Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

Kong, Weijia, Wei, Jing, Abidi, Parveen, Lin, Meihong, Inaba, Satoru, Li, Cong, Wang, Yanling, Wang, Zizheng +8 more·2004·Nature Medicine

Cited by (1,002)

Items 601–700 of 1,002

  1. MG132, a proteasome inhibitor, enhances LDL uptake in HepG2 cells in vitro by regulating LDLR and PCSK9 expression
    Hong Yan, Yanling Ma, Yuzhou Gui, Shu-mei Wang, Xin-bo Wang, Fei Gao, Yiping Wang · 2014 · Acta Pharmacologica Sinica
  2. Berberine nanoparticles protects tubular epithelial cells from renal ischemia-reperfusion injury
    Da Xie, Yong Xu, Wang Jing, Zeng Ju-xiang, Li Hailun, Hu Yu, Donghui Zheng, Yongtao Lin · 2017 · Oncotarget
  3. Sustained release effects of berberine-loaded chitosan microspheres on in vitro chondrocyte culture
    Yan Zhou, Shiqing Liu, Jianghua Ming, Yaming Li, Ming Deng, Bin He · 2017 · Drug Development and Industrial Pharmacy
  4. Recent perspectives on the role of nutraceuticals as cholesterol-lowering agents
    Natalie C. Ward, Amirhossein Sahebkar, Maciej Banach, Gerald Francis Watts · 2017 · Current Opinion in Lipidology
  5. Caffeine-free hawk tea lowers cholesterol by reducing free cholesterol uptake and the production of very-low-density lipoprotein
    Juan Feng, Jian Tao Yang, Yu-Jun Chang, Liansheng Qiao, Honglei Dang, Kun Luo, Hongyan Guo, Yan-Nan An, Chengmei Ma, Hong Shao et al. · 2019 · Communications Biology
  6. The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood–testis barrier and results in hypospermatogenesis
    Ruilou Zhu, Jiangnan Wang, Tianxiang Feng, Xuechun Hu, Jiang Chen, Xiuxing Wang, Kang Li, Yongjuan Sang, Yue Hua, Haixiang Sun et al. · 2019 · Cell Death and Disease
  7. The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials
    Liangzhen Xie, Duojia Zhang, Hongli Ma, Hui Rong He, Qing Xia, Wenjuan Shen, Hui Chang, Yingying Deng, Qi Wu, Jing Cong et al. · 2019 · Evidence-based Complementary and Alternative Medicine
  8. Remodelling of gut microbiota by Berberine attenuates trimethylamine N-oxide-induced platelet hyperreaction and thrombus formation
    Zulong Xie, Xinxin Liu, Xingtao Huang, Qi Liu, Mengyue Yang, Dan Huang, Peng Zhao, Jinwei Tian, Xuedong Wang, Jingbo Hou · 2021 · European Journal of Pharmacology
  9. Berberine regulates melanin synthesis by activating PI3K/AKT, ERK and GSK3β in B16F10 melanoma cells
    Young Chan Song, Yonghee Lee, Hyeong Mi Kim, Moo Yeol Hyun, Yun Young Lim, Kye Yong Song, Beom Joon Kim · 2015 · International Journal of Molecular Medicine
  10. Berberine inhibits SREBP‐1‐related clozapine and risperidone induced adipogenesis in 3T3‐L1 cells
    Yueshan Hu, Eric C Kutscher, Gareth E. Davies · 2010 · Phytotherapy Research
  11. Traditional Japanese Herbal (Kampo) Medicines and Treatment of Ocular Diseases: A Review
    Seiji Hayasaka, Tatsuo Kodama, Akihiro Ohira · 2012 · The American Journal of Chinese Medicine
  12. Berberine targets KIF20A and CCNE2 to inhibit the progression of nonsmall cell lung cancer via the PI3K/AKT pathway
    Qi Wang, Hua Wu, Qingquan Wu, Sheng Zhong · 2023 · Drug Development Research
  13. Validated UPLC–MS/MS method for simultaneous determination of simvastatin, simvastatin hydroxy acid and berberine in rat plasma: Application to the drug–drug pharmacokinetic interaction study of simvastatin combined with berberine after oral administration in rats
    Mei Liu, Xianying Su, Guofei Li, Gui-Lian Zhao, Limei Zhao · 2015 · Journal of Chromatography B
  14. Statin Intolerance: Diagnosis and Remedies
