Genome engineering using the CRISPR-Cas9 system

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Items 801–900 of 1,083

1. MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer
   Sylwia Gawrzak, Lorenzo Rinaldi, Sara Gregorio, Enrique Javier Arenas, Fernando Salvador, Jelena Urosevic, Cristina Figueras-Puig, Federico Rojo, Iván del Barco Barrantes, Juan Miguel Cejalvo et al. · 2018 · Nature Cell Biology
2. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
   Julia K Götzl, Matthias Brendel, Georg Werner, Samira Parhizkar, Laura Sebastián Monasor, Gernot Kleinberger, Alessio-Vittorio Colombo, Maximilian Deußing, Matias Wagner, Juliane Winkelmann et al. · 2019 · EMBO Molecular Medicine
3. How to Choose the Right Inducible Gene Expression System for Mammalian Studies?
   Tuula Kallunki, Marin Barišić, Marja Jäättelä, Bin Liu · 2019 · Cells
4. A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR
   Hongmei Liu, Yuxin Xu, Bing Yao, Tingting Sui, Liangxue Lai, Zhanjun Li · 2020 · Cell Death and Disease
5. Exploring the human lacrimal gland using organoids and single-cell sequencing
   Marie Bannier-Hélaouët, Yorick Post, Jeroen Korving, Marc Trani Bustos, Helmuth Gehart, Harry Begthel, Yotam E. Bar‐Ephraïm, Jelte van der Vaart, Rachel Kalmann, Saskia M. Imhoff et al. · 2021 · Cell stem cell
6. PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress
   Ranek, Mark J., Kokkonen-Simon, Kristen M., Chen, Anna, Dunkerly-Eyring, Brittany L., Vera, Miguel Pinilla, Oeing, Christian U., Patel, Chirag H., Nakamura, Taishi, Zhu, Guangshuo, Bedja, Djahida et al. · 2019 · Nature
7. DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune cell activation
   Xiao, Qian, Wu, Jibo, Wang, Wei-Jia, Chen, Shiyang, Zheng, Yingxia, Yu, Xiaoqing, Meeth, Katrina, Sahraei, Mahnaz, Bothwell, Alfred L M, Chen, Lieping et al. · 2018 · Nature Medicine
8. A secretory kinase complex regulates extracellular protein phosphorylation
   Jixin Cui, Junyu Xiao, Vincent S. Tagliabracci, Jianzhong Wen, Meghdad Rahdar, Jack E. Dixon · 2015 · eLife
9. “Off-Spotter”: very fast and exhaustive enumeration of genomic lookalikes for designing CRISPR/Cas guide RNAs
   Venetia Pliatsika, Isidore Rigoutsos · 2015 · Biology Direct
10. Recent Advances in Genome Editing Using CRISPR/Cas9
    Yuduan Ding, Hong Li, Ling‐Ling Chen, Kabin Xie · 2016 · Frontiers in Plant Science
11. Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis
    Tamsin R.M. Lannagan, Young K Lee, Tongtong Wang, Jatin Roper, Mark L. Bettington, Lochlan Fennell, Laura Vrbanac, Lisa Jonavicius, Roshini Somashekar, Krystyna A. Gieniec et al. · 2018 · Gut
12. The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression
    Cindy Meyer, Aitor Garzia, Michael C. Mazzola, Stefanie C. Gerstberger, Henrik Molina, Thomas Tuschl · 2018 · Molecular Cell
13. Structure of the human volume regulated anion channel
    Jennifer M. Kefauver, Kei Saotome, Adrienne E. Dubin, Jesper Pallesen, Christopher A. Cottrell, Stuart M. Cahalan, Zhaozhu Qiu, Gunhee Hong, Christopher S. Crowley, Tess Whitwam et al. · 2018 · eLife
14. Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models
    Isabel Y. Buchsbaum, Silvia Cappello · 2019 · Development
15. Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons
    Daniel del Toro, Maria Carrasquero, Amy Chu, Tobias Ruff, Meriam Shahin, Verity A. Jackson, Matthieu G. Chavent, Miguel Berbeira-Santana, Goenuel Seyit-Bremer, Sara Brignani et al. · 2020 · Cell
16. CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection
    Sean Chen, Sabrina Sun, Dewi P. I. Moonen, Clancy Lee, Angus Yiu-Fai Lee, David V. Schaffer, Lin He · 2019 · Cell Reports
17. Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
    Fansen Meng, Zhengyang Yu, Dan Zhang, Shasha Chen, Hongxin Guan, Ruyuan Zhou, Qirou Wu, Qian Yun Zhang, Shengduo Liu, Mukesh Kumar Venkat Ramani et al. · 2021 · Molecular Cell
