Genome engineering using the CRISPR-Cas9 system

Cited by (1,083)

Items 901–1,000 of 1,083

1. CRISPR/Cas9-mediated noncoding RNA editing in human cancers
   Jie Yang, Xiaodan Meng, Jinchang Pan, Nan Jiang, Chengwei Zhou, Zhenhua Wu, Zhaohui Gong · 2017 · RNA Biology
2. In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway
   Beeke Wienert, Jiyung J. Shin, Elena Zelin, Kathleen Pestal, Jacob E. Corn · 2018 · PLoS Biology
3. Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells
   Aki Stubb, Camilo Guzmán, Elisa Närvä, Jesse Aaron, Teng‐Leong Chew, Markku A. Saari, Mitro Miihkinen, Guillaume Jacquemet, Johanna Ivaska · 2019 · Nature Communications
4. Advanced CRISPR/Cas-based genome editing tools for microbial biofuels production: A review
   Sabarathinam Shanmugam, Huu Hao Ngo, Yi‐Rui Wu · 2019 · Renewable Energy
5. Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions
   Thomas Gonatopoulos-Pournatzis, Rieko Niibori, Eric W. Salter, Robert J. Weatheritt, Brian Tsang, Shaghayegh Farhangmehr, Xinyi Liang, Ulrich Braunschweig, Jonathan F. Roth, Shen Zhang et al. · 2020 · Molecular Cell
6. Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
   Deshka S. Foster, Clement D. Marshall, Gunsagar Singh Gulati, Malini S. Chinta, Alan T. Nguyen, Ankit Salhotra, Ruth Ellen Jones, Austin R. Burcham, Tristan Lerbs, Lu Cui et al. · 2020 · Nature Communications
7. Genome editing and its applications in genetic improvement in aquaculture
   Zituo Yang, Yepin Yu, Yi Xuan Tay, Gen Hua Yue · 2021 · Reviews in Aquaculture
8. Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing
   Katherine C. Goldfarb, Thomas R. Cech · 2017 · Genes & Development
9. Mechanisms of site‐specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits
   Kruse, Thomas, Gnosa, Sebastian Peter, Nasa, Isha, Garvanska, Dimitriya Hristoforova, Hein, Jamin B, Nguyen, Hieu, Samsøe‐Petersen, Jacob, Lopez‐Mendez, Blanca, Hertz, Emil Peter Thrane, Schwarz, Jeanette et al. · 2020 · The EMBO Journal
10. A chemical approach for global protein knockdown from mice to non-human primates
    Sun, Xiuyun, Wang, Jun, Yao, Xia, Zheng, Wen, Mao, Yang, Lan, Tianlong, Wang, Liguo, Sun, Yonghui, Zhang, Xinyi, Zhao, Qiuye et al. · 2019 · Cell Discovery
11. Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains
    Bianca Schrul, Ron R. Kopito · 2016 · Nature Cell Biology
12. Precise and efficient scarless genome editing in stem cells using CORRECT
    Dylan Kwart, Dominik Paquet, Shaun Teo, Marc Tessier‐Lavigne · 2017 · Nature Protocols
13. BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes
    Niek van Wietmarschen, Sarra Merzouk, Nancy Halsema, Diana C.J. Spierings, Victor Guryev, Peter M. Lansdorp · 2018 · Nature Communications
14. CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells
    J. Jackow, Zongyou Guo, Corey S. Hansen, Hasan Erbil Abaci, Y. Doucet, Jung U Shin, Ryota Hayashi, Dominick DeLorenzo, Yudai Kabata, Satoru Shinkuma et al. · 2019 · Proceedings of the National Academy of Sciences
15. PE-Designer and PE-Analyzer: web-based design and analysis tools for CRISPR prime editing
    Gue‐Ho Hwang, You Kyeong Jeong, Omer Habib, Sung-Ah Hong, Kayeong Lim, Jin‐Soo Kim, Sangsu Bae · 2021 · Nucleic Acids Research
16. RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia
