Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

Kong, Weijia, Wei, Jing, Abidi, Parveen, Lin, Meihong, Inaba, Satoru, Li, Cong, Wang, Yanling, Wang, Zizheng, Si, Shuyi, Pan, Huaining, Wang, Shukui, Wu, Jingdan, Wang, Yue, Li, Zhuorong, Liu, Jingwen, Jiang, Jian-Dong·2004·Nature Medicine

DOI 10.1038/nm1135

Cited by (1,002)

Items 801–900 of 1,002

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Hu-Shan Cui, Seiji Hayasaka, Xue-Yun Zhang, Yoriko Hayasaka, Zai‐Long Chi, Lianshun Zheng · 2006 · Life Sciences
The effect of berberine adjunctive treatment on glycolipid metabolism in patients with schizophrenia: A randomized, double-blind, placebo-controlled clinical trial
Li, Meijuan, Liu, Ying, Qiu, Yuying, Zhang, Jing, Zhang, Yonghui, Zhao, Yongping, Jia, Qiong, Li, Jie · 2021 · Psychiatry Research
Berberine dissociates mitochondrial complex I by SIRT3-dependent deacetylation of NDUFS1 to improve hepatocellular glucose and lipid metabolism
Xuekai Wang, Hu Li, Jianrui Li, Lei Lei, Jingchen Xu, Han Sun, Jiayu Li, Jing Jiang, Hongying Li, Mei Tang et al. · 2025 · Science China Life Sciences
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Berberine decreases plasma triglyceride levels and upregulates hepatic TRIB1 in LDLR wild type mice and in LDLR deficient mice
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Gang Ren, Jianghong Guo, Chen‐Lin Feng, Yu-Wei Ding, Biao Dong, Yanxing Han, Yuhuan Li, Lulu Wang, Jian‐Dong Jiang · 2022 · Molecular Therapy — Oncolytics
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Therapeutic Application of Berberine: a Consolidated Review
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Berberine ameliorates nonalcoholic fatty liver disease-induced bone loss by inhibiting ferroptosis
Shaobo Gu, Junzhuo Wang, Siyi Yu, Shunyao Zhang, Ting Gao, Deyi Yan, Runxiang Xie, Mengli Gu, Mengli Yu, Zongkai Zhang et al. · 2024 · Bone
Inhibiting Roles of Berberine in Gut Movement of Rodents are Related to Activation of the Endogenous Opioid System
Ya-jing Feng, Yongyu Li, Chunqiu Chen, Xuhong Lin, Yuehua Yang, Haidong Cai, Zhongwei Lv, Minghua Cao, Kun Li, Jing Xu et al. · 2013 · Phytotherapy Research
Selective Regulation of Multidrug Resistance Protein in Vascular Smooth Muscle Cells by the Isoquinoline Alkaloid Coptisine
Hiroka Suzuki, Hiroki Tanabe, Hajime Mizukami, Makoto Inoue · 2010 · Biological and Pharmaceutical Bulletin
Activity of isoflavones and berberine on vasomotor symptoms and lipid profile in menopausal women
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Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine
Waranya Chatuphonprasert, Thewtas Sangkawat, Nobuo Nemoto, Kanokwan Jarukamjorn · 2011 · Fitoterapia
Molecular pathology of familial hypercholesterolemia, related dyslipidemias and therapies beyond the statins
Fathimath Faiz, Amanda J. Hooper, Frank M. VAN BOCKXMEER · 2012 · Critical Reviews in Clinical Laboratory Sciences
Effects of Yiqi Sanju Formula on non-alcoholic fatty liver disease: a randomized controlled trial
SY Lou · 2008 · Journal of Chinese Integrative Medicine
The hypolipidemic effect of artesunate and ursolic acid in rats
Yuliang Wang · 2015 · Pakistan Journal of Pharmaceutical Sciences
Review of systematic reviews and Meta-analyses investigating Traditional Chinese Medicine treatment for type 2 diabetes mellitus
Liu Meijun, Zhicheng Liu, Bin Xu, Wei Zhang, Cai Jian-wei · 2016 · 中医杂志：英文版
Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids
Francesca Ghirga, Alessandra Bonamore, Lorenzo Calisti, Ilaria D’Acquarica, Mattia Mori, Bruno Botta, Alberto Boffi, Alberto Macone · 2017 · International Journal of Molecular Sciences
Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling
