Genome engineering using the CRISPR-Cas9 system

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

Barrangou, R., Fremaux, C., Deveau, H., Richards, M., Boyaval, P., Moineau, S., Romero, D. A., & Horvath, P. (2007) · Science · doi:10.1126/science.1138140 · Cited by 5,947

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Qi, L. S., Larson, M. H., Gilbert, L. A., Doudna, J. A., Weissman, J. S., Arkin, A. P., & Lim, W. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.022 · Cited by 5,016

DNA targeting specificity of RNA-guided Cas9 nucleases

Hsu, P. D., Scott, D. A., Weinstein, J. A., Ran, F. A., Konermann, S., Agarwala, V., Li, Y., Fine, E. J., Wu, X., Shalem, O., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2647 · Cited by 4,741

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Gilbert, L. A., Larson, M. H., Morsut, L., Liu, Z., Brar, G. A., Torres, S. E., Stern-Ginossar, N., Brandman, O., Whitehead, E. H., Doudna, J. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.044 · Cited by 3,696

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.04.025 · Cited by 3,495

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

Ran, F. A., Hsu, P. D., Lin, C.-Y., Gootenberg, J. S., Konermann, S., Trevino, A. E., Scott, D. A., Inoue, A., Matoba, S., Zhang, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.021 · Cited by 3,299

High-Frequency off-Target Mutagenesis Induced by CRISPR-Cas Nucleases in Human Cells

Fu, Y., Foden, J. A., Khayter, C., Maeder, M. L., Reyon, D., Joung, J. K., & Sander, J. D. (2013) · Nature Biotechnology · doi:10.1038/nbt.2623 · Cited by 3,292

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

Mancias, J. D., Pontano Vaites, L., Nissim, S., Biancur, D. E., Kim, A. J., Wang, X., Liu, Y., Goessling, W., Kimmelman, A. C., & Harper, J. W. (2015) · eLife · doi:10.7554/elife.10308 · Cited by 552

DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning

Graving, J. M., Chae, D., Naik, H., Li, L., Koger, B., Costelloe, B. R., & Couzin, I. D. (2019) · eLife · doi:10.7554/elife.47994 · Cited by 547

Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA

Miller, J. B., Zhang, S., Kos, P., Xiong, H., Zhou, K., Perelman, S. S., Zhu, H., & Siegwart, D. J. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201610209 · Cited by 540

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

Chung, H., Calis, J. J. A., Wu, X., Sun, T., Yu, Y., Sarbanes, S. L., Dao Thi, V. L., Shilvock, A. R., Hoffmann, H.-H., Rosenberg, B. R., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.038 · Cited by 538

ATG2 transports lipids to promote autophagosome biogenesis

Valverde, D. P., Yu, S., Boggavarapu, V., Kumar, N., Lees, J. A., Walz, T., Reinisch, K. M., & Melia, T. J. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201811139 · Cited by 537

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

Svensson, R. U., Parker, S. J., Eichner, L. J., Kolar, M. J., Wallace, M., Brun, S. N., Lombardo, P. S., Van Nostrand, J. L., Hutchins, A., Vera, L., et al. (2016) · Nature Medicine · doi:10.1038/nm.4181 · Cited by 536

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

Mohammad, F., Weissmann, S., Leblanc, B., Pandey, D. P., Højfeldt, J. W., Comet, I., Zheng, C., Johansen, J. V., Rapin, N., Porse, B. T., et al. (2017) · Nature Medicine · doi:10.1038/nm.4293 · Cited by 535

CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation

Narendra, V., Rocha, P. P., An, D., Raviram, R., Skok, J. A., Mazzoni, E. O., & Reinberg, D. (2015) · Science · doi:10.1126/science.1262088 · Cited by 535

Glucocorticoid receptor control of transcription: precision and plasticity via allostery

Weikum, E. R., Knuesel, M. T., Ortlund, E. A., & Yamamoto, K. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.152 · Cited by 533

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Meng, Z., Moroishi, T., Mottier, V., Plouffe, S. W., Hansen, C. G., Hong, A. W., Park, H. W., Mo, J., Lü, W., Lu, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9357 · Cited by 537

An essential receptor for adeno-associated virus infection

Pillay, S., Meyer, N. L., Puschnik, A. S., Davulcu, O., Diep, J., Ishikawa, Y., Jae, L. T., Wosen, J. E., Nagamine, C. M., Chapman, M. S., et al. (2016) · Nature · doi:10.1038/nature16465 · Cited by 532

NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8

Anandhan, A., Dodson, M. B., Shakya, A., Chen, J., Liu, P., Wei, Y., Tan, H., Wang, Q., Jiang, Z., Yang, K. B., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade9585 · Cited by 531

