The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Oxytocin and vasopressin modulate the social response to threat: a preclinical study
Open accessAbstract
Individuals in many species increase their proximity to others in threatening situations (defensive aggregation), increasing their chance of survival and reducing the adverse psychological impact of stressors. However, the basic neurobiology of defensive aggregation is not well understood. Here we examined the role of the social neuropeptides oxytocin (OT) and vasopressin (AVP) in this response. Groups of rats were exposed to a ball of cat fur (an innate threat stimulus) in a large arena, causing prolonged periods of tight social grouping (huddling). The modulatory effects of OT and AVP on huddling were examined both alone and in conjunction with relevant antagonists. To determine specificity of treatment effects to social grouping, the effects of the same treatments were also assessed in individual rats exposed to cat fur and given the opportunity to hide. OT (0.5 mg/kg, i.p.) and AVP (0.01 mg/kg, i.p.) increased huddling in rats socially exposed to cat fur, whereas the selective V1A AVP receptor antagonist SR49059 (3 mg/kg, i.p.) decreased huddling. The effects of OT were prevented by pre-treatment with SR49059 (3 mg/kg), while those of AVP were prevented by the V1B receptor antagonist SSR149415 (30 mg/kg, i.p.). OT had no effect on huddling when groups of four rats were tested with no cat fur present whereas AVP increased huddling under these conditions. Neither OT, nor SR49059, affected hiding in individual rats exposed to cat fur. However, AVP increased hiding, an effect prevented by SSR149415 (30 mg/kg, i.p.). These results suggest that OT acts on V1A receptors to promote a social response to threat without altering the more general defensive response. Conversely, AVP appears to increase generalised anxiety via V1B receptors, which subsequently results in huddling. A hitherto unrecognised function of oxytocin is therefore to promote social affiliation during threatening situations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Peripheral administration of either OT or AVP increases social huddling in response to threatening stimuli (cat fur), and these effects are inhibited by a selective V1aR antagonist.
“Peripheral administration of either OT or AVP also increases social huddling in response to threatening stimuli (i.e., cat fur) and these effects are inhibited by a selective V1aR antagonist [45].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [45]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hamilton, W. D. (1971) · Journal of Theoretical Biology · doi:10.1016/0022-5193(71)90189-5 · Cited by 3,506
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · cited 1×
“(Young and Wang, 2004), maternal care (Blanchard et al.”
Brain oxytocin: A key regulator of emotional and social behaviours in both females and males
Neumann, I. D. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01726.x · Cited by 743
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689
Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300360 · Cited by 531
Young, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R., & Insel, T. R. (1999) · Nature · doi:10.1038/23475 · Cited by 488
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403
Sala, M., Braida, D., Lentini, D., Busnelli, M., Bulgheroni, E., Capurro, V., Finardi, A., Donzelli, A., Pattini, L., Rubino, T., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.022 · Cited by 375
Pedersen, C. A., Gibson, C. M., Rau, S. W., Salimi, K., Smedley, K. L., Casey, R. L., Leserman, J., Jarskog, L. F., & Penn, D. L. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.07.027 · Cited by 305
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162
Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.125 · Cited by 128
Self-citationAgonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges
Chini, B., & Manning, M. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350737 · Cited by 123
