A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory
Open accessAbstract
The intense associative memories that develop between cocaine-paired contexts and rewarding stimuli contribute to cocaine seeking and relapse. Previous studies have shown impairment in cocaine reward memories by manipulating a labile state induced by memory retrieval, but the mechanisms that underlie the destabilization of cocaine reward memory are unknown. In this study, using a Pavlovian cocaine-induced conditioned place preference (CPP) procedure in rats, we tested the contribution of ubiquitin-proteasome system-dependent protein degradation in destabilization of cocaine reward memory. First, we found that polyubiquitinated protein expression levels and polyubiquitinated N-ethylmaleimide-sensitive fusion (NSF) markedly increased 15 min after retrieval while NSF protein levels decreased 1 h after retrieval in the synaptosomal membrane fraction in the nucleus accumbens (NAc) core. We then found that infusion of the proteasome inhibitor lactacystin into the NAc core prevented the impairment of memory reconsolidation induced by the protein synthesis inhibitor anisomycin and reversed the effects of anisomycin on NSF and glutamate receptor 2 (GluR2) protein levels in the synaptosomal membrane fraction in the NAc core. We also found that lactacystin infusion into the NAc core but not into the shell immediately after extinction training sessions inhibited CPP extinction and reversed the extinction training-induced decrease in NSF and GluR2 in the synaptosomal membrane fraction in the NAc core. Finally, infusions of lactacystin by itself into the NAc core immediately after each training session or before the CPP retrieval test had no effect on the consolidation and retrieval of cocaine reward memory. These findings suggest that ubiquitin-proteasome system-dependent protein degradation is critical for retrieval-induced memory destabilization.
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Memory destabilisation depends upon the ubiquitin- and proteasome-dependent degradation of pre-existing postsynaptic proteins, as shown for fear, spatial, object recognition, and drug memories.
“Memory destabilisation depends upon the ubiquitin- and proteasome-dependent degradation of pre-existing postsynaptic proteins, as shown for fear (Lee et al., 2008; Fukushima et al., 2014; Fustiñana et al., 2014; Jarome et al., 2015; Orsi et al., 2019; Tay et al., 2019), spatial (Artinian et al., 2008), object recognition (Furini et al., 2015; Stiver et al., 2017) and drug memories (Ren et al., 201”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Ren et al., 2013
Extinction appears to depend upon activation of LVGCCs and protein degradation.
“extinction appears to depend upon activation of LVGCCs and protein degradation.”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Ren et al., 2013
Inhibition of protein degradation following brief exposure prevents memory destabilisation.
“while inhibition of protein degradation following brief exposure prevents memory destabilisation (Ren et al., 2013).”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Ren et al., 2013
Inhibiting protein degradation by infusing the proteasome inhibitor lactacystin immediately following extinction training prevents extinction of cocaine reward memory in the conditioned place preference procedure.
“inhibiting protein degradation by infusing the proteasome inhibitor lactacystin immediately following extinction training prevents extinction of cocaine reward memory in the conditioned place preference procedure”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Ren et al., 2013
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- Authors
- Ren, Z.-Y., Liu, M.-M., Xue, Y.-X., Ding, Z.-B., Xue, L.-F., Zhai, S.-D., & Lu, L.
- Affiliations
- Peking University (CN)
- Peking University Third Hospital (CN)
- Venue
- Neuropsychopharmacology
- Published
- 2012-11-29
- Volume
- 38
- Issue
- 5
- Pages
- 778-790
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3672001
- OpenAlex
- W2101667399
- Cited by
- 73
- References
- 77
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 14 · 2014: 11 · 2013: 4
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31070958, 31230033)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- nucleus accumbens core, ubiquitin-proteasome system, protein degradation, memory reconsolidation, memory retrieval, conditioned place preference, NSF, GluR2, lactacystin, anisomycin, memory extinction, cocaine seeking
- MeSH terms
- Analysis of Variance, Animals, Cocaine, Conditioning, Operant, Enzyme Inhibitors, Extinction, Psychological, Male, Memory, Nucleus Accumbens, Reward, Time Factors, Rats, Sprague-Dawley, Receptors, AMPA, Dopamine Uptake Inhibitors, Ubiquitin, Polyubiquitin, Rats, Proteolysis
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