Genome engineering using the CRISPR-Cas9 system

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

Barrangou, R., Fremaux, C., Deveau, H., Richards, M., Boyaval, P., Moineau, S., Romero, D. A., & Horvath, P. (2007) · Science · doi:10.1126/science.1138140 · Cited by 5,947

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Qi, L. S., Larson, M. H., Gilbert, L. A., Doudna, J. A., Weissman, J. S., Arkin, A. P., & Lim, W. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.022 · Cited by 5,016

DNA targeting specificity of RNA-guided Cas9 nucleases

Hsu, P. D., Scott, D. A., Weinstein, J. A., Ran, F. A., Konermann, S., Agarwala, V., Li, Y., Fine, E. J., Wu, X., Shalem, O., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2647 · Cited by 4,741

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Gilbert, L. A., Larson, M. H., Morsut, L., Liu, Z., Brar, G. A., Torres, S. E., Stern-Ginossar, N., Brandman, O., Whitehead, E. H., Doudna, J. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.044 · Cited by 3,696

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.04.025 · Cited by 3,495

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

Ran, F. A., Hsu, P. D., Lin, C.-Y., Gootenberg, J. S., Konermann, S., Trevino, A. E., Scott, D. A., Inoue, A., Matoba, S., Zhang, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.021 · Cited by 3,299

High-Frequency off-Target Mutagenesis Induced by CRISPR-Cas Nucleases in Human Cells

Fu, Y., Foden, J. A., Khayter, C., Maeder, M. L., Reyon, D., Joung, J. K., & Sander, J. D. (2013) · Nature Biotechnology · doi:10.1038/nbt.2623 · Cited by 3,292

ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan

Gerin, I., Ury, B., Breloy, I., Bouchet-Séraphin, C., Bolsée, J., Halbout, M., Graff, J., Vertommen, D., Muccioli, G. G., Séta, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms11534 · Cited by 145

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics

Salzer, E., Cağdaş, D. N., Hons, M., Mace, E. M., Garncarz, W., Petronczki, Ö. Y., Platzer, R., Pfajfer, L., Bilić, I., Ban, S. A., et al. (2016) · Nature Immunology · doi:10.1038/ni.3575 · Cited by 145

Morphogen gradient reconstitution reveals Hedgehog pathway design principles

Li, P., Markson, J. S., Wang, S., Chen, S., Vachharajani, V. T., & Elowitz, M. B. (2018) · Science · doi:10.1126/science.aao0645 · Cited by 141

Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

Okumura, M., Natsume, T., Kanemaki, M. T., & Kiyomitsu, T. (2018) · eLife · doi:10.7554/elife.36559 · Cited by 146

A way forward with eco evo devo: an extended theory of resource polymorphism with postglacial fishes as model systems

Skúlason, S., Parsons, K. J., Svanbäck, R., Räsänen, K., Ferguson, M. M., Adams, C. E., Amundsen, P., Bartels, P., Bean, C. W., BOUGHMAN, J. W., et al. (2019) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12534 · Cited by 145

Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance

Freeman, S. A., Uderhardt, S., Sarić, A., Collins, R. F., Buckley, C. M. F., Mylvaganam, S., Boroumand, P., Plumb, J. D., Germain, R. N., Ren, D., et al. (2019) · Science · doi:10.1126/science.aaw9544 · Cited by 141

CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteinsPreprint

Savic, D., Partridge, E. C., Newberry, K. M., Smith, S. B., Meadows, S. K., Roberts, B. S., Mackiewicz, M., Mendenhall, E. M., & Myers, R. (2015) · Genome Research · doi:10.1101/gr.193540.115 · Cited by 141

Dissection of transcriptional and cis‐regulatory control of differentiation in human pancreatic cancer

Diaferia, G. R., Balestrieri, C., Prosperini, E., Nicoli, P., Spaggiari, P., Zerbi, A., & Natoli, G. (2016) · The EMBO Journal · doi:10.15252/embj.201592404 · Cited by 149