    Angela Pirillo, Alberico Luigi Catapano · 2015 · Current Cardiology Reports
  15. 5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element
    Takuya Yashiro, Manami Nanmoku, Makoto Shimizu, Jun Inoue, Ryuichiro Sato · 2012 · Atherosclerosis
  16. Berberine inhibits Chlamydia pneumoniae infection-induced vascular smooth muscle cell migration through downregulating MMP3 and MMP9 via PI3K
    Lu Ma, Lijun Zhang, Beibei Wang, Junyan Wei, Jingya Liu, Lijun Zhang · 2015 · European Journal of Pharmacology
  17. Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells
    Lei Zhang, Xiaojie Miao, Xin Wang, Haihui Pan, Pu Li, Hong Ren, Yongrui Jia, Chuang Lu, Hongbing Wang, Lan Yuan et al. · 2016 · Scientific Reports
  18. Exploring thermodynamic parameters and the binding energetic of berberine chloride to bovine serum albumin (BSA): Spectroscopy, isothermal titration calorimetry and molecular docking techniques
    Shama Yasmeen, Riyazuddeen · 2017 · Thermochimica Acta
  19. Biocatalyzed C−C Bond Formation for the Production of Alkaloids
    Mahesh Daga Patil, Gideon Grogan, Hyungdon Yun · 2018 · ChemCatChem
  20. Multipath effects of berberine on peach Brown rot fungus Monilinia fructicola
    Qinghui Pei, Ying Li, Xizhen Ge, Pingfang Tian · 2018 · Crop Protection
  21. Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
    Maria Deolinda Auxtero, Susana Chalante, Mário Rui Abade, Rui Jorge, Ana Isabel Fernandes · 2021 · Pharmaceutics
  22. Regulation of in vivo delivery of nanomedicines by herbal medicines
    Juan Guan, Wei Chen, Min Yang, Ercan Wu, Jun Qian, Changyou Zhan · 2021 · Advanced Drug Delivery Reviews
  23. Uncoupling protein‐2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS ‐1 E cells and in diabetic mouse islets
    Limei Liu, Jian Liu, Yuansheng Gao, Xiaoxing Yu, Gang Xu, Yü Huang · 2014 · British Journal of Pharmacology
  24. Effect of Berberine on Proinflammatory Cytokine Production by ARPE-19 Cells following Stimulation with Tumor Necrosis Factor-α
    Qian Wang, Jian Qi, Ranran Hu, Ying Chen, Aize Kijlstra, Peizeng Yang · 2012 · Investigative Ophthalmology & Visual Science
  25. Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice
    Ji Hoon Yoo, E.-M. Yang, J.-H. Cho, J.-H. Lee, S. M. Jeong, S Y Nah, H.-C. Kim, K.-W. Kim, Sung‐Hoon Kim, S.-Y. Lee et al. · 2006 · Neuroscience
  26. Avocado‐derived extracellular vesicles loaded with ginkgetin and berberine prevent inflammation and macrophage foam cell formation
    Shweta Sharma, Manisha Mahanty, Suneha G. Rahaman, Pritha Mukherjee, Bidisha Dutta, Mohammad Imran Khan, Karunakaran Reddy Sankaran, Xiaoming He, Lakshmyya N. Kesavalu, Wei Li et al. · 2024 · Journal of Cellular and Molecular Medicine
  27. Role of JNK and c-Jun signaling pathway in regulation of human serum paraoxonase 1 gene transcription by berberine in human HepG2 cells
    Chi‐Chih Cheng, Chi‐Mei Hsueh, Kae‐Woei Liang, Chih-Tai Ting, Chi-Luan Wen, Shih‐Lan Hsu · 2010 · European Journal of Pharmacology
  28. Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q10 on lipid levels: a randomized, double-blind, placebo controlled study
    Sergio D’Addato, Luciana Scandiani, Giuliana Germana Mombelli, Francesca Focanti, Federica Pelacchi, Enrica Salvatori, Giorgio Di Loreto, Alessandro Comandini, Pamela Maffioli, Giuseppe Derosa · 2017 · Drug Design Development and Therapy
  29. Berberine exerts antioxidant effects via protection of spiral ganglion cells against cytomegalovirus-induced apoptosis
