Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

Kong, Weijia, Wei, Jing, Abidi, Parveen, Lin, Meihong, Inaba, Satoru, Li, Cong, Wang, Yanling, Wang, Zizheng +8 more·2004·Nature Medicine

DOI 10.1038/nm1135

Cited by (1,002)

Items 101–200 of 1,002

Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease
Min Huang, Xin Jiang, Yubin Liang, Qiong Liu, Siyan Chen, Yi Chen Guo · 2017 · Experimental Gerontology
Berberine on metabolic and cardiovascular risk factors: An analysis from preclinical evidences to clinical trials
Derosa, Giuseppe, Maffioli, Pamela, Cicero, Arrigo FG · 2012 · Expert Opinion on Biological Therapy
The Effects of Berberine on Blood Lipids: A Systemic Review and Meta-Analysis of Randomized Controlled Trials
Dong, Hui, Zhao, Yan, Zhao, Li, Lu, Fuer · 2013 · Planta Medica
Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats
Keke Chen, Guohua Li, Fenghao Geng, Zhao Zhang, Jiani Li, Min Hee Yang, Ling Dong, Feng Gao · 2014 · APOPTOSIS
Berberine Ameliorates Intestinal Epithelial Tight-Junction Damage and Down-regulates Myosin Light Chain Kinase Pathways in a Mouse Model of Endotoxinemia
Lili Gu, Ning Li, Jianfeng Gong, Qiurong Li, Weiming Zhu, Jieshou Li · 2011 · The Journal of Infectious Diseases
Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
Hong‐Fang Ji, Liang Shen · 2011 · Molecules
Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte
Bong-Hyuk Choi, In‐Sook Ahn, Yu‐Hee Kim, Ji-Won Park, So Young Lee, Chang‐Kee Hyun, Myoung‐Sool Do · 2006 · Experimental & Molecular Medicine
Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase
Yiqun Wang, Yü Huang, Karen S.L. Lam, Yiming Li, Wing Tak Wong, Hongying Ye, Chi‐Wai Lau, Paul M. Vanhoutte, Aimin Xu · 2009 · Cardiovascular Research
Naringenin Decreases Progression of Atherosclerosis by Improving Dyslipidemia in High-Fat–Fed Low-Density Lipoprotein Receptor–Null Mice
Erin E. Mulvihill, Julia M. Assini, Brian G. Sutherland, Alessandra S. DiMattia, Maryam Khami, Julie B. Koppes, Cynthia G. Sawyez, Stewart C. Whitman, Murray W. Huff · 2010 · Arteriosclerosis Thrombosis and Vascular Biology
Combination of simvastatin with berberine improves the lipid-lowering efficacy
Weijia Kong, Jin Wei, Zeng-Yan Zuo, Yueming Wang, Danqing Song, Xuefu You, Li‐Xun Zhao, Huai-Ning Pan, Jian‐Dong Jiang · 2008 · Metabolism
Berberine and its metabolites: Relationship between physicochemical properties and plasma levels after administration to human subjects
Spinozzi, Silvia, Colliva, Carolina, Camborata, Cecilia, Roberti, Marinella, Ianni, Cristina, Neri, Flavia, Calvarese, Claudio, Lisotti, Andrea, Mazzella, Giuseppe, Roda, Aldo · 2014 · Journal of Natural Products
Nano-cellulose 3D-networks as controlled-release drug carriers
Lin Huang, Xiuli Chen, Thanh Xuan Nguyen, Huiru Tang, Liming Zhang, Guang Yang · 2013 · Journal of Materials Chemistry B
Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine
Ihab M. Almasri, Mohammad K. Mohammad, Mutasem O. Taha · 2009 · Journal of Enzyme Inhibition and Medicinal Chemistry
Major achievements of evidence-based traditional Chinese medicine in treating major diseases
Jung Chao, Yuntao Dai, Robert Verpoorte, Wing Lam, Yung‐Chi Cheng, Li‐Heng Pao, Wei Zhang, Shilin Chen · 2017 · Biochemical Pharmacology
Inhibition of PCSK9 Transcription by Berberine Involves Down-regulation of Hepatic HNF1α Protein Expression through the Ubiquitin-Proteasome Degradation Pathway
