Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

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Items 701–800 of 1,002

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  3. Potential Benefits of Berberine in the Management of Perimenopausal Syndrome
    Cristiana Caliceti, Paola Rizzo, Arrigo F.G. Cicero · 2015 · Oxidative Medicine and Cellular Longevity
  4. Amelioration effects of berberine on diabetic microendothelial injury model by the combination of high glucose and advanced glycation end products in vitro
    Min Hao, Shuyuan Li, Changkai Sun, Jingyu-Xu, Yuan Lin, Kexin Liu, Li Wang, LI Chuan-xun, Qin Zhou, Jianling Du et al. · 2011 · European Journal of Pharmacology
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    Zhi-Yi Yuan, Xi Lü, Lei Fan, Yu-Shuang Chai, Yu-Gang Wang, Jing-Fei Jiang, Tian-Shi Feng, Xin-Pei Wang, Xuan Yu, Xiao-Jin Yan et al. · 2015 · Scientific Reports
  6. Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells
    Yu Jin Ko, Jong-Suk Lee, Byung Chul Park, Heung‐Mook Shin, Jung‐Ae Kim · 2007 · Vascular Pharmacology
  7. Effect of ion pairing on the fluorescence of berberine, a natural isoquinoline alkaloid
    Mónika Megyesi, László Biczók · 2007 · Chemical Physics Letters
  8. The effects of berberine supplementation on cardiovascular risk factors in adults: a systematic review and dose-response meta-analysis
    Zamani, Mohammad, Zarei, Mahtab, Nikbaf-Shandiz, Mahlagha, Hosseini, Shabnam, Shiraseb, Farideh, Asbaghi, Omid · 2022 · Frontiers in Nutrition
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    Yue Kong, Haokun Yang, Rong Nie, Xuxiang Zhang, Hongtao Zhang, Xin Nian · 2025 · European journal of medical research
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  11. Berberine improves advanced glycation end products‑induced osteogenic differentiation responses in human periodontal ligament stem cells through the canonical Wnt/β‑catenin pathway
    Lína Zhang, Xu‐Xia Wang, Zhi Wang, Ke‐Yi Li, Baohua Xu, Jun Zhang · 2019 · Molecular Medicine Reports
  12. Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats
    Mia Kim, Tae-Woon Kim, Chang-Ju Kim, Mal‐Soon Shin, Minha Hong, Hye-Sang Park, Sang-Seo Park · 2019 · International Neurourology Journal
  13. The mitohormetic response as part of the cytoprotection mechanism of berberine
    Xiaofei Zhu, Yihui Wei, Beibei Yang, Xiaoxiao Yin, Xiaofang Guo · 2020 · Molecular Medicine
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    Bo Cao, Chengke Bai, Kunyi Wu, Ying Xue, H. J. Yang, Pufan Gao, Hui Liang, Guishuang Li · 2020 · Industrial Crops and Products
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  16. Improvement of Benzylisoquinoline Alkaloid Productivity by Overexpression of 3′-Hydroxy-N-methylcoclaurine 4′-O-Methyltransferase in Transgenic Coptis japonica Plants
    Takayuki Inui, Noriaki Kawano, Nobukazu Shitan, Kazufumi Yazaki, Fumiyuki Kiuchi, Nobuo Kawahara, Fumihiko Sato, Kayo Yoshimatsu · 2012 · Biological and Pharmaceutical Bulletin
  17. Genetic Variants of LDLR and PCSK9 Associated with Variations in Response to Antihypercholesterolemic Effects of Armolipid Plus with Berberine
    Isabel de Castro-Orós, Rosa Solà, Rosa M. Valls, Ángel Brea, Pilar Mozas, José Puzo, Miguel Pocovı́ · 2016 · PLoS ONE
  18. Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
    Chenglin Wu, Cong Xi, Junhua Tong, Jing Zhang Zhao, Hualiang Jiang, Jiang Wang, Yiping Wang, Hong Liu · 2019 · Acta Pharmaceutica Sinica B
  19. Role of JAK2 in the Pathogenesis of Diabetic Erectile Dysfunction and an Intervention With Berberine
    Jingyu Song, Zhe Tang, Hao Li, Hongyang Jiang, Taotao Sun, Ruzhu Lan, Tao Wang, Shaogang Wang, Zhangqun Ye, Jihong Liu · 2019 · The Journal of Sexual Medicine
  20. Feeding brown fat: dietary phytochemicals targeting non-shivering thermogenesis to control body weight
    Carla Horváth, Christian Wolfrum · 2020 · Proceedings of The Nutrition Society
  21. Seed dormancy and germination in J effersonia dubia ( B erberidaceae) as affected by temperature and gibberellic acid
    Yong Ha Rhie, S. Y. Lee, Kwang Soo Kim · 2014 · Plant Biology
  22. Thermodynamics of the binding of cytotoxic protoberberine molecule coralyne to deoxyribonucleic acids
    Kakali Bhadra, Motilal Maiti, Gopinatha Suresh Kumar · 2007 · Biochimica et Biophysica Acta (BBA) - General Subjects
  23. Berberine alleviates inflammation in polycystic ovary syndrome by inhibiting hyaluronan synthase 2 expression
    Shaojing He, Hui Li, Qianjie Zhang, Weimin Zhao, Wei Li, Chaohui Dai, Bixia Li, Jinhua Cheng, Shuang Wu, Zhongming Zhou et al. · 2024 · Phytomedicine
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  26. Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management
