Cancer and the chemokine network

Inflammation and cancer

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Stem cells, cancer, and cancer stem cells

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Inflammation and cancer: back to Virchow?

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International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

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Involvement of chemokine receptors in breast cancer metastasis

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Chemokines

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Tumour-educated macrophages promote tumour progression and metastasis

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Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

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A multigenic program mediating breast cancer metastasis to bone

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Suppression of neuroblastoma growth by dipeptidyl peptidase IV: relevance of chemokine regulation and caspase activation

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Stabilization of perturbed Boolean network attractors through compensatory interactions

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Molecular immunological approaches to biotherapy of human cancers--a review, hypothesis and implications.

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CCL 2 as a potential therapeutic target for clear cell renal cell carcinoma

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Cancer microenvironment, inflammation and cancer stem cells: A hypothesis for a paradigm change and new targets in cancer control

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Ionizing radiation augments glioma tropism of mesenchymal stem cells

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Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis

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Tumor Response to Combination Celecoxib and Erlotinib Therapy in Non-small Cell Lung Cancer Is Associated with a Low Baseline Matrix Metalloproteinase-9 and a Decline in Serum-Soluble E-Cadherin

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G‐protein‐coupled receptors and melanoma

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Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer

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The role of CXC chemokines and their receptors in the progression and treatment of tumors

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ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling

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−251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case–control studies

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Notch1 regulates chemotaxis and proliferation by controlling the CC‐chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia

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Expression and function of the chemokine receptor CCR7 in thyroid carcinomas

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CXCR4 antagonists suppress small cell lung cancer progression

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CXCL5 Facilitates Melanoma Cell–Neutrophil Interaction and Lymph Node Metastasis

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Evaluation of the cytotoxic properties, gene expression profiles and secondary signalling responses of cultured cells exposed to fumonisin B1, deoxynivalenol and zearalenone mycotoxins

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Tumor-associated macrophage (TAM)-derived CCL22 induces FAK addiction in esophageal squamous cell carcinoma (ESCC)

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Lung adenocarcinoma invasion in TGFβRII-deficient cells is mediated by CCL5/RANTES

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Mechanisms regulating colorectal cancer cell metastasis into liver (Review)

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GPR56 and TG2: Possible Roles in Suppression of Tumor Growth by the Microenvironment

Xu, L., & Hynes, R. O. (2007) · Cell Cycle · doi:10.4161/cc.6.2.3760 · Cited by 62

The Chemokine Receptor CXCR4 Strongly Promotes Neuroblastoma Primary Tumour and Metastatic Growth, but not Invasion

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CXCR4/CXCL12 in Non-Small-Cell Lung Cancer Metastasis to the Brain

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Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies

Peng, S.-B., Zhang, X., Paul, D. C., Kays, L. M., Ye, M., Vaillancourt, P., Dowless, M. S., Stancato, L. F., Stewart, J. A., Uhlik, M. T., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150585 · Cited by 62

Chemokine-Enhanced Chemotaxis of Lymphangioleiomyomatosis Cells with Mutations in the Tumor Suppressor TSC2 Gene

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Chemokine Receptor CXCR4 Enhances Proliferation in Pancreatic Cancer Cells Through AKT and ERK Dependent Pathways

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CXCL13 Is Highly Produced by Sezary Cells and Enhances Their Migratory Ability via a Synergistic Mechanism Involving CCL19 and CCL21 Chemokines

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Introduction of Functional Groups into Peptides via N-Alkylation

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Transforming growth factor-β1 upregulates the expression of CXC chemokine receptor 4 (CXCR4) in human breast cancer MCF-7 cells

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Oncogenic roles and drug target of CXCR4/CXCL12 axis in lung cancer and cancer stem cell

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NF-κB signaling regulates cell-autonomous regulation of CXCL10 in breast cancer 4T1 cells

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Colon-specific microspheres loaded with puerarin reduce tumorigenesis and metastasis in colitis-associated colorectal cancer

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The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance

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Inflammatory cell-associated tumors. Not only macrophages (TAMs), fibroblasts (TAFs) and neutrophils (TANs) can infiltrate the tumor microenvironment. The unique role of tumor associated platelets (TAPs)

Dymicka-Piekarska, V., Koper‐Lenkiewicz, O. M., Dorf, J., Kratz, E. M., & Kamińska, J. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02758-7 · Cited by 59

Endothelial CXCR7 regulates breast cancer metastasis

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Influence of transforming growth factor-β1 and tumor necrosis factor-α genes polymorphisms on the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis C patients

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PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression

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Protective Effects of Mastic Oil FromPistacia LentiscusVariationChiaAgainst Experimental Growth of Lewis Lung Carcinoma

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Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation

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Host-Derived MCP-1 and MIP-1α Regulate Protective Anti-Tumor Immunity to Localized and Metastatic B16 Melanoma

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Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma

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Inhibition of stromal CXCR4 impairs development of lung metastases

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Macrophages: Key orchestrators of a tumor microenvironment defined by therapeutic resistance

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Role of bile acids in liver diseases mediated by the gut microbiome

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The Chemokine Network in Acute Myelogenous Leukemia: Molecular Mechanisms Involved in Leukemogenesis and Therapeutic Implications

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Chemokines, Costimulatory Molecules and Fusion Proteins for the Immunotherapy of Solid Tumors

