Cited by 128Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

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Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the V1A Receptor

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Ramos, Linnet, Hicks, Callum, Kevin, Richard, Caminer, Alex, Narlawar, Rajeshwar, Kassiou, Michael, McGregor, Iain S·2013·Neuropsychopharmacology

DOI 10.1038/npp.2013.125PMC PMC3773675

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Abstract

The neuropeptides oxytocin (OT) and vasopressin (AVP) are recognized for their modulation of social processes in humans when delivered peripherally. However, there is surprisingly little evidence for acute social effects of peripherally administered OT or AVP in animal models. On the other hand, the party drug 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') has powerful prosocial effects in rats that appear to occur through stimulation of central OT release. Here, we directly compared the social effects of peripherally administered OT and AVP with those of MDMA, and examined a possible role for the vasopressin 1A receptor (V1AR) in the observed prosocial effects. Adult male Long-Evans rats were tested in a social interaction paradigm after OT (0.1, 0.25, 0.5, and 1 mg/kg, intraperitoneal (IP)), AVP (0.001, 0.0025, 0.005, 0.01, and 0.1 mg/kg, IP), and MDMA (2.5, 5 mg/kg, IP), or combined low doses of OT and MDMA, or AVP and MDMA. The effects of pretreatment with the non-peptide OT receptor antagonist compound 25 (C25; 5 mg/kg, IP) and the V1AR antagonist SR49059 (1 mg/kg, IP) were also examined. OT (0.5 mg/kg), AVP (0.01 mg/kg), and MDMA (5 mg/kg) potently increased 'adjacent lying', where rats meeting for the first time lie passively next to each other. C25 did not inhibit adjacent lying induced by OT, whereas SR49059 inhibited adjacent lying induced by MDMA (5 mg/kg), OT (0.5 mg/kg), and AVP (0.01 mg/kg). Interestingly, when ineffective doses of OT and MDMA, or AVP and MDMA, were combined, a robust increase in adjacent lying was observed. These results show for the first time acute prosocial effects of peripherally injected OT and AVP in laboratory rats, and suggest a commonality of action of OT, AVP, and MDMA in stimulating social behavior that involves V1ARs.

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Authors: Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S.
Affiliations: The University of Sydney (AU)
Corresponding author: McGregor, Iain S
ORCID: Ramos, Linnet
Hicks, Callum
Kevin, Richard
Narlawar, Rajeshwar
Kassiou, Michael
McGregor, Iain S
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2013-05-16
Volume: 38
Issue: 11
Pages: 2249-2259
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2013.125
PMC: PMC3773675
OpenAlex: W2033282483
Cited by: 128
References: 76
Citations by year: 2026: 6 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 12 · 2018: 9 · 2017: 14 · 2016: 17 · 2015: 19 · 2014: 17
FWCI: 26.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Australian Research Council
National Health and Medical Research Council (1011518, 1033444)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: oxytocin, vasopressin, MDMA, ecstasy, prosocial behavior, vasopressin V1a receptor, social interaction, neuropeptides, drug combination effects
MeSH terms: Animals, Dose-Response Relationship, Drug, Drug Synergism, Hallucinogens, Hormone Antagonists, Indoles, Male, Oxytocin, Pyrrolidines, Social Behavior, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin, N-Methyl-3,4-methylenedioxyamphetamine, Rats, Antidiuretic Hormone Receptor Antagonists

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Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the V1A Receptor

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