18. Manipulating mitochondrial electron flow enhances tumor immunogenicity
    Kailash Chandra Mangalhara, Siva Karthik Varanasi, Melissa A. Johnson, Mannix J. Burns, Gladys R. Rojas, Pau B. Esparza‐Moltó, Alva G. Sainz, Nimesha Tadepalle, Keene L. Abbott, Gaurav Mendiratta et al. · 2023 · Science
19. Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context
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20. Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells
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21. Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene
    Genshiro A. Sunagawa, Kenta Sumiyama, Maki Ukai‐Tadenuma, Dimitri Perrin, Hiroshi Fujishima, Hideki Ukai, Osamu Nishimura, Shoi Shi, Rei-ichiro Ohno, Ryohei Narumi et al. · 2016 · Cell Reports
22. The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage
    Hafida Sellou, Théo Lebeaupin, Catherine Chapuis, Rebecca Smith, Anna Hegele, H. R. Singh, M. Kozłowski, Sebastian Bultmann, A. Ladurner, G. Timinszky et al. · 2016 · Molecular Biology of the Cell
23. CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog
    Ganesh Varma Pusapati, Jennifer H. Kong, Bhaven B. Patel, Arunkumar Krishnan, Andreas Sagner, Maia Kinnebrew, James Briscoe, Lakshminarayanan Aravind, Rajat Rohatgi · 2017 · Developmental Cell
24. Cryo-EM structures of the human volume-regulated anion channel LRRC8
    Go Kasuya, Takanori Nakane, Takeshi Yokoyama, Yanyan Jia, Masato Inoue, Kengo Watanabe, Ryoki Nakamura, Tomohiro Nishizawa, Tsukasa Kusakizako, Akihisa Tsutsumi et al. · 2018 · Nature Structural & Molecular Biology
25. Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase
    Joe Carroll, Jiuya He, Shujing Ding, Ian M. Fearnley, John E. Walker · 2019 · Proceedings of the National Academy of Sciences
26. Type I IFN protects cancer cells from CD8+ T cell–mediated cytotoxicity after radiation
    Jianzhou Chen, Yunhong Cao, Boštjan Markelc, Jakob Kaeppler, Jenny A. F. Vermeer, Ruth J. Muschel · 2019 · Journal of Clinical Investigation
27. A shared transcriptional code orchestrates temporal patterning of the central nervous system
    Andreas Sagner, Isabel Zhang, Thomas Watson, Jorge Lázaro, Manuela Melchionda, James Briscoe · 2021 · PLoS Biology
28. Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants
    Zhang, Siwei, Zhang, Hanwen, Zhou, Yifan, Qiao, Min, Zhao, Siming, Kozlova, Alena, Shi, Jianxin, Sanders, Alan R., Wang, Gao, Luo, Kaixuan et al. · 2020 · Science
29. Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells
    Alison E. Mungenast, Sandra Siegert, Li‐Huei Tsai · 2015 · Molecular and Cellular Neuroscience
30. Gene editing for cell engineering: trends and applications
    Sanjeev Kumar Gupta, Pratyoosh Shukla · 2016 · Critical Reviews in Biotechnology
31. Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery
    Serena Gea Giannelli, Mirko Luoni, Valerio Castoldi, Luca Massimino, Tommaso Cabassi, Debora Angeloni, Gian Carlo Demontis, Letizia Leocani, Massimiliano Andreazzoli, Vania Broccoli · 2017 · Human Molecular Genetics
32. CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions
    Judd F. Hultquist, Joseph B Hiatt, Kathrin Schumann, Michael McGregor, Theodore L. Roth, Paige Haas, Jennifer A. Doudna, Alexander Marson, Nevan J. Krogan · 2018 · Nature Protocols
33. USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability
    Maura Sonego, Ilenia Pellarin, Alice Costa, Gian Luca Rampioni Vinciguerra, Michela Coan, Alexandra Kraut, Sara D’Andrea, Alessandra Dall’Acqua, Dan Cacsire Castillo‐Tong, Daniela Califano et al. · 2019 · Science Advances
34. Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole
    Aisha Yesbolatova, Toyoaki Natsume, Ken‐ichiro Hayashi, Masato T. Kanemaki · 2019 · Methods