    Mohd Waiz, Sahir Sultan Alvi, M. Salman Khan · 2021 · EXCLI journal
  27. Berberine attenuates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice.
    Dan Xu, Chun Wan, Tao Wang, Panwen Tian, Diandian Li, Yanqiu Wu, Siyi Fan, Lei Chen, Yongchun Shen, Fuqiang Wen · 2015 · Europe PMC (PubMed Central)
  28. The Compound of Mangiferin-Berberine Salt Has Potent Activities in Modulating Lipid and Glucose Metabolisms in HepG2 Cells
    Can Wang, Jian‐Dong Jiang, Wei Wu, Weijia Kong · 2016 · BioMed Research International
  29. Integration of microRNA–mRNA profiles and pathway analysis of plant isoquinoline alkaloid berberine in SGC-7901 gastric cancers cells
    Yanhong Yang, Na Zhang, Kundong Li, Juan Chen, Lang Qiu, Jufeng Zhang · 2018 · Drug Design Development and Therapy
  30. Ellagic acid affects mRNA expression levels of genes that regulate cholesterol metabolism in HepG2 cells
    Shizuka Kubota, Yuma Tanaka, Satoshi Nagaoka · 2019 · Bioscience Biotechnology and Biochemistry
  31. Structure–activity relationship and biological evaluation of berberine derivatives as PCSK9 down-regulating agents
    Tianyun Fan, Yuxin Yang, Qingxuan Zeng, Xuelei Wang, Wei Wei, Xixi Guo, Liping Zhao, Danqing Song, Yanxiang Wang, Li Wang et al. · 2021 · Bioorganic Chemistry
  32. Epiberberine reduces serum cholesterol in diet-induced dyslipidemia Syrian golden hamsters via network pathways involving cholesterol metabolism
    Zongyao Zou, Yinran Hu, Hang Ma, Min Feng, Xuegang Li, Xiaoli Ye · 2015 · European Journal of Pharmacology
  33. Berberine might block colorectal carcinogenesis by inhibiting the regulation of B-cell function by Veillonella parvula
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  34. Berberine-induced glucagon-like peptide-1 and its mechanism for controlling type 2 diabetes mellitus: a comprehensive pathway review
    Mostafa Araj‐Khodaei, Mohammad Hossein Ayati, Akbar Azizi-Zeinalhajlou, Tannaz Novinbahador, Mehdi Yousefi, Mahdi Shiri, Ata Mahmoodpoor, Ali Shamekh, Nazli Namazi, Sarvin Sanaie · 2023 · Archives of Physiology and Biochemistry
  35. Berberine partially ameliorates cardiolipotoxicity in diabetic cardiomyopathy by modulating SIRT3‐mediated lipophagy to remodel lipid droplets homeostasis
    Wenxian Chen, Tongzhu Jin, Yilin Xie, Changsheng Zhong, Huiying Gao, Lei Zhang, Jin Ju, Ting Cheng, Mengyang Li, Huifang Wang et al. · 2025 · British Journal of Pharmacology
  36. Nutraceutical combination (red yeast rice, berberine and policosanols) improves aortic stiffness in low-moderate risk hypercholesterolemic patients
    Matteo Pirro, Graziana Lupattelli, Rosaria Del Giorno, Giuseppe Schillaci, Sokol Berisha, Massimo Raffaele Mannarino, Francesco Bagaglia, Francesco Melis, Elmo Mannarino · 2013 · PharmaNutrition
  37. Randomised clinical trial of Berberis vulgaris root extract on glycemic and lipid parameters in type 2 diabetes mellitus patients
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  39. Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis
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  40. An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia
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  43. Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway
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  46. Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
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  47. Biochemical components of Berberis lycium fruit and its effects on lipid profile in diabetic rats
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  49. Dynamic monitoring of the cytotoxic effects of protoberberine alkaloids from Rhizoma Coptidis on HepG2 cells using the xCELLigence system
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  66. Discovery, synthesis and biological evaluation of cycloprotoberberine derivatives as potential antitumor agents
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  67. The protective effect of berberine on β-cell lipoapoptosis
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  73. New therapies to reduce low-density lipoprotein cholesterol
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  74. Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling
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  75. Investigation on intermolecular interaction between berberine and β-cyclodextrin by 2D UV–Vis asynchronous spectra
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  76. Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells
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  77. Neuroprotective effects of berberine in neurodegeneration model rats induced by ibotenic acid
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  78. Chemopreventive effects of berberine on intestinal tumor development in Apc min/+mice
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  79. Atheroprotective Effects and Molecular Mechanism of Berberine
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  80. Discovery and structural optimization of 9-O-phenylsulfonyl-berberines as new lipid-lowering agents
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  83. Upregulating Reverse Cholesterol Transport With Cholesteryl Ester Transfer Protein Inhibition Requires Combination With the LDL-Lowering Drug Berberine in Dyslipidemic Hamsters
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  84. Berberine regulates neurite outgrowth through AMPK-dependent pathways by lowering energy status
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  85. Immunomodulatory and hepatoprotective role of feed‐added Berberis lycium in broiler chicks
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  86. Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells
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  89. Emerging Fixed-Dose Combination Treatments for Hyperlipidemia
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  90. Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules—A Meta-Analysis
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  92. Modular and Divergent Syntheses of Protoberberine and Protonitidine Alkaloids
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  93. Berberine in fish nutrition: Impact on hepatoenteric health, antioxidative and immune status
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  94. Berberine Regulation of Cellular Oxidative Stress, Apoptosis and Autophagy by Modulation of m6A mRNA Methylation through Targeting the Camk1db/ERK Pathway in Zebrafish-Hepatocytes
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  97. Physiological Effects of Berberine
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  98. Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77
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  100. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane
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