Bone morphogenetic protein and retinoic acid synergistically specify female germ‐cell fate in mice

Miyauchi, H., Ohta, H., Nagaoka, S. I., Nakaki, F., Sasaki, K., Hayashi, K., Yabuta, Y., Nakamura, T., Yamamoto, T., & Saitou, M. (2017) · The EMBO Journal · doi:10.15252/embj.201796875 · Cited by 144

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

Valdez, C., Wong, Y. C., Schwake, M., Bu, G., Wszołek, Z. K., & Krainc, D. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx364 · Cited by 148

Delivery of CRISPR/Cas9 for therapeutic genome editing

Xu, X., Wan, T., Xin, H., Li, D., Pan, H., Wu, J., & Ping, Y. (2019) · The Journal of Gene Medicine · doi:10.1002/jgm.3107 · Cited by 134

The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase

McKenna, M. J., Sim, S. I., Ordureau, A., Wei, L., Harper, J. W., Shao, S., & Park, E. (2020) · Science · doi:10.1126/science.abc5809 · Cited by 138

Cerebral organoid and mouse models reveal a RAB39b–PI3K–mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypesPreprint

Zhang, W., Ma, L., Yang, M., Shao, Q., Xu, J., Lu, Z., Zhao, Z., Chen, R., Chai, Y., & Chen, J. (2020) · Genes & Development · doi:10.1101/gad.332494.119 · Cited by 143

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

Sarraf, S. A., Shah, H. V., Kanfer, G., Pickrell, A. M., Holtzclaw, L. A., Ward, M. E., & Youle, R. J. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.10.041 · Cited by 143

Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing

Wyvekens, N., Topkar, V. V., Khayter, C., Joung, J. K., & Tsai, S. Q. (2015) · Human Gene Therapy · doi:10.1089/hum.2015.084 · Cited by 147

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

Rose, N. R., King, H. W., Blackledge, N. P., Fursova, N. A., Ember, K. J., Fischer, R., Kessler, B. M., & Klose, R. J. (2016) · eLife · doi:10.7554/elife.18591 · Cited by 156

FMNL formins boost lamellipodial force generation

Kage, F., Winterhoff, M., Dimchev, V., Mueller, J. O., Thalheim, T., Freise, A., Brühmann, S., Kollasser, J., Block, J., Dimchev, G. A., et al. (2017) · Nature Communications · doi:10.1038/ncomms14832 · Cited by 143

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice

Chen, W. V., Nwakeze, C. L., Denny, C. A., O’Keeffe, S., Rieger, M. A., Mountoufaris, G., Kirner, A., Dougherty, J. D., Hen, R., Wu, Q., et al. (2017) · Science · doi:10.1126/science.aal3231 · Cited by 143

Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration

Burnight, E. R., Gupta, M., Wiley, L. A., Anfinson, K. R., Tran, A. A., Triboulet, R., Hoffmann, J. M., Klaahsen, D., Andorf, J. L., Jiao, C., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.05.015 · Cited by 153

Harnessing accurate non-homologous end joining for efficient precise deletion in CRISPR/Cas9-mediated genome editing

Guo, T., Feng, Y.-L., Xiao, J., Liu, Q., Sun, X., Xiang, J.-F., Kong, N., Liu, S., Chen, G., Wang, Y., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1518-x · Cited by 151

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer

Kim, J., Lee, H. M., Cai, F., Ko, B., Yang, C., Lieu, E. L., Muhammad, N., Rhyne, S., Li, K., Haloul, M., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00316-0 · Cited by 143

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

Martins, R., Maier, J., Gorki, A.-D., Huber, K. V. M., Sharif, O., Starkl, P., Saluzzo, S., Quattrone, F., Gawish, R., Lakovits, K., et al. (2016) · Nature Immunology · doi:10.1038/ni.3590 · Cited by 142