    Wei Zhuang, Ting Li, Caiji Wang, Xi Shi, Yalan Li, Shili Zhang, Zeqi Zhao, Hongyan Dong, Yuehua Qiao · 2018 · Free Radical Biology and Medicine
  30. Syntaxin 1B Mediates Berberine’s Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model
    Yangmin Zheng, Bo Chen, Jian‐Dong Jiang, Jingpu Zhang · 2018 · Frontiers in Molecular Neuroscience
  31. Pharmacology of Nutraceuticals with Lipid Lowering Properties
    Andrea Poli, Francesco Visioli · 2019 · High Blood Pressure & Cardiovascular Prevention
  32. Hsa-miR-140-5p down-regulates LDL receptor and attenuates LDL-C uptake in human hepatocytes
    Yaqiong Xu, Jie Gao, Yaqin Gong, Manman Chen, Jiali Chen, Wenfeng Zhao, Shuhua Tan · 2020 · Atherosclerosis
  33. Multicomponent Therapeutics of Berberine Alkaloids
    Jiaoyang Luo, Dan Yan, Meihua Yang, Xiao‐Ping Dong, Xiaohe Xiao · 2013 · Evidence-based Complementary and Alternative Medicine
  34. A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression
    Amar Bahadur Singh, Chin Fung Kelvin Kan, Vikram Ravindra Shende, Bin Dong, Jingwen Liu · 2014 · Journal of Lipid Research
  35. Effects of Dietary Coptis Chinensis Herb Extract on Growth Performance, Nutrient Digestibility, Blood Characteristics and Meat Quality in Growing-finishing Pigs
    T.X. Zhou, Z.F. Zhang, In Ho Kim · 2013 · Asian-Australasian Journal of Animal Sciences
  36. 13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cells
    Yit‐Lai Chow, Mami Sogame, Fumihiko Sato · 2016 · Scientific Reports
  37. Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation
    Qiqi Tang, Beibei Liang, Lisha Zhang, Xuhui Li, Hengyu Li, Wei Jing, Yingjie Jiang, Felix Zhou, Jian Zhang, Yanchun Meng et al. · 2022 · Scientific Reports
  38. Exosomes‐transferred LINC00668 Contributes to Thrombosis by Promoting NETs Formation in Inflammatory Bowel Disease
    Long Zhang, Bin Zheng, Yang Bai, Jing Zhou, Xin‐hua Zhang, Yu‐qin Yang, Jing Yu, Hong‐Ye Zhao, Dong Ma, Han Wu et al. · 2023 · Advanced Science
  39. Molecular mechanisms, targets and clinical potential of berberine in regulating metabolism: a review focussing on databases and molecular docking studies
    Aru Sun, Haoyu Yang, Tao Li, Jinli Luo, Ling Zhou, Rui Chen, Lin Han, Yiqun Lin · 2024 · Frontiers in Pharmacology
  40. Inhibition of proprotein convertase subtilisin/kexin type 9: A novel mechanism of berberine and 8-hydroxy dihydroberberine against hyperlipidemia
    Deliang Liu, Lijun Xu, Hui Dong, Guang Chen, Zhaoyi Huang, Xin Guo Zou, Kaifu Wang, Yun-huan Luo, Fuer Lu · 2014 · Chinese Journal of Integrative Medicine
  41. Molecular characterization of carnitine palmitoyltransferase IA in Megalobrama amblycephala and effects on its expression of feeding status and dietary lipid and berberine
    Kangle Lu, Dingdong Zhang, Lina Wang, Weina Xu, Wenbin Liu · 2015 · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology
  42. Identification of candidate genes involved in isoquinoline alkaloids biosynthesis in Dactylicapnos scandens by transcriptome analysis
    Simei He, Wan Ling Song, Kun Cong, Xiao Wang, Yang Dong, Jing Cai, Jia Jin Zhang, Guang Hui Zhang, Jianli Yang, Sheng Chao Yang et al. · 2017 · Scientific Reports
  43. Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis
    Haidong Sun, Qian Liu, Hai Hu, Yisheng Jiang, Wentao Shao, Qihan Wang, Zhaoyan Jiang, Aihua Gu · 2018 · Cell Death and Disease
  44. Farnesoid X Receptor Activation by Obeticholic Acid Elevates Liver Low-Density Lipoprotein Receptor Expression by mRNA Stabilization and Reduces Plasma Low-Density Lipoprotein Cholesterol in Mice