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Small interfering RNA‐mediated CXCR1 or CXCR2 knock‐down inhibits melanoma tumor growth and invasion

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High tumor necrosis factor-α/interleukin-10 ratio is associated with hepatocellular carcinoma in patients with chronic hepatitis C

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Activation of Thromboxane A2 Receptor (TP) Increases the Expression of Monocyte Chemoattractant Protein -1 (MCP-1)/Chemokine (C-C motif) Ligand 2 (CCL2) and Recruits Macrophages to Promote Invasion of Lung Cancer Cells

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RACK1 Regulates Directional Cell Migration by Acting on Gβγ at the Interface with Its Effectors PLCβ and PI3Kγ

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Targeting CXCR1/CXCR2 receptor antagonism in malignant melanoma

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Oncolysis by paramyxoviruses: multiple mechanisms contribute to therapeutic efficiency

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Docking Studies for Multi-Target Drugs

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Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression

Rovito, D., Gionfriddo, G., Barone, I., Giordano, C., Grande, F., Amicis, F. D., Lanzino, M., Catalano, S., Andò, S., & Bonofiglio, D. (2016) · Oncotarget · doi:10.18632/oncotarget.11371 · Cited by 58

Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Gα13/RhoA-mediated Migration

Scarlett, K. A., White, E. Z., Coke, C. J., Carter, J. R., Bryant, L. K., & Hinton, C. V. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0481 · Cited by 58

The current status of anti-GPCR drugs against different cancers

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CCL22 Signaling in the Tumor Environment

Röhrle, N., Knott, M. M. L., & Anz, D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-36667-4_8 · Cited by 62

Pharmacological modulation of monocytes and macrophages

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Tumor inhibition or tumor promotion? The duplicity of CXCR3 in cancer

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Therapeutic Potential of Targeting SK1 in Human Cancers

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The immune response in cancer: from immunology to pathology to immunotherapy

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The Expression of Monocyte Chemotactic Protein-1 in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Tumor Recurrence

Tanaka, K., Kurebayashi, J., Sohda, M., Nomura, T., Prabhakar, U., Li, Y., & Sonoo, H. (2008) · Thyroid · doi:10.1089/thy.2008.0237 · Cited by 57

Targeting of the Akt-Nuclear Factor-κB Signaling Network by [1-(4-Chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a Novel Indole-3-Carbinol Derivative, in a Mouse Model of Hepatocellular Carcinoma

Omar, H. A., Sargeant, A. M., Weng, J., Wang, D.-S., Kulp, S. K., Patel, T. C., & Chen, C. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058180 · Cited by 57

Microenvironmental Regulation of Chemokine (C-X-C-Motif) Receptor 4 in Ovarian Carcinoma

Barbolina, M. V., Kim, M., Liu, Y., Shepard, J. A., Belmadani, A. A., Miller, R. J., Shea, L. D., & Stack, M. S. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0463 · Cited by 57

Predictive role of serum and urinary cytokines in invasion and recurrence of bladder cancer

Kumari, N., Agrawal, U., Mishra, A. K., Kumar, A., Vasudeva, P., Mohanty, N. K., & Saxena, S. (2017) · Tumor Biology · doi:10.1177/1010428317697552 · Cited by 57

Inflammatory cytokines are associated with response and prognosis in patients with esophageal cancer

Blank, S., Nienhüser, H., Dreikhausen, L., Sisic, L., Heger, U., Ott, K., & Schmidt, T. (2017) · Oncotarget · doi:10.18632/oncotarget.17671 · Cited by 57

Crosstalk between stromal components and tumor cells of TNBC via secreted factors enhances tumor growth and metastasis

Jin, K., Pandey, N. B., & Popel, A. S. (2017) · Oncotarget · doi:10.18632/oncotarget.19417 · Cited by 55

Overexpression of CXCL2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma

Ding, J., Xu, K., Zhang, J., Lin, B., Wang, Y., Yin, S., Xie, H., Zhou, L., & Zheng, S. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.12.140 · Cited by 57

CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration

Zhang, R., Liu, Q., Peng, J., Wang, M., Li, T., Liu, J., Cui, M., Zhang, X., Gao, X., Liao, Q., et al. (2020) · Journal of Cancer · doi:10.7150/jca.40517 · Cited by 57

CXCR5 may be involved in the attraction of human metastatic neuroblastoma cells to the bone marrow

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Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma

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Low expression of MicroRNA‐126 is associated with poor prognosis in colorectal cancer

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AMD3100 reduces CXCR4-mediated survival and metastasis of osteosarcoma by inhibiting JNK and Akt, but not p38 or Erk1/2, pathways in in vitro and mouse experiments

Liao, Y., Fu, Z., Zhou, C., Shan, L., Wang, Z., YIN, F., Zheng, L., Hua, Y., & CAI, Z.-D. (2015) · Oncology Reports · doi:10.3892/or.2015.3992 · Cited by 57

CXCR4 Mediated Chemotaxis Is Regulated by 5T4 Oncofetal Glycoprotein in Mouse Embryonic Cells

Southgate, T. D., McGinn, O. J., Castro, F., Rutkowski, A. J., Al-Muftah, M., Marinov, G., Smethurst, G. J., Shaw, D. M., Ward, C. M., Miller, C. J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009982 · Cited by 56

Mogamulizumab and the Treatment of Ccr4-Positive T-Cell Lymphomas

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