    McMillan, Michael, Gomez, Nicolas, Hsieh, Caroline, Bekier, Michael, Li, Xingli, Miguez, Roberto, Tank, Elizabeth M.H., Barmada, Sami J. · 2023 · Molecular Cell
17. Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication
    Jie Wang · 2015 · World Journal of Gastroenterology
18. Efficient, Complete Deletion of Synaptic Proteins using CRISPR
    Salvatore Incontro, Cédric S. Asensio, Robert H. Edwards, Roger A. Nicoll · 2014 · Neuron
19. CRISPR/Cas9-mediated genome engineering of CHO cell factories: application and perspectives
    Lee, Jae Seong, Grav, Lise Marie, Lewis, Nathan E., Faustrup Kildegaard, Helene · 2015 · Biotechnology Journal
20. Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
    Kristine Pettersen, Sonja Benedikte Andersen, Simone Degen, Valentina Tadini, Joël Grosjean, Shinji Hatakeyama, Almaz Nigatu Tesfahun, Siver Andreas Moestue, Jana Kim, Unni Nonstad et al. · 2017 · Scientific Reports
21. An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells
    Yifang Xie, Daqi Wang, Feng Lan, Gang Wei, Ting Ni, Renjie Chai, Dong Liu, Shijun Hu, Ming‐Qing Li, Da‐Jin Li et al. · 2017 · Scientific Reports
22. Material solutions for delivery of CRISPR/Cas-based genome editing tools: Current status and future outlook
    Tao Yu Wan, Dong Niu, Chuanbin Wu, Fu‐Jian Xu, George McDonald Church, Ping Yuan · 2019 · Materials Today
23. The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
    Sam A. Menzies, Norbert Volkmar, Dick J. H. van den Boomen, Richard T. Timms, Anna S. Dickson, James A. Nathan, Paul J. Lehner · 2018 · eLife
24. MORC2 regulates DNA damage response through a PARP1-dependent pathway
    Lin Zhang, Da‐Qiang Li · 2019 · Nucleic Acids Research
25. ZGLP1 is a determinant for the oogenic fate in mice
    So I Nagaoka, Fumio Nakaki, Hidetaka Miyauchi, Yoshiaki Nosaka, Hiroshi Ohta, Yukihiro Yabuta, Kazuki Kurimoto, Katsuhiko Hayashi, Tomonori Nakamura, Takuya Yamamoto et al. · 2020 · Science
26. Reduced thermal tolerance in a coral carrying CRISPR-induced mutations in the gene for a heat-shock transcription factor
    Phillip A. Cleves, Amanda I. Tinoco, Jacob Bradford, Dimitri Perrin, Line Kolind Bay, John R. Pringle · 2020 · Proceedings of the National Academy of Sciences
27. Targeted creation of new mutants with compact plant architecture using CRISPR/Cas9 genome editing by an optimized genetic transformation procedure in cucurbit plants
    Tongxu Xin, Haojie Tian, Yalin Ma, Shenhao Wang, Li Yang, Xutong Li, Mengzhuo Zhang, Chen Chen, Huaisong Wang, Haizhen Li et al. · 2022 · Horticulture Research
28. G-quadruplexes associated with R-loops promote CTCF binding
    Phillip Wulfridge, Qingqing Yan, Nathaniel Rell, J. Kenneth Doherty, Skye Jacobson, Sarah R. Offley, Sandra Deliard, Kelly Feng, Jennifer E. Phillips‐Cremins, Alessandro Gardini et al. · 2023 · Molecular Cell
29. Creating resistance to avian influenza infection through genome editing of the ANP32 gene family
    Alewo Idoko-Akoh, Daniel H. Goldhill, Carol Sheppard, Dagmara Bialy, Jessica L. Quantrill, Ksenia Sukhova, Jonathan C. Brown, Samuel Richardson, Ciara Campbell, Lorna Taylor et al. · 2023 · Nature Communications
30. Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents
