Genome engineering using the CRISPR-Cas9 system

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Items 601–700 of 1,083

1. Clathrin-associated AP-1 controls termination of STING signalling
   Ying Liu, Pengbiao Xu, Sophie Rivara, Chong Liu, Jonathan Ricci, Xuefeng Ren, James H. Hurley, Andrea Ablasser · 2022 · Nature
2. Therapy-induced APOBEC3A drives evolution of persistent cancer cells
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3. The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s
   Tunbak, Hale, Enriquez-Gasca, Rocio, Tie, Christopher H. C., Gould, Poppy A., Mlcochova, Petra, Gupta, Ravindra K., Fernandes, Liane, Holt, James, van der Veen, Annemarthe G., Giampazolias, Evangelos et al. · 2020 · Nature Communications
4. SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis
   Yanhui Zhang, Litao Xie, Susheel K. Gunasekar, Dan Tong, Anil Mishra, William J. Gibson, Chuansong Wang, Trevor P. Fidler, Brodie R. Marthaler, Aloysius John Klingelhutz et al. · 2017 · Nature Cell Biology
5. RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin
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6. Syntenin mediates SRC function in exosomal cell-to-cell communication
   Naga Sailaja Imjeti, Kerstin Menck, Antonio Luis Egea-Jiménez, Céline Lecointre, Frédérique Lembo, Habib Bouguenina, Ali Badache, Rania Ghossoub, Guido David, Serge Roche et al. · 2017 · Proceedings of the National Academy of Sciences
7. Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis
   Xu-Yun Zhao, Xuelian Xiong, Tongyu Liu, Lin Mi, Xiaoling Peng, Crystal Rui, Liang Guo, Siming Li, Xiaoying Li, Jiandie D. Lin · 2018 · Nature Communications
8. Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility
   Wondwossen M Yeshaw, Marianne van der Zwaag, Francesco Pinto, Liza L. Lahaye, Anita I. E. Faber, Rubén Gómez‐Sánchez, Amalia M. Dolga, Conor Poland, Anthony P. Monaco, Sven CD van IJzendoorn et al. · 2019 · eLife
9. Yeasts as probiotics: Mechanisms, outcomes, and future potential
   Swastik Sen, Thomas J. Mansell · 2020 · Fungal Genetics and Biology
10. RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis
    Erika Sugisawa, Yasunori Takayama, Naoki Takemura, Takeshi Kondo, Shigetsugu Hatakeyama, Yutaro Kumagai, Masataka Sunagawa, Makoto Tominaga, Kenta Maruyama · 2020 · Cell
11. GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control
    Kelsey L. Hickey, Kimberley Dickson, J. Zachery Cogan, Joseph M. Replogle, Michael Schoof, Karole N. D’Orazio, Niladri K. Sinha, Jeffrey A. Hussmann, Marco Jost, Adam S. Frost et al. · 2020 · Molecular Cell
12. Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes
    Leonore Wigger, Marko Barovic, Andreas‐David Brunner, Flavia Marzetta, Eyke Schöniger, Florence Mehl, Nicole Kipke, Daniela Friedland, Frédéric Burdet, Camille Kessler et al. · 2021 · Nature Metabolism
13. Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
    Vinay V. Eapen, Sharan Swarup, Melissa Hoyer, João A. Paulo, J. Wade Harper · 2021 · eLife
14. Uridine-derived ribose fuels glucose-restricted pancreatic cancer
    Zeribe C. Nwosu, Matthew H. Ward, Peter Sajjakulnukit, Pawan Poudel, Chanthirika Ragulan, Steven Kasperek, Megan D. Radyk, Damien Sutton, Rosa Elena Menjivar, Anthony C. Andren et al. · 2023 · Nature
15. ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells
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16. An endosomal tether undergoes an entropic collapse to bring vesicles together
    David H. Murray, Marcus Jahnel, Janelle L. Lauer, Mario J. Avellaneda, Nicolas Brouilly, Alice Cezanne, Hernán Andrés Morales-Navarrete, Enrico D. Perini, Charles Ferguson, Andrei N. Lupas et al. · 2016 · Nature
17. Genome Editing in Induced Pluripotent Stem Cells using CRISPR/Cas9
    Ronen Ben Jehuda, Yuval Shemer, Ofer Binah · 2018 · Stem Cell Reviews and Reports
18. Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus
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19. TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
    Franz Meitinger, Midori Ohta, Kian-Yong Lee, Sadanori Watanabe, Robert Lowell Davis, John V. Anzola, Ruth Kabeche, David A. Jenkins, Andrew K. Shiau, Arshad B. Desai et al. · 2020 · Nature
20. Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver
    Delilah F. G. Hendriks, Benedetta Artegiani, Huili Hu, Susana M. Chuva de Sousa Lopes, Hans C. Clevers · 2020 · Nature Protocols
21. Insulin secretory granules control autophagy in pancreatic β cells
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22. The power of multiplexed functional analysis of genetic variants
    Gasperini, Molly, Starita, Lea, Shendure, Jay · 2016 · Nature Protocols
23. Poultry genetics and breeding
    Giridhar Athrey · 2020 · Elsevier eBooks
24. CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia
    Zhongsheng Hu, Nan Deng, Kai‐Li Liu, Nan Zhou, Yue Sun, Wenwen Zeng · 2020 · Cell Reports
25. Histone H3.3 phosphorylation amplifies stimulation-induced transcription
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26. Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex
    Ming-Feng Tsai, Charles B Phillips, Matthew J. Ranaghan, Chen-Wei Tsai, Yujiao Wu, Carole Williams, Christopher Miller · 2016 · eLife
27. A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage
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28. NIPSNAP1 and NIPSNAP2 Act as “Eat Me” Signals for Mitophagy