    Amar Bahadur Singh, Bin Dong, Fredric B. Kraemer, Yanyong Xu, Yanqiao Zhang, Jingwen Liu · 2018 · Arteriosclerosis Thrombosis and Vascular Biology
  45. Berberine as a Potential Multi-Target Agent for Metabolic Diseases: A Review of Investigations for Berberine
    Shengju Wang, Xu Zhang, Baochao Cai, Qiu Chen · 2020 · Endocrine Metabolic & Immune Disorders - Drug Targets
  46. Nuciferine reduced fat deposition by controlling triglyceride and cholesterol concentration in broiler chickens
    Yingying Zhou, Zhanghan Chen, Qiumin Lin, Yang Yang, Yunzhen Hang, Xinni Zhou, Changbiao Wu, Zhenglu Xie · 2020 · Poultry Science
  47. Berberine exerts anti-adipogenic activity through up-regulation of C/EBP inhibitors, CHOP and DEC2
    Truc P.T. Pham, Jeongho Kwon, Jaekyoon Shin · 2011 · Biochemical and Biophysical Research Communications
  48. Gossypin Up-Regulates LDL Receptor through Activation of ERK Pathway: A Signaling Mechanism for the Hypocholesterolemic Effect
    Na Lu, Ying Li, Hong Qin, Yuling Zhang, Changhao Sun · 2008 · Journal of Agricultural and Food Chemistry
  49. Low molecular weight inhibitors of Prolyl Oligopeptidase: a review of compounds patented from 2003 to 2010
    Abraham López, Teresa Tarragó, Ernest Giralt · 2011 · Expert Opinion on Therapeutic Patents
  50. Nutraceutical approaches to metabolic syndrome
    Cesare Riccardo Sirtori, Chiara Pavanello, Laura Calabresi, Massimiliano Ruscica · 2017 · Annals of Medicine
  51. Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway
    Tadeusz Issat, Marek Jakóbisiak, Jakub Gołąb · 2006 · Oncology Reports
  52. Conformation-activity studies on the interaction of berberine with acetylcholinesterase: Physical chemistry approach
    Jin Xiang, Changping Yu, Fang Yang, Ling Yang, Hong Ding · 2009 · Progress in Natural Science Materials International
  53. Emerging oral therapeutic strategies for inhibiting PCSK9
    Nicola Ferri, Giorgia Marodin · 2024 · Atherosclerosis Plus
  54. Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression
    M. Marek Nagiec, Adam P. Skepner, Joseph M. Negri, Michelle Eichhorn, Nicolas Kuperwasser, Eamon Comer, Giovanni Muncipinto, Aravind Subramanian, Clary B. Clish, Kiran Musunuru et al. · 2015 · PLoS ONE
  55. Interaction of Cationic Protoberberine Alkaloids with Human Serum Albumin. No Spectroscopic Evidence on Binding to Sudlow’s Site 1
    Milena Marszalek, Anna Konarska, Ewa Szajdzińska‐Piętek, Marian Wolszczak · 2013 · The Journal of Physical Chemistry B
  56. Berberine Hydrochloride Protects C2C12 Myoblast Cells Against Oxidative Stress‐Induced Damage via Induction of Nrf‐2‐Mediated HO‐1 Expression
    Yung Hyun Choi · 2016 · Drug Development Research
  57. Berberine Protects Against Palmitate-Induced Apoptosis in Tubular Epithelial Cells by Promoting Fatty Acid Oxidation
    Ji-ye Sun, Xuemei Chen, Ting Liu, Xu-shun Jiang, Yue Wu, Shan Yang, Wei Hua, Zhengdong Li, Huizhe Huang, Xiong Zhong Ruan et al. · 2018 · Medical Science Monitor
  58. Cryptotanshinone suppresses key onco-proliferative and drug-resistant pathways of chronic myeloid leukemia by targeting STAT5 and STAT3 phosphorylation
    Bowen Dong, Zirui Liang, Zhirong Chen, Bin Li, Ling‐Ling Zheng, Jianhua Yang, Hui Zhou, Liang‐Hu Qu · 2018 · Science China Life Sciences
  59. Berberine-loaded solid proliposomes prepared using solution enhanced dispersion by supercritical CO2: Sustained release and bioavailability enhancement