LINE-1 protein localization and functional dynamics during the cell cycle

Mita, P., Wudzinska, A., Sun, X., Andrade, J., Nayak, S., Kahler, D. J., Badri, S., LaCava, J., Ueberheide, B., Yun, C. Y., et al. (2018) · eLife · doi:10.7554/elife.30058 · Cited by 142

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

Tong, X., Patel, A. S., Kim, E., Li, H., Chen, Y., Li, S., Liu, S., Dilly, J., Kapner, K. S., Zhang, N., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.01.012 · Cited by 142

Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2

Lee, C., Holder, M., Grau, D., Saldaña-Meyer, R., Yu, J.-R., Ganai, R. A., Zhang, J., Wang, M., LeRoy, G., Dobenecker, M., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.03.019 · Cited by 150

CRISPR/Cas9 technology as a potent molecular tool for gene therapy

Karimian, A., Azizian, K., Parsian, H., Rafieyan, S., Shafiei‐Irannejad, V., Kheyrollah, M., Yousefi, M., Majidinia, M., & Yousefi, B. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27972 · Cited by 148

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

Tang, M., Li, Z., Zhang, C., Lu, X., Tu, B., Cao, Z., Li, Y., Chen, Y., Jiang, L., Wang, H., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav1118 · Cited by 144

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation

Bhattacharya, K., Weidenauer, L., Luengo, T. M., Pieters, E. C., Echeverría, P. C., Bernasconi, L., Wider, D., Sadian, Y., Koopman, M. B., Villemin, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19783-w · Cited by 142

Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair

Mianné, J., Chessum, L., Kumar, S., Aguilar, C., Codner, G. F., Hutchison, M., Parker, A. J., Mallon, A., Wells, S. E., Simon, M. M., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0273-4 · Cited by 138

Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease

Wadhwani, A. R., Affaneh, A., Van Gulden, S., & Kessler, J. A. (2019) · Annals of Neurology · doi:10.1002/ana.25455 · Cited by 142

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

Banh, R. S., Iorio, C., Marcotte, R., Xu, Y., Cojocari, D., Rahman, A. M. A., Pawling, J., Zhang, W., Sinha, A., Rose, C. M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3376 · Cited by 136

An anti-CRISPR protein disables type V Cas12a by acetylation

Dong, L., Guan, X., Li, N., Zhang, F., Zhu, Y., Ren, K., Yu, L., Zhou, F., Han, Z., Gao, N., et al. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0206-1 · Cited by 141

Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells

Todd, C. D., Deniz, Ö., Taylor, D., & Branco, M. R. (2019) · eLife · doi:10.7554/elife.44344 · Cited by 148

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

Zhu, P., Wang, Y., Du, Y., He, L., Huang, G., Zhang, G., Yan, X., & Fan, Z. (2015) · Nature Communications · doi:10.1038/ncomms8122 · Cited by 141

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

Velde, R. V., Yoon, N., Marusyk, V., Durmaz, A., Dhawan, A., Miroshnychenko, D., Lozano‐Peral, D., Desai, B., Balynska, O. V., Poleszczuk, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16212-w · Cited by 141

Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue

Park, S.-J., Zhang, D., Qi, Y., Li, Y., Lee, K. Y., Bezzerides, V. J., Yang, P., Xia, S., Kim, S. L., Liu, X., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.039711 · Cited by 140

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

Heijink, A. M., Talens, F., Jae, L. T., van Gijn, S. E., Fehrmann, R. S. N., Brummelkamp, T. R., & van Vugt, M. A. T. M. (2019) · Nature Communications · doi:10.1038/s41467-018-07927-y · Cited by 140

SCAF4 and SCAF8, mRNA Anti-Terminator Proteins

Gregersen, L. H., Mitter, R., Ugalde, A. P., Nojima, T., Proudfoot, N. J., Agami, R., Stewart, A., & Svejstrup, J. Q. (2019) · Cell · doi:10.1016/j.cell.2019.04.038 · Cited by 140