    Yakubu Princely Abudu, Serhiy Pankiv, Benan John Mathai, Alf Håkon Lystad, Christian Bindesbøll, Hanne Britt Brenne, Matthew Yoke Wui Ng, Bernd Thiede, Ai Yamamoto, Thaddaeus Mutugi Nthiga et al. · 2019 · Developmental Cell
29. PAK4 inhibition improves PD-1 blockade immunotherapy
    Gabriel Abril-Rodríguez, Davis Yuri Torrejon, Wei Liu, Jesse Meir Zaretsky, Theodore Scott Nowicki, Jennifer Tsoi, Cristina Puig-Saus, Ignacio Baselga-Carretero, Egmidio Medina, Michael J. Quist et al. · 2019 · Nature Cancer
30. The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation
    Cindy Meyer, Aitor Garzia, Pavel S Morozov, Henrik Molina, Thomas Tuschl · 2020 · Molecular Cell
31. Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor
    Sarah Balderston, Jeffrey J. Taulbee, Elizabeth Celaya, Kandace Fung, Amanda Jiao, Kasey Smith, Reza Hajian, Giedrius Gasiūnas, Simonas Kutanovas, Dae‐Hwan Kim et al. · 2021 · Nature Biomedical Engineering
32. Development of fisheries in China
    Fangzhou Hu, Haitao Zhong, Chang Wu, Shi Wang, Zijian Guo, Min Tao, Chun Zhang, Dingbin Gong, Xin Gao, Chenchen Tang et al. · 2021 · Reproduction and Breeding
33. Programmable CRISPR-Cas9 microneedle patch for long-term capture and real-time monitoring of universal cell-free DNA
    Bin Yang, Jilie Kong, Xueen Fang · 2022 · Nature Communications
34. Dual role of USP30 in controlling basal pexophagy and mitophagy
    Marcassa, Elena, Kallinos, Andreas, Jardine, Jane, Rusilowicz‐Jones, Emma V, Martinez, Aitor, Kuehl, Sandra, Islinger, Markus, Clague, Michael J, Urbé, Sylvie · 2018 · The EMBO Reports
35. Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9
    Daniel E. Bauer, Matthew C. Canver, Stuart H. Orkin · 2014 · Journal of Visualized Experiments
36. Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
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37. Gene therapy and gene correction: targets, progress, and challenges for treating human diseases
    Matthew R. Cring, Val C. Sheffield · 2020 · Gene Therapy
38. Cas9-mediated genome editing in the methanogenic archaeon Methanosarcina acetivorans
    Dipti D. Nayak, William W. Metcalf · 2017 · Proceedings of the National Academy of Sciences
39. Next-Generation Sequencing and Genome Editing in Plant Virology
    Ahmed Hadidi, Ricardo Flores, Thierry Candresse, Marina Barba · 2016 · Frontiers in Microbiology
40. Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line
    Yize Li, Shuvojit Banerjee, Stephen A. Goldstein, Beihua Dong, Christina Gaughan, Sneha P. Rath, Jesse Donovan, Alexei V. Korennykh, Robert H. Silverman, Susan Reich Weiss · 2017 · eLife
41. Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic
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42. YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3
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43. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
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44. The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation
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45. Long non-coding RNAs as prognostic markers in human breast cancer
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46. CRISPR/Cas9-mediated genome editing in a reef-building coral
    Phillip A. Cleves, Marie E. Strader, Line Kolind Bay, John R. Pringle, Mikhail V. Matz · 2018 · Proceedings of the National Academy of Sciences
47. ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm
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48. Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions
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49. Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease
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50. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy
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51. Cross-talk between macrophages and atrial myocytes in atrial fibrillation
    Zewei Sun, Dongchen Zhou, Xudong Xie, Shuai Wang, Zhen Wang, Wenting Zhao, Hongfei Xu, Liangrong Zheng · 2016 · Basic Research in Cardiology
52. Regulatory Expansion in Mammals of Multivalent hnRNP Assemblies that Globally Control Alternative Splicing
    Serge Gueroussov, Robert J. Weatheritt, Dave O’Hanlon, Zhen‐Yuan Lin, Ashrut Narula, Anne‐Claude Gingras, Benjamin J. Blencowe · 2017 · Cell
53. Delivery approaches for CRISPR/Cas9 therapeutics in vivo: advances and challenges
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54. Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
    Baotong Zhang, Yixiang Li, Qiao Wu, Lin Xie, Benjamin G. Barwick, Changying Fu, Xin Li, Daqing Wu, Siyuan Xia, Jing Chen et al. · 2021 · Nature Communications
55. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
    Xufen Yu, Dongxu Li, Jithesh Kottur, Yudao Shen, Huen Suk Kim, Kwang‐Su Park, Yi‐Hsuan Tsai, Weida Gong, Jun Wang, Kyogo Suzuki et al. · 2021 · Science Translational Medicine
56. Structure and dynamics of the EGFR/HER2 heterodimer
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57. Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
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58. AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production
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59. Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation
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60. Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System
