Zhao, Chunyan Hao, Shuai Feng, Haiyang Guo, Bing Xu, Qifeng Yang et al. · 2011 · PLoS ONE
Cardiovascular and metabolic effects of Berberine
Flora Affuso · 2010 · World Journal of Cardiology
Naturally Occurring PCSK9 Inhibitors
Maria Pia Adorni, Francesca Zimetti, Maria Giovanna Lupo, Massimiliano Ruscica, Nicola Ferri · 2020 · Nutrients
Nutraceuticals for the treatment of hypercholesterolemia
Mannarino, Massimo R., Ministrini, Stefano, Pirro, Matteo · 2014 · European Journal of Internal Medicine
Therapeutic potential of berberine against neurodegenerative diseases
Wenxiao Jiang, ShiHua Li, Xiaojiang Li · 2015 · Science China Life Sciences
The dual actions of Sanmiao wan as a hypouricemic agent: Down-regulation of hepatic XOD and renal mURAT1 in hyperuricemic mice
Xing Wang, Caiping Wang, Qinghua Hu, Yao-Zhong Lv, Xian Zhang, Zhen Ouyang, Ling‐Dong Kong · 2010 · Journal of Ethnopharmacology
Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements
Hai Li, Wei Chen, Yue Zhou, Parveen Abidi, Orr Sharpe, William H. Robinson, Fredric B. Kraemer, Jingwen Liu · 2009 · Journal of Lipid Research
Recent Advances in the Herbal Treatment of Non-Alcoholic Fatty Liver Disease
Jia Xiao, Kwok‐Fai So, Emily C. Liong, George Lim Tipoe · 2013 · Journal of Traditional and Complementary Medicine
Berberine: New Insights from Pharmacological Aspects to Clinical Evidences in the Management of Metabolic Disorders
Cristiana Caliceti, Placido Franco, Silvia Spinozzi, Aldo Roda, Arrigo F.G. Cicero · 2016 · Current Medicinal Chemistry
Chronic Alcohol Consumption Disrupted Cholesterol Homeostasis in Rats: Down‐Regulation of Low‐Density Lipoprotein Receptor and Enhancement of Cholesterol Biosynthesis Pathway in the Liver
Zhigang Wang, Tong Yao, Zhenyuan Song · 2009 · Alcoholism Clinical and Experimental Research
Berberine inhibits the expression of TNFα, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARγ pathway
F. L. Chen, Zeng-Jin Yang, Y. Liu, L. X. Li, W. C. Liang, X. C. Wang, W. B. Zhou, Yehong Yang, Renming Hu · 2008 · Endocrine
Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: Clinical and pharmacokinetic study
Wu, Xiaochun, Li, Qing, Xin, Huawen, Yu, Airong, Zhong, Mingyuan · 2005 · European Journal of Clinical Pharmacology
Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose
Weihua Liu, Peiqinq Liu, Sha Tao, Yanhui Deng, Xuejuan Li, Tian Lan, Xiaoyan Zhang, Fenfen Guo, Wenge Huang, Fengying Chen et al. · 2008 · Archives of Biochemistry and Biophysics
Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells
Kae‐Woei Liang, Sui‐Chu Yin, Chih-Tai Ting, Shing‐Jong Lin, Chi‐Mei Hsueh, Chiu-Yuan Chen, Shih‐Lan Hsu · 2008 · European Journal of Pharmacology
Berberine attenuates pro-inflammatory cytokine-induced tight junction disruption in an in vitro model of intestinal epithelial cells
Ning Li, Lili Gu, Linlin Qu, Jianfeng Gong, Qiurong Li, Weiming Zhu, Jieshou Li · 2010 · European Journal of Pharmaceutical Sciences
Effects of Mulberry (Morus albaL.) Extracts on Lipid Homeostasis in Vitro and in Vivo
Li-Kaung Liu, Fen‐Pi Chou, Yi‐Chen Chen, Charng-Cherng Chyau, Hsieh-Hsun Ho, Chau‐Jong Wang · 2009 · Journal of Agricultural and Food Chemistry
