Cancer and the chemokine network

Inflammation and cancer

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Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738

Inflammation and cancer: back to Virchow?

Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

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Involvement of chemokine receptors in breast cancer metastasis

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Chemokines

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Tumour-educated macrophages promote tumour progression and metastasis

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Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

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A multigenic program mediating breast cancer metastasis to bone

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QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity

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Leveraging macrophages for cancer theranostics

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Expression of CX3CR1 associates with cellular migration, metastasis, and prognosis in human clear cell renal cell carcinoma

Yao, X., Qi, L., Chen, X., Du, J., Zhang, Z., & Liu, S. (2013) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2012.12.006 · Cited by 53

Sulfopeptide Probes of the CXCR4/CXCL12 Interface Reveal Oligomer-Specific Contacts and Chemokine Allostery

Ziarek, J. J., Getschman, A. E., Butler, S. J., Taleski, D., Stephens, B. S., Kufareva, I., Handel, T. M., Payne, R. J., & Volkman, B. F. (2013) · ACS Chemical Biology · doi:10.1021/cb400274z · Cited by 53

Elucidating a Key Component of Cancer Metastasis: CXCL12 (SDF-1α) Binding to CXCR4

Tamamis, P., & Floudas, C. A. (2014) · Journal of Chemical Information and Modeling · doi:10.1021/ci500069y · Cited by 53

Building Cell Selectivity into CPP-Mediated Strategies

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GPCR Signaling Mediates Tumor Metastasis via PI3Kβ

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Cellular microenvironment modulates the galvanotaxis of brain tumor initiating cells

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Reduced expression of CXCR4, a novel renal cancer stem cell marker, is associated with high-grade renal cell carcinoma

Rasti, A., Abolhasani, M., Zanjani, L. S., Asgari, M., Mehrazma, M., & Madjd, Z. (2016) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-016-2239-8 · Cited by 54

Pathophysiology of bone metastases from solid malignancies

Clézardin, P. (2017) · Joint Bone Spine · doi:10.1016/j.jbspin.2017.05.006 · Cited by 53

Insulin‐like growth factor‐1 signaling is responsible for cathepsin G‐induced aggregation of breast cancer MCF ‐7 cells

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Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer

Ma, J., Sun, X., Su, H., Chen, Q., Guo, T., Li, Y., Chen, X.-C., Guo, J., Gong, Z., Zhao, X., et al. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i28.5167 · Cited by 53

Neural precursor cell–secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity

Feo, D. D., Merlini, A., Brambilla, E., Ottoboni, L., Laterza, C., Menon, R., Srinivasan, S., Farina, C., Manteiga, J. M. G., Butti, E., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92387 · Cited by 54

Prognostic significance of CXCL5 expression in cancer patients: a meta-analysis

Hu, B., Fan, H., Lv, X., Chen, S., & Shao, Z. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0562-7 · Cited by 54

Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 over-expression

Grigorakaki, C., Morceau, F., Chateauvieux, S., Dicato, M. A., & Diederich, M. F. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.03.030 · Cited by 57

Chemokine Receptor CCR7 Expression Correlates with Lymph Node Metastasis in Pancreatic Cancer

Nakata, B., Fukunaga, S., Noda, E., Amano, R., Yamada, N., & Hirakawa, K. (2008) · Oncology · doi:10.1159/000139126 · Cited by 53

Angiogenesis as an immunopharmacologic target in inflammation and cancer

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Cysteine-Rich 61 (CCN1) Enhances Chemotactic Migration, Transendothelial Cell Migration, and Intravasation by Concomitantly Up-Regulating Chemokine Receptor 1 and 2

Lin, B.-R., Chang, C.-C., Chen, L.-R., Wu, M.-H., Wang, M.-Y., Kuo, I.-H., Chu, C.-Y., Chang, K.-J., Lee, P.-H., Chen, W.-J., et al. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0289 · Cited by 51

Macrophages, Neutrophils, and Cancer: A Double Edged Sword

Mantovani, A. (2014) · New Journal of Science · doi:10.1155/2014/271940 · Cited by 55

Computational Intelligence for Medical Imaging Simulations

Chang, V. I. C. (2017) · Journal of Medical Systems · doi:10.1007/s10916-017-0861-x · Cited by 52

Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity

Saxena, S., & Singh, R. K. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09970-6 · Cited by 54

Chemokines driven ovarian cancer progression, metastasis and chemoresistance: Potential pharmacological targets for cancer therapy

Bose, S., Saha, P., Chatterjee, B., & Srivastava, A. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.03.028 · Cited by 52