Bin Dong, Hai Li, Amar Bahadur Singh, Aiqin Cao, Jingwen Liu · 2014 · Journal of Biological Chemistry
Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells
H Ruan, Yan-yan Zhan, Jingjing Hou, Beibei Xu, B Chen, Y Tian, Di Wu, Yujie Zhao, Y Zhang, Xiao Dong Chen et al. · 2017 · Oncogene
Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats
Xinxia Chang, Hongmei Yan, Fei Jing, Minghong Jiang, Hongguang Zhu, Daru Lu, Xin Gao · 2010 · Journal of Lipid Research
Chronic Effects of Berberine on Blood, Liver Glucolipid Metabolism and Liver PPARs Expression in Diabetic Hyperlipidemic Rats
Ji Yin Zhou, Shi wen Zhou, Ke Bin Zhang, Jian Tang, Li Xia Guang, Yi Ying, Ying Xin Xu, Le Zhang, Dan Dan Li · 2008 · Biological and Pharmaceutical Bulletin
Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota are Attributable to Its Key Ingredient Berberine
Xizhan Xu, Zezheng Gao, Fuquan Yang, Yingying Yang, Liang Chen, Han Lin, Na Zhao, Jiayue Xu, Xinmiao Wang, Yue Ma et al. · 2020 · Genomics Proteomics & Bioinformatics
A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome
Wei, Wei, Zhao, Hongmin, Wang, Aili, Sui, Ming, Liang, Kun, Deng, Haiyun, Ma, Yukun, Zhang, Yajuan, Zhang, Hongxiu, Guan, Yuanyuan · 2012 · European Journal of Endocrinology
Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles
Mei Xue, Ming-xing Yang, Wei Zhang, Xiu-Min Li, Dehong Gao, Zhimin Ou, Zhipeng Li, Xuejun Li, Su-huan Liu, Shuyu Yang · 2013 · International Journal of Nanomedicine
Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities
Puiyan Lam, Fan Cheung, Hor Tan, Ning Wang, Man‐Fung Yuen, Yibin Feng · 2016 · International Journal of Molecular Sciences
Curcumin induces changes in expression of genes involved in cholesterol homeostasis
Dieter Peschel, Ramona Koerting, Norbert Naß · 2006 · The Journal of Nutritional Biochemistry
Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21
Yixuan Sun, Mingfeng Xia, Hongmei Yan, Yamei Han, Feifei Zhang, Zhimin Hu, Aoyuan Cui, Fengguang Ma, Zhengshuai Liu, Qi Gong et al. · 2017 · British Journal of Pharmacology
Berberine alleviates cardiac ischemia/reperfusion injury by inhibiting excessive autophagy in cardiomyocytes
Zhouqing Huang, Zhihua Han, Bozhi Ye, Zhenyu Dai, Peiren Shan, Zhongqiu Lu, Kezhi Dai, Changqian Wang, Weijian Huang · 2015 · European Journal of Pharmacology
Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid
Chandraiah Godugu, Apurva R. Patel, Ravi Doddapaneni, Jaganmohan Somagoni, Mandip S. Singh · 2014 · PLoS ONE
Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-κB and Akt pathways
Jin-Ping Hu, Kazuhisa Nishishita, Eiko Sakai, Hajime Yoshida, Yuzo Kato, Takayuki Tsukuba, Kuniaki Okamoto · 2007 · European Journal of Pharmacology
Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome
Xingxing Li, Chunyan Su, Zhibo Jiang, Yuxin Yang, Yue Zhang, Mengxia Yang, Xiumin Zhang, Yu Du, Jin Zhang, Li Wang et al. · 2021 · npj Biofilms and Microbiomes
Berberine attenuates oxidative stress and hepatocytes apoptosis via protecting mitochondria in blunt snout bream Megalobrama amblycephala fed high-fat diets
Kangle Lu, Lina Wang, Dingdong Zhang, Wenbin Liu, Weina Xu · 2016 · Fish Physiology and Biochemistry
Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance
Ying Chen, Yuling Chen, Yubin Liang, Hong-Da Chen, Xiaoying Ji, Min Huang · 2019 · Biomedicine & Pharmacotherapy
Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2
Qilong Wang, Miao Zhang, Bin Liang, Najeeb A. Shirwany, Yi Zhu, Ming‐Hui Zou · 2011 · PLoS ONE
Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-κB signaling pathway
Qin Li Jiang, Peiqing Liu, Xiaoqian Wu, Weihua Liu, Xiaoyan Shen, Tian Lan, Suowen Xu, Jing Peng, Xi Sheng Xie, Heqing Huang · 2010 · Molecular and Cellular Endocrinology
The effect of Berberine on weight loss in order to prevent obesity: A systematic review
Ilyas, Zahra, Perna, Simone, Al-thawadi, Salwa, Alalwan, Tariq A., Riva, Antonella, Petrangolini, Giovanna, Gasparri, Clara, Infantino, Vittoria, Peroni, Gabriella, Rondanelli, Mariangela · 2020 · Biomedicine & Pharmacotherapy
Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction
Mohammad Adil, Amit Dattatraya Kandhare, Gautami Dalvi, Pinaki Ghosh, Shiva Kumar Venkata, Kiran S. Raygude, Subhash L. Bodhankar · 2016 · Renal Failure
Herbal medicines and nonalcoholic fatty liver disease
Hong Yao, Yu-Jie Qiao, Zhao Ya-li, Xufeng Tao, Lina Xu, Lianhong Yin, Yan Qi, Jinyong Peng · 2016 · World Journal of Gastroenterology
Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation
Zhifang Xu, Wei Feng, Qian Shen, Nan‐Nan Yu, Kun Yu, Shenjun Wang, Zhigang Chen, Seiji Shioda, Yi Guo · 2017 · Aging and Disease
Effects of berberine on growth, liver histology, and expression of lipid-related genes in blunt snout bream (Megalobrama amblycephala) fed high-fat diets
Wenhao Zhou, Samad Rahimnejad, Kangle Lu, Lina Wang, Wenbin Liu · 2018 · Fish Physiology and Biochemistry
Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage
Zhaojian Liu, Qiao Liu, Bing Xu, Jingjing Wu, Chun Hua Guo, Faliang Zhu, Qiaozi Yang, Guimin Gao, Yaoqin Gong, Changshun Shao · 2009 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways
Kai He, Yinran Hu, Hang Ma, Zongyao Zou, Yubo Xiao, Yong Yang, Min Feng, Xuegang Li, Xiaoli Ye · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway
Dan Liu, Yiyi Zhang, Yunhui Liu, Li-qiong Hou, Sheyu Li, Haoming Tian, Tie-yun Zhao · 2018 · Experimental and Clinical Endocrinology & Diabetes
Berberine Activates GLUT1-Mediated Glucose Uptake in 3T3-L1 Adipocytes
So Hui Kim, Eun-Jung Shin, Eun-Do Kim, Tsenguun Bayaraa, Susan Cooke Frost, Chang‐Kee Hyun · 2007 · Biological and Pharmaceutical Bulletin
Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans
Lingyan Wu, Mingfeng Xia, Yanan Duan, Lina Zhang, Haowen Jiang, Xiaobei Hu, Hongmei Yan, Yiqiu Zhang, Yushen Gu, Hongcheng Shi et al. · 2019 · Cell Death and Disease
Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper
Poli, Andrea, Barbagallo, Carlo M., Cicero, Arrigo F.G., Corsini, Alberto, Manzato, Enzo, Trimarco, Bruno, Bernini, Franco, Visioli, Francesco, Bianchi, Alfio, Canzone, Giuseppe et al. · 2018 · Pharmacological Research
Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study
Flora Affuso, Antonio Ruvolo, Filomena Micillo, Luigi Saccà, Sergio Fazio · 2009 · Nutrition Metabolism and Cardiovascular Diseases
Network-based drug discovery by integrating systems biology and computational technologies
Elaine Lai‐Han Leung, Zhiwei Cao, Zhi‐Hong Jiang, Hua Zhou, Lei Liu · 2012 · Briefings in Bioinformatics
ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria
Xing‐Xing Fan, Mengze Xu, Elaine Lai‐Han Leung, Cai Jun, Zhen Yuan, Liang Liu · 2020 · Nano-Micro Letters
Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase
Hyun Ah Jung, Na Young Yoon, Hyun Ju Bae, Byung-Sun Min, Jae Sue Choi · 2008 · Archives of Pharmacal Research
Gut Microbiota-Mediated Personalized Treatment of Hyperlipidemia Using Berberine
Wang, Yan, Tong, Qian, Shou, Jia-Wen, Zhao, Zhen-Xiong, Li, Xiao-Yang, Zhang, Xian-Feng, Ma, Shu-Rong, He, Chi-Yu, Lin, Yuan, Wen, Bao-Ying et al. · 2017 · Theranostics
Regulation of PCSK9 by nutraceuticals
Momtazi, Amir Abbas, Banach, Maciej, Pirro, Matteo, Katsiki, Niki, Sahebkar, Amirhossein · 2017 · Pharmacological Research
A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes
Stephen A. Harrison, Nadege Gunn, Guy W. Neff, Anita Kohli, Liping Liu, Abbey Flyer, Lawrence Goldkind, Adrian M. Di Bisceglie · 2021 · Nature Communications
PEG–lipid–PLGA hybrid nanoparticles loaded with berberine–phospholipid complex to facilitate the oral delivery efficiency
Fei Yu, Mingtao Ao, Xiao Zheng, Nini Li, Junjie Xia, Li Yang, Donghui Li, Zhenqing Hou, Zhongquan Qi, Xiao Dong Chen · 2017 · Drug Delivery
Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids
Shi‐Jun Yue, Juan Liu, Ai-Ting Wang, Xintong Meng, Zhi-Rui Yang, Cheng Yun Peng, Huashi Guan, Chang‐Yun Wang, Dan Yan · 2018 · American Journal of Physiology-Endocrinology and Metabolism
Berberine Promotes Osteoblast Differentiation by Runx2 Activation With p38 MAPK
Hyun Woo Lee, Jung Hee Suh, Hyun-Nam Kim, Ayoung Kim, So Yun Park, Chan Soo Shin, Je‐Yong Choi, Jae Bum Kim · 2008 · Journal of Bone and Mineral Research
Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats
Xinchi Feng, Kun Wang, Shijie Cao, Liqin Ding, Feng Qiu · 2021 · Frontiers in Pharmacology
Effects of Berberine on the Gastrointestinal Microbiota
Lichao Zhang, Xiaoying Wu, Ruibing Yang, Fang Chen, Yao Liao, Zifeng Zhu, Zhongdao Wu, Xi Hong Sun, Lifu Wang · 2021 · Frontiers in Cellular and Infection Microbiology
Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles
Xinlu Yuan, Jie Wang, Xiaoyan Tang, Yixue Li, Pu Xia, Xin Gao · 2015 · Journal of Translational Medicine
Natural products drug discovery: accelerating the clinical candidate development using reverse pharmacology approaches.
Bhushan Patwardhan, Ashok D. B. Vaidya · 2010 · PubMed
Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
Ju, Jianqing, Li, Jingen, Lin, Qian, Xu, Hao · 2018 · Phytomedicine
Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20
Magdalena Winiarska, Jacek Bil, Ewa Wilczek, Grzegorz Marek Wilczynski, Małgorzata Lekka, Patrick J. Engelberts, Wendy J.M. Mackus, Elżbieta Górska, Łukasz Bojarski, Tomasz Stokłosa et al. · 2008 · PLoS Medicine
Curcumin enhances cell‐surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells
Mi‐Hsueh Tai, Po‐Kong Chen, Pei‐Yi Chen, Ming‐Jiuan Wu, Chi‐Tang Ho, Jui‐Hung Yen · 2014 · Molecular Nutrition & Food Research
Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism
Qian Zhang, Xinhua Xiao, Kai Feng, Tong Wang, Wenhui Li, Tao Yuan, Xiaofang Sun, Qi Sun, Hongding Xiang, Heng Wang · 2010 · Evidence-based Complementary and Alternative Medicine
Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation
In‐Ah Lee, Yang-Jin Hyun, Dong-Hyun Kim · 2010 · European Journal of Pharmacology
Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor
Lihong Wang, Liping Liu, Yan Shi, Hanwei Cao, Rupesh Chaturvedi, M. Wade Calcutt, Tianhui Hu, Xiubao Ren, Keith T. Wilson, D. Brent Polk et al. · 2012 · PLoS ONE
Metformin and berberine, two versatile drugs in treatment of common metabolic diseases
Haoran Wang, Chen Zhu, Ying Ying, Lingyu Luo, Deqiang Huang, Zhijun Luo · 2017 · Oncotarget
Rutin Inhibits Oleic Acid Induced Lipid Accumulation via Reducing Lipogenesis and Oxidative Stress in Hepatocarcinoma Cells
Cheng‐Hsun Wu, Ming‐Cheng Lin, Hsueh‐Chun Wang, Mon‐Yuan Yang, Ming‐Jia Jou, Chau‐Jong Wang · 2011 · Journal of Food Science
Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling
Yan Zhou, Shiqing Liu, Ling Yu, Bin He, Shi-Hao Wu, Qi Zhao, Sijia Xia, Hongjun Mei · 2015 · APOPTOSIS
Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs
Wuwen Feng, Juan Liu, Hui Ao, Shi‐Jun Yue, Cheng Yun Peng · 2020 · Theranostics
Isolation and Identification of Urinary Metabolites of Berberine in Rats and Humans
Feng Qiu, Zhiyong Zhu, Ning Kang, Shu‐Juan Piao, Gengyao Qin, Xin‐Sheng Yao · 2008 · Drug Metabolism and Disposition
Regulation of Th1 and Th17 Cell Differentiation and Amelioration of Experimental Autoimmune Encephalomyelitis by Natural Product Compound Berberine
Xia Qin, Bing-shi Guo, Bing Wan, Lei Fang, Limin Lü, Lili Wu, Ying Qin Zang, Jingwu Z. Zhang · 2010 · The Journal of Immunology
Natural Deep Eutectic Solvents (NADES) to Enhance Berberine Absorption: An In Vivo Pharmacokinetic Study
Sut, Stefania, Faggian, Marta, Baldan, Valeria, Poloniato, Gabriele, Castagliuolo, Ignazio, Grabnar, Iztok, Perissutti, Beatrice, Brun, Paola, Maggi, Filippo, Voinovich, Dario et al. · 2017 · Molecules
Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms
Wei‐Jian Ni, Hai‐Hua Ding, Liqin Tang · 2015 · European Journal of Pharmacology
Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model
Wenxiao Jiang, Wenjie Wei, Marta A. Gaertig, Shihua Li, Xiao-Jiang Li · 2015 · PLoS ONE
Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity
Qingxuan Zeng, Hongbin Deng, Yinghong Li, Tianyun Fan, Yang Liu, Sheng Tang, Wei Wei, Xiaojia Liu, Xixi Guo, Jian‐Dong Jiang et al. · 2020 · Journal of Medicinal Chemistry
Berberine ameliorate inflammation and apoptosis via modulating PI3K/AKT/NFκB and MAPK pathway on dry eye
Yi Han, Shujia Guo, Yunpeng Li, Jiani Li, Linfangzi Zhu, Jiani Li, Yufei Lv, Yu Dong, Lan Zheng, Caihong Huang et al. · 2023 · Phytomedicine
Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy
Minghui Li, Yao‐Jun Zhang, Yihui Yu, Shaohua Yang, Javaid Iqbal, Qiong‐Yu Mi, Bing Li, Zhimei Wang, Wenxing Mao, Hong‐Guang Xie et al. · 2014 · European Journal of Pharmacology
Learning from berberine: Treating chronic diseases through multiple targets
Jing Yao, Weijia Kong, Jian‐Dong Jiang · 2013 · Science China Life Sciences
Berberine: Alkaloid with wide spectrum of pharmacological activities
Amritpal Singh, Sanjiv Duggal, Navpreet Kaur, Jaswinder Singh · 2010
Biological screening of natural products and drug innovation in China
Ming‐Wei Wang, Xiao‐Jiang Hao, Kaixian Chen · 2007 · Philosophical Transactions of the Royal Society B Biological Sciences
Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art
Beniamino Pagliaro, Caterina Santolamazza, Francesca Simonelli, Speranza Donatella Rubattu · 2015 · BioMed Research International
A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome.
