Genome engineering using the CRISPR-Cas9 system

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Items 301–400 of 1,090

1. Translation control of the immune checkpoint in cancer and its therapeutic targeting
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2. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism
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4. Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation
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5. A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response
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6. Species-specific segmentation clock periods are due to differential biochemical reaction speeds
   Matsuda, Mitsuhiro, Hayashi, Hanako, Garcia-Ojalvo, Jordi, Yoshioka-Kobayashi, Kumiko, Kageyama, Ryoichiro, Yamanaka, Yoshihiro, Ikeya, Makoto, Toguchida, Junya, Alev, Cantas, Ebisuya, Miki · 2020 · Science
7. Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
   Hu, Meiqin, Li, Ping, Wang, Ce, Feng, Xinghua, Geng, Qi, Chen, Wei, Marthi, Matangi, Zhang, Wenlong, Gao, Chenlang, Reid, Whitney et al. · 2022 · Cell
8. YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression
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9. EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer
   Katherine L. Morel, Anjali V. Sheahan, Deborah L. Burkhart, Sylvan C. Baca, Nadia Boufaied, Yin Liu, Xintao Qiu, Israel Cañadas, Kevin Roehle, Max Heckler et al. · 2021 · Nature Cancer
10. Genetically modified foods: A critical review of their promise and problems
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11. SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells
    Xuan Yang, Huogang Wang, Mingo M. H. Yung, Fushun Chen, Wai-Sun Chan, Yau-Sang Chan, Stephen Kwok‐Wing Tsui, Hys Ngan, Karen K. L. Chan, David W. Chan · 2022 · Theranostics
12. Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
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13. A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
    El Khattabi, Laila, Zhao, Haiyan, Kalchschmidt, Jens, Young, Natalie, Jung, Seolkyoung, Van Blerkom, Peter, Kieffer-Kwon, Philippe, Kieffer-Kwon, Kyong-Rim, Park, Solji, Wang, Xiang et al. · 2019 · Cell
14. CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells
    Yi-Li Min, Hui zi Li, Cristina Rodríguez-Caycedo, Alex A. Mireault, Jian Hua Huang, John Michael Shelton, John McAnally, Leonela Amoasii, Pradeep P.A. Mammen, Rhonda Bassel‐Duby et al. · 2019 · Science Advances
15. Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase
    He, Jiuya, Ford, Holly C., Carroll, Joe, Ding, Shujing, Fearnley, Ian M., Walker, John E. · 2017 · Proceedings of the National Academy of Sciences
16. Comprehensive review of CRISPR-based gene editing: Mechanisms, challenges, and applications in cancer therapy
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17. PTEN Counteracts FBXL2 to Promote IP3R3- and Ca2+-Mediated Apoptosis Limiting Tumour Growth
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18. Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery
    Rong Yu, Shaobo Jin, Urban Lendahl, Monica Nistér, Jian Zhao · 2019 · The EMBO Journal
19. Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis
    Delilah F. G. Hendriks, Jos F.H.M. Brouwers, Karien M. Hamer, Maarten H. Geurts, Léa Luciana, Simone Massalini, Carmen López‐Iglesias, Peter J. Peters, Maria J. Rodríguez Colman, Susana M. Chuva de Sousa Lopes et al. · 2023 · Nature Biotechnology
20. Pathophysiology of diabetic retinopathy: The old and the new
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21. LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
    Ruhma Syeda, Zhaozhu Qiu, Adrienne E. Dubin, Swetha E. Murthy, Maria Noelle Florendo, Daniel E. Mason, Jayanti Mathur, Stuart M. Cahalan, Eric C. Peters, Mauricio Montal et al. · 2016 · Cell
22. A molecular mechanism for Wnt ligand-specific signaling
    Marie Eubelen, Naguissa Bostaille, Pauline Cabochette, Anne Gauquier, Patricia Tebabi, Andra C. Dumitru, Melanie Koehler, Philipp Gut, David Alsteens, Didier Y. R. Stainier et al. · 2018 · Science
23. Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
    Marta N. Shahbazi, Antonio Scialdone, Natalia Skorupska, Antonia Weberling, Gaëlle Recher, Meng Zhu, Agnieszka Jędrusik, Liani Devito, Laila Noli, Iain C. Macaulay et al. · 2017 · Nature
24. Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing
    Francesco Chemello, Andreas C. Chai, Hui zi Li, Cristina Rodríguez-Caycedo, Efrain Sanchez‐Ortiz, Ayhan Atmanli, Alex A. Mireault, Ning Liu, Rhonda Bassel‐Duby, Eric N. Olson · 2021 · Science Advances
25. Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response
    Mackenzie, Karen J, Carroll, Paula, Lettice, Laura, Tarnauskaitė, Žygimantė, Reddy, Kaalak, Dix, Flora, Revuelta, Ailsa, Abbondati, Erika, Rigby, Rachel E, Rabe, Björn et al. · 2016 · The EMBO Journal
26. Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy
    Amoasii, Leonela, Long, Chengzu, Li, Hui, Mireault, Alex A., Shelton, John M., Sanchez-Ortiz, Efrain, McAnally, John R., Bhattacharyya, Samadrita, Schmidt, Florian, Grimm, Dirk et al. · 2017 · Science Translational Medicine
27. Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
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28. Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease
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29. Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human
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30. TP53 loss creates therapeutic vulnerability in colorectal cancer
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31. CRISPR Mediated Biosensing Toward Understanding Cellular Biology and Point‐of‐Care Diagnosis
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32. Regulation of appressorium development in pathogenic fungi
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33. Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM
    Alan S.L. Wong, Gigi C.G. Choi, Cheryl H. Cui, Gabriela Pregernig, Pamela Milani, Miriam Adam, Samuel David Perli, Samuel W. Kazer, Aleth Gaillard, Mario Hermann et al. · 2016 · Proceedings of the National Academy of Sciences
34. Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions
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35. Histone H3 globular domain acetylation identifies a new class of enhancers
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36. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration
    Franz Meitinger, John V. Anzola, Manuel Kaulich, Amelia Richardson, Joshua D. Stender, Christopher W. Benner, Christopher K. Glass, Steven F. Dowdy, Arshad B. Desai, Andrew K. Shiau et al. · 2016 · The Journal of Cell Biology
37. CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma
    Josephine B. Walton, Julianna Blagih, Darren P. Ennis, Elaine Y L Leung, Suzanne Dowson, Malcolm Farquharson, Laura A. Tookman, Clare Orange, Dimitris Athineos, Susan M. Mason et al. · 2016 · Cancer Research
38. CDK9-dependent RNA polymerase II pausing controls transcription initiation
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39. Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells
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40. Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas
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41. Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens
    Papalexi, Efthymia, Mimitou, Eleni P., Butler, Andrew W., Foster, Samantha, Bracken, Bernadette, Mauck, William M., Wessels, Hans-Hermann, Hao, Yuhan, Yeung, Bertrand Z., Smibert, Peter et al. · 2021 · Nature Genetics
42. DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes
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43. Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair
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44. Enzymatic processing of lignocellulosic biomass: principles, recent advances and perspectives
    Heidi Østby, Line Degn Hansen, Svein Jarle Horn, Vincent G. H. Eijsink, Anikó Várnai · 2020 · Journal of Industrial Microbiology & Biotechnology
45. Prime editing for functional repair in patient-derived disease models
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46. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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47. Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations
    de Wispelaere, Mélissanne, Du, Guangyan, Donovan, Katherine A., Zhang, Tinghu, Eleuteri, Nicholas A., Yuan, Jingting C., Kalabathula, Joann, Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S. et al. · 2019 · Nature Communications
48. Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer
    Wan‐Xin Peng, Jianguo Huang, Liu Yang, Aihua Gong, Yin‐Yuan Mo · 2017 · Molecular Cancer
49. Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system
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50. CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing
    Jonas Dehairs, Ali Talebi, Yacine Chérifi, Johannes V. Swinnen · 2016 · Scientific Reports
51. SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation
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52. Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA
    Yasuyuki Hosono, Yashar S. Niknafs, John R. Prensner, Matthew K. Iyer, Saravana Mohan Dhanasekaran, Rohit Mehra, Sethuramasundaram Pitchiaya, Jean Ching-Yi Tien, June F Escara-Wilke, Anton Poliakov et al. · 2017 · Cell
53. Heterotypic CAF-tumor spheroids promote early peritoneal metastasis of ovarian cancer
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54. RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops
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55. Propionibacterium spp.—source of propionic acid, vitamin B12, and other metabolites important for the industry
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56. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
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57. Human GBP1 is a microbe‐specific gatekeeper of macrophage apoptosis and pyroptosis
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58. Mutations in a translation initiation factor identify the target of a memory-enhancing compound
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59. iPS cell technologies: significance and applications to CNS regeneration and disease
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60. Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism
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61. NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation
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62. Glutamine and asparagine activate mTORC1 independently of Rag GTPases