Genome Engineering Using CRISPR-Cas9 System

Cong, L., & Zhang, F. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1862-1_10 · Cited by 536

Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR

Boettcher, M., & McManus, M. T. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.04.028 · Cited by 539

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

Quadros, R. M., Miura, H., Harms, D. W., Akatsuka, H., Sato, T., Aida, T., Redder, R. J., Richardson, G. P., Inagaki, Y., Sakai, D., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1220-4 · Cited by 512

Metabolic heterogeneity confers differences in melanoma metastatic potential

Tasdogan, A., Faubert, B., Ramesh, V., Ubellacker, J. M., Shen, B., Solmonson, A., Murphy, M. M., Gu, Z., Gu, W., Martin, M., et al. (2020) · Nature · doi:10.1038/s41586-019-1847-2 · Cited by 509

Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging

Gabriele, M., Brandão, H. B., Grosse-Holz, S., Jha, A., Dailey, G. M., Cattoglio, C., Hsieh, T.-H. S., Mirny, L., Zechner, C., & Hansen, A. S. (2022) · Science · doi:10.1126/science.abn6583 · Cited by 506

Severe acute respiratory syndrome Coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3‐dependent ubiquitination of ASC

Siu, K., Yuen, K., Castaño-Rodríguez, C., Ye, Z., Yeung, M. L., Fung, S., Yuan, S., Chan, C., Yuen, K., Enjuanes, L., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802418r · Cited by 500

An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells

Gonzãlez, F., Zhu, Z., Shi, Z., Lelli, K. M., Verma, N., Li, Q. V., & Huangfu, D. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.05.018 · Cited by 504

Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification

Yoo, S., Mittelstein, D. R., Hurt, R. C., Lacroix, J. J., & Shapiro, M. G. (2022) · Nature Communications · doi:10.1038/s41467-022-28040-1 · Cited by 514

ER-mitochondria tethering by PDZD8 regulates Ca 2+ dynamics in mammalian neurons

Hirabayashi, Y., Kwon, S., Paek, H., Pernice, W. M., Paul, M. A., Lee, J., Erfani, P., Raczkowski, A. M., Petrey, D. S., Pon, L. A., et al. (2017) · Science · doi:10.1126/science.aan6009 · Cited by 505

The functional landscape of the human phosphoproteome

Ochoa, D., Jarnuczak, A. F., Viéitez, C., Gehre, M., Soucheray, M., Mateus, A., Kleefeldt, A. A., Hill, A., Garcia-Alonso, L., Stein, F., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-019-0344-3 · Cited by 491

Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer

Liu, X., Bao, X., Hu, M., Chang, H., Jiao, M., Cheng, J., Xie, L., Huang, Q., Li, F., & Li, C.-Y. (2020) · Nature · doi:10.1038/s41586-020-2911-7 · Cited by 490

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane

Tsuboyama, K., Koyama-Honda, I., Sakamaki, Y., Koike, M., Morishita, H., & Mizushima, N. (2016) · Science · doi:10.1126/science.aaf6136 · Cited by 485

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

Chauhan, S., Kumar, S. G., Jain, A., Ponpuak, M., Mudd, M. H., Kimura, T., Choi, S. W., Peters, R. S., Mandell, M. A., Bruun, J., et al. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.08.003 · Cited by 487

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

Wong, Y. L., Anzola, J. V., Davis, R. L., Yoon, M., Motamedi, A., Kroll, A. V., Seo, C. P., Hsia, J. E., Kim, S. K., Mitchell, J. W., et al. (2015) · Science · doi:10.1126/science.aaa5111 · Cited by 485

Regulation of Single-Strand Annealing and its Role in Genome Maintenance

Bhargava, R., Onyango, D. O., & Stark, J. M. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.06.007 · Cited by 512

Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases

Kim, Y.-R., Lee, E.-J., Shin, K., Kim, M. H., Pewzner‐Jung, Y., Lee, Y.-M., Park, J., Futerman, A. H., & Park, W. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0340-1 · Cited by 481

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

Yan, W., Wu, X., Zhou, W., Fong, M., Cao, M., Liu, J., Liu, X., Chen, C.-H., Fadare, O., Pizzo, D. P., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0083-6 · Cited by 474

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

Guo, L. E., Kim, H. J., Wang, H. H., Monaghan, J., Freyermuth, F., Sung, J. C., O’Donovan, K., Fare, C. M., Diaz, Z., Singh, N., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.002 · Cited by 467

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

Winter, G. E., Mayer, A., Buckley, D. L., Erb, M. A., Roderick, J. E., Vittori, S., Reyes, J. M., di Iulio, J., Souza, A., Ott, C. J., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.06.004 · Cited by 465