Jiajing Zhao, Yingjue Wang, Xi Wu, Ping Tong, Yaohan Yue, Shurong Gao, Dongping Huang, Jianwei Huang · 2018 · Molecular Medicine Reports
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Kaixian Chen · 2020 · World Journal of Traditional Chinese Medicine
Extraction of Alkaloids from Coptidis Rhizoma via Betaine‐Based Deep Eutectic Solvents
Yuanbin Li, Yun‐Hao Hsieh, Zuchen Pan, Ling Zhang, Wen Bing Yu, Binshen Wang, Jiaheng Zhang · 2020 · ChemistrySelect
The effects of Berberis vulgaris L. and Berberis aristata L. in metabolic syndrome patients: a systematic and meta-analysis study
Babak Roshanravan, Shahnaz Yousefizadeh, Betül Apaydın Yıldırım, Tahereh Farkhondeh, Alireza Amirabadizadeh, Milad Ashrafizadeh, Marjan Talebi, Saeed Samarghandian · 2020 · Archives of Physiology and Biochemistry
Detection of New Human Metabolic Urinary Markers in Chronic Alcoholism and Their Reversal by Aqueous Extract of Tinospora cordifolia Stem
Ashwani Mittal, Rajesh Dabur · 2015 · Alcohol and Alcoholism
Enzyme-inducing effects of berberine on cytochrome P450 1A2 in vitro and in vivo
Bo Jiang, Liyuan Meng, Feng Zhang, Xiaoling Jin, Guiliang Zhang · 2017 · Life Sciences
Primate-specific evolution of an LDLR enhancer
Qian‐Fei Wang, Shyam Prabhakar, Qianben Wang, Alan M Moses, Sumita Chanan, Myles A Brown, Michael B. Eisen, Jan‐Fang Cheng, Edward M. Rubin, Dario Boffelli · 2006 · Genome biology
Berberine as a Bioactive Alkaloid: Multi-Omics Perspectives on Its Role in Obesity Management
Bartłomiej Zieniuk, Magdalena Ewa Pawełkowicz · 2025 · Metabolites
The Rhizome Mixture ofAnemarrhena asphodeloidesandCoptidis chinensisAmeliorates Acute and Chronic Colitis in Mice by Inhibiting the Binding of Lipopolysaccharide to TLR4 and IRAK1 Phosphorylation
Jin-Ju Jeong, Se‐Eun Jang, Supriya Rajesh Hyam, Myung Joo Han, Dong‐Hyun Kim · 2014 · Evidence-based Complementary and Alternative Medicine
The effects of berberine on reactive oxygen species production in human neutrophils and in cell-free assays
Rami B. Kassab, Ondřej Vašíček, Milan Čı́ž, Antonı́n Lojek, Tomáš Perečko · 2017 · Interdisciplinary Toxicology
Effects of a nutraceutical combination of fermented red rice, liposomal berberine, and curcumin on lipid and inflammatory parameters in patients with mild-to-moderate hypercholesterolemia: an 8-week, open-label, single-arm pilot study
Marco Biagi, Piercarlo Minoretti, Marco Bertona, Enzo Emanuele · 2018 · Archives of Medical Science - Atherosclerotic Diseases
Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease
Jie Wang, Yongmei Liu, Jun Hu, Cong Chen · 2023 · Frontiers in Pharmacology
Neuroprotective effect of Berberine Nanoparticles Against Seizures in Pentylenetetrazole Induced Kindling Model of Epileptogenesis: Role of Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms
Lekha Saha, Puja Kumari, Kajal Rawat, Vipasha Gautam, Arushi Sandhu, Neha Singh, Alka Bhatia, Shalmoli Bhattacharya, Vivek Ranjan Sinha, Amitava Chakrabarti · 2023 · Neurochemical Research
Effect of Berberine on Monocyte Chemotactic Protein-1 and Cytokine-Induced Neutrophil Chemoattractant-1 Expression in Rat Lipopolysaccharide-Induced Uveitis
Hu-Shan Cui, Seiji Hayasaka, Lianshun Zheng, Yoriko Hayasaka, Xue-Yun Zhang, Zai‐Long Chi · 2006 · Ophthalmic Research
HPLC Method Development and Validation for Quantification of Berberine from Berberis aristata and Berberis tinctoria
Hemant Shigwan, Arvind Saklani, Purnima D. Hamrapurkar, Tukaram Namdev Mane, Priyanka Bhatt · 2013
Nucleic acids binding strategies of small molecules: Lessons from alkaloids
Anirban Basu, Gopinatha Suresh Kumar · 2018 · Biochimica et Biophysica Acta (BBA) - General Subjects
SREBP-2, a new target of metformin?