The complete chloroplast genome sequence of Mahonia bealei (Berberidaceae) reveals a significant expansion of the inverted repeat and phylogenetic relationship with other angiosperms
Ji Ma, Bingxian Yang, Wei Zhu, Lianli Sun, Jingkui Tian, Xumin Wang · 2013 · Gene
Berberine ameliorates lipopolysaccharide‐induced acute lung injury via the PERK ‐mediated Nrf2/HO‐1 signaling axis
Yuan Liang, Chongxi Fan, Xiaolong Yan, Xi Lü, Hua Jiang, Shouyin Di, Zhiqiang Ma, Yingtong Feng, Zhengbin Zhang, Pan Feng et al. · 2018 · Phytotherapy Research
Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders
Weijia Kong, Claudio Vernieri, Marco Foiani, Jian‐Dong Jiang · 2020 · Pharmacology & Therapeutics
Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways
Yaoxing Dou, Ronglei Huang, Qiaoping Li, Yuhong Liu, Yucui Li, Hanbin Chen, Gaoxiang Ai, Jianhui Xie, Huifang Zeng, Jiannan Chen et al. · 2021 · Biomedicine & Pharmacotherapy
Binding of isoquinoline alkaloids berberine, palmatine and coralyne to hemoglobin: structural and thermodynamic characterization studies
Soumitra Hazra, Maidul Hossain, Gopinatha Suresh Kumar · 2012 · Molecular BioSystems
Total Syntheses of Menisporphine and Daurioxoisoporphine C Enabled by Photoredox-Catalyzed Direct C–H Arylation of Isoquinoline with Aryldiazonium Salt
Jing Zhang, Jie Chen, Xiaoyun Zhang, Xiaoguang Lei · 2014 · The Journal of Organic Chemistry
Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends
Tapan Behl, Sukhbir Singh, Neelam Sharma, Ishrat Zahoor, Ali Albarrati, Mohammed Albratty, Abdulkarim M. Meraya, Asim Najmi, SIMONA GABRIELA BUNGAU · 2022 · Molecules
Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control
Francesco Di Pierro, Villanova, F. Agostini, Valentina Soverini, Giulio Marchesini, Marzocchi · 2012 · Diabetes Metabolic Syndrome and Obesity
Berberine Inhibits HIV Protease Inhibitor-Induced Inflammatory Response by Modulating ER Stress Signaling Pathways in Murine Macrophages
Weibin Zha, Guang Liang, Jian Xiao, Elaine J. Studer, Phillip B. Hylemon, William M. Pandak, Guangji Wang, Xiaokun Li, Huiping Zhou · 2010 · PLoS ONE
Berberine alleviates nonalcoholic fatty liver induced by a high‐fat diet in mice by activating SIRT3
Xi Xu, Xiaopeng Zhu, Jinyun Bai, Pu Xia, Yu Li, Yan Lü, Xiao-Ying Li, Xin Gao · 2019 · The FASEB Journal
Research progress on nanotechnology for delivery of active ingredients from traditional Chinese medicines
Li Qiao, Maosen Han, Shi-Jie Gao, Xinxin Shao, Xiaoming Wang, Linlin Sun, Xianjun Fu, Qingcong Wei · 2020 · Journal of Materials Chemistry B
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels
Jian Hui Xu, Xingzhen Liu, Wei Pan, Da Jin Zou · 2017 · Molecular Medicine Reports
Nutraceuticals as therapeutic agents for atherosclerosis
Joe W. E. Moss, Jessica O. Williams, Dipak P. Ramji · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Extraction of berberine from rhizome of Coptis chinensis Franch using supercritical fluid extraction
Ben Liu, Wenjing Li, Yiling Chang, Wenhong Dong, Li Ni · 2006 · Journal of Pharmaceutical and Biomedical Analysis
Down-regulation of cyclin B1 and up-regulation of Wee1 by berberine promotes entry of leukemia cells into the G2/M-phase of the cell cycle.