    Jingfu Jia, Kerong Zhang, Xue Zhou, Jinfang Ma, Xiaojing Liu, Anya Xiang, Fahuan Ge · 2019 · Journal of Drug Delivery Science and Technology
  60. Differential effects of red yeast rice, Berberis aristata and Morus alba extracts on PCSK9 and LDL uptake
    Maria Giovanna Lupo, Chiara Macchi, Silvia Marchianò, Riccardo Cristofani, Maria Francesca Greco, Stefano Dall’Acqua, Hạixia Chen, Cesare Riccardo Sirtori, Alberto Corsini, Massimiliano Ruscica et al. · 2019 · Nutrition Metabolism and Cardiovascular Diseases
  61. Berberine inhibits colorectal tumor growth by suppressing SHH secretion
    Zhu-qing Shen, Juan Wang, Wenfu Tan, Taomin Huang · 2020 · Acta Pharmacologica Sinica
  62. Factors Associated with White Fat Browning: New Regulators of Lipid Metabolism
    Peiwen Zhang, Yuxu He, Shuang Wu, Xinrong Li, Xutao Lin, Mailin Gan, Lei Chen, Ye Zhao, Lili Niu, Shunhua Zhang et al. · 2022 · International Journal of Molecular Sciences
  63. Role of 13-(di)phenylalkyl berberine derivatives in the modulation of the activity of human topoisomerase IB
    Sara D. Vieira, Silvia Castelli, Mattia Falconi, Jéssica Emi Takarada, Gaetano Fiorillo, Franco Buzzetti, Paolo Lombardi, Alessandro Desideri · 2015 · International Journal of Biological Macromolecules
  64. Chemistry and Biological Activities ofBerberis lyciumRoyle
    Hazrat Ali, Shahab Uddin M.S., Sajid Jalal · 2015 · Journal of Biologically Active Products from Nature
  65. Berberine on the prevention and management of cardiometabolic disease: clinical applications and mechanisms of action
    Cao, Richard Y., Zheng, Yuntao, Zhang, Ying, Jiang, Lingling, Li, Qing, Sun, Wanqun, Gu, Wenqin, Cao, Weifeng, Zhou, Linyan, Zheng, Hongchao et al. · 2021 · The American Journal of Chinese Medicine
  66. Protective effects of berberine on various kidney diseases: Emphasis on the promising effects and the underlined molecular mechanisms
    Emad H. M. Hassanein, Islam Mohamed Ibrahim, Esraa K. Abd‐alhameed, Nesma M. Mohamed, Samir Anis Ross · 2022 · Life Sciences
  67. Preparation of Berberine-montmorillonite-metolachlor formulations from hydrophobic/hydrophilic mixtures
    Giora Rytwo · 2007 · Applied Clay Science
  68. Effects of a nutraceutical combination containing berberine (BRB), policosanol, and red yeast rice (RYR), on lipid profile in hypercholesterolemic patients: A meta-analysis of randomised controlled trials
    Jesús Millán, Arrigo F.G. Cicero, Francisco Torres, Anna Anguera · 2016 · Clínica e Investigación en Arteriosclerosis
  69. Activating transcription factor-3 induction is involved in the anti-inflammatory action of berberine in RAW264.7 murine macrophages
    Young‐An Bae, Hyae Gyeong Cheon · 2016 · Korean Journal of Physiology and Pharmacology
  70. Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease
    Ming Zhang, Linjing Feng, Junnan Li, Li Chen · 2016 · Current Pharmacology Reports
  71. Popular functional foods and nutraceuticals with lipid lowering activity and in relation to cardiovascular disease, dyslipidemia, and related complications: an overview
    Hui‐Fang Chiu, You‐Cheng Shen, Kamesh Venkatakrishnan, Chin‐Kun Wang · 2018 · Journal of Food Bioactives
  72. Berberine Represses β-Catenin Translation Involving 4E-BPs in Hepatocellular Carcinoma Cells
    Kanchan Vishnoi, Rong Ke, Karan Singh Saini, Navin Viswakarma, Rakesh Sathish Nair, Subhasis Das, Zhengjia Chen, Ajay Rana, Basabi Rana · 2020 · Molecular Pharmacology
  73. Trans-Epithelial Transport, Metabolism, and Biological Activity Assessment of the Multi-Target Lupin Peptide LILPKHSDAD (P5) and Its Metabolite LPKHSDAD (P5-Met)
