Cited by 128Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

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Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the V1A Receptor

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Ramos, Linnet, Hicks, Callum, Kevin, Richard, Caminer, Alex, Narlawar, Rajeshwar, Kassiou, Michael, McGregor, Iain S·2013·Neuropsychopharmacology

DOI 10.1038/npp.2013.125PMC PMC3773675

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Abstract

The neuropeptides oxytocin (OT) and vasopressin (AVP) are recognized for their modulation of social processes in humans when delivered peripherally. However, there is surprisingly little evidence for acute social effects of peripherally administered OT or AVP in animal models. On the other hand, the party drug 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') has powerful prosocial effects in rats that appear to occur through stimulation of central OT release. Here, we directly compared the social effects of peripherally administered OT and AVP with those of MDMA, and examined a possible role for the vasopressin 1A receptor (V1AR) in the observed prosocial effects. Adult male Long-Evans rats were tested in a social interaction paradigm after OT (0.1, 0.25, 0.5, and 1 mg/kg, intraperitoneal (IP)), AVP (0.001, 0.0025, 0.005, 0.01, and 0.1 mg/kg, IP), and MDMA (2.5, 5 mg/kg, IP), or combined low doses of OT and MDMA, or AVP and MDMA. The effects of pretreatment with the non-peptide OT receptor antagonist compound 25 (C25; 5 mg/kg, IP) and the V1AR antagonist SR49059 (1 mg/kg, IP) were also examined. OT (0.5 mg/kg), AVP (0.01 mg/kg), and MDMA (5 mg/kg) potently increased 'adjacent lying', where rats meeting for the first time lie passively next to each other. C25 did not inhibit adjacent lying induced by OT, whereas SR49059 inhibited adjacent lying induced by MDMA (5 mg/kg), OT (0.5 mg/kg), and AVP (0.01 mg/kg). Interestingly, when ineffective doses of OT and MDMA, or AVP and MDMA, were combined, a robust increase in adjacent lying was observed. These results show for the first time acute prosocial effects of peripherally injected OT and AVP in laboratory rats, and suggest a commonality of action of OT, AVP, and MDMA in stimulating social behavior that involves V1ARs.