35. Multiplexed profiling facilitates robust m6A quantification at site, gene and sample resolution
    David Dierks, Miguel Angel García-Campos, Anna Uzonyi, Modi Safra, Sarit Edelheit, Alice Rossi, Theodora C. Sideri, Radhika A. Varier, Alexander S. Brandis, Yonatan Stelzer et al. · 2021 · Nature Methods
36. Reconstruction and deconstruction of human somitogenesis in vitro
    Yuchuan Miao, Yannis Djeffal, Alessandro De Simone, Kongju Zhu, Jong Gwan Lee, Ziqi Lu, Andrew Silberfeld, Jyoti Rao, Oscar A. Tarazona, Alessandro Mongera et al. · 2022 · Nature
37. Highly efficient CRISPR/Cas9-mediated TAR cloning of genes and chromosomal loci from complex genomes in yeast
    Nathan Lee, Vladimir Larionov, Natalay Kouprina · 2015 · Nucleic Acids Research
38. Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1)
    Hongjae Sunwoo, David Colognori, John E. Froberg, Yesu Jeon, Jeannie T. Lee · 2017 · Proceedings of the National Academy of Sciences
39. A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay
    Timon Seeger, Rajani Shrestha, Chi Keung Lam, Caressa S. Chen, Wesley L. McKeithan, Edward Lau, Alexa N. Wnorowski, George McMullen, Matthew Greenhaw, Jaecheol Lee et al. · 2019 · Circulation
40. Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability
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41. SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC
    Qingzhu Gao, Guiji Zhang, Yaqiu Zheng, Yi Yang, Chen Chang, Jie Lai Xia, Li Liang, Chong Lei, Yuan Hu, Xue-Fei Cai et al. · 2019 · Cell Death and Differentiation
42. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney
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43. The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation
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44. Clinical delivery of circular RNA: Lessons learned from RNA drug development
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45. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes
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46. Comprehensive, integrated, and phased whole-genome analysis of the primary ENCODE cell line K562
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47. Afatinib restrains K-RAS–driven lung tumorigenesis
    Moll, Herwig P., Pranz, Klemens, Musteanu, Monica, Grabner, Beatrice, Hruschka, Natascha, Mohrherr, Julian, Aigner, Petra, Stiedl, Patricia, Brcic, Luka, Laszlo, Viktoria et al. · 2018 · Science Translational Medicine
48. Drosophila melanogaster Oogenesis: An Overview
    John M. McLaughlin, Diana P. Bratu · 2015 · Methods in molecular biology
49. ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins
    Anna Caballe, Dawn M. Wenzel, Monica Agromayor, Steven L. Alam, Jack J. Skalicky, Magdalena Kloc, Jeremy Graham Carlton, Leticia Labrador, Wesley I. Sundquist, Juan Martin‐Serrano · 2015 · eLife
50. AAV-mediated CRISPR/cas gene editing of retinal cells in vivo
    Hung, Sandy S. C., Chrysostomou, Vicki, Li, Fan, Lim, Jeremiah K. H., Wang, Jiang-Hui, Powell, Joseph E., Tu, Leilei, Daniszewski, Maciej, Lo, Camden, Wong, Raymond C. et al. · 2016 · Investigative Opthalmology & Visual Science
51. Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis
    Yoshiko Kubota, Kazumi Nomura, Yasutake Katoh, Rina Yamashita, Kiriko Kaneko, Kazumichi Furuyama · 2016 · Journal of Biological Chemistry
52. IRE1α–XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain
    Sahil Chopra, Paolo Giovanelli, Perla Abigail Alvarado-Vazquez, Sara Alonso, Minkyung Song, Tito Alejandro Sandoval, Chang-Suk Chae, Chen Tan, Miriam M. Fonseca, Silvia Gutierrez et al. · 2019 · Science
53. Aptamer assisted CRISPR-Cas12a strategy for small molecule diagnostics
    Chenqi Niu, Chuyi Wang, Fan Li, Xiang Zheng, Xin‐Hui Xing, Chong Zhang · 2021 · Biosensors and Bioelectronics
54. APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation
    Laurie Arnaud, Philippe Benech, Louise Greetham, Delphine Stephan, Angélique Jimenez, Nicolas Jullien, Laura García‐González, Philipp O. Tsvetkov, François Devred, Ignacio Sancho-Martinez et al. · 2022 · Cell Reports
55. CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting
    David Courtney, Jonathan Edward Moore, Sarah D. Atkinson, Eleonora Maurizi, Edwin H. A. Allen, Deena M. Leslie Pedrioli, W.H. Irwin McLean, M. Andrew Nesbit, Tara Moore · 2015 · Gene Therapy
56. Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase
    Eric Aeby, Wareed Ahmed, Sophie Redon, Viesturs Simanis, Joachim Lingner · 2016 · Cell Reports
57. Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency
    Jorik M. van Rijn, Rico Chandra Ardy, Zarife Kuloğlu, Bettina Härter, Désirée Y. van Haaften–Visser, Hubert P. J. van der Doef, Marliek van Hoesel, Aydan Kansu, Anke H.M. van Vugt, Marini Thian et al. · 2018 · Gastroenterology
58. CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning
    Suvi Jain, Zhaoqing Ba, Yu Zhang, Hai‐Qiang Dai, Frederick W. Alt · 2018 · Cell
59. ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets
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60. CTCF-mediated chromatin looping provides a topological framework for the formation of phase-separated transcriptional condensates
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61. BRD4 promotes gastric cancer progression and metastasis through acetylation-dependent stabilization of Snail
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62. Drusen in patient-derived hiPSC-RPE models of macular dystrophies
    Galloway, Chad A., Dalvi, Sonal, Hung, Sandy S. C., MacDonald, Leslie A., Latchney, Lisa R., Wong, Raymond C. B., Guymer, Robyn H., Mackey, David A., Williams, David S., Chung, Mina M. et al. · 2017 · Proceedings of the National Academy of Sciences
63. PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis
    Christian Friberg Nielsen, Diana Huttner, Anna H. Bizard, Seiki Hirano, Tian‐Neng Li, Timea Palmai‐Pallag, Victoria Alexandra Bjerregaard, Ying Liu, Erich A. Nigg, Lily Hui-Ching Wang et al. · 2015 · Nature Communications
64. Significance of optineurin mutations in glaucoma and other diseases
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65. Reactivation of FMR1 by CRISPR/Cas9-Mediated Deletion of the Expanded CGG-Repeat of the Fragile X Chromosome
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66. Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve
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67. In utero gene editing for monogenic lung disease
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68. Immunosuppression by Mutated Calreticulin Released from Malignant Cells
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69. Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology
    Chen Ning Zhao, Anna‐Claire Devlin, Amit K. Chouhan, Bhuvaneish Thangaraj Selvaraj, Maria Stavrou, Karen Burr, Veronica Brivio, Xin He, Arpan R. Mehta, David Story et al. · 2019 · Glia
70. Type I interferon signaling mediates Mycobacterium tuberculosis –induced macrophage death
    Li Zhang, Xiuju Jiang, Daniel J. Pfau, Yan Ling, Carl Nathan · 2020 · The Journal of Experimental Medicine
71. BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states
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72. Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage
    Kai Cao, Joel S. Riley, Rosalie Heilig, Alfredo E. Montes-Gómez, Esmee Vringer, Kévin Berthenet, Catherine Cloix, Yassmin Elmasry, David G. Spiller, Gabriel Ichim et al. · 2022 · Developmental Cell
73. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses
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74. Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing
    Ciaran M. Lee, Thomas James Cradick, Eli J. Fine, Gang Bao · 2016 · Molecular Therapy
75. GONAD: Genome-editing via Oviductal Nucleic Acids Delivery system: a novel microinjection independent genome engineering method in mice
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76. AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells
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77. A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release
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78. Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis
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79. CRISPR/dCas9-Based Systems: Mechanisms and Applications in Plant Sciences
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80. Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy
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81. Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression
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82. CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells
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83. Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells
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84. Therapeutic gene editing: delivery and regulatory perspectives
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85. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors.
    Jingjing Gan, Y. Dou, Yu-Rong Li, Zhen-Zhen Wang, Lintao Wang, Shang Liu, Qiu Li, Heran Yu, Chunyan Liu, Congwei Han et al. · 2018 · Biomaterials
86. Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy
    Maksymilian Prondzynski, Marc Daniel Lemoine, Antonia T.L. Zech, András Horváth, Vittoria Di Mauro, Jussi T. Koivumäki, Nico Kresin, Josefine Busch, Tobias Krause, Elisabeth Krämer et al. · 2019 · EMBO Molecular Medicine
87. ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation
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88. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme
    Sui, Xuewu, Wang, Kun, Gluchowski, Nina L., Elliott, Shane D., Liao, Maofu, Walther, Tobias C., Farese, Robert V. · 2020 · Nature
89. Telomeric RNAs are essential to maintain telomeres
    Juán José Montero, Isabel López de Silanes, Osvaldo Graña‐Castro, Marı́a A. Blasco · 2016 · Nature Communications
90. ACBD5 deficiency causes a defect in peroxisomal very long-chain fatty acid metabolism
    Ferdinandusse, Sacha, Falkenberg, Kim D, Koster, Janet, Mooyer, Petra A, Jones, Richard, van Roermund, Carlo W T, Pizzino, Amy, Schrader, Michael, Wanders, Ronald J A, Vanderver, Adeline et al. · 2017 · Journal of Medical Genetics
91. MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells
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92. GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells
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93. Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci
    Marc P. Forrest, Hanwen Zhang, Winton Moy, Heather McGowan, Catherine Leites, Leonardo E. Dionisio, Zihui Xu, Jianxin Shi, Alan R. Sanders, William James Greenleaf et al. · 2017 · Cell stem cell
94. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
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95. Unravelling Plant Responses to Stress—The Importance of Targeted and Untargeted Metabolomics
    James William Allwood, Alex Williams, Henriette Uthe, Nicole M. van Dam, Luis A. J. Mur, Murray Grant, Pierre Pétriacq · 2021 · Metabolites
96. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth
    Minghui Cao, Roi Isaac, Wei Yan, Xianhui Ruan, Li Jiang, Yuhao Wan, Jessica Wang, Emily Wang, Christine Caron, S Neben et al. · 2022 · Nature Cell Biology
97. ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
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