Characterization of the V1a antagonist, JNJ-17308616, in rodent models of anxiety-like behavior
Bleickardt, C. J., Mullins, D. E., MacSweeney, C. P., Werner, B. J., Pond, A. J., Guzzi, M. F., Martin, F. D. C., Varty, G. B., & Hodgson, R. A. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1354-x · Cited by 71
Flagged first, then by citations
Research works printed but not linked: 47
- 10.1016/S0149-7634(01)00044-6 · DOI
- 10.1016/j.schres.2005.05.006 · DOI · Paper page
- 10.1038/285400a0 · DOI
- 10.1016/j.psyneuen.2013.03.003 · DOI · Paper page
- 10.1007/s00213-011-2482-2 · DOI
- 10.1016/j.tins.2012.08.004 · DOI · Paper page
- 10.1371/journal.pone.0068483 · DOI
- 10.1016/j.beproc.2012.03.014 · DOI
- 10.1371/journal.pone.0027237 · DOI · Paper page
- 10.1111/j.1467-6494.1966.tb02366.x · DOI
- 10.1016/j.yhbeh.2011.11.002 · DOI · Paper page
- 10.1038/nn.3083 · DOI
- 10.1016/j.physbeh.2012.03.007 · DOI
- 2000, Psychobiology, 28, 339, 10.3758/BF03331992 · DOI
- 2011, Intracerebral Hemorrhage Research, 191
- 10.1177/0269881111416687 · DOI
- 10.1016/j.pbb.2004.10.024 · DOI
- 10.1038/sj.npp.1300360 · DOI · Paper page
- 10.1016/j.yhbeh.2011.08.003 · DOI
- 10.1093/schbul/7.1.58 · DOI
- 10.1098/rstb.2006.1941 · DOI
- 10.1016/j.biopsych.2012.08.025 · DOI · Paper page
- 10.1016/j.bbr.2011.07.058 · DOI
- 10.1016/j.neubiorev.2005.05.005 · DOI
- 10.1016/j.yhbeh.2011.01.012 · DOI
- 1992, Pharmacol Biochem Behav, 43, 855
- 10.1002/dev.20190 · DOI · Paper page
- 10.1016/0006-8993(93)90795-O · DOI
- 10.1111/j.1601-183X.2006.00281.x · DOI
- 10.1016/j.vph.2005.01.002 · DOI
- 10.1016/0006-8993(88)91437-0 · DOI · Paper page
- 10.1016/S0006-3223(03)00465-7 · DOI · Paper page
- 1994, J Biol Chem, 269, 3304, 10.1016/S0021-9258(17)41863-1 · DOI
- 2008, J Physiol, 586, 377, 10.1113/jphysiol.2007.145896 · DOI
- 10.1037/0022-3514.72.2.305 · DOI
- 2010, Am J Play, 2, 297
- 10.2174/1381612053764797 · DOI
- 10.1016/j.neubiorev.2008.05.004 · DOI
- 10.1073/pnas.092012099 · DOI · Paper page
- 10.1172/JCI116554 · DOI
- 10.1126/science.1174929 · DOI · Paper page
- 10.1176/appi.ajp.2007.06091515 · DOI
- 10.1038/293466a0 · DOI
- 10.1016/j.anbehav.2007.04.022 · DOI
- 10.1016/j.schres.2012.05.018 · DOI
- 10.1016/j.bbr.2004.01.015 · DOI
- 10.1016/S0006-8993(01)02227-2 · DOI
Cited by
Sorted by citations
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244
Oxytocin: Parallel Processing in the Social Brain?
Dölen, G. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12284 · Cited by 65
Clark-Elford, R., Nathan, P. J., Auyeung, B., Mogg, K., Bradley, B. P., Sule, A., Müller, U., Dudas, R. B., Sahakian, B. J., & Baron-Cohen, S. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu012 · Cited by 41
Ramos, L., Hicks, C., Caminer, A., Couto, K., Narlawar, R., Kassiou, M., & McGregor, I. S. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.10.002 · Cited by 25
Self-citationHicks, C., Ramos, L., Dampney, B., Baracz, S. J., McGregor, I. S., & Hunt, G. E. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.10.005 · Cited by 22
Self-citation
Metadata
- Authors
- Bowen, M. T., & McGregor, I. S.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- McGregor, Iain S.
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-05-07
- Volume
- 17
- Issue
- 10
- Pages
- 1621-1633
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2112215578
- Cited by
- 63
- References
- 16
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 5
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Australian Research Council (DP0988609)
- National Health and Medical Research Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, vasopressin, huddling, threat response, social affiliation, V1a receptor, V1b receptor, anxiety, rats
- MeSH terms
- Aggression, Analysis of Variance, Animals, Cats, Disease Models, Animal, Drug Interactions, Hormone Antagonists, Indoles, Male, Odorants, Oxytocin, Pyrrolidines, Stress, Psychological, Vasopressins, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