    Carmen Lammi, Gilda Aiello, Carlotta Bollati, Jianqiang Li, Martina Bartolomei, Giulia Ranaldi, Simonetta Ferruzza, Enrico Mario Alessandro Fassi, Giovanni Grazioso, Yula Sambuy et al. · 2021 · Nutrients
  74. Regulation of low-density lipoprotein receptor expression in triple negative breast cancer by EGFR-MAPK signaling
    Tiffany Scully, NATHAN G. KASE, Emily J. Gallagher, Derek LeRoith · 2021 · Scientific Reports
  75. Discovery of Novel Small Molecule Inhibitors Disrupting the PCSK9-LDLR Interaction
    Hengzhi Sun, Jin‐Zheng Wang, Shengjie Liu, Xinyu Zhou, Liang Xiang Dai, Caiping Chen, Qing‐Long Xu, Xiaoan Wen, Keguang Cheng, Hongbin Sun et al. · 2021 · Journal of Chemical Information and Modeling
  76. Berberine: metabolic and cardiovascular effects in preclinical and clinical trials
    Arrigo F.G. Cicero · 2009 · Nutrition and Dietary Supplements
  77. Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats
    Doaa Ahmad Ghareeb, Sofia Khalil, Hani S. Hafez, Jürgen Bajorath, Hany E. A. Ahmed, Eman Sarhan, Eiman Elwakeel, Maha El Demellawy · 2015 · Evidence-based Complementary and Alternative Medicine
  78. Validation of a liquid chromatography–tandem mass spectrometric assay for the quantitative determination of hydrastine and berberine in human serum
    Prem K. Gupta, Martha A. Hubbard, Bill J. Gurley, Howard P. Hendrickson · 2009 · Journal of Pharmaceutical and Biomedical Analysis
  79. Berberine reduces Toll-like receptor-mediated macrophage migration by suppression of Src enhancement
    Wei-Erh Cheng, Miao Ying Chang, Jyun-Yan Wei, Yen-Jen Chen, Ming‐Chei Maa, Tzeng‐Horng Leu · 2015 · European Journal of Pharmacology
  80. The Critical Role of mRNA Destabilizing Protein Heterogeneous Nuclear Ribonucleoprotein D in 3′ Untranslated Region–Mediated Decay of Low-Density Lipoprotein Receptor mRNA in Liver Tissue
    Amar Bahadur Singh, Hai Li, Chin Fung Kelvin Kan, Bin Dong, Mark Robert Nicolls, Jingwen Liu · 2013 · Arteriosclerosis Thrombosis and Vascular Biology
  81. Lipid-Regulating Effect of Traditional Chinese Medicine: Mechanisms of Actions
    Weijian Bei, Jiao Guo, Haiyun Wu, Yang Cao · 2012 · Evidence-based Complementary and Alternative Medicine
  82. Moderate alcohol consumption in chronic form enhances the synthesis of cholesterol and C-21 steroid hormones, while treatment with Tinospora cordifolia modulate these events in men
    Suman Kumari, Ashwani Mittal, Rajesh Dabur · 2016 · Steroids
  83. Effects of a Combination of Berberis aristata, Silybum marianum and Monacolin on Lipid Profile in Subjects at Low Cardiovascular Risk; A Double-Blind, Randomized, Placebo-Controlled Trial
    Giuseppe Derosa, Angela D’Angelo, Davide Romano, Pamela Maffioli · 2017 · International Journal of Molecular Sciences
  84. Determination of berberine-upregulated endogenous short-chain fatty acids through derivatization by 2-bromoacetophenone
    Shurong Ma, Qian Tong, Zhenxiong Zhao, Lin Cong, Jinbo Yu, Jie Fu, Pei Han, Li‐Bin Pan, Randy Gu, Ran Peng et al. · 2019 · Analytical and Bioanalytical Chemistry
  85. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials
    2023
  86. Pharmacokinetics and pharmacodynamics of HTD1801 (berberine ursodeoxycholate, BUDCA) in patients with hyperlipidemia
    Adrian M. Di Bisceglie, Gerald Francis Watts, Philip T. Lavin, Meng Yu, Ru Bai, Liping Liu · 2020 · Lipids in Health and Disease
  87. Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?