CCT complex restricts neuropathogenic protein aggregation via autophagy

Tanasa, M. P., Imarisio, S., Menzies, F. M., Jiménez-Sánchez, M., Siddiqi, F. H., Wu, X., Renna, M., O’Kane, C. J., Crowther, D. C., & Rubinsztein, D. C. (2016) · Nature Communications · doi:10.1038/ncomms13821 · Cited by 141

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome

Yao, Z., Darowski, K. D., St‐Denis, N., Wong, V., Offensperger, F., Villedieu, A., Amin, S., Malty, R. H., Aoki, H., Guo, H., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.12.004 · Cited by 140

Dynamic nanoscale morphology of the ER surveyed by STED microscopy

Schroeder, L. K., Barentine, A. E. S., Merta, H., Schweighofer, S., Zhang, Y., Baddeley, D., Bewersdorf, J., & Bahmanyar, S. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201809107 · Cited by 140

BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

Hiepen, C., Jatzlau, J., Hildebrandt, S., Kampfrath, B., Goktas, M., Murgai, A., Cuellar‐Camacho, J. L., Haag, R., Ruppert, C., Sengle, G., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000557 · Cited by 148

Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment

Kregel, S., Wang, C., Han, X., Xiao, L., Fernández‐Salas, E., Bawa, P., McCollum, B. L., Wilder-Romans, K., Apel, I. J., Cao, X., et al. (2020) · Neoplasia · doi:10.1016/j.neo.2019.12.003 · Cited by 144

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA -deficient cells to PARP inhibitors

Fugger, K., Bajrami, I., dos Santos, M. S., Young, S. J., Kunzelmann, S., Kelly, G. P., Hewitt, G., Patel, H., Goldstone, R. J., Carell, T., et al. (2021) · Science · doi:10.1126/science.abb4542 · Cited by 141

A multi-omic single-cell landscape of human gynecologic malignancies

Regner, M. J., Wiśniewska, K., García‐Recio, S., Thennavan, A., Méndez-Giráldez, R., Malladi, V. S., Hawkins, G. M., Parker, J. S., Perou, C. M., Bae-Jump, V. L., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.10.013 · Cited by 144

The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family

Busch, B., Bley, N., Müller, S., Glaß, M., Misiak, D., Lederer, M., Vetter, M., Strauß, H., Thomssen, C., & Hüttelmaier, S. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw099 · Cited by 139

Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux

Vaites, L. P., Paulo, J. A., Huttlin, E. L., & Harper, J. W. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00392-17 · Cited by 120

DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling

Zheng, P., Chen, Q., Tian, X., Qian, N., Chai, P., Liu, B., Hu, J., Blackstone, C. D., Zhu, D., Teng, J., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0065-z · Cited by 144

AMPK contributes to autophagosome maturation and lysosomal fusion

Jang, M., Park, R., Kim, H.-J., Namkoong, S., Jo, D., Huh, Y. H., Jang, I., Lee, J. I., & Park, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-30977-7 · Cited by 143

Developmentally regulated Shh expression is robust to TAD perturbations

Williamson, I., Kane, L., Devenney, P. S., Flyamer, I. M., Anderson, E., Kilanowski, F. M., Hill, R. E., Bickmore, W. A., & Lettice, L. A. (2019) · Development · doi:10.1242/dev.179523 · Cited by 148

iPSC-Derived Hepatocytes as a Platform for Disease Modeling and Drug Discovery

Corbett, J., & Duncan, S. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00265 · Cited by 116

Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain

Zhang, X., Chen, L., Zhu, B., Wang, L., Chen, C., Hong, M., Huang, Y., Li, H., Han, H., Cai, B., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0518-8 · Cited by 141

Melanoma‐derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes

Leary, N., Walser, S., He, Y., Cousin, N., Pereira, P., Gallo, A., Collado‐Díaz, V., Halin, C., Garcı́a-Silva, S., Peinado, H., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12197 · Cited by 142

The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA

Xie, Y., Chai, P., Till, N. A., Hemberger, H., Lebedenko, C. G., Porat, J., Watkins, C. P., Caldwell, R. M., George, B. M., Perr, J., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.044 · Cited by 139