    Póti, Ádám, Gyergyák, Hella, Németh, Eszter, Rusz, Orsolya, Tóth, Szilárd, Kovácsházi, Csenger, Chen, Dan, Szikriszt, Bernadett, Spisák, Sándor, Takeda, Shunichi et al. · 2019 · Genome Biology
31. Linc-RoR promotes c-Myc expression through hnRNP I and AUF1
    Jianguo Huang, Ali Zhang, Tsui-Ting Ho, Ziqiang Zhang, Nanjiang Zhou, Xianfeng Ding, Xu Zhang, Min Xu, Yin‐Yuan Mo · 2015 · Nucleic Acids Research
32. Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt
    Dominic Seiferling, Karolina Szczepanowska, Christina Becker, Katharina Senft, Steffen Hermans, Priyanka Maiti, Tim König, Alexandra Kukat, Aleksandra Trifunović · 2016 · EMBO Reports
33. Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation
    Faxiang Li, Daichao Xu, Yingli Wang, Zixuan Zhou, Jianping Liu, Shichen Hu, Yukang Gong, Junying Yuan, Lifeng Pan · 2018 · Autophagy
34. Targeted Deletion of the USTA and UvSLT2 Genes Efficiently in Ustilaginoidea virens With the CRISPR-Cas9 System
    Yafeng Liang, Han Yu, Chenfang Wang, Cong Jiang, Jin‐Rong Xu · 2018 · Frontiers in Plant Science
35. Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy
    Jonathan P. Bernardini, Jason M. Brouwer, Iris K. L. Tan, Jarrod John Sandow, Shuai Huang, Che A. Stafford, Aleksandra Bankovacki, Christopher D. Riffkin, Ahmad Z. Wardak, Peter E. Czabotar et al. · 2018 · The EMBO Journal
36. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
    Alfredo M. Valencia, Clayton K. Collings, Hai Thanh Dao, Roodolph St. Pierre, Yung‐Chih Cheng, Junwei Huang, Zhen-Yu Jim Sun, Hyuk‐Soo Seo, Nazar Mashtalir, Dawn E. Comstock et al. · 2019 · Cell
37. Efficient Cas9 multiplex editing using unspaced sgRNA arrays engineering in a Potato virus X vector
    Mireia Uranga, Verónica Aragonés, Sara Selma, Marta Vázquez‐Vilar, Diego Orzáez, José‐Antonio Daròs · 2021 · The Plant Journal
38. En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
    Kimura, Masaki, Iguchi, Takuma, Iwasawa, Kentaro, Dunn, Andrew, Thompson, Wendy L., Yoneyama, Yosuke, Chaturvedi, Praneet, Zorn, Aaron M., Wintzinger, Michelle, Quattrocelli, Mattia et al. · 2022 · Cell
39. PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF
    Satish Kumar Tadi, Carine Tellier-Lebègue, Clement Nemoz, Pascal Drevet, Stéphane Audebert, Sunetra Roy, Katheryn Meek, Jean‐Baptiste Charbonnier, Mauro Modesti · 2016 · Cell Reports
40. CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects
    Zhao Zhang, Yuelin Zhang, Fei Gao, Shuo Han, Kathryn S.E. Cheah, Hung‐Fat Tse, Qizhou Lian · 2017 · Molecular Therapy — Nucleic Acids
41. LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism
    Anastasia A. Chugunova, Elizaveta Loseva, Pavel Mazin, Aleksandra Mitina, Tsimafei Navalayeu, Dmitry S. Bilan, Polina Vishnyakova, Maria V. Marey, Anna Y. Golovina, Marina V. Serebryakova et al. · 2019 · Proceedings of the National Academy of Sciences
42. Mechanical stretch activates piezo1 in caveolae of alveolar type I cells to trigger ATP release and paracrine stimulation of surfactant secretion from alveolar type II cells
    Kathrin Diem, Michael Fauler, Giorgio Fois, Andreas Hellmann, Natalie Winokurow, Stefan Schumacher, Christine Kranz, Manfred Frick · 2020 · The FASEB Journal
43. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death