CCL2 overexpression is associated with paclitaxel resistance in ovarian cancer cells via autocrine signaling and macrophage recruitment

Yang, Y., Wang, Y., Ahn, J., Kim, B., & Choi, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113474 · Cited by 52

A pilot study on reparixin, a CXCR1/2 antagonist, to assess safety and efficacy in attenuating ischaemia–reperfusion injury and inflammation after on-pump coronary artery bypass graft surgery

Opfermann, P. L., Derhaschnig, U., Felli, A., Wenisch, J. M., Santer, D., Zuckermann, A. O., Dworschak, M., Jilma, B., & Steinlechner, B. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12488 · Cited by 52

Roles of CXCL8 in squamous cell carcinoma proliferation and migration

Christofakis, E. P., Miyazaki, H., Rubink, D. S., & Yeudall, W. A. (2008) · Oral Oncology · doi:10.1016/j.oraloncology.2007.12.002 · Cited by 52

Inhalation of sulfur mustard causes long-term T cell-dependent inflammation: Possible role of Th17 cells in chronic lung pathology

Mishra, N. C., Rir-sima-ah, J., Grotendorst, G. R., Langley, R. J., Singh, S. P., Gundavarapu, S., Weber, W., Peña-Philippides, J. C., Duncan, M. R., & Sopori, M. L. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.03.010 · Cited by 55

Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer

Baird, A., Gray, S. G., & O'Byrne, K. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014593 · Cited by 52

The role of cytokines in acute myeloid leukemia: A systematic review

Kupsa, T., Horáček, J. M., & Jebavý, L. (2012) · Biomedical Papers · doi:10.5507/bp.2012.108 · Cited by 50

Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer

Chen, J., Lan, T., Zhang, W., Dong, L., Kang, N., Zhang, S., Fu, M., Liu, B., Liu, K., & Zhan, Q. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1062 · Cited by 52

Roles of Tristetraprolin in Tumorigenesis

Park, J., Lee, T.-H., & Kang, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113384 · Cited by 51

Pivotal Involvement of the CX3CL1-CX3CR1 Axis for the Recruitment of M2 Tumor-Associated Macrophages in Skin Carcinogenesis

Ishida, Y., Kuninaka, Y., Yamamoto, Y., Nosaka, M., Kimura, A., Furukawa, F., Mukaida, N., & Kondo, T. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.02.023 · Cited by 52

Differential Expression of Chemokine Receptors on Uveal Melanoma Cells and Their Metastases

Li, H., ALIZADEH, H. M., & Niederkorn, J. Y. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1035 · Cited by 54

Functions of tumorigenic and migrating cancer progenitor cells in cancer progression and metastasis and their therapeutic implications

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Down-regulation of PKCzeta expression inhibits chemotaxis signal transduction in human lung cancer cells.

Liu, Y., Wang, B., Wang, J., Wan, W.-Z., Sun, R., Zhao, Y.-L., & Zhang, N. (2009) · Lung Cancer · doi:10.1016/j.lungcan.2008.05.010 · Cited by 47

CXCL3 overexpression promotes the tumorigenic potential of uterine cervical cancer cells via the MAPK/ERK pathway

Qi, Y., Li, Y., Man, X., Sui, H., Zhao, X., Zhang, P., Qu, X., Zhang, H., Wang, B., Li, J., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29353 · Cited by 53

An emerging paradigm of CXCL12 involvement in the metastatic cascade

Anastasiadou, D. P., Quesnel, A., Duran, C. L., Filippou, P. S., & Karagiannis, G. S. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.10.003 · Cited by 56

The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer

Chen, L., Huang, Z., Yao, G., Lyu, X., Li, J., Hu, X., Cai, Y., Li, W., Li, X., & Ye, C. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0521-1 · Cited by 51

CD117+ cells in the circulation are predictive of advanced prostate cancer

Kerr, B. A., Miocinovic, R., Smith, A. K., West, X. Z., Watts, K. E., Alzayed, A. W., Klink, J. C., Mir, M. C., Sturey, T., Hansel, D. E., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2796 · Cited by 51

ADAM‐mediated amphiregulin shedding and EGFR transactivation

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Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival

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Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling

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The CCL3 Family of Chemokines and Innate Immunity Cooperate In Vivo in the Eradication of an Established Lymphoma Xenograft by Rituximab

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1,2,3,4-Tetrahydroisoquinoline (THIQ) as privileged scaffold for anticancer de novo drug design

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Gliomas: Genetic alterations, mechanisms of metastasis, recurrence, drug resistance, and recent trends in molecular therapeutic options

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MCP-1 promotes invasion and adhesion of human ovarian cancer cells.