    Yunyun Quan, Li Li, Zhujun Yin, Shilong Chen, Jing Yi, Jirui Lang, Lu Zhang, Qianhua Yue, Junning Zhao · 2022 · Frontiers in Pharmacology
  88. A comprehensive review of phytoconstituents in liver cancer prevention and treatment: targeting insights into molecular signaling pathways
    Md. Rezaul Islam, Abdur Rauf, Shopnil Alash, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Mahbuba Sharmin Sowa, Dattatreya Mukherjee, Harendra ML Kumar, Md Sadique Hussain, Abdullah S. M. Aljohani et al. · 2024 · Medical Oncology
  89. Deep eutectic solvents in analysis, delivery and chemistry of pharmaceuticals
    Saurabh B. Ganorkar, Pranay M. Hadole, Mangesh R. Patil, Chandrakantsing Vijaysing Pardeshi, Preeti S. Bobade, Atul A. Shirkhedkar, Yvan Vander Heyden · 2025 · International Journal of Pharmaceutics
  90. Berberis aristata/Silybum marianum fixed combination (Berberol®) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: A randomized, placebo-controlled, clinical trial
    Giuseppe Derosa, Davide Romano, Angela D’Angelo, Pamela Maffioli · 2014 · Phytomedicine
  91. SR-BI as a target of natural products and its significance in cancer
    Dongdong Wang, Jiansheng Huang, Ting Gui, Yaxin Yang, Tingting Feng, Nikolay T. Tzvetkov, Tao Xu, Zhibo Gai, Ying Zhou, Jing-Jie Zhang et al. · 2020 · Seminars in Cancer Biology
  92. Berberine and Its Main Metabolite Berberrubine Inhibit Platelet Activation Through Suppressing the Class I PI3Kβ/Rasa3/Rap1 Pathway
    Can Wang, Yangyang Cheng, Yuanhui Zhang, Hongtao Jin, Zeng-Yan Zuo, Aiping Wang, Jianmei Huang, Jian‐Dong Jiang, Weijia Kong · 2021 · Frontiers in Pharmacology
  93. Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer
    Shihai Yan, Li-Mu Hu, Xue-Hui Hao, Jiang Liu, Xiying Tan, Zhirong Geng, Jing Ma, Zhilin Wang · 2022 · iScience
  94. Variability in Potency Among Commercial Preparations of Berberine
    Funk, Ryan S., Singh, Rakesh K., Winefield, Robert D., Kandel, Sylvie E., Ruisinger, Janelle F., Moriarty, Patrick M., Backes, James M. · 2018 · Journal of Dietary Supplements
  95. Effects of dietary berberine on growth performance, lipid metabolism, antioxidant capacity and lipometabolism-related genes expression of AMPK signaling pathway in juvenile black carp (Mylopharyngodon piceus) fed high-fat diets
    Jianhua Ming, Ting Wang, Ting-Hui Wang, Jinyun Ye, Yi-Xiang Zhang, Xia Yang, Xianping Shao, Zhong-Ying Ding · 2022 · Fish Physiology and Biochemistry
  96. Pathways and Molecular Mechanisms Governing LDL Receptor Regulation
    Heidi M. Schmidt, Kelsey E. Jarrett, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling · 2025 · Circulation Research
  97. Role of Nutraceuticals in Hypolipidemic Therapy
    Carlo Maria Barbagallo, Angelo Baldassare Cefalu, Davide Noto, Maurizio Rocco Averna · 2015 · Frontiers in Cardiovascular Medicine
  98. AMPK activation—protean potential for boosting healthspan
    Mark Frederick McCarty · 2013 · AGE
  99. Effect of barberry fruit (Berberis vulgaris) on serum glucose and lipids in streptozotocin-diabetic rats
    Ziba Rajaei, Mousa-Al-Reza Hajzadeh, Somayeh Shafiee, Azam Alavinejhad, Saeed Samarghandian · 2011 · Clinical Biochemistry
  100. Novel therapeutic strategy for cancer and autoimmune conditions: Modulating cell metabolism and redox capacity
    Xing‐Xing Fan, Hudan Pan, Ying Li, Ruijin Guo, Elaine Lai‐Han Leung, Liang Liu · 2018 · Pharmacology & Therapeutics