Chin Chung Lin, Shuw Yun Lin, Jing‐Gung Chung, Jing Lin, Guang Wei Chen, Shung Te Kao · 2006 · PubMed
Small molecules as inhibitors of PCSK9: Current status and future challenges
Xu, Shengtao, Luo, Shanshan, Zhu, Zheying, Xu, Jinyi · 2019 · European Journal of Medicinal Chemistry
The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol
Gaétan Mayer, Steve Poirier · 2013 · Drug Design Development and Therapy
Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway
Shengnan Wei, Ming Zhang, Yang Yu, Xiaoxin Lan, Fan Yao, Xin Yan, Li Chen, Grant Michael Hatch · 2016 · PLoS ONE
Developmental toxicity evaluation of berberine in rats and mice
Gloria D. Jahnke, Catherine J. Price, Melissa C. Marr, Christina B. Myers, Julia D. George · 2006 · Birth Defects Research Part B Developmental and Reproductive Toxicology
Nutraceutical approach to moderate cardiometabolic risk: Results of a randomized, double-blind and crossover study with Armolipid Plus
Massimiliano Ruscica, Monica Gomaraschi, Giuliana Germana Mombelli, Chiara Macchi, Raffaella Bosisio, Franco Pazzucconi, Chiara Pavanello, Laura Calabresi, Anna Arnoldi, Cesare Riccardo Sirtori et al. · 2013 · Journal of clinical lipidology
Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate
Ye Zhang, Yuan‐Lu Cui, Lina Gao, Heng-Li Jiang · 2013 · International Journal of Biological Macromolecules
Surface-Modified Bilosomes Nanogel Bearing a Natural Plant Alkaloid for Safe Management of Rheumatoid Arthritis Inflammation
Mohammed H. Elkomy, Nabil K. Alruwaili, Mohammed Elmowafy, Khaled Shalaby, Ameeduzzafar Zafar, Naveed Ahmad, Izzeddin Alsalahat, Mohammed M. Ghoneim, Essam M. Eissa, Hussein M. Eid · 2022 · Pharmaceutics
Pharmacological tools for the development of traditional Chinese medicine
Xuan Liu, Wanying Wu, Baohong Jiang, Min Yang, De‐an Guo · 2013 · Trends in Pharmacological Sciences
Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury
Weihua Liu, Xiaoyan Zhang, Peiqing Liu, Xiaoyan Shen, Tian Lan, Wenyuan Li, Qin Li Jiang, Xi Xie, Heqing Huang · 2010 · European Journal of Pharmacology
Butanol fraction containing berberine or related compound from nexrutine® inhibits NFκB signaling and induces apoptosis in prostate cancer cells
Sribalasubashini Muralimanoharan, Ajaikumar Bahulayan Kunnumakkara, Shylesh Bhaskaran, Kaustubh H. Kulkarni, Xu Haiyan, Ming Hu, Bharat Bhushan Aggarwal, Rita Ghosh, Addanki P. Kumar · 2008 · The Prostate
A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine
Shenghua Gu, Bei Cao, Runbin Sun, Yueqing Tang, Janice L. Paletta, Xiao‐Lei Wu, Linsheng Liu, Weibin Zha, Chunyan Zhao, Yan Li et al. · 2014 · Molecular BioSystems
Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells
Zhou, Yan, Cao, Shijie, Wang, Ying, Xu, Peixiang, Yan, Jiankun, Bin, Wen, Qiu, Feng, Kang, Ning · 2014 · Fitoterapia
Chinese Herbal Medicine for the Optimal Management of Polycystic Ovary Syndrome
Madeleine Ong, Jie Peng, Xingliang Jin, Xianqin Qu · 2017 · The American Journal of Chinese Medicine
Solubility and Stability Advantages of a New Cocrystal of Berberine Chloride with Fumaric Acid
Dezhi Yang, Junzi Cao, Ling-tai Jiao, Shiying Yang, Li Zhang, Yang Lü, Guanhua Du · 2020 · ACS Omega
Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine (BBR) and facilitates to predict BBR’s cholesterol-decreasing efficacy in patients
Chongming Wu, Ying Lan Zhao, Yingying Zhang, Yanan Yang, Wenquan Su, Yuanyuan Yang, Le Sun, Fang Zhang, Jiaqi Yu, Yaoxian Wang et al. · 2021 · Journal of Advanced Research
Integrated lipidomics and network pharmacology analysis to reveal the mechanisms of berberine in the treatment of hyperlipidemia
Yuting Chen, Kaipeng Li, Han Zhao, Zhangsen Hao, Yuxin Yang, Mingming Gao, Ding Zhao · 2022 · Journal of Translational Medicine
Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters
Xiaoyang Li, Zhenxiong Zhao, Min Huang, Ru Feng, Chi‐Yu He, Chao Ma, Shi-Heng Luo, Jie Fu, Bao‐Ying Wen, Long Ren et al. · 2015 · Journal of Translational Medicine
Berberine–DNA complexation: New insights into the cooperative binding and energetic aspects
Kakali Bhadra, Motilal Maiti, Gopinatha Suresh Kumar · 2008 · Biochimica et Biophysica Acta (BBA) - General Subjects
Berberine Exerts Neuroprotective Actions against in Vitro Ischemia-Induced Neuronal Cell Damage in Organotypic Hippocampal Slice Cultures: Involvement of B-Cell Lymphoma 2 Phosphorylation Suppression