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63. Lipid availability determines fate of skeletal progenitor cells via SOX9
    Nick van Gastel, Steve Stegen, Guy Eelen, Sandra Schoors, Aurélie Carlier, Veerle W. Daniëls, Ninib Baryawno, Dariusz Przybylski, Maarten Depypere, Pieter‐Jan Stiers et al. · 2020 · Nature
64. Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance
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65. Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein
    Richter-Dennerlein, Ricarda, Oeljeklaus, Silke, Lorenzi, Isotta, Ronsör, Christin, Bareth, Bettina, Schendzielorz, Alexander Benjamin, Wang, Cong, Warscheid, Bettina, Rehling, Peter, Dennerlein, Sven · 2016 · Cell
66. Transcription shapes 3D chromatin organization by interacting with loop extrusion
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67. Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons
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68. Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects
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69. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes
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70. Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology
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71. Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy
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72. High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells
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73. Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses
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74. Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives
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75. Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa
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76. Targeted mutagenesis using CRISPR/Cas system in medaka
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77. Arsenic Transport in Rice and Biological Solutions to Reduce Arsenic Risk from Rice
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78. LDAF1 and Seipin Form a Lipid Droplet Assembly Complex
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79. TCF/LEF dependent and independent transcriptional regulation of Wnt/β‐catenin target genes
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80. In vivo base editing of post-mitotic sensory cells
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81. Chromatin accessibility and guide sequence secondary structure affect CRISPR ‐Cas9 gene editing efficiency
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82. Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis
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83. GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
    Nitish Rana, Giuseppe Privitera, Hannah C. Kondolf, Katarzyna Bulek, Susana Lechuga, Carlo De Salvo, Daniele Corridoni, Agne Antanaviciute, Rebecca L. Maywald, Alexander M. Hurtado et al. · 2022 · Cell
84. A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer
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85. Untangling Genetic Risk for Alzheimer’s Disease
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86. Cardiovascular disease models: A game changing paradigm in drug discovery and screening
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87. Synthesizing AND gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells
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88. Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles
    Ying‐Li Luo, Cong‐Fei Xu, Hongjun Li, Zhiting Cao, Jing Liu, Jilong Wang, Xiao‐Jiao Du, Xianzhu Yang, Zhen Gu, Jun Wang · 2018 · ACS Nano
89. CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells
    Hoban, Megan D, Lumaquin, Dianne, Kuo, Caroline Y, Romero, Zulema, Long, Joseph, Ho, Michelle, Young, Courtney S, Mojadidi, Michelle, Fitz-Gibbon, Sorel, Cooper, Aaron R et al. · 2016 · Molecular Therapy
90. The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs
    Aitor Garzia, Seyed Mehdi Jafarnejad, Cindy Meyer, Clément Chapat, Tasos Gogakos, Pavel S Morozov, Mehdi Amiri, Maayan Shapiro, Henrik Molina, Thomas Tuschl et al. · 2017 · Nature Communications
91. Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact
    Veijo T. Salo, Shiqian Li, Helena Vihinen, Maarit Hölttä‐Vuori, Ábel Szkalisity, Péter Horváth, Ilya N Belevich, Johan Peränen, Christoph Thiele, Pentti J. Somerharju et al. · 2019 · Developmental Cell
92. Bioengineering Approaches for the Advanced Organoid Research
    Yi, Sang Ah, Zhang, Yixiao, Rathnam, Christopher, Pongkulapa, Thanapat, Lee, Ki‐Bum · 2021 · Advanced Materials
93. Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids
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94. An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting
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95. Transgenic Mouse Models in Cancer Research
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96. Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras G12D in pancreatic cancer
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97. Mechanical cell competition kills cells via induction of lethal p53 levels
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