Jamshid Tabeshpour, Mohsen Imenshahidi, Hossein Hosseinzadeh · 2017 · Europe PMC (PubMed Central)
Binding of alkaloids berberine, palmatine and coralyne to lysozyme: a combined structural and thermodynamic study
Chandrima Jash, Gopinatha Suresh Kumar · 2014 · RSC Advances
Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases
Tarun Belwal, Aarti Bisht, Hari Prasad Devkota, Hammad Ullah, Haroon Zaman Khan, Aseesh Pandey, Indra Dutt BHATT, Javier Echeverría · 2020 · Frontiers in Pharmacology
Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion
Pérez-Rubio, Karina G., González-Ortiz, Manuel, Martínez-Abundis, Esperanza, Robles-Cervantes, José A., Espinel-Bermúdez, María C. · 2013 · Metabolic Syndrome and Related Disorders
Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride
Jia-Xiao Zhu, Dan Tang, Liang Feng, Zhaoguang Zheng, Ru-Shang Wang, Anguo Wu, Tingting Duan, Bao He, Zhu Quan · 2012 · Drug Development and Industrial Pharmacy
Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption
Yanwen Wang, Xin Yi, Khadija Ghanam, Shuocheng Zhang, Tian-Tian Zhao, Xuemei Zhu · 2014 · Metabolism
ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway
Shungo Adachi, Masae Homoto, Rikou Tanaka, Yusaku Hioki, Hiroshi Murakami, Hiroaki Suga, Masaki Matsumoto, Keiichi I. Nakayama, Tomohisa Hatta, Shun-ichiro Iemura et al. · 2014 · Nucleic Acids Research
Anti-Hyperlipidemic Effects and Potential Mechanisms of Action of the Caffeoylquinic Acid-Rich Pandanus tectorius Fruit Extract in Hamsters Fed a High Fat-Diet
Xiaopo Zhang, Chongming Wu, Haifeng Wu, Linghui Sheng, Yan Su, Xue Zhang, Hong Luan, Guibo Sun, Xiaobo Sun, Yu Tian et al. · 2013 · PLoS ONE
Natural isoquinoline alkaloids: binding aspects to functional proteins, serum albumins, hemoglobin, and lysozyme
Asma Yasmeen Khan, Gopinatha Suresh Kumar · 2015 · Biophysical Reviews
Berberine promotes glucagon-like peptide-1 (7–36) amide secretion in streptozotocin-induced diabetic rats
Shou-Si Lu, Yun-Li Yu, Hao‐Jie Zhu, Xiaodong Liu, Li Liu, Yao-Wu Liu, Ping Wang, Lin Ying Xie, Guang-Ji Wang · 2008 · Journal of Endocrinology
Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway
Xu, Yingxi, Yu, Tianhao, Ma, Guojing, Zheng, Lixia, Jiang, Xuehan, Yang, Fan, Wang, Zhuo, Li, Na, He, Zheng, Song, Xiaoyu et al. · 2021 · International Journal of Biological Sciences
A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect
Tung-Ting Sham, Chi-On Chan, Youhua Wang, Yang Jian-mei, Daniel Kam‐Wah Mok, Shun‐Wan Chan · 2014 · BioMed Research International
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway
Shasha Zheng, Hong Huang, Yizhuo Li, Ye Wang, Yawei Zheng, Junya Liang, Siqi Zhang, Ming Liu, Zhuyuan Fang · 2021 · Pharmacological Research
Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes
Li, Yi, Ren, Gang, Wang, Yan-Xiang, Kong, Wei-Jia, Yang, Peng, Wang, Yue-Ming, Li, Ying-Hong, Yi, Hong, Li, Zhuo-Rong, Song, Dan-Qing et al. · 2011 · Journal of Translational Medicine
Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Ye, Yu, Liu, Xiufen, Wu, Ninghua, Han, Yanqi, Wang, Jiawen, Yu, Yuandong, Chen, Qingjie · 2021 · Frontiers in Pharmacology
Berberine Ameliorates Collagen-Induced Arthritis in Rats Associated with Anti-inflammatory and Anti-angiogenic Effects
Zhigang Wang, Zhe Chen, Sisi Yang, Yu Wang, Zhaoyi Huang, Jianfei Gao, Shenghao Tu, Zhiguo Rao · 2014 · Inflammation
Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus
Wei Zhang, Yan-cheng XU, Fang-jian GUO, Meng Ye, Mingli Li · 2008 · Chinese Medical Journal
Neuroprotection of early and short-time applying berberine in the acute phase of cerebral ischemia: Up-regulated pAkt, pGSK and pCREB, down-regulated NF-κB expression, ameliorated BBB permeability
Xiaolin Zhang, Xiangjian Zhang, Chaohui Wang, Yànhuá Lǐ, Lipeng Dong, Lili Cui, Lina Wang, Zongjie Liu, Huimin Qiao, Chunhua Zhu et al. · 2012 · Brain Research
The pharmacological activity of berberine, a review for liver protection
Mengting Zhou, Ying Deng, Meichen Liu, Li Liao, Xuyang Dai, Chaocheng Guo, Xingtao Zhao, Linfeng He, Cheng Yun Peng, Yunxia Li · 2020 · European Journal of Pharmacology
Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study
Shujie Wang, Huahui Ren, Huanzi Zhong, Xinjie Zhao, Changkun Li, Jing Ma, Xuejiang Gu, Yaoming Xue, Shan Huang, Jialin Yang et al. · 2021 · Gut Microbes
Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans
Fei Cheng, Yan Wang, Jing Li, Chen Su, Fang Wu, Wenhao Xia, Zhen Yang, Bingbo Yu, Yanxia Qiu, Jun Tao · 2012 · International Journal of Cardiology