Fengxia Zhang, Wenxiu Sun, Jianbo Chen, Lusheng Jiang, Ping Yang, Yufang Huang, Aihua Gong, Shudong Liu, Shizhan Ma · 2018 · Drug Design Development and Therapy
Trapa bispinosa Roxb. and lutein ameliorate cataract in type 1 diabetic rats
Sho Kinoshita, Hikari Sugawa, Tomoaki Nanri, Rei-ichi Ohno, Jun‐ichi Shirakawa, Hikari Sato, Nana Katsuta, Shiori Sakake, Ryoji Nagai · 2019 · Journal of Clinical Biochemistry and Nutrition
Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds
MD Khurshidul Zahid, Hazera Binte Sufian, Mahua Choudhury, Masao Yamasaki, Ahmed Al‐Harrasi, Naïma Moustaïd‐Moussa, Shaikh Mizanoor Rahman · 2021 · Biochemical Journal
The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes by berberine is not mediated by leptin signaling
Bong-Hyuk Choi, Yu‐Hee Kim, In‐Sook Ahn, Jung‐Heun Ha, Jae-Min Byun, Myoung‐Sool Do · 2009 · Nutrition Research and Practice
New approaches to the treatment of metabolic dysfunction-associated steatotic liver with natural products
Pooja Yadav, Khushi Quadri, Renu Kadian, Aafrin Waziri, Pankaj Agrawal, Md Sabir Alam · 2024 · iLiver
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Zemin Yao, Li Rita Zhang, Guang Ji · 2014 · Journal of Chinese Integrative Medicine
Natural sources of antidyslipidaemic agents: is there an evidence-based approach for their prescription?
Arrigo F.G. Cicero, Sibel Ertek · 2008 · Mediterranean Journal of Nutrition and Metabolism
Berberine Inhibits Lipopolysaccharide- and Polyethylene Particle-Induced Mouse Calvarial Osteolysis In Vivo
Xiaoxiao Zhou, Chao Zhang, Xiaoqing Wang, Bingchen An, Peng Zhang, Zhenan Zhu · 2011 · Journal of Surgical Research
Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis
Chen‐Jie Qin, Huilu Zhang, Linghao Zhao, Min Zeng, Weijian Huang, Gongbo Fu, Weiping Zhou, Hongyang Wang, He‐Xin Yan · 2017 · Science China Life Sciences
Protective effect of berberine against cardiac ischemia/reperfusion injury by inhibiting apoptosis through the activation of Smad7
Weidong Yao, Xin Wang, Kun Xiao · 2017 · Molecular and Cellular Probes
Effectiveness and safety of bifidobacteria and berberine in people with hyperglycemia: study protocol for a randomized controlled trial
Jie Ming, Shaoyong Xu, Chun Liu, Xiangyang Liu, Aihua Jia, Qiuhe Ji · 2018 · Trials
Xiaokeyinshui extract combination, a berberine-containing agent, exerts anti-diabetic and renal protective effects on rats in multi-target mechanisms
Jiewen Zhou, Jun Pan, Zhi-Nan Xiang, Qiuyan Wang, Qilin Tong, Jinbo Fang, Luo-Sheng Wan, Jiachun Chen · 2020 · Journal of Ethnopharmacology
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Giovanni Sartore, Burlina Silvia, Eugenio Ragazzi, Stefania Ferraresso, Romina Valentini, Annunziata Lapolla · 2013 · Evidence-based Complementary and Alternative Medicine
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Elisabeth Uitz · 2014 · World Journal of Clinical Cases
A study of chemiluminescence characteristics of a novel peroxyoxalate system using berberine as the fluorophore
Sayed Yahya Kazemi, Seyed Mohammad Abedirad, Zahra Vaezi, Mohammad Reza Ganjali · 2012 · Dyes and Pigments
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Yilin Zhang, Haiqing Zhang, Shi-neng Hua, Lianghui Ma, Cong Chen, Xiaoyu Liu, Liqun Jiang, Huanming Yang, Pei‐Cheng Zhang, Dequan Yu et al. · 2007 · Biochemical Pharmacology