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Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 1×
“Intracranial administration of AVP facilitates social memory and recognition in rats (Le Moal et al, 1987), and it helps form partner preference as well as mediates selective aggression in prairie voles (Winslow, 1993).”
Background
The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs
File, S. E. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90012-6 · Cited by 820
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693
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Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300360 · Cited by 531
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423
The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and mice
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403
Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism
Sala, M., Braida, D., Lentini, D., Busnelli, M., Bulgheroni, E., Capurro, V., Finardi, A., Donzelli, A., Pattini, L., Rubino, T., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.022 · Cited by 375
The V1a Vasopressin Receptor Is Necessary and Sufficient for Normal Social Recognition: A Gene Replacement Study
Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.031 · Cited by 367
A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder
Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366
Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications
Ring, R. H., Malberg, J. E., Potestio, L., Ping, J., Boikess, S., Luo, B., Schechter, L. E., Rizzo, S., Rahman, Z., & Rosenzweig-Lipson, S. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0293-z · Cited by 319
Sex-specific influences of vasopressin on human social communication
Thompson, R. R., George, K., Walton, J. C., Orr, S. P., & Benson, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600406103 · Cited by 312
Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents☆
MANNING, M., STOEV, S., CHINI, B., DURROUX, T., MOUILLAC, B., & GUILLON, G. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00437-8 · Cited by 296
Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265
Septal vasopressin modulates social memory in male rats
Dantzer, R., Koob, G. F., Bluthe´, R.-M., & Le Moal, M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90066-2 · Cited by 262
Enhanced social interactions in rats following chronic, centrally infused oxytocin
Witt, D. M., Winslow, J. T., & Insel, T. R. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90418-f · Cited by 244
Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation
Grippo, A. J., Trahanas, D. M., Zimmerman, R. R., Porges, S. W., & Carter, C. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.017 · Cited by 240
Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration
Dumont, G. J. H., Sweep, F. C. G. J., van der Steen, R., Hermsen, R., Donders, A. R. T., Touw, D. J., van Gerven, J. M. A., Buitelaar, J. K., & Verkes, R. J. (2009) · Social Neuroscience · doi:10.1080/17470910802649470 · Cited by 238
A role for oxytocin and 5-HT1A receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine (“ecstasy”)
Thompson, M. R., Callaghan, P. D., Hunt, G. E., Cornish, J. L., & McGregor, I. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.032 · Cited by 237
Self-citation
Microdialysis administration of vasopressin into the septum improves social recognition in Brattleboro rats
Engelmann, M., & Landgraf, R. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90022-1 · Cited by 225
An intrinsic vasopressin system in the olfactory bulb is involved in social recognition
Tobin, V. A., Hashimoto, H., Wacker, D. W., Takayanagi, Y., Langnaese, K., Caquineau, C., Noack, J., Landgraf, R., Onaka, T., Leng, G., et al. (2010) · Nature · doi:10.1038/nature08826 · Cited by 213
Play as a reinforcer for maze-learning in juvenile rats
Humphreys, A. P., & Einon, D. F. (1981) · Animal Behaviour · doi:10.1016/s0003-3472(81)80173-x · Cited by 200
Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats
Slattery, D. A., & Neumann, I. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.038 · Cited by 195
Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice
Egashira, N., Tanoue, A., Matsuda, T., Koushi, E., Harada, S., Takano, Y., Tsujimoto, G., 三島, 健., Iwasaki, K., & Fujiwara, M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.12.009 · Cited by 193
Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse
Schorscher-Petcu, A., Sotocinal, S., Ciura, S., Dupre, A., Ritchie, J., Sorge, R. E., Crawley, J. N., Hu, S.-B., Nishimori, K., Young, L. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1594-10.2010 · Cited by 189
Central administration of oxytocin modulates the infant rats response to social isolation
Insel, T. R., & Winslow, J. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90806-2 · Cited by 185
The effects of vasopressin on human facial responses related to social communication
Thompson, R. R., Gupta, S., Miller, K., Mills, S. D., & Orr, S. P. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00133-6 · Cited by 184
Serotonin Receptors Involved in Vasopressin and Oxytocin Secretion
Jørgensen, H., Riis, M., Knigge, U., Kjær, A., & Warberg, J. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00978.x · Cited by 182
Low-dose MDMA (“ecstasy”) induces vasopressin secretion
