Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience
Open accessAbstract
Lack of a sensory input not only alters the cortical circuitry subserving the deprived sense, but also produces compensatory changes in the functionality of other sensory modalities. Here we report that visual deprivation produces opposite changes in synaptic function in primary visual and somatosensory cortices in rats, which are rapidly reversed by visual experience. This type of bidirectional cross-modal plasticity is associated with changes in synaptic AMPA receptor subunit composition.
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Visual deprivation-induced scaling-up in mouse visual cortex involves the recruitment of synaptic CP-AMPARs and increased GluA1 S845 phosphorylation.
“Homeostatic scaling-up has also been observed in the visual cortex in mice in response to visual deprivation, and involves the recruitment of synaptic CP-AMPARs and increased GluA1 S845 phosphorylation (Goel et al., 2006, Goel et al., 2011).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Goel et al., 2006
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- Authors
- Goel, A., Jiang, B., Xu, L. W., Song, L., Kirkwood, A., & Lee, H.-K.
- Affiliations
- University of Maryland, College Park (US)
- Johns Hopkins University (US)
- Corresponding author
- Lee, Hey-Kyoung
- Venue
- Nature Neuroscience
- Published
- 2006-07-02
- Volume
- 9
- Issue
- 8
- Pages
- 1001-1003
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC1905492
- OpenAlex
- W2008744372
- Cited by
- 210
- References
- 0
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 11 · 2019: 19 · 2018: 10 · 2017: 14 · 2016: 17 · 2015: 10 · 2014: 14 · 2013: 14 · 2012: 13
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute for Health and Care Research
- National Institutes of Health
- National Eye Institute (R01EY012124, R01EY014882)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- cross-modal plasticity, visual deprivation, AMPA receptor subunit composition, primary visual cortex, primary somatosensory cortex, sensory deprivation, visual experience, synaptic function, cortical circuits
- MeSH terms
- Animals, Synaptic Transmission, Neurons, Sensory Deprivation, Somatosensory Cortex, Synapses, Visual Perception, Receptors, AMPA, Rats, Long-Evans, Protein Subunits, Rats
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