    Nina E. Meyer, Lisa M. Henkel, Benedikt Linder, Svenja Zielke, Georg Tascher, Sandra Trautmann, Gerd Geißlinger, Christian Münch, Simone Fulda, Irmgard Tegeder et al. · 2021 · Autophagy
44. WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
    Sixian Qi, Yuwen Zhu, Xincheng Liu, Pengyue Li, Yebin Wang, Yan Jun Zeng, Aijuan Yu, Yu Wang, Zhao Sha, Zhenxing Zhong et al. · 2022 · Molecular Cell
45. Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis
    Mengnan Zhao, Rui Wang, Kunmeng Yang, Yuhong Jiang, Yachen Peng, Yuke Li, Zhen Zhang, Jianxun Ding, Sanjun Shi · 2022 · Acta Pharmaceutica Sinica B
46. The linear ubiquitin chain assembly complex regulates TRAIL‐induced gene activation and cell death
    Lafont, Elodie, Kantari‐Mimoun, Chahrazade, Draber, Peter, De Miguel, Diego, Hartwig, Torsten, Reichert, Matthias, Kupka, Sebastian, Shimizu, Yutaka, Taraborrelli, Lucia, Spit, Maureen et al. · 2017 · The EMBO Journal
47. Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms
    Alina Guna, Nancy J. Butcher, Anne S. Bassett · 2015 · Journal of Neurodevelopmental Disorders
48. From single molecules to life: microscopy at the nanoscale
    Bartosz Turkowyd, David Virant, Ulrike Endesfelder · 2016 · Analytical and Bioanalytical Chemistry
49. Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy
    Naonobu Fujita, Wilson Huang, Tzu-han Lin, Jean‐François Groulx, Steve Jean, Jen Nguyen, Yoshihiko Kuchitsu, Ikuko Koyama‐Honda, Noboru Mizushima, Mitsunori Fukuda et al. · 2017 · eLife
50. MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells
    Keisuke Ito, Yutaka Eguchi, Yusuke Imagawa, Shuji Akai, Hideki Mochizuki, Yoshihide Tsujimoto · 2017 · Cell Death Discovery
51. Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth
    Saverio Marchi, Mariangela Corricelli, Alessio Branchini, Veronica Angela Maria Vitto, Sonia Missiroli, Giampaolo Morciano, Mariasole Perrone, Mattia Ferrarese, Carlotta Giorgi, Mirko Pinotti et al. · 2018 · The EMBO Journal
52. Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment
    Rut Tejero, Yong Huang, Igor Katsyv, Michael Kluge, Jung‐Yi Lin, Jessica Tomé-García, Nicolas Daviaud, Yuanshuo Wang, Bin Zhang, Nadejda M. Tsankova et al. · 2019 · EBioMedicine
53. Regulation of gene expression by altered promoter methylation using a CRISPR/Cas9-mediated epigenetic editing system
    Jeong Gu Kang, Jin Suk Park, Jeong-Heosn Ko, Yong-Sam Kim · 2019 · Scientific Reports
54. Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
    Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Young Lee et al. · 2020 · Nature Communications
55. Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
    Thomas Montavon, Nicholas Shukeir, Galina A. Erikson, Bettina Engist, Megumi Onishi‐Seebacher, Devon Patrick Ryan, Yaarub Musa, Gerhard Mittler, Alexandra Graff Meyer, Christel Genoud et al. · 2021 · Nature Communications
56. TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
    Miriam Longo, Marica Meroni, Erika Paolini, Veronica Erconi, Fabrizia Carli, Francesco Fortunato, Dario Ronchi, Roberto Piciotti, Silvia Sabatini, Chiara Macchi et al. · 2021 · Cellular and Molecular Gastroenterology and Hepatology
57. Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders
    Daria Wojtal, Dwi U. Kemaladewi, Zeenat Malam, Sarah Abdullah, Tatianna Wai Ying Wong, Elzbieta Hyatt, Zahra Baghestani, Sérgio L. Pereira, James Stavropoulos, Vincent Mouly et al. · 2015 · The American Journal of Human Genetics
58. TUT‐DIS3L2 is a mammalian surveillance pathway for aberrant structured non‐coding RNAs
    Dmytro Ustianenko, Josef Pasulka, Zuzana Feketová, Lukas Bednarik, Dagmar Zigáčková, Andrea Fořtová, Mihaela Zavolan, Stepanka Vanacova · 2016 · The EMBO Journal
59. CRISPR/Cas9-Mediated Deletion of Large Genomic Fragments in Soybean
    Yupeng Cai, Li Chen, Shi Sun, Cunxiang Wu, Weiwei Yao, Bingjun Jiang, Tianfu Han, Wensheng Hou · 2018 · International Journal of Molecular Sciences
60. The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy
    Nicolò Salvarani, Silvia Crasto, Michele Miragoli, Alessandro Bertero, Marianna Paulis, Paolo Kunderfranco, Simone Serio, Alberto Forni, Carla Lucarelli, Matteo Dal Ferro et al. · 2019 · Nature Communications
61. SETD3 protein is the actin-specific histidine N-methyltransferase
    S. Kwiatkowski, Agnieszka Kinga Seliga, Didier Vertommen, Marianna Terreri, Takao Ishikawa, Iwona Grabowska, Marcel Tiebe, Aurelio A. Teleman, Adam Konrad Jagielski, Maria Veiga‐da‐Cunha et al. · 2018 · eLife
62. CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes
    Anil Paul Chirackal Manavalan, Květa Pilařová, Michael Kluge, Koen Bartholomeeusen, Michal Rájecký, Jan Oppelt, Prashant Khirsariya, Kamil Paruch, Lumír Krejčí, Caroline C. Friedel et al. · 2019 · EMBO Reports
63. Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
    Aditya Mithal, Amalia Capilla, Dar M. Heinze, Andrew C. Berical, Carlos Villacorta-Martín, Marall Vedaie, Anjali Jacob, Kristine M. Abo, Aleksander D. Szymaniak, Megan Peasley et al. · 2020 · Nature Communications
64. Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases
    Lin Zhang, Jun Yao, Yongkun Wei, Zhifen Zhou, Ping Li, Jingkun Qu, Akosua Badu-Nkansah, Xiangliang Yuan, Yu-Wen Huang, Kazutaka Fukumura et al. · 2020 · Science Translational Medicine
65. Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance
    Qiujun Wang, Guang Yu, Xuan Ming, Weikun Xia, Xiguang Xu, Yu Zhang, Wenhao Zhang, Yuanyuan Li, Chunyi Huang, Hehuang Xie et al. · 2020 · Nature Genetics
66. Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome
    Joanna W. Jachowicz, Mackenzie M. Strehle, Abhik K. Banerjee, Mario R. Blanco, Jasmine Thai, Mitchell Guttman · 2022 · Nature Structural & Molecular Biology
67. Simultaneous live imaging of the transcription and nuclear position of specific genes
    Hiroshi Ochiai, Takeshi Sugawara, Takashi Yamamoto · 2015 · Nucleic Acids Research
68. EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression
    Aline Renneville, Peter van Galen, Matthew C. Canver, Marie Ellen McConkey, John Michael Krill-Burger, David M. Dorfman, Edward B. Holson, B Bernstein, Stuart H. Orkin, Daniel E. Bauer et al. · 2015 · Blood
69. Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis
    Lindsey A. Lonowski, Yoshiki Narimatsu, Anjum Riaz, Catherine M. Delay, Zhang Yang, Francesco Niola, Katarzyna Duda, Elke Annette Ober, Henrik Clausen, Hans Heugh Wandall et al. · 2017 · Nature Protocols
70. CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma
    Lars Henning Engelholm, Anjum Riaz, Denise Serra, Frederik Dagnæs‐Hansen, Jens Vilstrup Johansen, Eric Santoni‐Rugiu, Steen H. Hansen, Francesco Niola, Morten Frödin · 2017 · Gastroenterology
71. Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor α-Bound Enhancers
    Julia B. Carleton, Kristofer C. Berrett, Jason Gertz · 2017 · Cell Systems
72. CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis
    Alberto di Ronza, Lakshya Bajaj, Jaiprakash Sharma, Deepthi Sanagasetti, Parisa Lotfi, Carolyn J. Adamski, John R. Collette, Michela Palmieri, Abdallah Amawi, Lauren Popp et al. · 2018 · Nature Cell Biology
73. Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit
    Christopher S. Morrow, Tiaira J. Porter, Nan Xu, Zachary P. Arndt, Kayla Ako-Asare, Helen J. Heo, Elizabeth A.N. Thompson, Darcie L. Moore · 2020 · Cell stem cell
74. Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy
    Xing Li, Qian Xia, Meng Mao, Huijuan Zhou, Lu Zheng, Yi Wang, Zhen Zeng, Lulu Yan, Yin Zhao, Jing Shi · 2021 · Science Advances
75. Bacterial exopolysaccharides: Chemical structures, gene clusters and genetic engineering
    Xiaqing Sun, Jianfa Zhang · 2021 · International Journal of Biological Macromolecules
76. An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion
    Kizhakke Mattada Sathyan, Brian D. McKenna, Warren D. Anderson, Fabiana M. Duarte, Leighton J. Core, Michael J. Guertin · 2019 · Genes & Development
77. Genetically Encoded Fluorescent Biosensors for Live-Cell Visualization of Protein Phosphorylation
    Laurel Oldach, Jin Zhang · 2014 · Chemistry & Biology
78. Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit
    Jacob Stewart-Ornstein, Galit Lahav · 2016 · Cell Reports
79. A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation
    Iman Farasat, Howard M. Salis · 2016 · PLoS Computational Biology
80. p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex
    Shasha Tao, Pengfei Liu, Gang Luo, Montserrat Rojo de la Vega, Richard Chen, Tongde Wu, Joseph Tillotson, Eli Chapman, Donna D. Zhang · 2017 · Molecular and Cellular Biology
81. Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice
    Lara De Tomasi, Pierre David, Camille Humbert, Flora Silbermann, Christelle Arrondel, Frédéric Torès, Stéphane Fouquet, Audrey Desgrange, Olivier Niel, Christine Bôle‐Feysot et al. · 2017 · The American Journal of Human Genetics
82. CRISPRed Macrophages for Cell-Based Cancer Immunotherapy
    Moumita Ray, Yi-Wei Lee, Joseph Michael Hardie, Rubul Mout, Gülen Yesilbag Tonga, Michelle E. Farkas, Vincent M. Rotello · 2018 · Bioconjugate Chemistry
83. RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature
    William R. Swindell, Maria A. Beamer, Mrinal K. Sarkar, Shannon N. Loftus, Joseph M. Fullmer, Xianying Xing, Nicole L. Ward, Lam C. Tsoi, M. Kahlenberg, Yun Liang et al. · 2018 · Frontiers in Immunology
84. Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep
    Yasutaka Niwa, Genki N. Kanda, Rikuhiro G. Yamada, Shoi Shi, Genshiro A. Sunagawa, Maki Ukai‐Tadenuma, Hiroshi Fujishima, Naomi Matsumoto, Koh‐hei Masumoto, Mamoru Nagano et al. · 2018 · Cell Reports
85. Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150
    Christian Karl Pfaller, Ryan C. Donohue, Stepan A. Nersisyan, Leonid Brodsky, Roberto Cattaneo · 2018 · PLoS Biology
86. Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing
