Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

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1. Significant pharmacokinetic differences of berberine are attributable to variations in gut microbiota between Africans and Chinese
   Raphael Nammahime Alolga, Yong Fan, Zhuo Chen, Liwei Liu, Yijing Zhao, Jin Li, Yan Chen, Maode Lai, Ping Li, Lian‐Wen Qi · 2016 · Scientific Reports
2. Combination of berberine and evodiamine inhibits intestinal cholesterol absorption in high fat diet induced hyperlipidemic rats
   Xin Zhou, Fengying Ren, Hong Kui WEI, Liyun Liu, Tao Shen, Shijun Xu, Jiangping Wei, Jiayue Ren, Hengfan Ni · 2017 · Lipids in Health and Disease
3. SWOT analysis and revelation in traditional Chinese medicine internationalization
   Haitao Tang, Wenlong Huang, Jimei Ma, Li Liu · 2018 · Chinese Medicine
4. Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling
   Jian Liu, Peng Liu, Tiantian Xu, Zhiwei Chen, Huimin Kong, Weihong Chu, Yingchao Wang, Yufeng Liu · 2020 · Drug Design Development and Therapy
5. BIAdb: A curated database of benzylisoquinoline alkaloids
   Deepak Singla, Arun B. Sharma, Jasjit Kaur, Bharat Panwar, Gajendra P. S. Raghava · 2010 · BMC Pharmacology
6. Medicinal plants and bioactive natural products as inhibitors of NLRP3 inflammasome
   Mohammad Bagherniya, Hamed Khedmatgozar, Omid Fakheran, Suowen Xu, Thomas Patrick Johnston, Amirhossein Sahebkar · 2021 · Phytotherapy Research
7. Development of small-molecule PCSK9 inhibitors for the treatment of hypercholesterolemia
   Shakir Ahamad, Shintu Mathew, Waqas A. Khan, Kishor Mohanan · 2022 · Drug Discovery Today
8. The role of berberine in Covid-19: potential adjunct therapy
   Ahmad O. Babalghith, Hayder Mutter Al-Kuraishy, Ali Ismail Al-Gareeb, Michel MDW DE WAARD, Sadiq Mohammed Al-Hamash, Jean‐Marc Sabatier, Walaa A. Negm, Gaber El‐Saber Batiha · 2022 · Inflammopharmacology
9. Hypoglycemic and Hypocholesterolemic Effects of Coptis chinensis Franch Inflorescence
   Lujiang Yuan, Dawei Tu, Xiaoli Ye, JIANPING WU · 2006 · Plant Foods for Human Nutrition
10. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats
    Feng Ling Wang, Li Qin Tang, Feng Yang, Ling Na Zhu, Ming Cai, Wei Wei · 2012 · Molecular Biology Reports
11. Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection
    Lihong Liu, Zilin Chen · 2012 · Analytica Chimica Acta
12. Effects of Poly-Bioactive Compounds on Lipid Profile and Body Weight in a Moderately Hypercholesterolemic Population with Low Cardiovascular Disease Risk: A Multicenter Randomized Trial
    Rosa Solà, Rosa M. Valls, José Puzo, José-Ramón Calabuig, Ángel Brea, Anna Pedret, David Moriña, Jose Ramon Villar, Jesús Millán, Anna Anguera · 2014 · PLoS ONE
13. Chinese herbal medicines for hypercholesterolemia
    Zhao Lan Liu, Jianping Liu, Anthony Lin Zhang, Qiong Wu, Yao Ruan, George T. Lewith, Denise Visconte · 2011 · Cochrane Database of Systematic Reviews
14. Berberine modulates amyloid-β peptide generation by activating AMP-activated protein kinase
    Haijing Zhang, Chunhui Zhao, Guoqiong Cao, Limin Guo, Shuai Zhang, Yuexia Liang, Chunxia Qin, Ping Su, Hang Li, Wensheng Zhang · 2017 · Neuropharmacology
15. Berberrubine and its analog, hydroxypropyl‐berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol‐lowering effects in human hepatoma HepG2 cells
    Shijie Cao, Peixiang Xu, Jian‐Kun Yan, Hui Liu, Lu Liu, Lina Cheng, Feng Qiu, Ning Kang · 2018 · Journal of Cellular Biochemistry
16. Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGF β R Regulating TGF‐ β /Smad Pathway