Comparative analysis of assays to measure CAR T cell-mediated cytotoxicity

Kiesgen, S., Messinger, J. C., Chintala, N. K., Tano, Z., & Adusumilli, P. S. (2021) · Nature Protocols · doi:10.1038/s41596-020-00467-0 · Cited by 138

Identifying Drug-Target Selectivity of Small-Molecule CRM1/XPO1 Inhibitors by CRISPR/Cas9 Genome Editing

Neggers, J. E., Vercruysse, T., Jacquemyn, M., Vanstreels, E., Baloglu, E., Shacham, S., Crochiere, M. L., Landesman, Y., & Daelemans, D. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.11.015 · Cited by 139

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies

Ding, X., Chaudhuri, A. R., Callén, E., Pang, Y., Biswas, K., Klarmann, K. D., Martin, B. K., Burkett, S. S., Cleveland, L., Stauffer, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12425 · Cited by 140

A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment

Zhao, X., Liu, L., Lang, J., Cheng, K., Wang, Y., Li, X., Shi, J. Y., Wang, Y., & Nie, G. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.042 · Cited by 139

GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease

Li, L., Tian, E., Chen, X., Chao, J., Klein, J. A., Qu, Q., Sun, G., Sun, G., Huang, Y., Warden, C., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.07.009 · Cited by 139

Determining cellular CTCF and cohesin abundances to constrain 3D genome models

Cattoglio, C., Pustova, I., Walther, N., Ho, J. J., Hantsche-Grininger, M., Inouye, C. J., Hossain, M. J., Dailey, G. M., Ellenberg, J., Darzacq, X., et al. (2019) · eLife · doi:10.7554/elife.40164 · Cited by 133

TTC5 mediates autoregulation of tubulin via mRNA degradation

Lin, Z., Gasic, I., Chandrasekaran, V., Peters, N., Shao, S., Mitchison, T. J., & Hegde, R. S. (2019) · Science · doi:10.1126/science.aaz4352 · Cited by 138

Partitioning of MLX-family transcription factors to lipid droplets regulates metabolic gene expression

Mejhert, N., Kuruvilla, L., Gabriel, K. R., Elliott, S. D., Guie, M.-A., Wang, H., Lai, Z. W., Lane, E. A., Christiano, R., Danial, N. N., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.01.014 · Cited by 121

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum

Preißler, S., Rato, C., Chen, R., Antrobus, R., Ding, S., Fearnley, I. M., & Ron, D. (2015) · eLife · doi:10.7554/elife.12621 · Cited by 134

The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia

Fernando, T. R., Contreras, J. R., Zampini, M., Rodriguez-Malave, N. I., Alberti, M. O., Anguiano, J., Tran, T. M., Palanichamy, J. K., Gajeton, J., Ung, N. M., et al. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0692-x · Cited by 141

Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells

Hung, K. L., Meitlis, I., Hale, M. R., Chen, C., Singh, S., Jackson, S. W., Miao, C. H., Khan, I., Rawlings, D. J., & James, R. G. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.11.012 · Cited by 140

Peroxisomes can oxidize medium‐ and long‐chain fatty acids through a pathway involving ABCD3 and HSD17B4

Violante, S. N., Achetib, N., van Roermund, C. W. T., Hagen, J., Dodatko, T., Vaz, F. M., Waterham, H. R., Chen, H., Baes, M. I., Yu, C., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201801498r · Cited by 139

Genetics, Mechanisms, and Therapeutic Progress in Polyglutamine Spinocerebellar Ataxias

Buijsen, R. A. M., Toonen, L. J. A., Gardiner, S. L., & van Roon‐Mom, W. (2019) · Neurotherapeutics · doi:10.1007/s13311-018-00696-y · Cited by 143

Microhomologies are prevalent at Cas9-induced larger deletions

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Loss-of-function variants of SETD5 cause intellectual disability and the core phenotype of microdeletion 3p25.3 syndrome

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