    Liang Chen, Mei-Yan Ma, Ming Sun, Lu-Yi Jiang, Xue-Tong Zhao, Xian-Xiu Fang, Sin Man Lam, Guanghou Shui, Jie Luo, Xiong-Jie Shi et al. · 2019 · Journal of Lipid Research
87. DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation
    Sigrid Uxa, Stephan H. Bernhart, Christina FS Mages, Martin Fischer, Robin Kohler, Steve Hoffmann, Peter Florian Stadler, Kurt Engeland, Gerd A. Müller · 2019 · Nucleic Acids Research
88. Using traditional machine learning and deep learning methods for on- and off-target prediction in CRISPR/Cas9: a review
    Zeinab Sherkatghanad, Moloud Abdar, Jérémy Charlier, Vladimir Makarenkov · 2023 · Briefings in Bioinformatics
89. NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings
    Ömer An, Giovanni Marco Dall’Olio, Thanos P. Mourikis, Francesca D. Ciccarelli · 2015 · Nucleic Acids Research
90. The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas
    P. McGrath, Carey L. Watson, Cameron Ingram, M. Helmrath, James M. Wells · 2015 · Diabetes
91. Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions
    Hendriks, William T., Warren, Curtis R., Cowan, Chad A. · 2016 · Cell Stem Cell
92. CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity
    Josephine B. Walton, Malcolm Farquharson, Susan M. Mason, Jennifer Port, Björn Kruspig, Suzanne Dowson, David Stevenson, Daniel J. Murphy, Martin Matthew Matzuk, Jaeyeon Kim et al. · 2017 · Scientific Reports
93. Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex
    Zheng, Yonggang, Liu, Bo, Wang, Li, Lei, Huiyan, Pulgar Prieto, Katiuska Daniela, Pan, Duojia · 2017 · Cell Reports
94. NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network
    David J. Anderson, David I. Kaplan, Katrina M. Bell, Katerina Koutsis, John M. Haynes, Richard J. Mills, Dean Phelan, Elizabeth Ling Qian, Ana Rita Leitoguinho, Deevina Arasaratnam et al. · 2018 · Nature Communications
95. Systemic delivery of CRISPR/Cas9 with PEG-PLGA nanoparticles for chronic myeloid leukemia targeted therapy
    Yang Liu, Gui Zhao, Cong‐Fei Xu, Ying‐Li Luo, Zi-Dong Lu, Jun Wang · 2018 · Biomaterials Science
96. A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits
    Le­onardo Almeida-Souza, René Frank, Javier García‐Nafría, Adeline Colussi, Nushan Gunawardana, Christopher M. Johnson, Minmin Yu, Gillian Howard, Byron Andrews, Yvonne Vallis et al. · 2018 · Cell
97. Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction
    Michael John Kerins, John Milligan, James Akira Wohlschlegel, Aikseng Ooi · 2018 · Cancer Science
98. <i>SMPD1</i> mutations, activity, and α‐synuclein accumulation in Parkinson's disease
    Alcalay, Roy N., Mallett, Victoria, Vanderperre, Benoît, Tavassoly, Omid, Dauvilliers, Yves, Wu, Richard Y.J., Ruskey, Jennifer A., Leblond, Claire S., Ambalavanan, Amirthagowri, Laurent, Sandra B. et al. · 2019 · Movement Disorders
99. TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains
    Ai Kaiho-Soma, Yoshino Akizuki, Katsuhide Igarashi, Akinori Endo, Takuji Shoda, Yasuko Kawase, Yosuke Demizu, Mikihiko Naito, Yasushi Saeki, Keiji Tanaka et al. · 2021 · Molecular Cell
100. Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones
     Jialiang S. Wang, Courtney M. Mazur, Marc Nathan Wein · 2021 · Frontiers in Endocrinology