    Haiyan Du, Jiangyong Gu, Qin Peng, Xiaolan Wang, Lei Liu, Xuanyu Shu, Qiuying He, Yuhui Tan · 2021 · Oxidative Medicine and Cellular Longevity · Retracted
17. Berberine in Non-Alcoholic Fatty Liver Disease—A Review
    Anna Koperska, Agnieszka Wesołek, Małgorzata Moszak, Monika Szulińska · 2022 · Nutrients
18. Gut microbiota-SCFAs-brain axis associated with the antidepressant activity of berberine in CUMS rats
    Mengnan Huang, Yuanyuan He, Lin Tian, Lu Yu, Qi Cheng, Zhu Li, Lina Gao, Shan Gao, Yu Chunquan · 2023 · Journal of Affective Disorders
19. A room-temperature protocol to access isoquinolines through Ag( i ) catalysed annulation of o-(1-alkynyl)arylaldehydes and ketones with NH 4 OAc: elaboration to berberine and palmatine
    Virsinha Reddy, Abhijeet S. Jadhav, Ramasamy Vijaya Anand · 2015 · Organic & Biomolecular Chemistry
20. The anti-atherogenic effects of berberine on foam cell formation are mediated through the upregulation of sirtuin 1
    Liyi Chi, Lijing Peng, NA PAN, Xiaojing Hu, Yanhai Zhang · 2014 · International Journal of Molecular Medicine
21. Molecular aspects on the specific interaction of cytotoxic plant alkaloid palmatine to poly(A)
    Prabal Giri, Maidul Hossain, Gopinatha Suresh Kumar · 2006 · International Journal of Biological Macromolecules
22. Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease
    Zhigang Wang, Tong Yao, Zhenyuan Song · 2010 · Journal of Lipid Research
23. Suppression of Lipogenesis via Reactive Oxygen Species–AMPK Signaling for Treating Malignant and Proliferative Diseases
    Xing‐Xing Fan, Elaine Lai‐Han Leung, Ying Xie, Zhong Qiu Liu, Yan Fang Zheng, Xiao Yao, Linlin Lu, Jian‐Lin Wu, Jianxing He, Zhongwen Yuan et al. · 2017 · Antioxidants and Redox Signaling
24. Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond
    Mark Frederick McCarty, Simon Bernard Iloki Assanga, Lidianys María Lewis Luján, James Henry O’Keefe, James J. DiNicolantonio · 2020 · Nutrients
25. Transcript and metabolite profiling in cell cultures of 18 plant species that produce benzylisoquinoline alkaloids
    Scott C. Farrow, Jillian M. Hagel, Peter J. Facchini · 2012 · Phytochemistry
26. Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells
    Ana Burgeiro, Consuelo Gajate, El Habib Dakir, Janny A. Villa-Pulgarín, Paulo Jorge Oliveira, Faustino Mollinedo · 2011 · Anti-Cancer Drugs
27. Antitumor effect of novel berberine derivatives in breast cancer cells
    Elisa Pierpaoli, Andrea G. Arcamone, Franco Buzzetti, Paolo Lombardi, Carmela Salvatore, Mauro Provinciali · 2013 · BioFactors
28. Imaging and therapeutic applications of Zn( ii )-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy
    Qi‐Pin Qin, Zu‐Zhuang Wei, Zhenfeng Wang, Xiaoling Huang, Ming‐Xiong Tan, Hua‐Hong Zou, Hong Liang · 2020 · Chemical Communications
29. Berberine Ameliorates Pro-inflammatory Cytokine-Induced Endoplasmic Reticulum Stress in Human Intestinal Epithelial Cells In Vitro
    Xianhua Hao, Anlong Yao, Jianfeng Gong, Weiming Zhu, Ning Li, Jieshou Li · 2011 · Inflammation
30. Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition
    Weihua Liu, Futian Tang, Yanhui Deng, Xuejuan Li, Tian Lan, Xiaoyan Zhang, Heqing Huang, Peiqing Liu · 2009 · Molecular and Cellular Biochemistry
31. Molecular pathways and agents for lowering LDL-cholesterol in addition to statins
    Philippe Costet · 2010 · Pharmacology & Therapeutics
32. Berberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein efflux
    Yongqiang Shan, Gang Ren, Yanxiang Wang, Jing Pang, Zhiyun Zhao, Jing Yao, Xuefu You, Shuyi Si, Danqing Song, Weijia Kong et al. · 2012 · Metabolism
33. Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells
    Feiqi Zhu, Fujun Wu, Ying Ma, Guangjian Liu, Zhong Li, Yongan Sun, Zhong Pei · 2011 · BMC Neuroscience
34. Regulation of miRNAs by herbal medicine: An emerging field in cancer therapies
    Ali Mohammadi, Behzad Mansoori, Behzad Baradaran · 2016 · Biomedicine & Pharmacotherapy
35. Growth performance, innate immune responses and disease resistance of fingerling blunt snout bream, Megalobrama amblycephala adapted to different berberine-dietary feeding modes
    Weina Xu, Dan-Hong Chen, Qingqing Chen, Wenbin Liu · 2017 · Fish & Shellfish Immunology
36. Reduction of blood lipid by berberine in hyperlipidemic patients with chronic hepatitis or liver cirrhosis
    Wei Zhao, Rong Xue, Zhenxian Zhou, Weijia Kong, Jian‐Dong Jiang · 2008 · Biomedicine & Pharmacotherapy
37. Human low-density lipoprotein receptor gene and its regulation
    Weijia Kong, Jingwen Liu, Jian‐Dong Jiang · 2005 · Journal of Molecular Medicine
38. The position of functional foods and supplements with a serum LDL-C lowering effect in the spectrum ranging from universal to care-related CVD risk management
    Sabine Baumgartner, Éric Bruckert, Antonio Gallo, Jogchum Plat · 2020 · Atherosclerosis
39. Berberine-loaded liposomes for oral delivery: Preparation, physicochemical characterization and in-vivo evaluation in an endogenous hyperlipidemic animal model
    Thuan Thi Duong, Trần Thị Hải Yến, Tran-Linh Nguyen, Thuy-Duong Nguyen, Thi-Quynh-Trang Nguyen, T. Ha Lien Nghiem, Huyen Thanh Pham, Aіn Raal, Jyrki Heinämäki, Thi-Minh-Hue Pham · 2022 · International Journal of Pharmaceutics
40. A quick overview on some aspects of endocrinological and therapeutic effects of Berberis vulgaris L.
    Ali Zarei, Saeed Changizi‐Ashtiyani, Soheila Taheri, Majid Ramezani · 2015 · Europe PMC (PubMed Central)
41. Enhancing effects of chitosan and chitosan hydrochloride on intestinal absorption of berberine in rats
    Wei Chen, Dongjiao Fan, Lingkuo Meng, Yuqiang Miao, Shenshen Yang, Yan Weng, Haibing He, Xing Tang · 2011 · Drug Development and Industrial Pharmacy
42. The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet
    Xinxia Chang, Hongmei Yan, Qiong Xu, Mingfeng Xia, Hua Bian, Tengfang Zhu, Xin Gao · 2012 · Lipids in Health and Disease
43. A sensitive spectrofluorometric method for detection of berberine hydrochloride using Ag nanoclusters directed by natural fish sperm DNA
    Sheng Liang, Yangfang Kuang, Fangfang Ma, Shu Chen, Yunfei Long · 2016 · Biosensors and Bioelectronics
44. Metabolites identification of berberine in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry
    Kun Wang, Liwei Chai, Xinchi Feng, Zhongbo Liu, Hongxia Liu, Liqin Ding, Feng Qiu · 2017 · Journal of Pharmaceutical and Biomedical Analysis
45. Emerging Importance of Phytochemicals in Regulation of Stem Cells Fate via Signaling Pathways
    Mehdi Dadashpour, Younes Pilehvar‐Soltanahmadi, Nosratollah Zarghami, Akram Firouzi‐Amandi, Mohammad Pourhassan‐Moghaddam, Mohammad Nouri · 2017 · Phytotherapy Research
46. PHYTO-PHARMACOLOGY of Berberis aristata DC: A REVIEW
    Papiya Mitra Mazumder, Saumya Das, Sanjita Das, Manas Kumar Das · 2011 · Journal of Drug Delivery and Therapeutics
47. Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment
    Han, Yunfeng, Xiang, Yunan, Shi, Yi, Tang, Xi, Pan, Lin, Gao, Jie, Bi, Ruohong, Lai, Xianrong · 2021 · Evidence-Based Complementary and Alternative Medicine
48. Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial.