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Francesco Orio, Giovanna Muscogiuri, Stefano Palomba, Silvia Savastano, Alessio Volpe, Marcello Orio, Giorgio Colarieti, Giovanni Battista La Sala, Annamaria Anita Livia Colao, Francesca Marciano et al. · 2013 · e-SPEN Journal
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Giuseppe Marazzi, Giuseppe Campolongo, Francesco Pelliccia, Paolo Calabrò, Luca Cacciotti, Cristiana Vitale, Rosalba Massaro, Maurizio Volterrani, Giuseppe M.C. Rosano · 2018 · The American Journal of Cardiology
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Bandala, Cindy, Carro-Rodríguez, Jazmín, Cárdenas-Rodríguez, Noemí, Peña-Montero, Itzel, Gómez-López, Modesto, Hernández-Roldán, Ana Paola, Huerta-Cruz, Juan Carlos, Muñoz-González, Felipe, Ignacio-Mejía, Iván, Domínguez, Brayan et al. · 2024 · Nutrients
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Berberine Promotes OATP1B1 Expression and Rosuvastatin Uptake by Inducing Nuclear Translocation of FXR and LXRα
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Marcos T. Oliveira, Carolina de Bovi Pontes, Grzegorz L. Ciesielski · 2020 · Genetics and Molecular Biology
Discovery of C-9 Modified Berberine Derivatives as Novel Lipid-Lowering Agents
Dong‐Dong Li, Pan Yu, Hui Wu Xu, Zhenzhong Wang, Wei Xiao, Lin-Guo Zhao · 2020 · Chemical and Pharmaceutical Bulletin
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Alec E. Morrison, Jeremy J. Hrudka, Gregory B. Dudley · 2016 · Organic Letters
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J Jin · 2010 · Journal of Chinese Integrative Medicine
Effect of Berberine on Interleukin 8 and Monocyte Chemotactic Protein 1 Expression in a Human Retinal Pigment Epithelial Cell Line
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Zhi-Bang Huang, Zhengkun Hou, Fengbin Liu, Mei Zhang, Wen Lang Hu, Shao-Fen Xu · 2021 · Frontiers in Pharmacology
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Berberine Regulated miR150-5p to Inhibit P2X7 Receptor, EMMPRIN and MMP-9 Expression in oxLDL Induced Macrophages
Lin Lü, Jianjian Huang, Xue Xia, Ting Wang, Zhouqing Huang, Jianmin Li · 2021 · Frontiers in Pharmacology
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The growth-promoting and lipid-lowering effects of berberine are associated with the regulation of intestinal bacteria and bile acid profiles in yellow catfish (Pelteobagrus fulvidraco)
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Effects of Berberine on glucolipid metabolism among dehydroepiandrosterone-induced rats of polycystic ovary syndrome with insulin-resistance
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Novel Effect of Berberine on Thermoregulation in Mice Model Induced by Hot and Cold Environmental Stimulation
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The orientation of protoberberine alkaloids and their binding activities to human serum albumin by surface-enhanced Raman scattering
Wei Zhang, Yu Zhao, Xueyuan Bai, Ying‐Ping Wang, Daqing Zhao · 2010 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
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Berberine alleviates LPS-induced apoptosis, oxidation, and skewed lineages during mouse preimplantation development
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Flavonoids activating adenosine monophosphate-activated protein kinase
Yeonjoong Yong, Soon Young Shin, Yearam Jung, Hyeryoung Jung, Seunghyun Ahn, Youhoon Chong, Yoongho Lim · 2015 · Journal of the Korean Society for Applied Biological Chemistry