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61. Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression
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62. Assessment of Cas12a‐mediated gene editing efficiency in plants
    Joan Miquel Bernabé‐Orts, Iván Casas‐Rodrigo, Eugenio G. Minguet, Viola Landolfi, Victor García‐Carpintero, Silvia Gianoglio, Marta Vázquez‐Vilar, Antonio Granell, Diego Orzáez · 2019 · Plant Biotechnology Journal
63. Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2
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64. Advances in identification and validation of protein targets of natural products without chemical modification
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65. The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases
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66. Graphene oxide-mediated Cas9/sgRNA delivery for efficient genome editing
    Yue, Huahua, Zhou, Xiaoming, Cheng, Meng, Xing, Da · 2018 · Nanoscale
67. Riboregulated toehold-gated gRNA for programmable CRISPR–Cas9 function
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68. Long QT Syndrome: Genetics and Future Perspective
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69. A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation
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70. Validating the concept of mutational signatures with isogenic cell models
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71. Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters
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72. On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease
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73. An alternative splicing event amplifies evolutionary differences between vertebrates
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74. Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis
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75. Molecular Pathway of Microtubule Organization at the Golgi Apparatus
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76. A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
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77. MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis
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78. MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress
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79. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing T _reg cells by inhibition of CDK8/19
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80. A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation
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81. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
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82. Evolution of Food Fermentation Processes and the Use of Multi-Omics in Deciphering the Roles of the Microbiota
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83. Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries
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84. Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9
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85. Inactivation of P haeodactylum tricornutum urease gene using transcription activator‐like effector nuclease‐based targeted mutagenesis
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86. Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1
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87. Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies
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88. Spatial Organization of Single mRNPs at Different Stages of the Gene Expression Pathway
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89. Topoisomerase IIα is essential for maintenance of mitotic chromosome structure
    Christian Friberg Nielsen, Tao Zhang, Marin Barišić, Paul Kalitsis, Damien F. Hudson · 2020 · Proceedings of the National Academy of Sciences
90. Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade
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91. Maternal DNA Methylation Regulates Early Trophoblast Development
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92. Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer
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93. Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys
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94. Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation
    Yang Su, Jinling Huang, Xiaohong Zhao, Jing Li, Wang Wang, Xuexian O. Yang, Yuling Shi, Xiaohu Wang, Yuping Lai, Chen Dong · 2019 · Science Immunology
95. Mitochondrial DNA stress signalling protects the nuclear genome
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96. Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk
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97. CRISPR-GPT for agentic automation of gene-editing experiments
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98. Microalgae with Artificial Intelligence: A Digitalized Perspective on Genetics, Systems and Products
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99. The ciliary membrane‐associated proteome reveals actin‐binding proteins as key components of cilia
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100. DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining
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