    Jiang Wang, Jing Zhao, Cong Yan, Cong Xi, Chenglin Wu, Jing-Xian Zhao, Feng-wei Li, Yan-Hua Ding, Rui Zhang, Shankang Qi et al. · 2022 · Cell Metabolism
49. Targeting metabolic syndrome: Candidate natural agents
    Xuan Xia, Jianping Weng · 2010 · Journal of Diabetes
50. Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters
    Yanwen Wang, Xiaoming Jia, Khadija Ghanam, Cécile Beaurepaire, Jeffrey A. Zidichouski, Lisa Miller · 2009 · Atherosclerosis
51. Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway
    Xi Xie, Wenyuan Li, Tian Lan, Weihua Liu, Jing Peng, Kaipeng Huang, Juan Huang, Xiaoyan Shen, Peiqing Liu, Heqing Huang · 2011 · Endocrine Journal
52. Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine
    Yinghong Li, Yi Li, Peng Yang, Weijia Kong, Xuefu You, Gang Ren, Hongbin Deng, Yueming Wang, Yanxiang Wang, Jian‐Dong Jiang et al. · 2010 · Bioorganic & Medicinal Chemistry
53. The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis
    Hao Wu, Kai He, YanZhi Wang, Dongfang Xue, Na Ning, Zongyao Zou, Xiaoli Ye, Xuegang Li, DeZhen Wang, Jie Pang · 2014 · Phytomedicine
54. Adenosine Monophosphate Activated Protein Kinase Regulates ABCG1-Mediated Oxysterol Efflux From Endothelial Cells and Protects Against Hypercholesterolemia-Induced Endothelial Dysfunction
    Dan Li, Yuan Zhang, Jing Ma, Wenhua Ling, Min Xia · 2010 · Arteriosclerosis Thrombosis and Vascular Biology
55. NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling
    Elisa Vivoli, Andrea Cappon, Stefano Milani, Benedetta Piombanti, Angela Provenzano, Erica Novo, Alessio Masi, Nadia Navari, Roberto Narducci, Guido Mannaioni et al. · 2016 · Clinical Science
56. Modulation of the Gut Microbiota by Krill Oil in Mice Fed a High-Sugar High-Fat Diet
    Chenyang Lu, Tingting Sun, Yanyan Li, Dijun Zhang, Jun Zhou, Xiurong Su · 2017 · Frontiers in Microbiology
57. Promising Anti-atherosclerotic Effect of Berberine: Evidence from In Vitro, In Vivo, and Clinical Studies
    Alireza Fatahian, Saeed Mohammadian Haftcheshmeh, Sara Azhdari, Helaleh Kaboli Farshchi, Banafsheh Nikfar, Amir Abbas Momtazi‐Borojeni · 2020 · Reviews of physiology, biochemistry and pharmacology
58. Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections
    Katarzyna Pacyga, Paweł Pacyga, Ewa Topola, Szymon Viscardi, Anna Duda-Madej · 2024 · International Journal of Molecular Sciences
59. Berberine elicits anti‐arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model
    Lihong Wang, Chang‐hua Yu, Ying Hui Fu, Qiang Li, Yu‐qian Sun · 2010 · Phytotherapy Research
60. Tetrandrine Potentiates the Hypoglycemic Efficacy of Berberine by Inhibiting P-Glycoprotein Function
    Yongqiang Shan, Yanping Zhu, Jing Pang, Yanxiang Wang, Danqing Song, Weijia Kong, Jian‐Dong Jiang · 2013 · Biological and Pharmaceutical Bulletin
61. Circadian pharmacological effects of berberine on chronic colitis in mice: Role of the clock component Rev-erbα
    Ziyue Zhou, Yanke Lin, Lu Gao, Zemin Yang, Shuai Wang, Baojian Wu · 2019 · Biochemical Pharmacology