Henry, J. A., Fallon, J. K., Kicman, A. T., Hutt, A. J., Cowan, D., & Forsling, M. L. (1998) · The Lancet · doi:10.1016/s0140-6736(05)78744-4 · Cited by 171
Oxytocin, Vasopressin, and the Neuroendocrine Basis of Pair Bond Formation
Insel, T. R., Winslow, J. T., Wang, Z., & Young, L. J. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_28 · Cited by 170
The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats
Dluzen, D. E., Muraoka, S., Engelmann, M., & Landgraf, R. (1998) · Peptides · doi:10.1016/s0196-9781(98)00047-3 · Cited by 169
Long-Term Administration of Intranasal Oxytocin Is a Safe and Promising Therapy for Early Adolescent Boys with Autism Spectrum Disorders
Tachibana, M., Kagitani-Shimono, K., Mohri, I., Yamamoto, T., Sanefuji, W., Nakamura, A., Oishi, M., Kimura, T., Onaka, T., Ozono, K., et al. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0048 · Cited by 151
A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers
Dumont, G. J. H., & Verkes, R. J. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106063271 · Cited by 149
Can aversive properties of (peripherally-injected) vasopressin account for its putative role in memory?
Ettenberg, A., VANDERKOOY, D., Moal, M. L., Koob, G. F., & Bloom, F. E. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90024-4 · Cited by 147
Adolescent oxytocin exposure causes persistent reductions in anxiety and alcohol consumption and enhances sociability in rats
Bowen, M. T., Carson, D. S., Spiro, A., Arnold, J. C., & McGregor, I. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027237 · Cited by 143
Self-citation
Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders
Lukas, M., & Neumann, I. D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.011 · Cited by 141
Effects of vasopressin on active and passive avoidance behavior
Bohus, B. (1972) · Hormones and Behavior · doi:10.1016/0018-506x(72)90031-1 · Cited by 136
Brain potential changes after intranasal vs. intravenous administration of vasopressin: evidence for a direct nose-brain pathway for peptide effects in humans
Pietrowsky, R., Strüben, C., Mölle, M., Fehm, H. L., & Jan Born, A. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00180-8 · Cited by 133
Centrally injected arginine vasopressin (AVP) facilitates social memory in rats
Moal, M. L., Dantzer, R., Michaud, B., & Koob, G. F. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90527-1 · Cited by 131
Vasopressin regulates social recognition in juvenile and adult rats of both sexes, but in sex- and age-specific ways
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.002 · Cited by 129
Strain differences in fear-motivated behavior of rats
Rex, A., Sondern, U., Voigt, J., Franck, S., & Fink, H. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02128-0 · Cited by 125
Increased Anxiety 3 Months after Brief Exposure to MDMA (‘Ecstasy’) in Rats: Association with Altered 5-HT Transporter and Receptor Density
McGregor, I. S., Clemens, K. J., Plasse, G., Li, K. M., Hunt, G. E., Chen, F., & Lawrence, A. J. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300185 · Cited by 122
Self-citation
Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating
Feifel, D., & Reza, T. L. (1999) · Psychopharmacology · doi:10.1007/s002130050811 · Cited by 121
Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia
Feifel, D., MacDonald, K. S., Cobb, P., & Minassian, A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.05.018 · Cited by 117
Vasotocin neurons and septal V1a-like receptors potently modulate songbird flocking and responses to novelty
Kelly, A. M., Kingsbury, M. A., Hoffbuhr, K., Schrock, S. E., Waxman, B., Kabelik, D., Thompson, R. R., & Goodson, J. L. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.01.012 · Cited by 106
Arginine vasopressin and a vasopressin antagonist peptide: Opposite effects on extinction of active avoidance in rats
Koob, G. F., Moal, M. L., Gaffori, O., Manning, M., Sawyer, W. H., Rivier, J., & Bloom, F. E. (1981) · Regulatory Peptides · doi:10.1016/0167-0115(81)90009-4 · Cited by 103
Identification and Characterization of Two Classes of Receptors for Oxytocin and Vasopressin in Porcine Tunica Albuginea, Epididymis, and Vas Deferens
Maggi, M., Malozowski, S., Kassis, S., Guardabasso, V., & Rodbard, D. (1987) · Endocrinology · doi:10.1210/endo-120-3-986 · Cited by 100
Vasopressin administration modulates anxiety-related behavior in rats
Appenrodt, E., Schnabel, R., & Schwarzberg, H. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00119-x · Cited by 91
Sex Differences in the Effects of MDMA (Ecstasy) on Plasma Copeptin in Healthy Subjects
Simmler, L. D., Hysek, C. M., & Liechti, M. E. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1143 · Cited by 91
Peptides of love and fear: vasopressin and oxytocin modulate the integration of information in the amygdala
Dębiec, J. (2005) · BioEssays · doi:10.1002/bies.20301 · Cited by 90
Simultaneous Monitoring of Intracerebral Release and Behavior: Endogenous Vasopressin Improves Social Recognition
Engelmann, M., Ludwig, M., & Landgraf, R. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00598.x · Cited by 76
The nonpeptide oxytocin receptor agonist WAY 267,464: receptor-binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats
Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C. W., Kassiou, M., Hunt, G. E., & McGregor, I. S. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02311.x · Cited by 73