Analyzing CRISPR genome-editing experiments with CRISPResso

Pinello, L., Canver, M. C., Hoban, M. D., Orkin, S. H., Kohn, D. B., Bauer, D. E., & Yuan, G. (2016) · Nature Biotechnology · doi:10.1038/nbt.3583 · Cited by 456

Long noncoding RNAs in cancer: mechanisms of action and technological advancements

Bartoniček, N., Mååg, J. L. V., & Dinger, M. E. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0530-6 · Cited by 464

SABER amplifies FISH: enhanced multiplexed imaging of RNA and DNA in cells and tissues

Kishi, J. Y., Lapan, S. W., Beliveau, B. J., West, E. R., Zhu, A., Sasaki, H. M., Saka, S. K., Wang, Y., Cepko, C. L., & Yin, P. (2019) · Nature Methods · doi:10.1038/s41592-019-0404-0 · Cited by 446

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

Bao, X. R., Ong, S., Goldberger, O., Peng, J., Sharma, R., Thompson, D. A., Vafai, S. B., Cox, A. G., Marutani, E., Ichinose, F., et al. (2016) · eLife · doi:10.7554/elife.10575 · Cited by 450

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires

Strønen, E., Toebes, M., Kelderman, S., van Buuren, M. M., Yang, W., van Rooij, N., Donia, M., Böschen, M.-L., Lund‐Johansen, F., Olweus, J., et al. (2016) · Science · doi:10.1126/science.aaf2288 · Cited by 453

Phase separation of 53BP1 determines liquid‐like behavior of DNA repair compartments

Kilic, S., Lezaja, A., Gatti, M., Bianco, E., Michelena, J., Imhof, R., & Altmeyer, M. (2019) · The EMBO Journal · doi:10.15252/embj.2018101379 · Cited by 456

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

Smith, M. D., Harley, M. E., Kemp, A. J., Wills, J. C., Lee, M. W., Arends, M. J., von Kriegsheim, A., Behrends, C., & Wilkinson, S. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.11.024 · Cited by 452

Cornerstones of CRISPR–Cas in drug discovery and therapy

Fellmann, C., Gowen, B. G., Lin, P., Doudna, J. A., & Corn, J. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.238 · Cited by 452

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

Grumati, P., Morozzi, G., Hölper, S., Mari, M. C., Harwardt, M.-L. I. E., Yan, R., Müller, S. P., Reggiori, F., Heilemann, M., & Đikić, I. (2017) · eLife · doi:10.7554/elife.25555 · Cited by 447

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture

Thiam, H. R., Wong, S. L., Qiu, R., Kittisopikul, M., Vahabikashi, A., Goldman, A. E., Goldman, R. D., Wagner, D. D., & Waterman, C. M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909546117 · Cited by 449

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

Huang, H.-T., Dobrovolsky, D., Paulk, J., Yang, G., Weisberg, E. L., Doctor, Z. M., Buckley, D. L., Cho, J.-H., Ko, E., Jang, J., et al. (2018) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.10.005 · Cited by 437

SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

Zhao, Y., Hu, Q., Cheng, F., Su, N., Wang, A., Zou, Y., Hu, H., Chen, X., Hai‐Meng, Z. H. O. U., Huang, X., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.009 · Cited by 442

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

Moroishi, T., Hayashi, T., Pan, W., Fujita, Y., Holt, M. V., Qin, J., Carson, D. A., & Guan, K. (2016) · Cell · doi:10.1016/j.cell.2016.11.005 · Cited by 441

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

Bartošovič, M., Molares, H. C., Gregorová, P., Hroššová, D., Kudla, G., & Vaňáčová, Š. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx778 · Cited by 436

High levels of AAV vector integration into CRISPR-induced DNA breaks

Hanlon, K. S., Kleinstiver, B. P., Garcia, S. P., Zaborowski, M. P., Volak, A., Spirig, S. E., Muller, A., Sousa, A. A., Tsai, S. Q., Bengtsson, N. E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12449-2 · Cited by 431

Resting zone of the growth plate houses a unique class of skeletal stem cells

Mizuhashi, K., Ono, W., Matsushita, Y., Sakagami, N., Takahashi, A., Saunders, T. L., Nagasawa, T., Kronenberg, H. M., & Ono, N. (2018) · Nature · doi:10.1038/s41586-018-0662-5 · Cited by 427

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

Rees, H. A., Komor, A. C., Yeh, W.-H., Caetano-Lopes, J., Warman, M., Edge, A. S. B., & Liu, D. R. (2017) · Nature Communications · doi:10.1038/ncomms15790 · Cited by 412

RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency

Song, J. W., Yang, D., Xu, J., Zhu, T., Chen, Y. E., & Zhang, J. (2016) · Nature Communications · doi:10.1038/ncomms10548 · Cited by 418

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism

Chen, L., Zhang, Z., Hoshino, A., Zheng, H. D., Morley, M. P., Arany, Z. P., & Rabinowitz, J. D. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0043-x · Cited by 426

FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy

Bhujabal, Z., Birgisdottir, Å. B., Sjøttem, E., Brenne, H. B., Øvervatn, A., Habisov, S., Kirkin, V., Lamark, T., & Johansen, T. (2017) · EMBO Reports · doi:10.15252/embr.201643147 · Cited by 430

Genetically engineered cerebral organoids model brain tumor formation

Bian, S., Repic, M., Guo, Z., Kavirayani, A. M., Burkard, T. R., Bagley, J. A., Krauditsch, C., & Knoblich, J. A. (2018) · Nature Methods · doi:10.1038/s41592-018-0070-7 · Cited by 427

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

Cai, D., Feliciano, D., Dong, P., Flores, E., Gruebele, M., Porat‐Shliom, N., Sukenik, S., Liu, Z. J., & Lippincott‐Schwartz, J. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0433-z · Cited by 426

Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway

Ducker, G. S., Chen, L., Morscher, R. J., Ghergurovich, J. M., Esposito, M., Teng, X., Kang, Y., & Rabinowitz, J. D. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.016 · Cited by 419

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo

Sala, L., van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312067 · Cited by 416

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

Wang, R., Simoneau, C. R., Kulsuptrakul, J., Bouhaddou, M., Travisano, K. A., Hayashi, J. M., Carlson-Stevermer, J., Zengel, J. R., Richards, C. M., Fozouni, P., et al. (2020) · Cell · doi:10.1016/j.cell.2020.12.004 · Cited by 417

Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities

Li, L., Hu, S., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.031 · Cited by 415

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

TCW, J., Qian, L., Pipalia, N. H., Chao, M. J., Liang, S. A., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., et al. (2022) · Cell · doi:10.1016/j.cell.2022.05.017 · Cited by 411

Thermo-triggered release of CRISPR-Cas9 system by lipid-encapsulated gold nanoparticles for tumor therapy

Wang, P., Zhang, L., Zheng, W., Cong, L., Guo, Z., Xie, Y., Wang, L., Tang, R., Feng, Q., Hamada, Y., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201708689 · Cited by 410

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

Zierhut, C., Yamaguchi, N., Paredes, M. C. G., Luo, J., Carroll, T., & Funabiki, H. (2019) · Cell · doi:10.1016/j.cell.2019.05.035 · Cited by 411

Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1

Hsieh, T.-H. S., Cattoglio, C., Slobodyanyuk, E., Hansen, A. S., Darzacq, X., & Tjian, R. (2022) · Nature Genetics · doi:10.1038/s41588-022-01223-8 · Cited by 406

N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

Ma, H., Wang, X., Cai, J., Dai, Q., Natchiar, S. K., Lyu, R., Chen, K., Lu, Z., Chen, H., Shi, Y. G., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0184-3 · Cited by 414

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

Zimmermann, M., Murina, O., Reijns, M. A. M., Agathanggelou, A., Challis, R. C., Tarnauskaitė, Ž., Muir, M., Fluteau, A., Aregger, M., McEwan, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0291-z · Cited by 388

CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy

Xu, Y., & Li, Z. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.08.031 · Cited by 457

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

Dorighi, K. M., Swigut, T., Henriques, T., Bhanu, N. V., Scruggs, B. S., Nady, N., Still, C. D., Garcia, B. A., Adelman, K., & Wysocka, J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.018 · Cited by 403

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

Mazur, P. K., Herner, A., Mello, S. S., Wirth, M., Hausmann, S., Rivera, F. J. S., Lofgren, S., Kuschma, T., Hahn, S. A., Vangala, D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3952 · Cited by 413

Microscopy-Based High-Content Screening

Boutros, M., Heigwer, F., & Laufer, C. (2015) · Cell · doi:10.1016/j.cell.2015.11.007 · Cited by 383

Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes

Feyen, D. A. M., McKeithan, W. L., Bruyneel, A. A. N., Spiering, S., Hörmann, L., Ulmer, B., Zhang, H., Briganti, F., Schweizer, M., Hegyi, B., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107925 · Cited by 400

High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population

Wagner, D. L., Amini, L., Wendering, D. J., Burkhardt, L.-M., Akyüz, L., Reinke, P., Volk, H.-D., & Schmueck-Henneresse, M. (2019) · Nature Medicine · doi:10.1038/s41591-018-0204-6 · Cited by 399

LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern

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