62. Improvement of Endothelial Dysfunction of Berberine in Atherosclerotic Mice and Mechanism Exploring through TMT-Based Proteomics
    Wangxiao Tan, Yu Wang, Kaiyue Wang, Siwei Wang, Jinghua Liu, Xiaoyan Qin, Yongna Dai, Xiaoying Wang, Xiumei Gao · 2020 · Oxidative Medicine and Cellular Longevity
63. The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis
    Runbin Sun, Bo Kong, Na Yang, Bei Cao, Dong Feng, Xiaoyi Yu, Chun Ge, Siqi Feng, Fei Fei, Jingqiu Huang et al. · 2020 · Drug Metabolism and Disposition
64. A Song of Ice and Fire: Cold and Hot Properties of Traditional Chinese Medicines
    Juan Liu, Wuwen Feng, Cheng Yun Peng · 2021 · Frontiers in Pharmacology
65. Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota
    Zhengwei Zhang, Lin Cong, Ran Peng, Pei Han, Shurong Ma, Li‐Bin Pan, Jie Fu, Hang Yu, Yan Wang, Jian‐Dong Jiang · 2020 · Journal of Pharmaceutical Analysis
66. Berberine prevents NAFLD and HCC by modulating metabolic disorders.
    Xinyue Lin, Juan-Hong Zhang, Yajun Chu, Qiu-Ying Nie, Jun-Min Zhang · 2024 · Pharmacology and Therapeutics
67. Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols, and Berberine) in Patients with Low-Moderate Risk Hypercholesterolemia: A Double-Blind, Placebo-Controlled Study
    Stefano Gonnelli, Carla Caffarelli, Kostantinos Stolakis, C. Cuda, Nicola G. Giordano, Ranuccio Nuti · 2014 · Current Therapeutic Research
68. Berberine-induced inhibition of adipocyte enhancer-binding protein 1 attenuates oxidized low-density lipoprotein accumulation and foam cell formation in phorbol 12-myristate 13-acetate-induced macrophages
    Zhouqing Huang, Fengquan Dong, Sheng Li, Maoping Chu, Hao Zhou, Zhongqiu Lu, Weijian Huang · 2012 · European Journal of Pharmacology
69. Beneficial Effects of Berberine on Oxidized LDL-Induced Cytotoxicity to Human Retinal Müller Cells
    Dongxu Fu, Yongxin Yu, Anna R. Connell, Shihe Yang, Michelle B. Hookham, Rebecca H. McLeese, Timothy J. Lyons · 2016 · Investigative Ophthalmology & Visual Science
70. Two telomerase-targeting Pt( ii ) complexes of jatrorrhizine and berberine derivatives induce apoptosis in human bladder tumor cells
    Qi‐Pin Qin, Zhenfeng Wang, Xiaoling Huang, Ming‐Xiong Tan, Zhihui Luo, Shu-Long Wang, Bi‐Qun Zou, Hong Liang · 2019 · Dalton Transactions
71. Berberine Inhibits Growth and Induces G1 Arrest and Apoptosis in Human Cholangiocarcinoma QBC939 Cells
    Wei He, Bin Wang, Yun Zhuang, Dong Shao, Kewen Sun, Jianping Chen · 2012 · Journal of Pharmacological Sciences
72. Correction: A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine
    Shenghua Gu, Bei Cao, Runbin Sun, Yueqing Tang, Janice L. Paletta, Xiao‐Lei Wu, Linsheng Liu, Weibin Zha, Chunyan Zhao, Yan Li et al. · 2014 · Molecular BioSystems
73. Usefulness of Nutraceuticals (Armolipid Plus) Versus Ezetimibe and Combination in Statin-Intolerant Patients With Dyslipidemia With Coronary Heart Disease
    Marazzi, Giuseppe, Pelliccia, Francesco, Campolongo, Giuseppe, Quattrino, Silvia, Cacciotti, Luca, Volterrani, Maurizio, Gaudio, Carlo, Rosano, Giuseppe · 2015 · The American Journal of Cardiology
74. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins
    Di Pierro, Francesco, Bellone, Iaele, Rapacioli, Giuliana, Putignano, Pietro · 2015 · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
75. Berberine Ameliorates Cold and Mechanical Allodynia in a Rat Model of Diabetic Neuropathy
    Si‐Oh Kim, Hyun Jee Kim · 2013 · Journal of Medicinal Food
76. Protonated structures of naturally occurring deoxyribonucleic acids and their interaction with berberine
    Kakali Bhadra, Gopinatha Suresh Kumar, Suman Das, Md. Maidul Islam, Motilal Maiti · 2005 · Bioorganic & Medicinal Chemistry
77. Berberine Up-Regulates Hepatic Low-Density Lipoprotein Receptor through Ras-Independent but AMP-Activated Protein Kinase-Dependent Raf-1 Activation
    Zheng Li, Jian‐Dong Jiang, Weijia Kong · 2014 · Biological and Pharmaceutical Bulletin
78. Process‐Induced Phase Transformation of Berberine Chloride Hydrates
    Henry H. Y. Tong, Aviva S.F. Chow, Hak‐Kim Chan, Albert H.L. Chow, Yetta K.Y. Wan, Ian Duncan Williams, Fanny L. Y. Shek, Chak Keung Chan · 2009 · Journal of Pharmaceutical Sciences
79. Metabolic and cardiovascular effects of berberine: from preclinical evidences to clinical trial results
    Arrigo F.G. Cicero, Sibel Ertek · 2009 · Clinical Lipidology
80. Knowns and unknowns in the care of pediatric familial hypercholesterolemia
    Andrew C. Martin, Samuel S. Gidding, Albert Wiegman, Gerald Francis Watts · 2017 · Journal of Lipid Research
81. Berberine promotes ischemia-induced angiogenesis in mice heart via upregulation of microRNA-29b
    Mo‐Li Zhu, Yaling Yin, Ping Song, YU Hai-ya, Guang‐Rui Wan, Jian Chu Xu, Peng Li · 2017 · Clinical and Experimental Hypertension
82. The enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins
    Panfeng Feng, Lei Zhao, Feng-Feng Guo, Bo Zhang, Fang Li, Ge Zhan, Xueqi Xu, Qing Ze Fang, Zhaoguang Liang, Baoxin Li · 2018 · Chemico-Biological Interactions
83. Dual‐Stimuli‐Responsive Gut Microbiota‐Targeting Berberine‐CS/PT‐NPs Improved Metabolic Status in Obese Hamsters
    Huihui Guo, Chen Ma, Wensheng Zheng, Yang Luo, Cong Li, Xiaolin Li, Xiaolei Ma, Chen‐Lin Feng, Tingting Zhang, Yanxing Han et al. · 2019 · Advanced Functional Materials
84. Molecular targeted study in tumors: From western medicine to active ingredients of traditional Chinese medicine
    Ruixiao Li, Qi Li, Qing Ji · 2019 · Biomedicine & Pharmacotherapy
85. Efficacy and safety of traditional Chinese medicines for non-alcoholic fatty liver disease: a systematic literature review of randomized controlled trials
    Zuanji Liang, Xianwen Chen, Junnan Shi, Hao Hu, Yan Xue, Carolina Oi Lam Ung · 2021 · Chinese Medicine
86. Berberine, a natural lipid-lowering drug, exerts prothrombotic effects on vascular cells
    Erik Walter Holy, Alexander Akhmedov, Thomas Felix Lüscher, Felix Christoph Tanner · 2008 · Journal of Molecular and Cellular Cardiology
87. Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes
    Libin Zhou, Xiao Wang, Ying Yang, Ling Wu, Fengying Li, Rong Zhang, Guoyue Yuan, Ning Wang, Ming‐Dao Chen, Guang Ning · 2010 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