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Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent
Brown, A. D., Brown, T. B., Calabrese, A. A., Ellis, D. J., Puhalo, N., Ralph, M. J., & Watson, L. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.11.097 · Cited by 73
Dimethyl sulfoxide (DMSO) toxicology, pharmacology, and clinical experience
Jacob, S. W., & Wood, D. C. (1967) · The American Journal of Surgery · doi:10.1016/0002-9610(67)90166-3 · Cited by 71
Binding of the Non-Peptide Vasopressin V1a Receptor Antagonist SR-49059 in the Rat Brain: An in vitro and in vivo Autoradiographic Study
Tribollet, E., Raufaste, D., Maffrand, J., & Gal, C. S. (1999) · Neuroendocrinology · doi:10.1159/000054409 · Cited by 66
Social interactions among rats housed in grouped and enriched conditions
Renner, M., & Rosenzweig, M. R. (1986) · Developmental Psychobiology · doi:10.1002/dev.420190403 · Cited by 62
Social deprivation, housing density, and gregariousness in rats.
Latané, B., Cappell, H., & Joy, V. (1970) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0028742 · Cited by 60
MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635
Hunt, G. E., McGregor, I. S., Cornish, J. L., & Callaghan, P. D. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.06.011 · Cited by 54
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Action of MDMA (Ecstasy) and Its Metabolites on Arginine Vasopressin Release
Fallon, J. K., Shah, D., Kicman, A. T., Hutt, A. J., Henry, J. A., Cowan, D., & Forsling, M. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04181.x · Cited by 52
MDMA (‘ecstasy’) exhibits an anxiogenic-like activity in social encounters between male mice
Maldonado, E., & Navarro, J. F. (2001) · Pharmacological Research · doi:10.1006/phrs.2001.0824 · Cited by 51
Neural correlates of MDMA (“Ecstasy”)-induced social interaction in rats
Thompson, M. R., Hunt, G. E., & McGregor, I. S. (2008) · Social Neuroscience · doi:10.1080/17470910802045042 · Cited by 48
Self-citation
Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test
Andó, R. D., Benkő, A., Ferrington, L., Kirilly, E., Kelly, P. A. T., & Bagdy, G. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.12.010 · Cited by 46
Examining the role of oxytocin in the interoceptive effects of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) using a drug discrimination paradigm in the rat
Broadbear, J. H., Tunstall, B. J., & Beringer, K. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00267.x · Cited by 38
Social interaction between drugged and undrugged rats
File, S. E., & Pope, J. H. (1974) · Animal Learning & Behavior · doi:10.3758/bf03199167 · Cited by 30
The effects of vasopressin on positively rewarded responding and on locomotor activity in rats
Andrews, J. S., Newton, B. A., & Sahgal, A. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90004-5 · Cited by 26
Reduced sensitivity to MDMA-induced facilitation of social behaviour in MDMA pre-exposed rats
Thompson, M. R., Callaghan, P. D., Hunt, G. E., & McGregor, I. S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.01.014 · Cited by 25
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Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors
Loyens, E., Vermoesen, K., Schallier, A., Michotte, Y., & Smolders, I. (2012) · Brain Research · doi:10.1016/j.brainres.2011.11.059 · Cited by 25
Verbal memory after three months of intranasal vasopressin in healthy old humans
Perras, B., Droste, C., Jan Born, A., Fehm, H. L., & Pietrowsky, R. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00047-4 · Cited by 21
Aggressive behavior and jamming avoidance response in the weakly electric fish Gymnotus carapo: Effects of 3,4-methylenedioxymethamphetamine (MDMA)
Capurro, A., Reyes-Parada, M. I., Olazábal, D. E., Perrone, R., Silveira, R., & Macadar, O. (1997) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/s0300-9629(97)00132-1 · Cited by 17

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Authors: Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S.
Affiliations: The University of Sydney (AU)
Corresponding author: McGregor, Iain S
ORCID: Ramos, Linnet
Hicks, Callum
Kevin, Richard
Narlawar, Rajeshwar
Kassiou, Michael
McGregor, Iain S
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2013-05-16
Volume: 38
Issue: 11
Pages: 2249-2259
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2013.125
PMC: PMC3773675
OpenAlex: W2033282483
Cited by: 128
References: 76
Citations by year: 2026: 6 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 12 · 2018: 9 · 2017: 14 · 2016: 17 · 2015: 19 · 2014: 17
FWCI: 26.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Australian Research Council
National Health and Medical Research Council (1011518, 1033444)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: oxytocin, vasopressin, MDMA, ecstasy, prosocial behavior, vasopressin V1a receptor, social interaction, neuropeptides, drug combination effects
MeSH terms: Animals, Dose-Response Relationship, Drug, Drug Synergism, Hallucinogens, Hormone Antagonists, Indoles, Male, Oxytocin, Pyrrolidines, Social Behavior, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin, N-Methyl-3,4-methylenedioxyamphetamine, Rats, Antidiuretic Hormone Receptor Antagonists

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Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the V1A Receptor

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