The first neurons of the human cerebral cortex

Bystron, Irina; Rakic, Pasko; Molnár, Zoltán; Blakemore, Colin

doi:10.1038/nn1726

Cited by 183Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationFetal and Pediatric Neurological Disorders

The first neurons of the human cerebral cortex

Bystron, Irina, Rakic, Pasko, Molnár, Zoltán, Blakemore, Colin·2006·Nature Neuroscience

DOI 10.1038/nn1726

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Abstract

We describe a distinctive, widespread population of neurons situated beneath the pial surface of the human embryonic forebrain even before complete closure of the neural tube. These 'predecessor' cells include the first neurons seen in the primordium of the cerebral cortex, before the onset of local neurogenesis. Morphological analysis, combined with the study of centrosome location, regional transcription factors and patterns of mitosis and neurogenesis, indicates that predecessor cells invade the cortical primordium by tangential migration from the subpallium. These neurons, described here for the first time, precede all other known cell types of the developing cortex.

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The developing human CNS has derived features including expanded proliferative zones and diverse neural stem/progenitor cell subtypes with enhanced proliferative capacity that facilitate brain expansion, especially neocortical expansion.
“the developing human CNS possesses certain divergent and highly derived features, such as expanded proliferative zones and diverse subtypes of neural stem and progenitor cells with enhanced proliferative capacities that facilitate brain expansion, especially of the neocortex (Bae et al., 2015; Bystron et al., 2006; Dehay et al., 2015; Gulden and Sestan, 2014; Howard et al., 2008; Lui et al., 2011;”
From The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016) · cites this paper as Bystron et al., 2006

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Authors: Bystron, I., Rakic, P., Molnár, Z., & Blakemore, C.
Affiliations: University of Oxford (GB)
Yale University (US)
Corresponding author: Bystron, Irina
ORCID: Rakic, Pasko
Molnár, Zoltán
Blakemore, Colin
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2006-06-18
Volume: 9
Issue: 7
Pages: 880-886
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1726
OpenAlex: W1969413827
Cited by: 183
References: 44
Citations by year: 2026: 4 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 8 · 2020: 5 · 2019: 11 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 9
FWCI: 3.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Yale University
Russian Foundation for Basic Research
Medical Research Council
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords: cortical development, tangential migration, subpallium, transcription factors, mitosis, neurogenesis, neural tube closure
MeSH terms: Cell Differentiation, Cell Movement, Cerebral Cortex, Fetus, Humans, Immunohistochemistry, Nerve Tissue Proteins, Neurons, Stem Cells, Transcription Factors, Gene Expression, Body Patterning

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