88. Characterization and Pharmacokinetic Assessment of a New Berberine Formulation with Enhanced Absorption In Vitro and in Human Volunteers
    Solnier, Julia, Zhang, Yiming, Kuo, Yun, Du, Min, Roh, Kyle, Gahler, Roland, Wood, Simon, Chang, Chuck · 2023 · Pharmaceutics
89. Efficacy of berberine alone and in combination for the treatment of hyperlipidemia: A systematic review
    Koppen, Laura M., Whitaker, Andrea, Rosene, Audrey, Beckett, Robert D. · 2017 · Journal of Evidence-Based Complementary & Alternative Medicine
90. Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor
    Yanxiang Wang, Yuping Wang, Hao Zhang, Weijia Kong, Yinghong Li, Fei Liu, Rong‐Mei Gao, Ting Liu, Jian‐Dong Jiang, Danqing Song · 2009 · Bioorganic & Medicinal Chemistry Letters
91. Clinical evidence of efficacy of red yeast rice and berberine in a large controlled study versus diet
    Bruno Trimarco, Claudio Benvenuti, Francesco Rozza, Claudia Sara Cimmino, Renata Giudice, Salvatore Crispo · 2011 · Mediterranean Journal of Nutrition and Metabolism
92. Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes
    Yun Li, Pengcheng Wang, Yuan Zhuang, Huan Lin, Yehua Li, Ling Liu, Qinghang Meng, Ting Cui, Jing Liu, Zhen Li · 2011 · FEBS Letters
93. Hypolipidemic Effect and Mechanism of Palmatine fromCoptis chinensisin Hamsters Fed High-Fat diet
    Na Ning, Kai He, Yan-Zhi Wang, Zongyao Zou, Hao Wu, Xuegang Li, Xiaoli Ye · 2015 · Phytotherapy Research
94. Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia
    Nan Wu, Lindsei K. Sarna, Yaw Loong Siow, O Karmin · 2010 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
95. Development and evaluation of vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate-mixed polymeric phospholipid micelles of berberine as an anticancer nanopharmaceutical
    Tamer A. ElBayoumi, Roger Shen, Jane Kim, Mingyi Yao · 2016 · International Journal of Nanomedicine
96. Chemiluminescence recognition of berberine triggered by biomimetically synthesized silver nanoparticles
    Pourya Biparva, Seyed Mohammad Abedirad, Sayed Yahya Kazemi, Maryam Shanehsaz · 2016 · Sensors and Actuators B Chemical
97. Induction of G2/M Arrest by Berberine via Activation of PI3K/Akt and p38 in Human Chondrosarcoma Cell Line
    Seong-Hui Eo, Juhee Kim, Song Ja Kim · 2015 · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
98. The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence
    Pratibha Anchi, Amit Khurana, Swarna Bale, Chandraiah Godugu · 2017 · Phytotherapy Research
99. Berberine induces miR-373 expression in hepatocytes to inactivate hepatic steatosis associated AKT-S6 kinase pathway
    Chi Han Li, Shing Chun Tang, Chi Hin Wong, Yan Wang, Jian‐Dong Jiang, Yangchao Chen · 2018 · European Journal of Pharmacology
100. Effects of Berberine on Expression of LOX-1 and SR-BI in Human Macrophage-Derived Foam Cells Induced by ox-LDL
     Siming Guan, Bin Wang, Wei Li, Jinghuan Guan, Xin Fang · 2010 · The American Journal of Chinese Medicine