Hu-Shan Cui, Kinzo Matsumoto, Yukihisa Murakami, Hitomi Hori, Qi Zhao, Ryosuke Obi · 2009 · Biological and Pharmaceutical Bulletin
Berberine alleviates postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice
Zhijie Zhang, Xiuhua Li, Fayin Li, Lijun An · 2016 · International Immunopharmacology
RETRACTED: Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK–S1P signaling pathway
Tian Lan, Xiaoyan Shen, Peiqing Liu, Weihua Liu, Suowen Xu, Xi Sheng Xie, Qin Li Jiang, Wenyuan Li, Heqing Huang · 2010 · Archives of Biochemistry and Biophysics · Retracted
Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential
Dahua Fan, Liping Liu, Zhengzhi Wu, Meiqun Cao · 2018 · Current Neuropharmacology
Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery
Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, Can Wang, Lulu Yang, Zhong‐Mei Zou, Lingyu Li, Ke Liu et al. · 2024 · Nature Communications
Nutraceutical pill containing berberine versus ezetimibe on plasma lipid pattern in hypercholesterolemic subjects and its additive effect in patients with familial hypercholesterolemia on stable cholesterol-lowering treatment
Pisciotta, Livia, Bellocchio, Antonella, Bertolini, Stefano · 2012 · Lipids in Health and Disease
Berberine attenuates hepatic oxidative stress in rats with non‑alcoholic fatty liver disease via the Nrf2/ARE signalling pathway
Yuanjun Deng, Kairui Tang, Runsen Chen, Huan Nie, Liang Shu, Jinwen Zhang, Yupei Zhang, Qinhe Yang · 2019 · Experimental and Therapeutic Medicine
Berberine: A Plant-derived Alkaloid with Therapeutic Potential to Combat Alzheimer’s disease
Anurag Kumar Singh, Santosh Kumar Singh, Manmath K. Nandi, Gaurav Mishra, Anand Maurya, Arati Rai, Gopal K. Rai, Rajendra Awasthi, Bhupesh Sharma, Giriraj Thirupathirao Kulkarni · 2019 · Central Nervous System Agents in Medicinal Chemistry
Effects of isoquinoline alkaloid berberine on lipid peroxidation, antioxidant defense system, and liver damage induced by lead acetate in rats
Parisa Hasanein, Masumeh Ghafari-Vahed, Iraj Khodadadi · 2016 · Redox Report
Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes
Francesco Di Pierro, Pietro Putignano, Luca Montesi, Simona Moscatiello, Giulio Marchesini, Nicola Villanova · 2013 · Clinical Pharmacology Advances and Applications
Berberis vulgaris: specifications and traditional uses.
Mohammad Rahimi‐Madiseh, Zahra Lorigooini, Hajar Zamani-Gharaghoshi, Mahmoud Rafieian‐Kopaei · 2017 · Europe PMC (PubMed Central)
Gut Microbiota-Regulated Pharmacokinetics of Berberine and Active Metabolites in Beagle Dogs After Oral Administration
Ru Feng, Zhenxiong Zhao, Shu-Rong Ma, Fang Guo, Yan Wang, Jian-Dong Jiang · 2018 · Frontiers in Pharmacology
Combined Influence of LDLR and HMGCR Sequence Variation on Lipid-Lowering Response to Simvastatin
Lara M. Mangravite, Marisa Wong Medina, Jinrui Cui, Sheila Pressman, Joshua D. Smith, Mark J. Rieder, Xiuqing Guo, Deborah A. Nickerson, Jerome I. Rotter, Ronald M. Krauss · 2010 · Arteriosclerosis Thrombosis and Vascular Biology
Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling
Junfang Zhang, Hailong Cao, Bing Zhang, Hanwei Cao, Xiuqin Xu, Hang Ruan, Tingting Yi, Li Tan, Rui Qu, Gang Song et al. · 2013 · Journal of Cellular and Molecular Medicine
Adenosine Monophosphate–Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity, and Pharmacological Activation
Sukriti Krishan, Des Raymond Richardson, Sumit Sahni · 2014 · Molecular Pharmacology
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model
Xuefei Liu, Xinghua Zhang, Lin Ye, Haitao Yuan · 2016 · Biomedicine & Pharmacotherapy
Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition of P-Glycoprotein and Intestinal Metabolism in Rats Using a Berberine Mixed Micelle Formulation
Kwon, Mihwa, Lim, Dong Yu, Lee, Chul Haeng, Jeon, Ji-Hyeon, Choi, Min-Koo, Song, Im-Sook · 2020 · Pharmaceutics
Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes
Rui Zhou, Changpei Xiang, Guangzhao Cao, He Xu, Yi Zhang, Hongjun Yang, Jingjing Zhang · 2021 · Clinical Science
Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo
Seahyoung Lee, Hyun‐Joung Lim, Hyun‐Young Park, Kuy‐Sook Lee, Jinhee Park, Yangsoo Jang · 2005 · Atherosclerosis