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p53-dependent expression of CXCR5 chemokine receptor in MCF-7 breast cancer cells

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Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis

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A forward loop between glioma and microglia: Glioma‐derived extracellular matrix‐activated microglia secrete IL‐18 to enhance the migration of glioma cells

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Unconventional cytokine profiles and development of T cell memory in long-term survivors after cancer vaccination

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CXC Receptor and Chemokine Expression in Human Meningioma

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Prognostic impact of CXCR4 and CXCR7 expression in pancreatic adenocarcinoma

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Plerixafor: A chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation after high-dose chemotherapy for non-hodgkin's lymphoma or multiple myeloma

Steinberg, M., & Silva, M. J. (2010) · Clinical Therapeutics · doi:10.1016/j.clinthera.2010.05.007 · Cited by 50

Tumor Microenvironment and Angiogenic Blood Vessels Dual-Targeting for Enhanced Anti-Glioma Therapy

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Distinct signatures of B‐cell homeostatic and activation‐dependent chemokine receptors in the development and progression of extragastric MALT lymphomas

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Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia

Gao, X., Qin, S., Wu, Y., Chu, C., Jiang, B., Johnson, R. H., Kuang, D., Zhang, J., Wang, X., Mehta, A. S., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143119 · Cited by 48

Roles of RNA-binding proteins in immune diseases and cancer

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The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening

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CCR5 blockage by maraviroc induces cytotoxic and apoptotic effects in colorectal cancer cells

Pervaiz, A., Ansari, S. S., Berger, M. R., & Adwan, H. (2015) · Medical Oncology · doi:10.1007/s12032-015-0607-x · Cited by 49

Hepatocyte growth factor in invasive growth of carcinomas

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Stress-Adaptive Response in Ovarian Cancer Drug Resistance

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Epithelial mesenchymal transition induced by the CXCL9/CXCR3 axis through AKT activation promotes invasion and metastasis in tongue squamous cell carcinoma

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CXCL-13 Regulates Resistance to 5-Fluorouracil in Colorectal Cancer

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Effective Treatments for Bladder Cancer Affecting CXCL9/CXCL10/CXCL11/ CXCR3 Axis: A Review

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Molecular approaches for targeted drug delivery towards cancer: A concise review with respect to nanotechnology

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Hormone receptor-independent CXCL10 production is associated with the regulation of cellular factors linked to breast cancer progression and metastasis

Ejaeidi, A. A., Craft, B. S., Puneky, L. V., Lewis, R. E., & Cruse, J. M. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.06.002 · Cited by 49

Colorectal Cancer: The Contribution of CXCL12 and Its Receptors CXCR4 and CXCR7

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Prospects for targeting ACKR1 in cancer and other diseases

Crawford, K. S., & Volkman, B. F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1111960 · Cited by 52

Chemokine receptor CCR6 as a prognostic factor after hepatic resection for hepatocellular carcinoma

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Immunological milieu in mycosis fungoides and S ézary syndrome

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The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep

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CXCL14 antagonizes the CXCL12-CXCR4 signaling axis

Hara, T., & Tanegashima, K. (2014) · BioMolecular Concepts · doi:10.1515/bmc-2014-0007 · Cited by 48

Tissue Plasminogen Activator Potently Stimulates Pleural Effusion via a Monocyte Chemotactic Protein-1–Dependent Mechanism

Lansley, S. M., Cheah, H. M., della Vergiliana, J. F. V., Chakera, A., & Lee, G. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0017oc · Cited by 48

CXCL12 Does Not Attract CXCR4+ Human Metastatic Neuroblastoma Cells: Clinical Implications

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Circulating levels of transforming growth factor-βeta (TGF-β) and chemokine (C-X-C motif) ligand-1 (CXCL1) as predictors of distant seeding of circulating tumor cells in patients with metastatic breast cancer.

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The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma

Stronach, E. A., Cunnea, P., Turner, C. J., Güney, T. G., Aiyappa‐Maudsley, R., Jeyapalan, S., de Sousa, C. H., Browne, A. L., Magdy, N., Studd, J. B., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3415 · Cited by 47

A prognostic classifier consisting of 17 circulating cytokines is a novel predictor of overall survival for metastatic colorectal cancer patients

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Involvement of the nuclear factor-κB signaling pathway in the regulation of CXC chemokine receptor-4 expression in neuroblastoma cells induced by tumor necrosis factor-α

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Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4

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Type I interferons inhibit the generation of tumor-associated macrophages

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USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity

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Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF‐α

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